The emergence of DNAM-1 as the facilitator of NK cell-mediated killing in ovarian cancer by Pounds, R, Croft, W, Pearce, H, Hossain, T, Singh, K, Balega, J, Jeevan, DN, Sundar, S, Kehoe, S, Yap, J, Moss, P, Zuo, J

“…Introduction: Ovarian cancer (OC) is the sixth most common malignancy in women and the poor 5-year survival emphasises the need for novel therapies. …”

International trends in shoulder replacement: a meta-analysis from 11 public joint registers by Rupani, N, Combescure, C, Silman, A, Lübbeke, A, Rees, J

“…</p> <br> <p><strong>Methods:</strong> Patient characteristics, indication and year of surgery, type of replacement, and collection methods of patient-reported outcomes (PROMs) was extracted from 11 public joint registries. …”

Territorial movements of African lions: can waterholes shape multiple central-place territories in a savanna ecosystem? by Dejeante, R, Loveridge, A, Macdonald, D, Madlamoto, D, Chamaille-James, S, Valeix, M

“…Here, we explored how territoriality may shape the spatial behaviour of African lions (Panthera leo) in a savanna where waterholes are associated with aggregations of large herbivores throughout the year and are therefore well-known prey hotspots and key hunting sites for large carnivores. …”

De novo transcriptome assembly and discovery of drought-responsive genes in white spruce ( Picea glauca ) by Ribeyre, Z, Depardieu, C, Prunier, J, Pelletier, G, Parent, GJ, Mackay, J, Droit, A, Bousquet, J, Nolet, P, Messier, C

“…We assembled a de novo transcriptome, performed differential gene expression analyses at four time points over 22 days during a controlled drought stress experiment involving 2-year-old plants and three genetically distinct clones, and conducted gene enrichment analyses. …”

The effects and costs of an anti-bullying program (KiVa) in UK primary schools: a multicenter cluster randomized controlled trial by Badger, JR, Bowes, L, Babu, M, Broome, M, Cannings-John, R, Clarkson, S, Coulman, E, Tudor Edwards, R, Ford, T, Hastings, RP, Hayes, R, Lugg-Widger, F, Owen-Jones, E, Patterson, P, Segrott, J, Sydenham, M, Townson, J, Watkins, RC, Whiteley, H, Williams, ME, Stand Together Team, Hutchings, J

“…KiVa costs £20.78 more per pupil than usual practice in the first year, and £1.65 more per pupil in subsequent years. …”

Acquisition of musical skills and abilities in older adults—results of 12 months of music training by Losch, H, Altenmüller, E, Marie, D, Passarotto, E, Kretschmer, CR, Scholz, DS, Kliegel, M, Krüger, THC, Sinke, C, Jünemann, K, James, CE, Worschech, F

“…Methods: One hundred fifty-six healthy older adults (age = 69.5 years ± 3.2) from Hannover and Geneva with no prior musical training participated in weekly piano practice (PP) or ‘music culture’ (MC) sessions over a one-year period. …”

Cost of the national malaria control program and cost-effectiveness of indoor residual spraying and insecticide-treated bed net interventions in two districts of Madagascar by Andrianantoandro, VTA, Audibert, M, Kesteman, T, Ravolanjarasoa, L, Randrianarivelojosia, M, Rogier, C

“…However, the number of malaria cases yearly increased since 2012. ITNs and IRS are key interventions for reducing malaria in Madagascar. …”

Comparative effectiveness of sodium-glucose cotransporter-2 inhibitors for new-onset gastric cancer and gastric diseases in patients with type 2 diabetes mellitus: a population-bas... by Chou, OHI, Chauhan, VK, Chung, CTS, Lu, L, Lee, TTL, Ng, ZMW, Wang, KKW, Lee, S, Liu, H, Pang, RTK, Kaewdech, A, Cheung, BMY, Tse, G, Zhou, J

“…In the matched cohort, the incidence of gastric cancer was lower in SGLT2I (Incidence rate per 1000 person-year, IR: 0.32; 95% confidence interval, CI 0.23&ndash;0.43) than in DPP4I (IR per 1000 person-year: 1.22; CI 1.03&ndash;1.42) users. …”

Samuel Johnson: Pembroke's angry young man by Mugglestone, L

“…This article re-examines the history of Samuel Johnson's links to Pembroke College in Oxford from his undergraduate years to his last visit shortly before his death.…”

US exceptionalism? International trends in midlife mortality by Dowd, JB, Doniec, K, Zhang, L, Tilstra, A

“…Midlife mortality also increased in the UK for people aged 45&ndash;54&nbsp;year and in Canada, Poland and Sweden among for those aged 25&ndash;44 years.…”

Hormone replacement therapy and cancer survival: a longitudinal cohort study: protocol paper by Ranger, TA, Burchardt, J, Clift, AK, Mei, WX, Coupland, C, Tan, PS, Dixon, S, Cardwell, CR, Hippisley-Cox, J

“…<p><strong> Methods and analysis </strong></p>We will conduct a population-based longitudinal cohort study of 18–79 year-old women diagnosed with cancer between 1998 and 2020, using the QResearch database. …”

Clinical and neuroimaging markers of prodromal neurodegeneration in rapid eye movement sleep behaviour disorder by Barber, TR

“…Using ioflupane SPECT, we found that 43% of RBD patients already had evidence of dopaminergic deficit, and that this declines by an estimated 7% per year. Neuromelaninsensitive and susceptibility weighted MRI of the substantia nigra revealed signal changes in RBD patients consistent with early neurodegeneration. …”

Most of the world's largest flowers (genus Rafflesia) are now on the brink of extinction by Malabrigo Jr, P, Tobias, AB, Witono, J, Mursidawati, S, Susatya, A, Siti-Munirah, MY, Wicaksono, A, Raihandhany, R, Edwards, S, Thorogood, CJ

“…Taxonomy is disputed, new species are described each year, and the plant has proven recalcitrant to cultivation. …”

Emergency care knowledge, utilization, and barriers in Northern Tanzania: A community-based survey by Shayo, F, Zaccheus, GG, Sakita, F, Hernandes, TR, Vissoci, JRN, Gordee, A, Kuchibhatla, M, Kiremeji, M, Minja, L, Mmbaga, BT, Staton, CA, Keating, EM, Joiner, AP

“…The mean monthly household income was 226,107.6 Tanzanian Shillings. 76 (14.1%) households reported experiencing an emergency condition in the past year and 225 (41.7%) of respondents had an inappropriate response to at least one hypothetical emergency condition. …”

Analysis of incidence of motor neuron disease in England 1998–2019: use of three linked datasets by Burchardt, JM, Mei, XW, Ranger, T, McDermott, CJ, Radunovic, A, Coupland, C, Hippisley-Cox, J

“…The median age of diagnosis was 72 years. Peak incidence occurred in the 80–84 year age group in men and 75–79 in women. …”

Optimising investigative pathways in military medicine: operational impact of a military cardiopulmonary exercise testing clinic by Holland, JL, Cowie, P, Gardner, L, Mulae, J, Richards, S, Holdsworth, D

“…Mean age was 36 (±11.3) years, and 91% were male. Median waiting time for an appointment was 14.4 weeks (cf NHS 17.4 weeks). …”

Galaxy bias in the era of LSST: perturbative bias expansions by Nicola, A, Hadzhiyska, B, Findlay, N, García-García, C, Alonso, D, Slosar, A, Guo, Z, Kokron, N, Angulo, R, Aviles, A, Blazek, J, Dunkley, J, Jain, B, Pellejero, M, Sullivan, J, Walter, CW, Zennaro, M

“…In this work, we present the results of the Rubin Observatory Legacy Survey of Space and Time (LSST) bias challenge, the goal of which is to compare the performance of different nonlinear galaxy bias models in the context of LSST Year 10 (Y10) data. Specifically, we compare two perturbative approaches, Lagrangian perturbation theory (LPT) and Eulerian perturbation theory (EPT) to two variants of Hybrid Effective Field Theory (HEFT), with our fiducial implementation of these models including terms up to second order in the bias expansion as well as nonlocal bias and deviations from Poissonian stochasticity. …”

Targeting c-Met for endoscopic detection of dysplastic lesions within Barrett’s esophagus using EMI-137 fluorescence imaging by Huang, Y-J, Rieder, J, Tan, KV, Tenditnaya, A, Vojnovic, B, Gorpas, D, Quante, M, Vallis, KA

“…<p>Purpose: Esophageal cancer (EC) carries a poor prognosis with 5-year overall survival of less than 20%. Barrett&rsquo;s esophagus (BE) increases the risk of esophageal adenocarcinoma (EAC). …”

A loss-of-function mutation in KCNJ11 causing sulfonylurea-sensitive diabetes in early adult life by Vedovato, N, Salguero, MV, Greeley, SAW, Yu, CH, Philipson, LH, Ashcroft, FM

“…<p><strong>Methods</strong></p> A 31-year-old woman was diagnosed with mild hyperglycaemia during an employee screen. …”

Association of Indoleamine 2,3-dioxygenase (ido) activity with outcome after cardiac surgery in adult patients by Stieger, A, Huber, M, Yu, Z, Kessler, BM, Fischer, R, Andereggen, L, Kobel, B, Stueber, F, Luedi, MM, Filipovic, MG

“…Perioperative dynamics were descriptively assessed and associated with pre-defined clinical outcome measures (30-day mortality, 1-year mortality, incidence of stroke and myocardial infarction, and length of hospital stay) through a multi-step exploratory regression analysis. …”