Pyrroloquinoline quinone aza-crown ether complexes as biomimetics for lanthanide and calcium dependent alcohol dehydrogenases by Vetsova, Violeta A., Fisher, Katherine R., Lumpe, Henning, Schäfer, Alexander, Schneider, Erik K., Weis, Patrik, Daumann, Lena J.

“…Lanthanides are the most recent group of metal ions that have been shown to be important in biology, that is, in quinone-dependent methanol dehydrogenases (MDH). …”
Get full text

Time to resolution and effect on quality of life of molluscum contagiosum in children in the UK: a prospective community cohort study by Olsen, JR, Gallacher, J, Finlay, AY, Piguet, V, Francis, NA

“…</p> <p><strong>Interpretation</strong> One in ten children with molluscum contagiosum is likely to have a substantial effect on their quality of life and therefore treatment should be considered for some children, especially those with many lesions or who have been identified as having a severe effect on quality of life. …”

Exploring the regulation of myofilament function in the heart using experimental and computational approaches by Folkmanaite, M

“…Specifically, the regulation of the myofilament by multiple distinct nanodomains has not been investigated. Similarly, the impact of PKA phase separation on myofilament function is unknown. …”

Investigation into ion channel- and nitric oxide-mediated vasodilation in resistance arteries by Wallis, LE

“…While the role of L-type VGCCs has been long established in larger arteries, recent research has highlighted the importance of T-type VGCCs in smaller resistance arteries and their potential involvement in vasodilation. …”

Controlling selectivity in the reductive activation of CO2 by mixed sandwich uranium(iii) complexes by Tsoureas, N, Castro, L, Kilpatrick, A, Cloke, FGN, Maron, L

“…Electrochemical studies on both the uranium(III) complexes and the dimeric uranium(IV) CO2 reduction products have been carried out and all exhibit quasi reversible redox processes; in particular, the similarities in the U(III)/U(IV) redox couples suggest that the selectivity in the outcome of CO2 reductive activation by these complexes is steric in origin rather than electronic. …”

Co-designing the implementation of a rural health systems-strengthening rheumatic heart disease program with remote First Nations Australian communities using Theory of Change by Jones, B, Mitchell, A, Haynes, E, Howard, NJ, Wade, V, Pears, C, Rossingh, B, Gatti, J, Ramadani, S, Corpus, E, Yan, J, Marangou, J, Kaethner, A, Bailey, M, Francis, JR, English, M, Nagraj, S

“…Task-sharing using local healthcare workers, trained to screen for active RHD cases (using handheld ultrasound with remote support from experts), has been proposed as a means of improving early detection whilst also strengthening referral pathways. …”

Social bonding among children in joint physically active play by Jefferies, M

“…Each of these features has been associated with interpersonal affiliation in either human or non-human primates. …”

Molluscum contagiosum and associations with atopic eczema in children: a retrospective longitudinal study in primary care by Olsen, JR, Piguet, V, Gallacher, J, Francis, NA

“…An association between the presence of atopic eczema (AE) and MC has been shown, but the subsequent risk of developing MC in children with a diagnosis of AE is not known.…”

Development of CRISPR gene therapy for retinal degenerations by Fry, LE

“…Gene-supplementation therapies using adeno-associated viral (AAV) vectors have been developed, however, they are limited to the treatment of recessive IRDs and genes with small coding sequences. …”

The influence of polarisation on the behaviour of anions within ion channels and nanopores by Phan, LX

“…Whilst cation channels have been studied in great depth, general mechanisms underlying anion selectivity and permeation within such pores remain unclear. …”

The political psychology of personality and attitudes towards immigrants by Buettner, N

“…Second, I build on Cybernetic Big Five Theory (CB5T), an influential causal, integrative theory which has recently been developed in the field of personality psychology, to derive and subsequently empirically test multiple hypotheses linking personality’s major dimensions of covariation on three levels of CB5T’s personality trait hierarchy to natives’ immigration attitudes based on survey data from the United Kingdom and the United States. …”

Deep brain stimulation of the hypothalamic region: a systematic review by Mofatteh, M, Mohamed, A, Mashayekhi, MS, Skandalakis, GP, Neudorfer, C, Arfaie, S, MohanaSundaram, A, Sabahi, M, Anand, A, Aboulhosn, R, Liao, X, Horn, A, Ashkan, K

“…Background: Deep brain stimulation (DBS) has been successfully used for the treatment of circuitopathies including movement, anxiety, and behavioral disorders. …”

Preterm birth and cardiometabolic health trajectories from birth to adulthood: the Avon Longitudinal Study of Parents and Children by Clayton, GL, Howe, LD, O’Keeffe, LM, Lewandowski, A, Lawlor, DA, Fraser, A

“…Our aim was to compare trajectories of multiple cardiometabolic risk factors from childhood to early adulthood between those who had and had not been born preterm.</p> <br> <p><strong>Methods and Results:</strong> Multilevel models were used to compare trajectories from early childhood (&lt;9 years) to age 25 of BMI, fat and lean mass, systolic and diastolic blood pressure (BP), lipids, glucose and insulin, between individuals born preterm (N=311-676, range 25-36 gestation) and term (N=4973-10534) in a UK birth cohort study. …”

Serological cross-reactivity between Crimean-Congo haemorrhagic fever virus and Nairobi sheep disease virus glycoprotein C by Maze, EA, Booth, G, Limon, G, Belij-Rammerstorfer, S, Tchakarova, SR, Alexandrov, T, Browning, C, Wilsden, G, Ludi, AB, Charleston, B, Lambe, T

“…Crucially, only one seropositive sample to NSDV Gc-specific out of a set of 224 (0.4%) showed a neutralizing capacity at the lowest serum dilution (1:8), suggesting these field sera have not been exposed to NSDV. Based on an analysis of known epitopes in NP targeted by antibodies in sheep serum, we propose that NP is less cross-reactive because dominant epitopes are highly dissimilar between CCHFV and NSDV. …”

The fragmented COVID-19 therapeutics research landscape: a living systematic review of clinical trial registrations evaluating priority pharmacological interventions by McLean, ARD, Rashan, S, Tran, L, Arena, L, Lawal, A, Maguire, BJ, Adele, S, Antonio, ES, Brack, M, Caldwell, F, Carrara, VI, Charles, R, Citarella, BW, Epie, TB, Feteh, VF, Kennon, K, Makuka, GJ, Ngu, R, Nwosu, A-P, Obiesie, S, Ogbonnaa-Njoku, C, Paul, P, Richmond, C, Singh-Phulgenda, S, Strudwick, S, Tyrrell, CSB, Stepniewska, K, Strub-Wourgaft, N, White, NJ, Guérin, PJ

“…<p><strong>Background:</strong> Many available medicines have been evaluated as potential repurposed treatments for coronavirus disease 2019 (COVID-19). …”

Characterising the metabolic functionality of the preterm neonatal gut microbiome prior to the onset of necrotising enterocolitis: a pilot study by Chapman, JA, Wroot, E, Brown, T, Beck, LC, Embleton, ND, Berrington, JE, Stewart, CJ

“…While gut microbiome compositions associated with NEC have been well studied, there is a lack of experimental work investigating microbiota functions and their associations with disease onset. …”

Personalised modelling of geographic movements in depression by Palmius, N

“…<p>It has been estimated that as many as 41% of individuals will experience depression at some point in their lives, a serious and debilitating mental illness. …”

Identifying falsified COVID-19 vaccines by analysing vaccine vial label and excipient profiles using MALDI-ToF mass spectrometry by Arman, BY, Clarke, R, Bharucha, T, Gomez Fernandez, L, Walsby-Tickle, J, Deats, M, Mosca, S, Lin, Q, Banerjee, S, Chunekar, S, Patil, K, Gairola, S, Dunachie, S, Merchant, H, Stokes, R, Kuwana, R, Maes, A, Charrier, J-P, Probert, F, Caillet, C, Matousek, P, McCullagh, J, Newton, P, Zitzmann, N, Gangadharan, B

“…However, these developments are associated with the risk of a surge of substandard and falsified (SF) vaccines, as illustrated by the 184 incidents with SF and diverted COVID-19 vaccines which have been reported during the pandemic in 48 countries, with a paucity of methods for their detection in supply chains. …”

Mobile health (mHealth) interventions for health promotion during the perinatal period in India: a scoping review by Small, Z, Thompson, SE, Sharma, A, Majumdar, S, Thout, SR, Praveen, D, Hirst, JE

“…Many mobile health (mHealth) interventions have been developed to improve maternal and infant health outcomes in India, however it is unclear how mHealth can best support women in this culturally and resource diverse setting. …”

An aerodynamic investigation of a high-pressure turbine using rotor casing static pressure measurements at engine representative conditions with different tip designs, tip gaps and... by Singh, D, Beard, PF, Cardwell, D, Staelens, V, Bahulekar, P, Stokes, M, Bather, S, Chana, KS

“…Since the 1970s, extensive research has been undertaken to understand the over-tip leakage flow, and develop mitigation strategies such as novel tip designs, to minimize the losses and heat load. …”