Centrioles generate two scaffolds with distinct biophysical properties to build mitotic centrosomes by Wong, S-S, Monteiro, JM, Chang, C-C, Peng, M, Mohamad, N, Steinacker, TL, Xiao, B, Saurya, S, Wainman, A, Raff, JW

“…Here, we show that Drosophila Spd-2 (human CEP192) fluxes out from centrioles, recruiting Polo and Aurora A kinases to catalyze the assembly of two distinct mitotic-PCM scaffolds: a Polo-dependent Cnn scaffold, and an Aurora A–dependent TACC scaffold, which exhibit solid- and liquid-like behaviors, respectively. Both scaffolds can independently recruit PCM proteins, but both are required for proper centrosome assembly, with the Cnn scaffold providing mechanical strength, and the TACC scaffold concentrating centriole and centrosome proteins. …”

A regulatory SNP causes a human genetic disease by creating a new transcriptional promoter by De Gobbi, M, Viprakasit, V, Hughes, JR, Fisher, C, Buckle, V, Ayyub, H, Gibbons, RJ, Vernimmen, D, Yoshinaga, Y, de Jong, P, Cheng, J-F, Rubin, EM, Wood, Wg, Bowden, D, Higgs, DR

“…The rSNP creates a new promoterlike element that interferes with normal activation of all downstream α-like globin genes. Thus, our work illustrates a strategy for distinguishing between neutral and functionally important rSNPs, and it also identifies a pathogenetic mechanism that could potentially underlie other genetic diseases.…”

Specialized replication mechanisms maintain genome stability at human centromeres by Scelfo, A, Angrisani, A, Grillo, M, Barnes, BM, Muyas, F, Sauer, CM, Leung, CWB, Dumont, M, Grison, M, Mazaud, D, Garnier, M, Guintini, L, Nelson, L, Esashi, F, Cortés-Ciriano, I, Taylor, SS, Déjardin, J, Wilhelm, T, Fachinetti, D

“…Prolonged stress causes centromeric alterations like ruptures and translocations, as observed in ovarian cancer models experiencing replication stress. …”

A survey of few-shot learning for biomedical time series by Li, C, Denison, T, Zhu, T

“…An emerging approach to overcome the scarcity of labeled data is to augment AI methods with human-like capabilities to leverage past experiences to learn new tasks with limited examples, called few-shot learning. …”

Strike a pose: tracking people by finding stylized poses by Ramanan, D, Forsyth, DA, Zisserman, A

“…Our basic assumption is that people tend to take on certain canonical poses, even when performing unusual activities like throwing a baseball or figure skating. We build a person detector that quite accurately detects and localizes limbs of people in lateral walking poses. …”

Lost in quantization: improving particular object retrieval in large scale image databases by Philbin, J, Chum, O, Isard, M, Sivic, J, Zisserman, A

“…Our results exceed the current state of the art retrieval performance on these datasets, particularly on queries with poor initial recall where techniques like query expansion suffer. Overall we show that soft-assignment is always beneficial for retrieval with large vocabularies, at a cost of increased storage requirements for the index.…”

Ant, spider and DNA: letting mindless generative mechanisms speak by Bråten, E

“…ANT and SPIDER share a blindness with respect to invisible beings like itself, DNA argues. Their privileging of spatiotemporal immediacy entails a one-dimensional (flat) ontology that tends to push mindless generative mechanisms out of view. …”

Baturaja inscription: a threats to Miańga by Andhifani, Wahyu Rizky, Tedjowasono, Ninny Susanti

“…This inscription, if seen from its paleographic form, most likely originates from around the VII century, like the early inscriptions of the Sriwijaya Kingdom, namely: the Kedukan Bukit inscription, the Talang Tuwo inscription, the Telaga Batu inscription, the Kota Kapur inscription, the Karang Brahi inscription, the Palas Pasemah inscription, and some the short Siddhayatra inscription. …”
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Thismia perlisensis (Thismiaceae), a new red-annulus Thismia species from Peninsular Malaysia by Besi, Edward Entalai, Mad Jabar, Qistina Anis, Abd Rahman, Syamil, Saad, Mohd Zulkifly, Ag Ahmadni, Ag Shaffie, Go, Rusea

“…The new species is easily distinguished from the similar species, T. arachnites, T. javanica, T. tentaculata, and T. kenyirensis by the prominent reddish dome-shaped annulus instead of ring-like with rim, deeply trilobed stigma with bifid and subulate lobes, and claviform apices of the inner tepals.…”
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The Role of Institutional Trust and Political Accountability in Pakistan: An Empirical Study by Sadiq, Saiqa, Mohd. Zain, Zawiyah, Ajis, Mohd Na'eim

“…However, data is thematically analyzed, that is expedient technique for multiethnic country like Pakistan. Therefore, it is find out that weak political accountability and lower government performance have robust trust eroding effects in Pakistan.Thus the overall results are categorical about people lacking trust over political accountability institutions…”
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Developing Animation Projects that Foster Student's Creativity: An Application of Design Thinking Process (S/O 14722) by Mohd Suki, Norbayah, Mohd Suki, Norazah, Ahmad, Rosliza

“…Minimal research has been investigated on nurturing students' behavioural intention and actual usage of creative animation using design thinking as the digital social innovation agent to foster creativity at tertiary level within Malaysia context, particularly from the aspects like performance expectancy, effort expectancy, social influence, and facilitating conditions. …”
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When mobile phone use becomes problematic : the influence of self, parents and peers on adolescents' mobile phone behavior in Singapore and Malaysia by Chuah, Soo Fei

“…This study found that adolescents with higher neuroticism trait and lower levels of self-control are more likely to involve in problematic mobile phone use. …”
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Evaluation of oil palm frond for biobutanol production by different Clostridia species by Abubakar, Abdurrahman, Md Salleh, Madihah, Yahya, Adibah, Hussin, Huszalina, Shiong, Chong Chun, Mohamad, Shaza Eva, Abd Aziz, Suraini

“…Fermentation inhibitors like gallic and ferulic acids were also detected in the juice using the HPLC technique, and their concentrations also increased with age. …”

A grid-based HIV expert system by Sloot, Peter M. A., Boukhanovsky, Alexander V., Boucher, Charles A. B., Keulen, Wilco.

“…Access to and integration of data is done through existing Internet servers and emerging grid-based frameworks like Globus. Data presentation is done by standalone PC based software, Web-access and PDA roaming WAP access. …”
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Blockchain and federated learning for data sharing in vehicular network by Qiu, Stanley

“…The blockchain primarily utilizes the principle of distributed consensus in its core, making it robustly reliable even in network systems with multi-millions of users with competing self-interests like in Ethereum or Bitcoin. This report endeavors to simulate a federated machine learning framework implemented in an internet of vehicles (IoV), with 2 classes of participating nodes: vehicles, and road side units (RSU). …”
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Developing optogenetics for use in vascular research by Rorsman, N

“…Isolated SMCs obtained from these mice demonstrated blue light induced depolarising whole-cell currents. Fine control of artery tone was attained by varying the intensity of the blue light stimulus. …”

Enhanced simulation of atmospheric blocking in a high-resolution earth system model: projected changes and implications for extreme weather events by Gao, Y, Guo, X, Lu, J, Woollings, T, Chen, D, Guo, X, Wu, L

“…This increase in summer blocking could exacerbate summer heatwaves in a warming climate, making severe heatwaves, like those observed recently, more common in the future.…”

Tracking people by learning their appearance by Ramanan, D, Forsyth, DA, Zisserman, A

“…But, finding people and localizing their limbs is hard because people can move fast and unpredictably, can appear in a variety of poses and clothes, and are often surrounded by limb-like clutter. We develop a completely automatic system that works in two stages; it first builds a model of appearance of each person in a video and then it tracks by detecting those models in each frame ("tracking by model-building and detection"). …”

Performance-based identity in a BIM environment : An architect’s perceptions and experiences by Syafizal, Shahruddin, Mohd, Zairul, Ahmad Tarmizi, Haron, Meor Mohammad, Fared

“…Findings: The data analysis resulted in the following five performance identity themes that revolve around the core identity of a successful designer: “performing as a design strategist”, “performing as a design translator”, “performing as a design facilitator”, “reinstating the identity of a design coordinator” and “performing as a design innovator”. …”
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Identification of potent new brain cancer EGFR inhibitor from usimine A and usimine B: computer-aided drug design perspective by Roney, Miah, Issahaku, Abdul Rashid, Wilhelm, Anke, Mohd Fadhlizil Fasihi, Mohd Aluwi

“…This compound exhibited five hydrogen bonds with the residues of Leu792, Met793, Asn842, Thr854, and Val843 in the active site of EGFR protein. …”
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