The synthesis and biological characterisation of high affinity, selective macrocyclic ligands targeting the CREBBP/p300 bromodomains by Boyd, AM

“…The work presented herein attempts to overcome this decrease in affinity through SAR investigation, identifying compound <strong>19</strong> as a high-affinity and highly selective macrocyclic ligand for the CBPBRD.…”

Interfacial characterization of SLM parts in multi-material processing : intermetallic phase formation between AlSi10Mg and C18400 copper alloy by Sing, Swee Leong, Lam, Lit Ping, Zhang, Dan Qing, Liu, Zhong Hong, Chua, Chee Kai

“…Multi-material processing in selective laser melting (SLM) using AlSi10Mg and UNS C18400 copper alloy was carried out. …”
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A flat carborane with multiple aromaticity beyond Wade–Mingos’ rules by Lu, Wei, Do, Dinh Cao Huan, Kinjo, Rei

“…Herein, we report the synthesis of a C2B4R4 carborane 2 featuring a flat ribbon-like structure. The C2B4 core of 2 bearing 16 skeletal electrons in the singlet-ground state defies both the [4n + 2] Hückel’s rule and Baird’s rule. …”
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Synthesis of a π-extended azacorannulenophane enabled by strain-induced 1,3-dipolar cycloaddition by Zhang, Xinjiang, Mackinnon, Marc R., Bodwell, Graham J., Ito, Shingo

“…The first example of a cyclophane bearing a nitrogen-containing buckybowl was synthesized via sequential 1,3-dipolar cycloaddition and palladium-catalyzed intramolecular cyclization. …”
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Tribochemical Characterization and Tribocorrosive Behavior of CoCrMo Alloys: A Review by Toh, Wei Quan, Tan, Xipeng, Bhowmik, Ayan, Liu, Erjia, Tor, Shu Beng

“…However, poor design and machinability as well as unsatisfactory surface finish subjected the all-metal joint replacement to being superseded by a polyethylene bearing. Continued improvement in manufacturing techniques together with the reality that polyethylene wear debris can cause hazardous reactions in the human body has brought about the revival of metal-on-metal (MOM) hip joints in recent years. …”
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Analysis of the revolving vane (RV-0) expander, part 1 : experimental investigations by Subiantoro, Alison, Ooi, Kim Tiow

“…The isentropic efficiency was found to be up to 17.5% with the frictional losses caused mainly by the journal bearings.…”
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Development and design of wearable textile antenna on various fabric substrate for unlicensed ultra-wideband applications by Nor Hadzfizah, Mohd Radi, Mohd Muzafar, Ismail, Zahriladha, Zakaria, Jeefferie, Abd Razak, Siti Nur Illia, Abdullah

“…The parameters obtained from the wearable textile antenna are return loss (S-11), directivity, gain, voltage standing wave ratio (VSWR) as well as the specific absorption rate (SAR) value. All these parameters are mostly influenced by the value of substrate dielectric constant and its thickness. …”
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Benzofuran-based estrogen receptor α modulators as anti-cancer therapeutics : in silico and experimental studies by Leow, Min Li, Chin, Christina Hui Li, Yu, Peggy Shuang, Pasunooti, Kalyan Kumar, Tay, Raymond Xu Zhan, Zhang, Dawei, Yoon, Ho Sup, Liu, Xue-Wei

“…The target molecular modelling molecule 1 and a series of 5,6-dihydroxybenzofurans have been synthesized and evaluated for their anti-proliferation activities against MCF-7 and MDA-MB-231 cells. From the SAR studies, potential functional groups have been identified, the two hydroxyl groups at C-5 and C-6 and the phenyl ring at C-2, which showed considerable cytotoxicity in MCF-7 breast cancer cells. …”
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Fire resistance of engineered cementitious composite by Ng, Wee Feng

“…Lastly, it is deduced that steel fibres are able to overcome abrupt failures of specimens after the melting of either PE or PVA fibres. Note that in the discussion of this study, NECC includes NECC-1 and NECC-2, and ECC includes both HSECC and NECC.…”
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Development of innovative refractory tile based on phase change material to improve efficiency of waste energy plant by Tan, Qi Chen

“…Aluminum was chosen as PCM due to favorable properties such as high thermal conductivity, high melting point for high temperature thermal energy storage environment, high latent heat of fusion as well as low cost. …”
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Development of image-based method for the quantitative assessment of cartilage damage from CT as a biomarker in osteoarthritis by Zheng, J-Q

“…</p> <p>The next phase included segmenting the cartilage from aligned CT volumes, utilizing a deep learning segmentation method, the Gate Attention-U-net, for enhanced precision and versatility in cartilage segmentation, achieving an 88% DSC and 9um ASD in the tibia's weight-bearing area.</p> <p>After extracting cartilage shape, we compared the thickness and remaining volume of tibial cartilage in the weight-bearing area with a prior semi-manual method, observing a Pearson correlation coefficient (R value) exceeding 0.8 with the semi-manual method (p&lt;0.0001) and a correlation with OA scores from histological images (p&lt;0.05). …”

Power- and area-efficient analog-to-digital conversion for in-memory computing by Wu, Yiheng

“…In this paper, a monotonic switching SAR ADC is implemented and some improvements are made to its comparator and control logic to reduce the power consumption and silicon area. …”
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The gravity of the status quo: the response of research governance to system-level shocks by Derrick, GE, Robson, J, Oancea, A, Xu, X, Stan, M-R

“…Across all the research systems studied (with particular focus on the UK, Australia, Norway, New Zealand, Hong Kong SAR and Italy), participants were concerned about how the shock provided by COVID-19 had both revealed and entrenched deep inequalities inherent in their research systems and globally. …”

Biological activity and structure–activity relationship of dehydrodieugenol B analogues against visceral leishmaniasis by Amaral, M, Asiki, H, Sear, CE, Singh, S, Pieper, P, Haugland, MM, Anderson, EA, Tempone, AG

“…A structure–activity relationship (SAR) analysis demonstrated a requirement for polar functionalities to improve activity. …”

Fabrication of a rotary MR brake and data collection by Sim, Desmond Huang De.

“…In this report, a finalized design of MR drum rotary brake which consists of 3 main sub-assemblies of external housing comprising of inner housing, rotor, coil holder, bearings and radial shaft seals can therefore ensure to achieve at least 5Nm of torque in the presence of magnetic field. …”
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Magnetic levitation using neodymium magnets for vertical axis wind turbine (VAWT) II by Lai, Chunji

“…Achieving magnetic levitation is the ultimate goal of the project. Bearing this in mind, the author and his partner did their research and study on magnetic levitation especially on the Inductrack system. …”
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Heat assisted magnetic recording (HAMR) head design and simulation by Chaw, Li Huey

“…ANSYS software is used to create a waveguide in the read/write head and thermal simulation is carried out to study the thermal protrusion and temperature distribution at the air bearing surface (ABS).…”
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Impact behaviour of prepreg laminates with dispersed core/shell particles in ply interfaces by Mubarak Ali Mohamed Ali

“…A significant improvement in the energy absorption capability, the impact load bearing capacity, the deflection characteristics of the C/SH modified laminates was observed. …”
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Experimental study on effects of multi-column removal affecting behaviour of RC frames to mitigate progressive collapse by Ye, Da Wei

“…Various studies were conducted in the last decade with majority focusing on instances whereby only a single load bearing member, such as a column, was removed. However, in most real life accidental situations (terrorist attack/ vehicular impact) involving progressive collapse, they will often result in heavy initial impact that will lead to multi-column loss in a RC structure. …”
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Regression analysis ofr characterization of materials for photovoltaic cells by Vundavalli, Bala Satya Manikanta

“…The traditional Design-of-Experiments (DoEs) adapted so far, are slow and the information obtained sometimes bears little relevance to optimizing the key performance parameters of merit. …”
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