DNA-damage orchestrates self-renewal and differentiation via reciprocal p53 family and Hippo/Wnt/TGF-β pathway activation in embryonic stem cells by Ye, Y, Xie, W, Wang, X, Tan, S, Yang, L, Ma, Z, Zhu, Z, Chen, X, Liu, X, O’Neill, E, Chang, L, Zhang, W

“…Here we show the impact of ionizing irradiation on the maintenance and early differentiation of mouse embryonic stem cells (ESCs). Our findings demonstrate that irradiation induces the upregulation of the p53 family genes, including p53, p63, and p73, resulting in elevated expression of the E3 ubiquitin ligases Itch and Trim32. …”

Numerical investigations of detonation reinitiation and failure modes from Mach reflection by Zhang, S, Lai, S, Tang, S, Yang, L, Qi, F, Fang, X

“…From different geometric parameters of the obstacle, we observe different detonation propagation modes after Mach reflection: detonation reinitiation characterized by the transverse detonation waves, decaying shock decoupled with flame, and inert shock with no ignition corresponding well to the experimental findings. Relying on the high resolution of the numerical simulations, we are able to obtain critical information about the detonation wave formation processes, and the corresponding detailed mechanisms are analyzed for various modes. …”

Resolution of proteotoxic stress in the endoplasmic reticulum by ubiquitin ligase complexes by Lari, F

“…To understand the contribution of ER E3s to cellular and organelle homeostasis, this study used mass spectrometry of purified E3 complexes to identify cofactors and build interaction networks of ER-resident E3s. These findings will form the foundation for investigating the biological roles of these ubiquitin ligases. …”

The attribution of February extremes over North America: a forecast-based storyline study by Lee, D, Sparrow, S, Leach, N, Osprey, S, Lee, J, Allen, M

“…In the globally averaged results, increasing CO₂ concentrations lead to distinct warming signals at the surface, resulting mainly from diabatic heating. Our study finds that CO₂-induced warming eventually affects the possibility of extreme events in North America, quantifying the impact of anthropogenic forcing over less than a week’s forecast simulation. …”

Iranian and Saudi mutual (mis)representations: a study of the relationship between discourses of othering, political confrontation and sectarian strife by Mohammad, T

“…Finally, by investigating three main Iranian and Saudi spheres/discourses, namely the political (speeches of the elite), religious (Friday prayer sermons) and media (newspaper editorials) discourses, this study will try to explain how <em>Othering</em> is understood and functions in the Iranian-Saudi discourse, its relationship to political rivalry and religious conflict and how they are understood as cases of political propaganda or religious polemics.</p> <p>The study findings identify a paradigm shift in analysis of the Saudi-Iranian relationship, moving away from conventional geopolitical and sectarian paradigms, which have been dominant. …”

Experience and perceptions of mental ill-health in people with epilepsy in rural Ethiopia: A qualitative study by Tsigebrhan, R, Newton, CR, Selamu, M, Hanlon, C

“…Participants sought to mitigate these interconnected psychosocial impacts through finding spiritual meaning in, or acceptance of, their experiences, drawing on family care and, for some, emotional support from health professionals. …”

A comparison of lesion mapping analyses based on CT versus MR imaging in stroke by Moore, MJ, Jenkinson, M, Griffanti, L, Huygelier, H, Gillebert, CR, Demeyere, N

“…<br> Overall, these results suggest that CT and MR-derived lesion-symptom mapping results do not reliably differ in accuracy. This finding is critically important as it suggests that future studies can employ CT-derived lesion masks if these scans are available within the appropriate time-window.…”

Characterisation of the genomes of brain metastases by Ulahannan, D

“…Although my sample size was modest the brain metastases had an increased number of copy number alterations in comparison to primary tumours. Furthermore, my findings suggest that chromothripsis may occur more frequently in brain metastases. …”

Community responses to a novel house design: A qualitative study of “Star Homes” in Mtwara, southeastern Tanzania by Mshamu, S, Meta, J, Adhikari, B, Halifa, S, Mmbando, A, Wood, HS, Wood, OS, Bøjstrup, TC, Day, NPJ, Lindsay, SW, Knudsen, J, Deen, J, Seidlein, LV, Pell, C

“…Star Homes residents described how the structures triggered praise but also envy from other community members. Conclusions: The findings highlight the need for close attention to the use of novel design houses and careful sensitization around the potential benefits of dwellings to ensure that the intended health impacts of interventions are achieved.…”

Mendelian Randomization analysis of the causal effect of cigarette smoking on hospital costs by Dixon, P, Sallis, H, Munafo, M, Davey Smith, G, Howe, L

“…</p> <br> <p><strong>CONCLUSIONS:</strong> Our findings have implications for the potential cost-effectiveness of smoking interventions.…”

Of blood and belonging: the practice of antiretroviral treatment among HIV-positive youth in South Africa's Eastern Cape by Vale, B

“…Data for this study was gathered through eight months of multi-method ethnographic fieldwork with 23 HIV-positive youth, their families, and local health workers.</p> <p>The findings elucidate adolescent ART as a complex (and often volatile) form of social incorporation, through which young people negotiate survival, care and moral connection in contemporary South Africa. …”

Risk factors for PTSD symptoms following PICU admission for childhood septic shock by Corbet Burcher, GJ, O’Dea, LA, Cooper, MK, Lancaster, R, McCutcheon, RA, Garralda, ME, Nadel, S

“…PTS symptoms in children who have survived septic shock are prevalent. These findings support a possible contribution of acute inflammatory changes, cumulative traumatic exposure, and female gender in post-PICU PTSD development.…”

Unlocking the gates: pedestrian route choice in transforming metro station paid areas into mobile public spaces by Chan, HY, Tse, W-Y, Chen, A

“…Routes with proprietary underground exits also promote underground usages. These findings reveal how deliberate design, ingrained habits and symbolic meanings collectively shape pedestrian decisions. …”

Lebensphilosophie in Rabbi Avraham Itzhak HaCohen Kook’s thought: the case of Henri Bergson by Amati, G

“…It isolates relevant overlaps between Bergson's philosophy of life and Kook's thought, the findings are then leveraged to provide a new, deeper, and enriched interpretation of Kook's philosophy on these topics, and, in some cases, present original perspectives to resolve existing contradictions in his thought.…”

A generative model for evaluating missing data methods in large epidemiological cohorts by Radosavljević, L, Smith, SM, Nichols, TE

“…We compare our evaluations based on synthetic data to an exemplar study which includes variable selection on a single real imputed dataset, finding only small differences between the imputation methods though with iterative imputation leading to the most informative selection of variables. …”

Adjustable wind selectivity in shearwaters implies knowledge of the foraging landscape by Harris, S, Bishop, C, Bond, S, Fernandes, P, Guilford, T, Lewin, P, Padget, O, Robins, P, Schneider, W, Waggitt, J, Wilmes, S, Cordes, L

“…Finally, birds are also less wind selective during longer continuous periods of flight, presumably also associated with target-oriented movement. Our findings reveal how an animal’s foraging strategy can dynamically optimize the complex trade-off between efficient travel and accessing known foraging areas, implying the incorporation of prior knowledge of the cost-benefit landscape well beyond the range of what can be detected directly. …”

Water resources and extreme events in the Awash basin: economic effects and policy implications: report prepared for the Global Green Growth Institute by Smale, R, Walker, O, Vadheim, B, Hope, R, Hope, R, Charles, K, Hall, J, Dadson, S, Borgomeo, E, Kebede, S, Alamirew, T, Bekele, F, Mengistu, A, Beyene, S

“…<br> Under current economic conditions, the report finds the consequences of hydrological variability to be severe. …”

Level and association of the general public knowledge and attitude on the role of technology in human trafficking: a quantitative study of Pakistan by Khan, Zeeshan, Mohammad Rahim Kamaluddin, Jamiah Manap, Surendran Rajaratnam, Masnizah Mohd, Chong, Ibrahim Maclean, Ratna Yunita Setiyani, Kalaivanan Syasyila

“…The stakeholders must leverage social media platforms to raise awareness about the ways in which human traffickers exploit technology. The findings of this study are also anticipated to enable the international community to achieve the UN Sustainable Development Goals (SDGs 2030), to focus on this new emerging issue to combat online human trafficking and safeguard the general public.…”
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Fostering motivation in TVET students: the role of learner-paced segments and computational thinking in digital video learning by Wan Nor Ashiqin Wan Ali, Wan Ahmad Jaafar Wan Yahaya, Syed Zulkarnain Syed Idrus, Mohd Noorul Fakhri Yaacob

“…Content delivered in the learner-paced mode allows students to progress through segments at their own pace, while the system-paced mode follows a fixed sequence. The findings from ANOVA analysis revealed that students in the learner-paced mode exhibited significantly higher motivation levels than those in the system-paced mode. …”
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News framing of the 2022 Russian-Ukrainian conflict: a comparative analysis of CNN (USA) and CCTV (China) from a war and peace journalism perspective by Wang, Yao, Shahrul Nazmi Sannusi, Shamsiah Abd Kadir

“…Analysing how CNN and CCTV present the conflict from WJ/PJ perspectives helps to facilitate an understanding of how two different media systems might shape their respective audiences’ perceptions according to different ideologies. The findings revealed that CNN mainly focused on “Humanitarian Crisis and Civilian Impacts” and “Military Operations and Strategic”, whereas CCTV predominantly centred on the themes of “Military Operations and Strategic” and “Political Reactions and Stances”. …”
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