Exploring the regulation of myofilament function in the heart using experimental and computational approaches by Folkmanaite, M

“…Dysregulation of cAMP-dependent, PKA-mediated phosphorylation of myofilament proteins, such as troponin I (TNI) and myosin binding protein C (MYBPC), contributes to cardiac pathologies like heart failure. Current therapies, such as beta-blockers and phosphodiesterase (PDE) inhibitors, often lack specificity and have adverse effects. …”

A population-based cohort study examining the incidence and impact of psychotic experiences from childhood to adulthood, and prediction of psychotic disorder by Sullivan, SA, Kounali, D, Cannon, M, David, AS, Fletcher, PC, Holmans, P, Jones, H, Jones, PB, Linden, DEJ, Lewis, G, Owen, MJ, O'Donovan, M, Rammos, A, Thompson, A, Wolke, D, Heron, J, Zammit, S

“…<p><strong>Methods:</strong></p> This was a population-based cohort study using the semistructured Psychosis-Like Symptoms Interview at ages 12, 18, and 24 (N=7,900 with any data). …”

Addressing inequities in research for early to mid-career women scientists in low- and middle-income countries: “Supporting Women in Science” programme by Das, JK, Raza, M, Padhani, ZA, Hussain, NF, Villar, J, Kennedy, S, Bhutta, ZA

“…Capacity-building initiatives like SWIS are crucial interventions to empower women scientists, foster equitable representation in academia, and create inclusive research environments and the programme acts as a steppingstone for future global leaders.…”

The critical role of IL-23 receptor positive T cells in the pathogenesis of anterior uveitis associated with spondyloarthropathy by Hedley, R

“…Consistent with the concept of IL-23 being a unifying factor in SpA, I show that like the gut, skin, and joints - IL-23 can also act locally on a resident IL-23 responsive cells to drive pathology within the eye.…”

Exploring the composition of placental microbiome and its potential origin in preterm birth by Saadaoui, M, Djekidel, MN, Murugesan, S, Kumar, M, Elhag, D, Singh, P, Kabeer, BSA, Marr, AK, Kino, T, Brummaier, T, McGready, R, Nosten, F, Chaussabel, D, Terranegra, A, Al Khodor, S

“…Additionally, it’s unclear whether the placental microbiome differs between healthy pregnancies and those with complications like preterm birth (PTB), which remains a leading cause of neonatal morbidity and mortality worldwide. …”

Clinical delineation and immunopathogenesis of autoimmune encephalitis by Varley, J

“…Finally, the underlying immunology in patients with AE secondary to leucinerich glioma inactivated protein-1 (LGI1) and contactin-associated protein-like 2 (CASPR2) antibodies remains unexplored and a likely source of novel, targeted immunotherapies.…”

Association between a selective 5-HT4 receptor agonist and incidence of major depressive disorder: emulated target trial by de Cates, AN, Harmer, CJ, Harrison, PJ, Cowen, PJ, Emmanuel, A, Travis, S, Murphy, SE, Taquet, M

“…Highly selective 5-HT4R agonists, such as prucalopride, have antidepressant-like and procognitive effects in preclinical models, but their clinical effects are not yet established. …”

Paradoxical choice and the value of information in animals by Ajuwon, V

“…</p> <br> <p>In Chapter 4, I use <em>GoFish</em> and the paradoxical choice protocol to explore non-instrumental information-seeking in fish (goldfish) for the first time. Like in birds and mammals, fish learned the programmed contingencies and showed rational preferences between stimuli predicting differing reward probabilities, but, unlike the other vertebrates studied so far, this did not translate into a preference for signalled outcomes.…”

May measurement month 2022: an analysis of blood pressure screening findings from Sierra Leone by Jalloh, MB, Williams, CEE, Jegede, OG, Malijan, GMB, Naveed, A, Kanu, A, Bah, AK, Jalloh, F, Jalloh, A, Faulkner, MMJ, Agboola, K, Baldeh, M, Russell, JBW, Oladapo, OO

“…Its high prevalence and underdiagnosis, especially in low-resource settings like Sierra Leone, make it a significant public health challenge. …”

Profiling the growth conditions and persistent organic pollutants (POPS) tolerance of Phenoliferia glacialis USM-PSY62 by Ain Nur Afifah Azman, Shazilah Kamaruddin, Quay, Doris Huai Xia, Farah Diba Abu Bakar, Noor Haza Fazlin Hashim, Abdul Munir Abdul Murad, Izwan Bharudin

“…These microorganisms have special adaptations to extreme cold and low-nutrient conditions. Some extremophiles, like psychrophiles can thrive in these harsh environments. …”
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Multi-Objective Multi-Exemplar Particle Swarm Optimization Algorithm with Local Awareness by Noori, Mustafa Sabah, Sahbudin, Ratna K.Z., Sali, Aduwati, Hashim, Fazirulhisyam

“…One of these MOO algorithms Multi-Objective Particle Swarm Optimization (MOPSO) extends it to handle problems with multiple objectives simultaneously, but like many swarm-based algorithms, MOPSO can suffer from premature convergence or local optima solutions. …”
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Fluorescent imaging and bio-cellular uptake assessment of gold-near infrared dye conjugated cockle shell calcium carbonate nanoparticles by Kiranda, H.K., Mahmud, R.B., Mahmood, S.K., Zakaria, Z.A.

“…Biocompatibility of Au-CsCaCO3NPs in cultured human breast carcinoma cells MCF-7 and mouse embryonic fibroblast cells NIH3T3 was evaluated using bioassays like Lactate Dehydrogenase LDH and Reactive Oxygen Species ROS for toxic examination. …”
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Frequency-dependent dielectric spectroscopic analysis on phytochemical and antioxidant activities in Radix Glycyrrhizae extract by Hong Liang, Ong, Ee Meng, Cheng, Mohamad, Che Wan Sharifah Robiah, Mohd Nasir, Nashrul Fazli, Xiao Jian, Tan, Chong You, Beh, Ziezie Mohd Tarmizi, Emma, Kim Yee, Lee, Kok Yeow, You, Shing Fhan, Khor, Kim Fey, Leu, Kian Keong, Te, Mohd Roslan, Mohd Riza, Baharuddin, Siti Aishah

“…It is particularly effective in relieving respiratory problems like coughs, sore throats, bronchitis, and asthma. …”
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Enhancing indoor positioning accuracy with WLAN and WSN: a QPSO hybrid algorithm with Surface tessellation by Scavino, Edgar, Abd Rahman, Mohd Amiruddin, Farid, Zahid, Ahmad, Sadique, Asim, Muhammad

“…Moreover, satellite-based Global Positioning System (GPS) signals are likely to be unusable in deep indoor spaces, and technologies like WiFi and Bluetooth are susceptible to signal noise and fading effects. …”
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Effects of temperature and velocity on chlorine dispersion in an indoor storage system using computational fluid dynamics simulation by Safakar, Mohsen

“…Results of the simulations showed that the chlorine dispersion would behave like the liquid when it was being flown on any surface. …”
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Aerodynamic Effects of High-Speed Train Positions During Tunnel Exit Under Crosswind Conditions Using Computational Fluid Dynamics by Rajendran, S, Ishak, I. A, Arafat, M, Mohammad, A. F, Salleh, Z. M, Samiran, N. A, Ja’a, M. N. M, Sulaiman, S

“…Strong crosswinds can cause catastrophic accidents like overturning and derailment in extreme circumstances, therefore the train's capacity to tolerate their impacts is crucial. …”
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Investigation of the reliability of nano-nickel/niobium oxide-based multilayer thin films deposited on polymer substrates for flexible electronic applications by Sahay, Rahul, Tu, Yen-Cheng, Aziz, Izzat, Budiman, Arief S., Tan, Cher Ming, Lee, Pooi See, Thomas, Olivier, Raghavan, Nagarajan

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Imprinting of IgA responses in previously infected individuals receiving bivalent mRNA vaccines (WT and BA.4/BA.5 or WT and BA.1) by Goh, Yun Shan, Fong, Siew-Wai, Hor, Pei Xiang, Loh, Chiew Yee, Tay, Matthew Zirui, Wang, Bei, Salleh, Siti Nazihah Mohd, Ngoh, Eve Zi Xian, Lee, Raphael Tze Chuen, Poh, Xuan Ying, Lee, I. Russel, Rao, Suma, Chia, Po Ying, Maurer-Stroh, Sebastian, Wang, Cheng-I, Leo, Yee Sin, Lye, David C., Young, Barnaby Edward, Ng, Lisa F. P., Renia, Laurent

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ENIGMA CHEK2gether project: a comprehensive study identifies functionally impaired CHEK2 germline missense variants associated with increased breast cancer risk by Stolarova, Lenka, Kleiblova, Petra, Zemankova, Petra, Stastna, Barbora, Janatova, Marketa, Soukupova, Jana, Achatz, Maria Isabel, Ambrosone, Christine, Apostolou, Paraskevi, Arun, Banu K., Auer, Paul, Barnard, Mollie, Bertelsen, Birgitte, Blok, Marinus J., Boddicker, Nicholas, Brunet, Joan, Burnside, Elizabeth S., Calvello, Mariarosaria, Campbell, Ian, Chan, Sock Hoai, Chen, Fei, Chiang, Jian Bang, Coppa, Anna, Cortesi, Laura, Crujeiras-González, Ana, De Leeneer, Kim, De Putter, Robin, DePersia, Allison, Devereux, Lisa, Domchek, Susan, Efremidis, Anna, Engel, Christoph, Ernst, Corinna, Evans, D. Gareth R., Feliubadaló, Lidia, Fostira, Florentia, Fuentes-Ríos, Olivia, Gómez-García, Encarna B., González, Sara, Haiman, Christopher, Hansen, Thomas van Overeem, Hauke, Jan, Hodge, James, Hu, Chunling, Huang, Hongyan, Ishak, Nur Diana Binte, Iwasaki, Yusuke, Konstantopoulou, Irene, Kraft, Peter, Lacey, James, Lázaro, Conxi, Li, Na, Lim, Weng Khong, Lindstrom, Sara, Lori, Adriana, Martinez, Elana, Martins, Alexandra, Matsuda, Koichi, Matullo, Giuseppe, McInerny, Simone, Michailidou, Kyriaki, Montagna, Marco, Monteiro, Alvaro N. A., Mori, Luigi, Nathanson, Katherine, Neuhausen, Susan L., Nevanlinna, Heli, Olson, Janet E., Palmer, Julie, Pasini, Barbara, Patel, Alpa, Piane, Maria, Poppe, Bruce, Radice, Paolo, Renieri, Alessandra, Resta, Nicoletta, Richardson, Marcy E., Rosseel, Toon, Ruddy, Kathryn J., Santamariña, Marta, Dos Santos, Elizabeth Santana, Teras, Lauren, Toland, Amanda E., Trentham-Dietz, Amy, Vachon, Celine M., Volk, Alexander E., Weber-Lassalle, Nana, Weitzel, Jeffrey N., Wiesmuller, Lisa, Winham, Stacey, Yadav, Siddhartha, Yannoukakos, Drakoulis, Yao, Song, Zampiga, Valentina, Zethoven, Magnus, Zhang, Ze Wen, Zima, Tomas, Spurdle, Amanda B., Vega, Ana, Rossing, Maria, Del Valle, Jesús, De Nicolo, Arcangela, Hahnen, Eric, Claes, Kathleen B. M., Ngeow, Joanne, Momozawa, Yukihide, James, Paul A., Couch, Fergus J., Macurek, Libor, Kleibl, Zdenek

“…The OR and 95% CI (confidence intervals) for carriers of functionally impaired, intermediate, and WT-like variants were 2.83 (95% CI, 2.35–3.41), 1.57 (95% CI, 1.41–1.75), and 1.19 (95% CI, 1.08–1.31), respectively. …”
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AI is a viable alternative to high throughput screening: a 318-target study by Wallach, Izhar, Bernard, Denzil, Nguyen, Kong, Ho, Gregory, Morrison, Adrian, Stecula, Adrian, Rosnik, Andreana, O’Sullivan, Ann Marie, Davtyan, Aram, Samudio, Ben, Thomas, Bill, Worley, Brad, Butler, Brittany, Laggner, Christian, Thayer, Desiree, Moharreri, Ehsan, Friedland, Greg, Truong, Ha, van den Bedem, Henry, Ng, Ho Leung, Stafford, Kate, Sarangapani, Krishna, Giesler, Kyle, Ngo, Lien, Mysinger, Michael, Ahmed, Mostafa, Anthis, Nicholas J., Henriksen, Niel, Gniewek, Pawel, Eckert, Sam, de Oliveira, Saulo, Suterwala, Shabbir, PrasadPrasad, Srimukh Veccham Krishna, Shek, Stefani, Contreras, Stephanie, Hare, Stephanie, Palazzo, Teresa, O’Brien, Terrence E., Van Grack, Tessa, Williams, Tiffany, Chern, Ting-Rong, Kenyon, Victor, Lee, Andreia H., Cann, Andrew B., Bergman, Bastiaan, Anderson, Brandon M., Cox, Bryan D., Warrington, Jeffrey M., Sorenson, Jon M., Goldenberg, Joshua M., Young, Matthew A., DeHaan, Nicholas, Pemberton, Ryan P., Schroedl, Stefan, Abramyan, Tigran M., Gupta, Tushita, Mysore, Venkatesh, Presser, Adam G., Ferrando, Adolfo A., Andricopulo, Adriano D., Ghosh, Agnidipta, Ayachi, Aicha Gharbi, Mushtaq, Aisha, Shaqra, Ala M., Toh, Alan Kie Leong, Smrcka, Alan V., Ciccia, Alberto, de Oliveira, Aldo Sena, Sverzhinsky, Aleksandr, de Sousa, Alessandra Mara, Agoulnik, Alexander I., Kushnir, Alexander, Freiberg, Alexander N., Statsyuk, Alexander V., Gingras, Alexandre R., Degterev, Alexei, Tomilov, Alexey, Vrielink, Alice, Garaeva, Alisa A., Bryant-Friedrich, Amanda, Caflisch, Amedeo, Patel, Amit K., Rangarajan, Amith Vikram, Matheeussen, An, Battistoni, Andrea, Caporali, Andrea, Chini, Andrea, Ilari, Andrea, Mattevi, Andrea, Foote, Andrea Talbot, Trabocchi, Andrea, Stahl, Andreas, Herr, Andrew B., Berti, Andrew, Freywald, Andrew, Reidenbach, Andrew G., Lam, Andrew, Cuddihy, Andrew R., White, Andrew, Taglialatela, Angelo

“…We address historical limitations of computational screening by demonstrating success for target proteins without known binders, high-quality X-ray crystal structures, or manual cherry-picking of compounds. We show that the molecules selected by the AtomNet® model are novel drug-like scaffolds rather than minor modifications to known bioactive compounds. …”
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