Estimating risk factor time paths among people with Type 2 Diabetes and QALY gains from risk factor management by Gao, N, Dakin, HA, Holman, RR, Lim, L-L, Leal, J, Clarke, P

“…UKPDS-OM2-derived lifetime QALYs were extrapolated over 70 years using historical and the new risk factor equations.…”

Using QALYs as an outcome for assessing global prediction accuracy in diabetes simulation models by Dakin, H, Gao, N, Leal, J, Holman, RR, Tran-Duy, A, Clarke, P

“…<p><strong>Objectives:</strong> (1) To demonstrate the use of quality-adjusted life-years (QALYs) as an outcome&nbsp;measure for comparing performance between simulation models and identifying the most&nbsp;accurate model for economic evaluation and health technology assessment. …”

Wireless measurement of elastic and plastic deformation by a metamaterial-based sensor by Ozbey, Burak, Demir, Hilmi Volkan, Kurc, Ozgur, Erturk, Vakur, Altintas, Ayhan

“…The NSRR probe is fixed on a standard steel reinforcing bar (rebar), and its frequency response is monitored telemetrically by a network analyzer connected to the antenna across the whole stress-strain curve. …”
Get full text
Get full text

Membranes with ZIF-8 regulated MXene nanosheet stacks for efficient molecular sieving by Li, Jian, Li, Lei, Li, Xin, Dong, Liangliang, Wang, Zhenyu, Shen, Jiangnan, Van der Bruggen, Bart

“…Compared with the pristine thin film composite membrane, the optimal membrane exhibited an excellent pure water permeability up to 40.8 L m−2 h−1 bar−1 while maintaining high rejections (>99.0 %) for Congo red, reactive blue 19, xylene brilliant cyaninG250 and methyl blue, respectively. …”
Get full text

Mechanical properties and cracking behaviour of marble and moulded gypsum under high strain rates by Zou, Chunjiang

“…The mechanical properties of both intact and non-intact specimens including the compressive strength, the tensile strength, the elastic modulus, and the failure strain are tested under different strain rates by using a servo compression machine and a split Hopkinson pressure bar (SHPB) system. Experimental results reveal that these mechanical properties all show strain rate-dependence to different degrees. …”
Get full text

Synthesis and performance analysis of a polysulfone braid-supported hollow fiber membrane for natural gas purification by Imtiaz, Aniqa, Kamaludin, Roziana, Othman, Mohd. Hafiz Dzarfan, Jilani, Asim, Khan, Imran Ullah, Muhammad Ayub, Muhammad Ayub, Samuel, Ojo, Iftikhar, Musawira

“…To assess the performance, gas separation tests were conducted using pure gases at 3 bar. Notably, the membrane sample with 21 wt% PSF and the 3rd coating layer (21_3 PSF) exhibited the most promising gas separation performance among all the samples selected to carry out the separation performance test, achieving a CO2/CH4 selectivity of 1.83. …”

Protein engineering using asparaginyl peptide ligases by Wang, Zhen

“…This expanded substrate scope is explored to engineer multi-functional proteins, including bi-specific protein engagers capable of mediating the killing of cancer cells by Car-NK cells. Finally, I report the design of an auto-processing mechanism of a C-terminal Cys-Asn dipeptide for traceless protein ligation by combining PAL ligation with native chemical ligation or subtiligation. …”
Get full text

Design and dynamic stiffness evaluation of magnetorheologicalelastomer bushing using FEMM and dynamic testing machine by Abdul Hamid, Mohamad Ihsan, Mazlan, Saiful Amri, Nordin, Nur Azmah

“…The design concept of MRE bushing is based on the design of the bushing used in the conventional car, only the natural rubber is being replaced by the MRE compound. …”
Get full text

Writing in Creole contexts: a study of Jamaican primary school students by Tucker, S-K, Chalmers, H, Murphy, VA

“…In the Caribbean in particular, the poor writing outcomes of Creole speakers across all levels of education has been a subject of lament for educators and policymakers for several years. Given the significant differences between the home and school languages, particularly in the areas of grammar and phonology, as well as the importance of these skills in writing, it is worth exploring the nature of writing challenges among Creole dominant learners in the Caribbean. …”

Warming alters plankton body-size distributions in a large field experiment by Albini, D, Ransome, E, Dumbrell, AJ, Pawar, S, O’Gorman, EJ, Smith, TP, Bell, T, Jackson, MC, Woodward, G

“…While substantial empirical evidence has accumulated in recent years on such changes, we still lack general insights due to a limited coverage of warming scenarios that span spatial and temporal scales of relevance to natural systems. …”

Piloting a drama-based oral language intervention by Faitaki, F, Liggins, S, Murphy, V

“…The present study piloted an eight-week drama-based intervention, designed to improve young children’s skills in English. 41 children in Years 1-3 took part. Of these, N=21 completed the intervention (12 followed a movement-based approach and 9 followed a text-based approach), while N=20 acted as a control group. …”

Large and unequal life expectancy declines during the COVID-19 pandemic in India in 2020 by Gupta, A, Hathi, P, Banaji, M, Gupta, P, Kashyap, R, Paikra, V, Sharma, K, Somanchi, A, Sudharsanan, N, Vyas, S

“…Compared to 2019, life expectancy at birth was 2.6 years lower and mortality was 17% higher in 2020, implying 1.19 million excess deaths in 2020. …”

Death and the doctor: the museum as a tool for understanding the needs of the dying by Harris, J, Moyse, A, Hadley, G, Frampton, S, Dempsey, A, Hordern, J, Saunders, K, Lane, R, De Luca, G

“…Over the past several years, the Ashmolean Museum at Oxford has been part of a multi- disciplinary team examining the question of how we train medical students to deal with those parts of their profession which are concerned primarily with the humanity of their patients. …”

Forecasting the UK top 1% income share in a shifting world by Castle, JL, Doornik, JA, Hendry, DF

“…We use the model to forecast the top 1% income share over the last 15 years, and compare to a range of forecast devices. …”

The 'Clisurean' finds from Climente II cave, Iron Gates, Romania by Bonsall, C, Boroneanţ, A, Evatt, A, Soficaru, A, Nica, C, Bartosiewicz, L, Cook, G, Higham, TFG, Pickard, C

“…Osteological analysis of the human remains confirms at least three individuals: a robust, young adult male aged between 18 and 28 years, a second (older) adult, and a neonate. Single-entity 14C dating of human bone and humanly modified animal bones suggests the Clisurean occupation occurred during the Bølling–Allerød warm period. …”

Improving clinical care of patients in Nipah outbreaks: moving beyond 'compassionate use' by Hassan, MZ, Rojek, A, Olliaro, P, Horby, P

“…The 2024 Nipah outbreak in Kerala, India—its fifth in six years—and the recurring annual outbreaks in Bangladesh underscore the persistent threat posed by the Nipah virus (NiV) in the region. …”

Elevated genetic risk for multiple sclerosis emerged in steppe pastoralist populations by Barrie, W, Yang, Y, Irving-Pease, EK, Attfield, KE, Scorrano, G, Jensen, LT, Armen, AP, Dimopoulos, EA, Stern, A, Refoyo-Martinez, A, Pearson, A, Ramsøe, A, Gaunitz, C, Demeter, F, Jørkov, MLS, Møller, SB, Springborg, B, Klassen, L, Hyldgård, IM, Wickmann, N, Vinner, L, Korneliussen, TS, Allentoft, ME, Sikora, M, Kristiansen, K, Rodriguez, S, Nielsen, R, Iversen, AKN, Lawson, DJ, Fugger, L, Willerslev, E

“…Here, by using a large ancient genome dataset from the Mesolithic period to the Bronze Age, along with new Medieval and post-Medieval genomes, we show that the genetic risk for MS rose among pastoralists from the Pontic steppe and was brought into Europe by the Yamnaya-related migration approximately 5,000 years ago. We further show that these MS-associated immunogenetic variants underwent positive selection both within the steppe population and later in Europe, probably driven by pathogenic challenges coinciding with changes in diet, lifestyle and population density. …”

Deep learning for detecting and early predicting chronic obstructive pulmonary disease from spirogram time series by Mei, S, Li, X, Zhou, Y, Xu, J, Zhang, Y, Wan, Y, Cao, S, Zhao, Q, Geng, S, Xie, J, Chen, S, Hong, S

“…DeepSpiro consists of four key components: SpiroSmoother for stabilizing the Volume-Flow curve, SpiroEncoder for capturing volume variability-pattern through key patches of varying lengths, SpiroExplainer for integrating heterogeneous data and explaining predictions through volume attention, and SpiroPredictor for predicting the disease risk of undiagnosed high-risk patients based on key patch concavity, with prediction horizons of 1–5 years, or even longer. Evaluated on the UK Biobank dataset, DeepSpiro achieved an AUC of 0.8328 for COPD detection and demonstrated strong predictive performance for future COPD risk (p-value &lt; 0.001). …”

Learning from the community: iterative co-production of a programme to support the development of attention, regulation and thinking skills in toddlers at elevated likelihood of au... by Hendry, A, Hulks, V, Murphy, S, Radford, H, Smith, S, Charman, T, Mathers, S, Rhodes, S, Scerif, G

“…The co-production process for this neurodiversity-affirming programme involved: Review of research priorities identified during published public-and-clinician consultations; iterative programme development through two pilot rounds with a general community sample; and consultation with stakeholders (parents with a connection to autism or ADHD, alongside early years specialists, psychologists and therapists) to check acceptability of the proposal, and refine the logic model and materials. …”

3D object recognition using invariance by Zisserman, A, Forsyth, D, Mundy, J, Rothwell, C, Liu, J, Pillow, N

“…<p>The systems and concepts described in this paper document the evolution of the geometric invariance approach to object recognition over the last five years. Invariance overcomes one of the fundamental difficulties in recognising objects from images: that the appearance of an object depends on viewpoint. …”