16.888 / ESD.77 Multidisciplinary System Design Optimization, Spring 2004 by Willcox, Karen, de Weck, Olivier

“…This course is mainly focused on the quantitative aspects of design and presents a unifying framework called "Multidisciplinary System Design Optimization" (MSDO). …”
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Fatigue in multilayered steels by Kumar, Punit, Msolli, Sabeur, Jhon, Mark H., Ramamurty, Upadrasta

“…While the quasistatic tensile stress-strain responses of both the sheets are nearly-identical, fatigue strength of sheets with austenitic outer layers is substantially higher than those with martensitic layers, due mainly to the nature of residual stress distribution in the two sheets. …”
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Effect of heat treatment on the spheroidisation process of carbon steel by Lam, Jiang Liang

“…In this report, study was done to understand the theory, microstructure and behavior of steel by alloying with different elements, various percentages of elements, and heat treated in different condition. This project will mainly focus on how the heat treatment duration affects the microstructure and hardness of the steel.…”
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Paper or Tablet? The Impact of Digital Tools on Sketching During Engineering Design Concept Generation by Das, Madhurima, Huang, May, Yang, Maria

“…This is especially important as tablets can automatically smooth lines and help perfect sketch features, but these features may also take longer to use and may result in fewer sketches produced.…”
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Selective targeting of MYC mRNA by stabilized antisense oligonucleotides by Gill, Taylor, Wang, Haichuan, Bandaru, Raj, Lawlor, Matthew, Lu, Chenyue, Nieman, Linda T, Tao, Junyan, Zhang, Yixian, Anderson, Daniel G, Ting, David T, Chen, Xin, Bradner, James E, Ott, Christopher J

“…MYCASO treatment of cancer cell lines leads to significant inhibition of cellular proliferation while specifically perturbing MYC-driven gene expression signatures. …”
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Unsupervised Learning for Generative Scene Editing and Motion by Fang, David S.

“…In this thesis, we propose two distinct lines of unsupervised learning work with generative applications: 1) BlobGSN and 2) optical flow estimation and flow generation with diffusion models. …”
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Analysis of subtelomeric virulence gene families in Plasmodium falciparum by comparative transcriptional profiling by Witmer, Kathrin, Schmid, Christoph D., Brancucci, Nicolas M. B., Luah, Yen-Hoon, Preiser, Peter Rainer, Bozdech, Zbynek, Voss, Till S.

“…Here, we analysed promoters of upsA, upsB and upsC var, rifA1-type rif, stevor, phist and pfmc-2tm genes and investigated their role in endogenous gene transcription by comparative genome-wide expression profiling of transgenic parasite lines. We find that the three major var promoter types are functionally equal and play an essential role in singular gene choice. …”
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A rapid CRISPR competitive assay for in vitro and in vivo discovery of potential drug targets affecting the hematopoietic system by Shen, Yunbing, Jiang, Long, Iyer, Vaishnavi Srinivasan, Raposo, Bruno, Dubnovitsky, Anatoly, Boddul, Sanjaykumar V., Kasza, Zsolt, Wermeling, Fredrik

“…Here, we present a rapid and universal experimental approach to functionally analyze a CRISPR-targeted cell population that does not involve generating clonal lines. As a simple readout, we leverage the CRISPR-induced genetic heterogeneity and use sequencing to identify how different genotypes are enriched or depleted in relation to the studied cellular behavior or phenotype. …”
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Elucidating the size-dependency of in vitro digested polystyrene microplastics on human intestinal cells health and function by Ma, Yiyuan, Koh, Cheryl Jie Yan, Lim, Hong Kit, Shi, Pujiang, Tay, Chor Yong

“…Herein, the potential deleterious biological effects of pristine and in vitro digested polystyrene (PS) MPs of varying sizes (i.e., 0.1, 1, and 10 µm) are systematically examined over a wide concentration range of 25–400 µg mL−1 on two human intestinal cell lines, namely Caco-2 and NCM 460. Specifically, significant internalization of 0.1 and 1 µm PS -MPs have been observed in both cell types 24 h postexposure. …”
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Label-free assessment of differentiation efficiency in iPSC-derived spinal cord progenitor cells via Magnetic Resonance Relaxometry (MRR) by Tan, Jerome Zu Yao, Chen, Jiahui, Roxby, Daniel, Chooi, Wai Hon, Nguyen, Tan Dai, Ng, Shi-Yan, Chew, Sing Yian, Han, Jongyoon

“…In this study, human iPSCs derived from Cord Lining Endothelial cells were differentiated into Spinal-cord Progenitor Cells (SCPCs) through a 10-day process. …”
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Flexible integrated sensor with asymmetric structure for simultaneously 3D tactile and thermal sensing by Wang, Yongqing, Sun, Kun, Zhang, Qisheng, Yu, Samson Shenglong, Han, Boon Siew, Wang, Jianpeng, Zhao, Mingyan, Meng, Xianglin, Chen, Sicheng, Zheng, Yuanjin

“…The resistive thermal sensors are fabricated with serpentine lines and possess stable heat-sensing performance (165 mV/°C) under shape deformation conditions. …”
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Luteolin restricts dengue virus replication through inhibition of the proprotein convertase furin by Peng, Minhua, Watanabe, Satoru, Chan, Kitti Wing Ki, He, Qiuyan, Zhao, Ya, Zhang, Zhongde, Lai, Xiaoping, Luo, Dahai, Vasudevan, Subhash G., Li, Geng

“…In addition, ADE-mediated dengue virus infection of human cell lines and primary PBMCs was inhibited. In a time-of-drug-addition study, luteolin was found to reduce infectious virus particle formation, but not viral RNA synthesis, in Huh-7 cells. …”
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Functional analysis of root-preferential oil palm metallothionein promoter in tobacco by Masura, Subhi Siti, Shaharuddin, Noor Azmi, Masani, Mat Yunus Abdul, Chan, Kuang-Lim, Low, Eng-Ti Leslie, Chan, Pek-Lan, Rahmah, Abdul Rahman Siti, Amiruddin, Nadzirah, Abdullah, Mohd Puad, Azzeme, Azzreena Mohamad, Parveez, Ghulam Kadir Ahmad, Abd Rasid, Omar

“…Stable functional characterisation of tobacco transgenic lines using the T1 generation showed that a deletion construct, designated as RSP-2D (1107 bp), directed strong GUS expression at all stages of root development, particularly in mature roots. …”

Determinants of Expatriate Manager Failures in the International Assignment by Mansor, Mohd Fitri, Abd Hamid, Nurzawani, Kamil, Syahida, Abu, Noor Hidayah

“…The international assignment requires an organization send their staff abroad for high potential career development, to coordinate global lines of business, transfer the organization knowledge in abroad, expand into new markets worldwide and also manage an international subsidiary. …”
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Motion and shape recovery from image frame sequences by Sung, Eric.

“…The thesis focuses mainly on motion and structure recovery of an object from a sequence of image frames. …”
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Robust perfluorophenylboronic acid-catalyzed stereoselective synthesis of 2,3-unsaturated O-, C-, N- and S-linked glycosides by Tatina, Madhu Babu, Xia, Mengxin, Rao, Peilin, Judeh, Zaher M. A.

“…Using this protocol, D-glucals and L-rhamnals reacted with various C-, O-, N- and S-nucleophiles to give a wide range of glycosides in up to 98% yields with mainly α-anomeric selectivity. The perflurophenylboronic acid successfully catalyzed a wide range of substrates (both glucals and nucleophiles) under very mild reaction conditions.…”
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Fracture and toughening mechanisms in nanotwinned and nanolayered materials by Zhao, Huaizhi, Li, Zhi, Gao, Huajian, Lu, Lei

“…New stratagems on manipulating both microstructure (such as the size of nanotwin bundles) and mechanics (mainly related to loading orientation with respect to twin boundaries) to mediate the deformation and toughening modes provide promising paths to further optimize the properties of nanotwinned and nanolayered materials.…”
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Understanding and implementing ISO 9001 for the building and civil engineering contracting firms by Tay, Daniel Chin Kwang.

“…This dissertation examines the practical aspect of the development and implementation of quality management system (QMS) according to the IS0 9001 : 1994 standards mainly for building and civil engineering contracting firms.…”
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Design and implementation of a synthesizable test-bench for testing the LDPC decoder IP by Yang, Shi

“…The simulation environment is mainly used for preliminary and functional checks, and the emulation environment is chosen for further verification due to its much higher run speed compared to simulation.…”
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Development of an app for Android phones 3 : Android fitness assistant application by Khairul Anwar Ishak

“…This Final Year Project (FYP) is on the development of an Android application named ‘QuickFit’. The application is mainly created to serve as a fitness assistant, in order to encourage the adoption of an active lifestyle, especially for young adults who lack the time or knowledge to do so. …”
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