A standardised fraction 1 (SF1) from clinacanthus nutans attenuates the stemness of cervical cancer stem-like cells via inhibition of notch1 signalling by Ismail, Faridah

“…Bioassay guided fractionation was employed for the isolation of SF1 from C. nutans leaf extract. The SiHa cell line was used for the enrichment of CCSCs by culturing the cells in CSC-conditioned medium (cervospheres). …”
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Dysregulation of the Pdx1/Ovol2/Zeb2 axis in dedifferentiated β-cells triggers the induction of genes associated with epithelial-mesenchymal transition in diabetes by de Jesus, Daniel S., Mak, Tracy C. S., Wang, Yi-Fang, von Ohlen, Yorrick, Bai, Ying, Kane, Eva, Chabosseau, Pauline, Chahrour, Catherine M., Distaso, Walter, Salem, Victoria, Tomas, Alejandra, Stoffel, Markus, Rutter, Guy A., Latreille, Mathieu

“…We carried out loss- and gain-of-function experiments in MIN6 and EndoC-bH1 cell lines. We analysed previously published mouse andhuman T2D data sets.Results:Bulk RNA-seq revealed thatb-cell dedifferentiation is associated with the induction of genes associated with epithelial-to-mesenchymal transition (EMT) in prediabetic (2-week-old) and diabetic (12-week-old) Tg7 mice. …”
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Novel method of probe design for characterising unclassified microbial taxa in wastewater by Tan, Shi Ming

“…Shimingles; distinct clades were in line with two draft genomes recovered through genomic binning. …”
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Use of smartphones to detect diabetic retinopathy : scoping review and meta-analysis of diagnostic test accuracy studies by Tan, Choon Han, Kyaw, Bhone Myint, Smith, Helen, Tan, Colin Siang Hui, Car, Lorainne Tudor

“…This review is reported in line with the Preferred Reporting Items for a Systematic Review and Meta-analysis of Diagnostic Test Accuracy Studies guidelines. …”
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Individual-fMRI-approaches reveal cerebellum and visual communities to be functionally connected in obsessive compulsive disorder by Kashyap, Rajan, Eng, Goi Khia, Bhattacharjee, Sagarika, Gupta, Bhanu, Ho, Roger, Ho, Cyrus S. H., Zhang, Melvyn, Mahendran, Rathi, Sim, Kang, Chen, Annabel Shen-Hsing

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Plasmonic semiconductor nanogroove array enhanced broad spectral band millimetre and terahertz wave detection by Tong, Jinchao, Suo, Fei, Zhang, Tianning, Huang, Zhiming, Chu, Junhao, Zhang, Dao Hua

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Tracking oxidation-induced alterations in fibrin clot formation by NMR-based methods by Lau, Wai-Hoe, White, Nathan J., Yeo, Tsin Wen, Gruen, Russell L., Pervushin, Konstantin

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Atypical DNA methylation, sRNA-size distribution, and female gametogenesis in Utricularia gibba by Cervantes-Pérez, Sergio Alan, Yong-Villalobos, Lenin, Florez-Zapata, Nathalia M. V., Oropeza-Aburto, Araceli, Rico-Reséndiz, Félix, Amasende-Morales, Itzel, Lan, Tianying, Martínez, Octavio, Vielle-Calzada, Jean Philippe, Albert, Victor A., Herrera-Estrella, Luis

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Shaped Bessel beam singulation of glass substrates by Chia, Hao Guang

“…However, the heat generated can cause chipping and debris along the cut line. In addition, the area surrounding the cut often has heat damage, which alters the material's mechanical properties. …”
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Development of reconstructed intestinal micronucleus cytome (RICyt) assay in 3D human gut model for genotoxicity assessment of orally ingested substances by Lim, Hui Kheng, Hughes, Christopher Owen, Lim, Michelle Jing Sin, Li, Jia'En Jasmine, Rakshit, Moumita, Yeo, Calvin, Chng, Kern Rei, Li, Angela, Chan, Joanne Sheot Harn, Ng, Kee Woei, Leavesley, David Ian, Smith, Benjamin Paul Chapman

“…Micronucleus assays typically utilise homogenous in vitro cell lines which poorly recapitulate the physiology, biochemistry and genomic events in the gut, the site of first contact for ingested materials. …”
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Ecosystem productivity has a stronger influence than soil age on surface soil carbon storage across global biomes by Plaza, César, García-Palacios, Pablo, Berhe, Asmeret Asefaw, Barquero, Jesús, Bastida, Felipe, Png, Kenny Guochen, Rey, Ana, Bardgett, Richard D., Delgado-Baquerizo, Manuel

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Signalling inhibition by ponatinib disrupts productive alternative lengthening of telomeres (ALT) by Kusuma, Frances Karla, Prabhu, Aishvaryaa, Tieo, Galen, Syed Moiz Ahmed, Dakle, Pushkar, Yong, Wai Khang, Pathak, Elina, Madan, Vikas, Jiang, Yan Yi, Tam, Wai Leong, Kappei, Dennis, Dröge, Peter, Koeffler, H. Phillip, Jeitany, Maya

“…By performing anti-cancer compound library screen on isogenic cell lines and using extrachromosomal telomeric C-circles, as a bona fide marker of ALT activity, we identify a receptor tyrosine kinase inhibitor ponatinib that deregulates ALT mechanisms, induces telomeric dysfunction, reduced ALT-associated telomere synthesis, and targets, in vivo, ALT-positive cells. …”
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NHC-catalyzed enantioselective access to β-cyano carboxylic esters via in situ substrate alternation and release by Wang, Qingyun, Wu, Shuquan, Zou, Juan, Liang, Xuyang, Mou, Chengli, Zheng, Pengcheng, Chi, Robin Yonggui

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Trajectory of immune evasion and cancer progression in hepatocellular carcinoma by Nguyen, Phuong H. D., Wasser, Martin, Tan, Chong Teik, Lim, Chun Jye, Lai, Hannah L. H., Seow, Justine Jia Wen, DasGupta, Ramanuj, Phua, Cheryl Z. J., Ma, Siming, Yang, Jicheng, Sheena D/O Suthen, Tam, Wai Leong, Lim, Tony K. H., Yeong, Joe, Leow, Wei Qiang, Pang, Yin Huei, Soon, Gwyneth, Loh, Tracy Jiezhen, Wan, Wei Keat, Chan, Chung Yip, Cheow, Peng Chung, Toh, Han Chong, Kow, Alfred, Dan, Yock Young, Kam, Juinn Huar, Iyer, Shridhar, Madhavan, Krishnakumar, Chung, Alexander, Bonney, Glenn K., Goh, Brian K. P., Fu, Naiyang, Yu, Victor C., Zhai, Weiwei, Albani, Salvatore, Chow, Pierce K. H., Chew, Valerie

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A conserved MTMR lipid phosphatase increasingly suppresses autophagy in brain neurons during aging by Kovács, Tibor, Szinyákovics, Janka, Billes, Viktor, Murányi, Gábor, Varga, Virginia B., Bjelik, Annamária, Légrádi, Ádám, Szabó, Melinda, Sándor, Sára, Kubinyi, Enikő, Szekeres-Paracky, Cecília, Szocsics, Péter, Lőke, János, Mulder, Jun, Gulyás, Balázs, Renner, Éva, Palkovits, Miklós, Gulya, Károly, Maglóczky, Zsófia, Vellai, Tibor

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Synergistic-potential engineering enables high-efficiency graphene photodetectors for near- to mid-infrared light by Jiang, Hao, Fu, Jintao, Wei, Jingxuan, Li, Shaojuan, Nie, Changbin, Sun, Feiying, Wu, Steve Qing Yang, Liu, Mingxiu, Dong, Zhaogang, Wei, Xingzhan, Gao, Weibo, Qiu, Cheng-Wei

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Scalable multifunctional MOFs-textiles via diazonium chemistry by Li, Wulong, Yu, Zhen, Zhang, Yaoxin, Lv, Cun, He, Xiaoxiang, Wang, Shuai, Wang, Zhixun, He, Bing, Yuan, Shixing, Xin, Jiwu, Liu, Yanting, Zhou, Tianzhu, Li, Zhanxiong, Tan, Swee Ching, Wei, Lei

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Pre-failure strain localization in siliclastic rocks: a comparative study of laboratory and numerical approaches by Bianchi, Patrick, Selvadurai, Paul Antony, Zilio, Dal Luca, Vásquez, Antonio Salazar, Madonna, Claudio, Gerya, Taras, Wiemer, Stefan

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Electrochemical kinetic energy harvesting mediated by ion solvation switching in two-immiscible liquid electrolyte by Lee, Donghoon, Song, You-Yeob, Wu, Angyin, Li, Jia, Yun, Jeonghun, Seo, Dong-Hwa, Lee, Seok Woo

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Metasurface-enabled broadband multidimensional photodetectors by Jiang, Hao, Chen, Yinzhu, Guo, Wenyu, Zhang, Yan, Zhou, Rigui, Gu, Mile, Zhong, Fan, Ni, Zhenhua, Lu, Junpeng, Qiu, Cheng-Wei, Gao, Weibo

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