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    Synthesis and development of novel small molecule inhibitors of nucleophilic hydrolases by Gayatri

    Published 2024
    “…The PPE inhibitory activity of both thiophene-fused γ-lactams and C6-functionalised benzoxaboroles is further supported by mass spectrometry and crystallographic studies which provide insights into their mechanisms of inhibition involving covalent reaction with the nucleophilic Ser195.</p> <p>Overall, the work presented in this thesis identifies benzoxaboroles and thiophene-fused γ-lactam compounds as promising templates for development of potent covalently reacting small molecule inhibitors of biologically important nucleophilic hydrolases.…”
    Thesis
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