Somatic gene mutation patterns and burden influence outcomes with enasidenib in relapsed/refractory IDH2-mutated AML by Risueño, A, See, WL, Bluemmert, I, de Botton, S, DiNardo, CD, Fathi, AT, Schuh, AC, Montesinos, P, Vyas, P, Prebet, T, Gandhi, A, Hasan, M

“…We recently reported results from the phase 3 IDHENTIFY trial (NCT02577406) showing improved response rates and event-free survival with enasidenib monotherapy compared with conventional care regimens (CCR) in heavily pretreated, older patients with late-stage R/R AML bearing IDH2 mutations. Here we investigated the prognostic impact of mutational burden and different co-mutation patterns at study entry within the predominant IDH2 variant subclasses, IDH2-R140 and IDH2-R172. …”

inPhocus: current state and challenges of phage research in Singapore by Verma, Navin Kumar, Tan, Si Jia, Chen, John, Chen, Hanrong, Muhammad Hafiz Ismail, Rice, Scott A., Bifani, Pablo, Hariharan, , Sukumar, Paul, , Vivek Daniel, Sriram, Bharathi, Dam, Linh Chi, Chan, Chia Ching, Ho, Peiying, Goh, Boon Chong, Chung, Jasmine Shimin, Goh, Kenneth Choon Meng, Thong, Shu Hua, Kwa, Andrea Lay-Hoon, Ostrowski, Adam, Aung, Thet Tun, Halimah Razali, Low, Shermaine W. Y., Bhattacharyya, Mani Shankar, Gautam, Hemant K., Lakshminarayanan, Rajamani, Sicheritz-Pontén, Thomas, Clokie, Martha R. J., Moreira, Wilfried, van Steensel, Maurice Adrianus Monique

Get full text

Normative modeling of brain morphometry in clinical high risk for psychosis by Haas, Shalaila S., Ge, Ruiyang, Agartz, Ingrid, Amminger, G. Paul, Andreassen, Ole A., Bachman, Peter, Baeza, Inmaculada, Choi, Sunah, Colibazzi, Tiziano, Cropley, Vanessa L., de la Fuente-Sandoval, Camilo, Ebdrup, Bjørn H., Fortea, Adriana, Fusar-Poli, Paolo, Glenthøj, Birte Yding, Glenthøj, Louise Birkedal, Haut, Kristen M., Hayes, Rebecca A., Heekeren, Karsten, Hooker, Christine I., Hwang, Wu Jeong, Jahanshad, Neda, Kaess, Michael, Kasai, Kiyoto, Katagiri, Naoyuki, Kim, Minah, Kindler, Jochen, Koike, Shinsuke, Kristensen, Tina D., Kwon, Jun Soo, Lawrie, Stephen M., Lebedeva, Irina, Lee, Jimmy, Lemmers-Jansen, Imke L. J., Lin, Ashleigh, Ma, Xiaoqian, Mathalon, Daniel H., McGuire, Philip, Michel, Chantal, Mizrahi, Romina, Mizuno, Masafumi, Møller, Paul, Mora-Durán, Ricardo, Nelson, Barnaby, Nemoto, Takahiro, Nordentoft, Merete, Nordholm, Dorte, Omelchenko, Maria A., Pantelis, Christos, Pariente, Jose C., Raghava, Jayachandra M., Reyes-Madrigal, Francisco, Røssberg, Jan I., Rössler, Wulf, Salisbury, Dean F., Sasabayashi, Daiki, Schall, Ulrich, Smigielski, Lukasz, Sugranyes, Gisela, Suzuki, Michio, Takahashi, Tsutomu, Tamnes, Christian K., Theodoridou, Anastasia, Thomopoulos, Sophia I., Thompson, Paul M., Tomyshev, Alexander S., Uhlhaas, Peter J., Værnes, Tor G., van Amelsvoort, Therese A. M. J., van Erp, Theo G. M., Waltz, James A., Wenneberg, Christina, Westlye, Lars T., Wood, Stephen J., Zhou, Juan H., Hernaus, Dennis, Jalbrzikowski, Maria, Kahn, René S., Corcoran, Cheryl M., Frangou, Sophia

“…Importance: The lack of robust neuroanatomical markers of psychosis risk has been traditionally attributed to heterogeneity. A complementary hypothesis is that variation in neuroanatomical measures in individuals at psychosis risk may be nested within the range observed in healthy individuals. …”
Get full text

Alteration of hippocampal CA2 plasticity and social memory in adult rats impacted by juvenile stress by Raghuraman, Radha, Navakkode, Sheeja, Sajikumar, Sreedharan

Get full text

Facial expression quantification and analysis by Ramya Sridharan

“…This dissertation mentions some of the latest techniques available in the above field and proposes two design techniques that exceed the performance of their peers in both technical aspects and applications.…”
Get full text

The Inspiration Design Toolkit: A Human-Centered Design Tool for a System Engineering Course by Lee, Sheng-Hung, Yang, Maria C, Carramolino, Beatriz, Rudnik, John

“…The aim of the IDT is to improve the participants’ learning experience and course engagement, increase opportunities for them to interact with their peers and teaching team, enable them to practice and reinforce the concepts through the creation of their own IDT cards, and share the cards in the discussion to increase learners’ engagement with course material and peers. …”
Get full text

How to Hold a Grudge : From Resentment to Contentment- the Power of Grudges to Transform Your Life / by Hannah, Sophie, 1971- author 649175

“…But aren't we supposed to just forgive, forget, and move on? Bearing a grudge is too negative, right? Wrong! Grudges, when held correctly, are an essential part of a healthy psychological diet. …”

Aminomethylation of enals through carbene and acid cooperative catalysis : concise access to β2-amino acids by Chi, Robin Yonggui, Xu, Jianfeng, Chen, Xingkuan, Wang, Ming, Zheng, Pengcheng, Song, Bao-An

“…This redox-neutral strategy is suitable for the scalable synthesis of enantiomerically enriched β2-amino acids bearing various substituents.…”
Get full text
Get full text
Get full text

Understanding systemic cooling poverty by Mazzone, A, De Cian, E, Falchetta, G, Jani, A, Mistry, M, Khosla, R

“…The poorest and most disadvantaged people, who contributed the least to global warming, are the ones bearing the most severe consequences of extreme heat because of their limited adaptive capacity. …”

A Pilot Study to Evaluate the Relationships between Supine Proprioception Assessments and Upright Functional Mobility by Bellisle, Rachel F., Peters, Brian T., Oddsson, Lars, Wood, Scott J., Macaulay, Timothy R.

“…We developed a tilt board mounted vertically with a horizontal air-bearing sled as a potential supine assessment tool for a future bedrest study. …”
Get full text

Stress analysis and stress intensity factor computation of DNV X65 pipes subjected to four point bending by Lee, Shaun Raphael Kwok Yuen

“…Proposed solution by Baik-Yamada for the shifting in neutral axis as a result of changing area of remaining load bearing ligament is also compared with finite element results. …”
Get full text

Photo-modulable molecular transport junctions based on organometallic molecular wires by Meng, Fanben, Hervault, Yves-Marie, Norel, Lucie, Costuas, Karine, Dyck, Colin Van, Geskin, Victor, Cornil, Jérôme, Hng, Huey Hoon, Rigaut, Stéphane, Chen, Xiaodong

“…Photo-modulable molecular transport junctions are developed via on-wire lithography-fabricated nanogaps functionalized with a dithienylethene unit bearing two ruthenium fragments. A reversible and repeatable bi-state conductive switching upon alternate irradiation of UV and visible light can be distinctly observed. …”
Get full text
Get full text

5G in Singapore : is the tide turning against Huawei? by Anuar, Amalina

“…Along with other countries also opting for non-Chinese 5G equipment, US Secretary of State Mike Pompeo declared this as evidence of Washington’s anti-Huawei campaign bearing fruit.…”
Get full text

Simplified seismic response of earth embankments by Low, Abigail Xiu Jun.

“…This study aims to validate the method proposed by Makdisi and Seed (1979), which provides a simplified procedure for determining the natural period and maximum crest acceleration of homogeneous earth embankments by hand calculation. …”
Get full text

Perceptions of gifted adolescents in Singapore towards the "gifted" label and its effects on their social relationships by Tan, Chee Soon.

“…Some of the disadvantages include high expectations from parents and teachers and being discriminated by peers in the mainstream. Results of case studies parallel these findings.…”
Get full text

Time frequency analysis of functional MR images by Arun Kumar

“…The proposed method is also less tedious than the other commonly used seed-based time-series analysis method, as it does not require pre-identification of brain seed regions. …”
Get full text

Experimental investigation into load settlement characteristics of piled rafts in sand by Leong, Hazel Xueling.

“…Studies by many notable researchers in the years to come suggest that the most effective combinations of piles and raft happens when all the initial loading can be borne with the raft’s bearing capacity alone. The role of the piles was solely to reduce the excessive settlement experienced by the plain raft.…”
Get full text

Dense/porous bioceramic composites by Hu, Yifei

“…The pores were designed for bone ingrowth, whereas the graded pores and the dense cores were introduced for load bearing capability. For bone ingrowth, the porous structures must have a high porosity, a high interconnectivity, and a suitable pore size.…”
Get full text

Signalling through deviance by Teo, Xin Yi, Chia, Gary Yong Wen, Ang, Yan Ting

“…Stimuli were presented in a 2X2 mixed-model design, by manipulating the subjects, whether they are more successful or less successful than their peers, and if the question presented encompasses an identity threat or not. …”
Get full text

Mothers’ social networks and socioeconomic gradients of isolation by Andrew, AR, Attanasio, O, Augsburg, B, Behrman, J, Day, M, Jervis, P, Meghir, C, Phimister, A

“…Wealthier women and women from more-advantaged castes and tribes have smaller networks than their less-advantaged peers, primarily because they know fewer women within their own socioeconomic group. …”