Stem cell-derived embryo models: moral advance or moral obfuscation? by Gyngell, C, Lynch, F, Sawai, T, Savulescu, J

“…There have been several rapid advances in creating SCEMs in recent years. These advances potentially provide a new avenue to study early human development. …”

Simple ecological indicators benchmark regeneration success of Amazonian forests by Giles, AL, Schietti, J, Rosenfield, MF, Mesquita, RC, Vieira, DLM, Vieira, ICG, Poorter, L, Brancalion, PHS, Peña-Claros, M, Siqueira, J, Oliveira Junior, L, do Espírito-Santo, MM, Sarmento, PSDM, Ferreira, JN, Berenguer, E, Barlow, J, Elias, F, Cassol, HLG, Silva, RC, Ribeiro, SC, Medeiros, N, Junqueira, AB, Massoca, P, Ferreira, MJ

“…By modeling optimal successional trajectories, we estimated reference values for vegetation structure, diversity, and functioning. After 20 years, successful regeneration should reach a minimum basal area of 14 m². ha−¹, at least 34 tree species per 100 individuals, a structural heterogeneity index of 0.27, and 123 Mg.ha−¹ of aboveground biomass. …”

MEASUR - Manufacturing Energy Assessment Software for Utility Reduction by Accawi, G, Root, R, Blondheim, N, Howard, D, Hernandez, R, Armstrong, K, Cranfill, K, Shires, P, Kaminski, M, Hadden, J, DePauw, J, Sakovets, Y, Causey, C, Beanblossom, K, Whitmer, M, Ledbetter, A, Rappoport, B, Saravanan, S, Merchant, C, Kokul, S, Fontenot, Z, Vance, D, Worley, A, Aziz, O, Ferree, A, Rosser, N, Jensen, J, Adams, M, Rios, R

“…MEASUR has been available for several years as a beta version, being tested by industry experts and real users, and will continue to be updated and improved in the coming years. …”

Fedratinib combined with ropeginterferon alfa-2b in patients with myelofibrosis (FEDORA): study protocol for a multicentre, open-label, Bayesian phase II trial by McIlroy, G, Gaskell, C, Jackson, A, Yafai, E, Tasker, R, Thomas, C, Fox, S, Boucher, R, Ghebretinsea, F, Harrison, C, Mead, AJ, McMullin, MF

“…Background: Myelofibrosis (MF) is a clonal haematopoietic disease, with median overall survival for patients with primary MF only 6.5 years. The most frequent gene mutation found in patients is JAK2V617F, causing constitutive activation of the kinase and activation of downstream signalling. …”

Canadians' opinions towards COVID-19 data-sharing: a national cross-sectional survey by Savić Kallesøe, SA, Rabbani, T, Gill, EE, Brinkman, F, Griffiths, EJ, Zawati, M, Liu, H, Palmour, N, Joly, Y, Hsiao, WWL

“…Generally supportive Canadians were characterised as being ≥50 years, with higher education, and being vaccinated against COVID-19 at least once. …”

Trends in end digit preference for blood pressure and associations with cardiovascular outcomes in Canadian and UK primary care: a retrospective observational study by Greiver, M, Kalia, S, Voruganti, T, Aliarzadeh, B, Moineddin, R, Hinton, W, Dawes, M, Sullivan, F, Syed, S, Williams, J, De Lusignan, S

“…Systolic BP readings ending in zero decreased from 41.8% to 32.5% in the 3 years following the purchase of an AOBP machine. …”

Intersection between individual, household, environmental and system level factors in defining risk and resilience for children in Kenya’s ASAL: A qualitative study by Chongwo, EJ, Aoko, B, Kaniala, M, Esala, M, Magoma, P, Njoroge, E, Nyamanya, S, Marangu, J, Khamis, A, Ng’asike, J, Huizink, AC, Abubakar, A

“…Results: The mean age of the participants was 44years (SD = 11 years). The findings, viewed through the lens of Bronfenbrenner’s ecological systems theory, reveal a complex interplay of contextual factors impacting children’s development. …”

Body composition, body mass, and cardiovascular health in mid-childhood and midlife: a compositional data analysis by Liu, M, Dumuid, D, Olds, T, Burgner, D, Ellul, S, Juonala, M, Wang, Y, Ranganathan, S, Cheung, M, Baur, L, Dwyer, T, Kerr, JA, Lycett, K, Wake, M

“…<p><strong>Background:</strong> We aimed to quantify associations of cardiovascular (CV) large and small artery measures with body composition and body mass (1) separately and (2) in combination in 11- to 12-year-old children and their parents.</p> <br> <p><strong>Methods:</strong> In the population-based cross-sectional Child Health CheckPoint study (1495 children, mean 12 ± 0.4 years, 49.3% girls; 1496 parents, mean 44.3 ± 5.0 years, 86.7% mothers), we measured weight, height, body composition [truncal fat, non-truncal fat, fat-free mass (FFM)], and CV functional (blood pressure, pulse wave velocity, arterial elasticity) and structural (carotid intima-media thickness, retinal arteriolar/venular caliber) outcomes. …”

Quality and outcomes of diabetes care in patients diagnosed with cancer by Griffiths, R

“…<b>Results of the Primary Research</b>: The primary research included 3,382 diabetic cancer patients and 11,135 matched, diabetic, non-cancer controls, who were followed from two years before, up to 10 years after, cancer or a matched date in controls. …”

Heart failure risk stratification using artificial intelligence applied to electrocardiogram images: a multinational study by Dhingra, LS, Aminorroaya, A, Sangha, V, Pedroso, AF, Asselbergs, FW, Brant, LCC, Barreto, SM, Ribeiro, ALP, Krumholz, HM, Oikonomou, EK, Khera, R

“…<p><strong> Results</strong></p> Among 231 285 YNHHS patients, 4472 had primary HF hospitalizations over 4.5 years (inter-quartile range 2.5–6.6). In UKB and ELSA-Brasil, among 42 141 and 13 454 people, 46 and 31 developed HF over 3.1 (2.1–4.5) and 4.2 (3.7–4.5) years. …”

Cost-utility analysis of molnupiravir plus usual care versus usual care alone as early treatment for community-based adults with COVID-19 and increased risk of adverse outcomes in... by Png, ME, Harris, V, Grabey, J, Hart, ND, Jani, BD, Butler, D, Carson-Stevens, A, Coates, M, Cureton, L, Dobson, M, Dorward, J, Evans, P, Francis, N, Gbinigie, OA, Hayward, G, Holmes, J, Hood, K, Khoo, S, Ahmed, H, Lown, M, McKenna, M, Mort, S, Nguyen-Van-Tam, J, Rahman, N, Richards, DB, Thomas, N, van Hecke, O, Hobbs, FR, Little, P, Yu, L-M, Butler, CC, Petrou, S

“…Sensitivity and subgroup analyses showed similar results, except for those aged ≥75 years, with a 55% probability of being cost-effective at a £30 000 per QALY threshold. …”

Individual differences in the effects of physical activity on classroom behaviour by Heemskerk, CHHM, Sumatic, M, Strand, S, Malmberg, L-E

“…</p> <p><strong>Method:</strong> Data was collected from 76 primary school-aged children (<em>M</em> age = 9.3 years, <em>SD</em> = 0.7 years; 46 females). The PE lesson intervention followed a 3 (intensity: low, medium, high) by 2 (complexity: low, high) within-person design. …”

Evaluation of naturally occurring IgG anti-Vi antibody titers as predictors and correlates of typhoid fever in Dhaka, Bangladesh by Khanam, F, Rickett, NY, Ahmmed, F, Islam, MT, Mbae, CK, Im, J, Aziz, AB, Ongadi, B, Chowdhury, F, Khan, AI, Akter, A, Firoj, MG, Rahman, SIA, Haile, K, Park, SE, Mwebia, MB, Mwangi, M, Ngugi, B, Behute, MG, Kering, K, Agampodi, S, Kanungo, S, Liu, X, Pollard, AJ

“…A positive correlation was observed between IgG anti-Vi titers and age (correlation coefficient 0·35; p &lt; 0·001), with a stepwise increase in detectable antibodies by age, ranging from 12·0% (280/2,333) in children under 5 years to 54·2% (463/854) in individuals 50 years and older (p &lt; 0·001). …”

Estimating risk factor time paths among people with Type 2 Diabetes and QALY gains from risk factor management by Gao, N, Dakin, HA, Holman, RR, Lim, L-L, Leal, J, Clarke, P

“…UKPDS-OM2-derived lifetime QALYs were extrapolated over 70 years using historical and the new risk factor equations.…”

Using QALYs as an outcome for assessing global prediction accuracy in diabetes simulation models by Dakin, H, Gao, N, Leal, J, Holman, RR, Tran-Duy, A, Clarke, P

“…<p><strong>Objectives:</strong> (1) To demonstrate the use of quality-adjusted life-years (QALYs) as an outcome&nbsp;measure for comparing performance between simulation models and identifying the most&nbsp;accurate model for economic evaluation and health technology assessment. …”

Wireless measurement of elastic and plastic deformation by a metamaterial-based sensor by Ozbey, Burak, Demir, Hilmi Volkan, Kurc, Ozgur, Erturk, Vakur, Altintas, Ayhan

“…The NSRR probe is fixed on a standard steel reinforcing bar (rebar), and its frequency response is monitored telemetrically by a network analyzer connected to the antenna across the whole stress-strain curve. …”
Get full text
Get full text

Membranes with ZIF-8 regulated MXene nanosheet stacks for efficient molecular sieving by Li, Jian, Li, Lei, Li, Xin, Dong, Liangliang, Wang, Zhenyu, Shen, Jiangnan, Van der Bruggen, Bart

“…Compared with the pristine thin film composite membrane, the optimal membrane exhibited an excellent pure water permeability up to 40.8 L m−2 h−1 bar−1 while maintaining high rejections (>99.0 %) for Congo red, reactive blue 19, xylene brilliant cyaninG250 and methyl blue, respectively. …”
Get full text

Mechanical properties and cracking behaviour of marble and moulded gypsum under high strain rates by Zou, Chunjiang

“…The mechanical properties of both intact and non-intact specimens including the compressive strength, the tensile strength, the elastic modulus, and the failure strain are tested under different strain rates by using a servo compression machine and a split Hopkinson pressure bar (SHPB) system. Experimental results reveal that these mechanical properties all show strain rate-dependence to different degrees. …”
Get full text

Synthesis and performance analysis of a polysulfone braid-supported hollow fiber membrane for natural gas purification by Imtiaz, Aniqa, Kamaludin, Roziana, Othman, Mohd. Hafiz Dzarfan, Jilani, Asim, Khan, Imran Ullah, Muhammad Ayub, Muhammad Ayub, Samuel, Ojo, Iftikhar, Musawira

“…To assess the performance, gas separation tests were conducted using pure gases at 3 bar. Notably, the membrane sample with 21 wt% PSF and the 3rd coating layer (21_3 PSF) exhibited the most promising gas separation performance among all the samples selected to carry out the separation performance test, achieving a CO2/CH4 selectivity of 1.83. …”

Protein engineering using asparaginyl peptide ligases by Wang, Zhen

“…This expanded substrate scope is explored to engineer multi-functional proteins, including bi-specific protein engagers capable of mediating the killing of cancer cells by Car-NK cells. Finally, I report the design of an auto-processing mechanism of a C-terminal Cys-Asn dipeptide for traceless protein ligation by combining PAL ligation with native chemical ligation or subtiligation. …”
Get full text