Posthospitalization COVID-19 cognitive deficits at 1 year are global and associated with elevated brain injury markers and gray matter volume reduction by Wood, GK, Sargent, BF, Ahmad, Z, Tharmaratnam, K, Dunai, C, Egbe, FN, Martin, NH, Facer, B, Pendered, SL, Rogers, HC, Hübel, C, van Wamelen, DJ, Bethlehem, RAI, Giunchiglia, V, Hellyer, PJ, Trender, W, Kalsi, G, Needham, E, Easton, A, Jackson, TA, Cunningham, C, Upthegrove, R, Pollak, TA, Hotopf, M, Miller, KL, Jezzard, P, Smith, SM, Husain, M, Vincent, A

“…The spectrum, pathophysiology and recovery trajectory of persistent post-COVID-19 cognitive deficits are unknown, limiting our ability to develop prevention and treatment strategies. We report the 1-year cognitive, serum biomarker and neuroimaging findings from a prospective, national study of cognition in 351 COVID-19 patients who required hospitalization, compared with 2,927 normative matched controls. …”

Effectiveness of a chronic obstructive pulmonary disease integrated care pathway in a regional health system : a propensity score matched cohort study by Wu, Christine Xia, Hwang, Chi Hong, Tan, Woan Shin, Tai, Kai Pik, Kwek, Lynette Siang Lim, Chee, Thong Gan, Choo, Yee Mun, Phng, Francis Wei Loong, Chua, Gerald Seng Wee

“…Adherence with recommended care elements for the COPD-ICP group was measured quarterly at baseline and during a 2-year follow-up period. …”
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Collaborative model of care between Orthopaedics and allied healthcare professionals in knee osteoarthritis (CONNACT) : study protocol for an effectiveness-implementation hybrid randomized control trial by Tan, Bryan Yijia, Pereira, Michelle Jessica, Yang, Su-Yin, Hunter, David J., Skou, Soren Thorgaard, Thumboo, Julian, Car, Josip

“…The Collaborative Model of Care between Orthopaedics and Allied Healthcare Professionals (CONNACT) Model of Care (MoC) was developed by optimizing evidence-based non-surgical treatments to deliver value-based care for people with knee OA. …”
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Associations between health literacy and health care utilization and mortality in patients with coexisting diabetes and end-stage renal disease : a prospective cohort study by Griva, Konstantina, Loong, Russel K. L., Nandakumar, Mooppil, Rajeswari, Moothathamby, Khoo, Eric Y. H., Lee, Vanessa Y. W., Kang, Augustine W. C., Osborne, Richard H., Brini, Stefano, Newman, Stanton P.

“…Results A total 221 participants [median age: 59 years, 61.6% men, 54.8% Chinese] were recruited. …”
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Recent 10-year development on surface modification of polymeric hollow fiber membranes via surface coating approach for gas separation: a review by Roslan, Rosyiela Azwa, Lau, Woei Jye, Ismail, Ahmad Fauzi, Sutrasno Kartohardjono, Sutrasno Kartohardjono

The association between learning style, academic performance, and participation in co-curricular activities among second-year medical students in Universiti Putra Malaysia by Azmah Sa’at, Suryati Mohd. Thani, Nizar Abd. Manan

“…This study explores how learning preferences impact academic performance and participation in extracurricular activities among second-year medical students at Universiti Putra Malaysia. …”
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Inter-relationship between ageing, body mass index, diabetes, systemic blood pressure and intraocular pressure in Asians : 6-year longitudinal study by Chua, Jacqueline, Chee, Miao Li, Chin, Calvin Woon Loong, Tham, Yih Chung, Tan, Nicholas, Lim, Sing Hui, Aung, Tin, Cheng, Ching-Yu, Wong, Tien Yin, Schmetterer, Leopold

“…Methods: Participants aged 40–80 years were recruited for baseline and 6-year follow-up visits between 2004–2009 and 2010–2015, respectively. …”
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The efficacy of cognitive behavioural therapy in treating selective mutism in young children aged 4 to 10 years old: a qualitative systematic review by Ng, Benjamin Zeming, Atikah Binte Hassan, Dun, Yawen

“…The present systematic review evaluates the quality of evidence of empirical studies about the efficacy of cognitive behavioural therapy (CBT) and combination therapy (psychopharmacotherapy) in the treatment of selective mutism in young children aged 4–10 years old. Of the 223 studies returned in a systematic review of the literature from a ten-year period from 2012 to 2022, only fifteen studies matched the selection criteria for the qualitative synthesis. …”
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The association between hip morphology parameters and 19-year risk of end-stage osteoarthritis of the hip in caucasian females: a case-control study by Nicholls, AS

“…Pelvis radiographs taken at study-year two were analyzed for variations in hip morphology using the software. …”

Trajectories of interferon-gamma release assay results over two years in independent cohorts from China, South Africa, Tanzania, and the United States by Chen, C, Xue, H, Horsburgh, CR, Amour, M, Hatherill, M, Tameris, M, von Reyn, CF, Rees, C, Shen, Y, McShane, H, García-Basteiro, AL, Liu, D, Wang, Y, Nathavitharana, RR, Graviss, EA, Shao, Y, Liu, Q, Lu, W, Zhu, L, Martinez, L

“…</p> <br> <p><strong>Results:</strong> 26,596 IGRA measurements were taken over 13,593 years of follow-up (Nparticipants=7,683). Stringent reversion at year 2 after stringent conversion at year 1 varied between cohorts, occurring in 48% (43/90) for WANTAI, 37% (22/59) for QuantiFERON, and 17% (2/12) for T-SPOT.TB, respectively. …”

Robust generation of neutralising antibodies against Omicron variants following bivalent mRNA booster vaccine in elderly people aged >80 years by Parry, H, Bruton, R, Uwenedi, G, Roberts, T, Sylla, P, Cook, J, Elzaidi, A, Lau, M, Drury, T, Bray, A, Mallick, S, Spencer, K, Bentley, C, McIlroy, G, Scott, S, Logan, N, Zuo, J, Willett, B, Moss, P

Multiple introductions of NRCS-A Staphylococcus capitis to the neonatal intensive care unit drive neonatal bloodstream infections: a case-control and environmental genomic survey by Lees, EA, Gentry, J, Webster, H, Sanderson, N, Eyre, D, Wilson, D, Lipworth, S, Crook, D, Wong, THN, Mark, A, Jeffery, K, Paulus, S, Young, BC

“…</strong> The Staphylococcus capitis NRCS-A strain has emerged as a global cause of late-onset sepsis associated with outbreaks in neonatal intensive care units (NICUs) whose transmission is incompletely understood.…”

The System Architecture-Function-Outcome Framework for Fostering and Assessing Systems Thinking in First-Year STEM Education and Its Potential Applications in Case-Based Learning by Lavi, Rea, Bertel, Lykke Brogaard

“…However, viable methods for teaching and assessing systems thinking with active learning across STEM disciplines, particularly in first-year undergraduate education, are still under-researched. …”
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Influences of East Asian winter monsoon and El Niño-southern oscillation variability on the Kuroshio intrusion to the South China Sea over the past 60 years by Lin, Ke, Han, Tao, Zhang, Yilin, Shen, Chuan-Chou, Lee, Shih-Yu, Wang, Jingyu, Mohtar, Ahmad T., Huang, Kuo-Fang, Chiang, Hong-Wei, Chen, Yue-Gau, Wang, Xianfeng

“…Here, we present a 60-year bi-monthly resolved coral oxygen isotope (δ18Oc) record from Dongsha Atoll, the northern SCS. …”
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A community-based intervention (the Omama Project) improves neurodevelopment in impoverished 2-year-old Roma children: a quasi-experimental observational study by Fernandes, M, Matuskova, O, Babelova, R, Santosa, WB, Shaw, O, Hrica, P

“…Interventions targeting early child development (ECD) during the first 2 years of life can improve neurodevelopmental outcomes in vulnerable children; however, evidence from Roma preschoolers is scarce. …”

Prevalence of diabetic peripheral neuropathy among type 2 diabetes mellitus and its associated factors in a primary care clinic in Malacca: a cross-sectional study by Ali, Hanifatiyah, May, Janarisa Mustar, Yein, Lee Ping, Abdul Rashid, Aneesa

“…This study aimed to determine the prevalence of diabetic peripheral neuropathy among type 2 diabetes mellitus patients and its associated factors in a primary care clinic. Materials and methods: A cross sectional study was done in a government funded primary care clinic in Melaka involving type 2 diabetes mellitus patients aged 18 years and above using a systematic random sampling. …”
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A service evaluation of the implementation of a novel digital intervention for hypertension self-monitoring and management system in primary care (SHIP): protocol for a mixed methods study by Smith, A, Tucker, KL, Barnes, RK, Drakesmith, CW, Agwunobi, A, Bateman, PA, Forbes, A, de Lusignan, S, Ford, GA, Fujiwara, T, Hobbs, FR, Koshiaris, C, Mant, J, McKinstry, B, Pollock, S, Rice, C, Yang, Y, McManus, RJ

“…Aim: The self-monitoring and management service evaluation in primary care (SHIP) study will evaluate a novel digital intervention for hypertension management and medication titration platform (“Hypertension-Plus”) that is currently undergoing initial implementation into primary care in several parts of the UK. …”

Exploring barriers and enablers of self-management behaviours in patients with diabetic foot ulcers: A qualitative study from the perceptions of patients, caregivers, and healthcare professionals in primary care by Zhu, Xiaoli, Lee, Eng Sing, Lim, Phoebe X. H., Chen, Yee Chui, Chan, Frederick H. F., Griva, Konstadina

“…Diabetes mellitus (DM) is a serious threat to global health and diabetic foot ulcers (DFU) remains one of the most common complications of DM1 affecting around 20 million people annually.2 DFUs are complex to treat, take months or years to heal, and the recurrence rates remain high up to 40% within 1 year of healing.3 People with DFUs are at risk of prolonged healing times and hospitalisation, reduced quality of life4, 5 and higher five-year mortality rates.3 Moreover, DFU is a causal factor for up to 85% of patients with diabetes who subsequently undergo lower extremity amputation3, 6 and is a leading cause of global disability.2 Singapore has the highest rate of diabetic lower extremity amputation (DLEA) in the world7 because of DFU and the trend is increasing.8 Additionally, DFU is a substantial clinical and economic burden to health systems in Singapore with escalating healthcare costs corresponding to more proximal amputation levels and high re-admission rates.9 Thus, understanding barriers to managing DFU is vital for improving patient care.…”
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A comparison of sodium-glucose co-transporter 2 inhibitor kidney outcome trial participants with a real-world chronic kidney disease primary care population by Forbes, AK, Hinton, W, Feher, MD, Elson, W, Ordóñez-Mena, JM, Joy, M, Fan, X, Banerjee, D, Cole, NI, Munro, N, Whyte, M, Suckling, RJ, Swift, PA, de Lusignan, S

“…Trial participants were 9–14 years younger than the real-world CKD population, and had more advanced CKD, including higher levels of albuminuria. …”

A Self-Polymerizing Mesh of Nano-Tethers for the Mechanical Constraint of Degraded Intervertebral Discs—A Review of 25 Years of Pre-Clinical and Early Clinical Research by Hedman, Thomas, Rogers, Adam, Beall, Douglas

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