The Mycobacterium tuberculosis cytochrome bcc:aa3 cryo-EM structure and discovery of novel putative cytochrome bcc:aa3 inhibitors by Mathiyazakan, Vikneswaran

“…The structure provides insights into the electron transfer pathways and further understanding on drug interaction with the enzyme complex. A whole cell library screen targeting cyt-bcc:aa3 identified hits that depleted whole cell ATP levels, inhibited growth and dramatically decreased oxygen consumption rate in real-time. …”
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Identification and antimicrobial susceptibility of enterococcal species isolated from cats exposed to different antibiotics by Mohd Amin, Nor Azimah

“…Two multi drug resistant (MDR) enterococci and two extensively drug resistant (XDR) enterococci were detected in this present study.…”
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Construction of novel optical imaging probes and their applications in bioassays by Shao, Qing

“…Chapter 3 describes the construction of a luminescent Ru(II) probe for intracellular imaging and lethal photosensitization of drug resistant bacteria. By combining enzyme recognizing specificity and photosensitizing function, this probe displays promising imaging and photokilling capabilities to the drug resistant strains, including pathogenic species like clinically isolated methicillin-resistant Staphylococcus aureus. …”
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Coupling photo-responsive transmembrane ion transport with transition metal catalysis by Chao, X, Johnson, T, Temian, M-C, Docker, A, Wallabregue, A, Scott, A, Conway, S, Langton, M

“…This work demonstrates that artificial transporters enable control over catalysis inside artificial cell-like systems, which could form the basis of biocompatible nanoreactors for applications such as drug synthesis and delivery or to mediate phototargeted catalyst delivery into cells.…”

The FGFR inhibitor PD173074 binds to the C-terminus of oncofetal HMGA2 and modulates its DNA-binding and transcriptional activation functions by Ahmed, Syed Moiz, Ragunathan, Priya, Shin, Joon, Peter, Sabrina, Kleissle, Sabrina, Neuenschwander, Martin, Schäfer, Reinhold, Kries, Jens Peter V., Grüber, Gerhard, Dröge, Peter

“…HMGA2 is not expressed in most normal adult somatic cells, which renders the protein an attractive drug target. …”
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Vypal2: a versatile peptide ligase for precision tailoring of proteins by Zhang, Dingpeng, Wang, Zhen, Hu, Side, Lescar, Julien, Tam, James P., Liu, Chuan-Fa

“…We also demonstrated on-cell labelling of protein ligands pre-bound to cellular receptors and cell-surface engineering via modifying a covalently anchored peptide substrate pre-installed on cell-surface glycans. …”
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MicroRNAs in tissue engineering & regenerative medicine by Chew, Sing Yian

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Cryogelation of human hair keratins by Chua, Huei Min

“…Human hair keratins (HHK) are natural structural proteins that can be extracted from abundant hair waste and valorised into biomaterials for tissue regeneration, wound healing, and drug delivery etc. The emergence of HHK in biomedical applications is attributed to their proven biocompatibility as well as their potential to promote cell adhesion and proliferation due to the presence of LDV (leucine-aspartic-valine) cell adhesion motifs and residual regulatory molecules. …”
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Online estimation of key battery states for management of vanadium redox flow battery by Wei, Zhongbao

“…Among various rechargeable battery systems, the all-vanadium redox flow battery (VRB) has received extensive attention especially in the field of large-scale energy storage. …”
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Structural and functional characterisation of chikungunya virus replication complex dynamics by Tan, Yaw Bia

“…The expansion of the experimental database will eventually build a structural-aided drug discovery platform to identify the effective antiviral drug candidates to treat the infections of CHIKV and +ssRNA group viruses.…”
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Exploring the regulation of myofilament function in the heart using experimental and computational approaches by Folkmanaite, M

“…The computational models offer a platform for investigating drug effects on cardiac function aiding cardiovascular drug development.…”

Wireless sensor network for intelligent lighting control by Teng, Yu Hau.

“…The high pace movement had drawn great attention in challenges from resources management and impact on earth natural habitat. …”
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Synthesis of chiral sulfinate esters by asymmetric condensation by Zhang, Xin, Ang, Esther Cai Xia, Yang, Ziqi, Kee, Choon Wee, Tan, Choon-Hong

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Detection of low frequency artemisinin resistance mutations, C469Y, P553L and A675V, and fixed antifolate resistance mutations in asymptomatic primary school children in Kenya by Osoti, V, Wamae, K, Ndwiga, L, Gichuki, PM, Okoyo, C, Kepha, S, Keitany, K, Kandie, R, Aricha, S, Kiplagat, R, Mwandawiro, C, Bejon, P, Snow, RW, Ochola-Oyier, LI

“…Background: To understand the emergence and spread of drug-resistant parasites in malaria-endemic areas, accurate assessment and monitoring of antimalarial drug resistance markers is critical. …”

SINGAPORE STANDARD : Specification for clean and green urban farms – Agriculture Incorporating Amendment No. 1 /

“…The Singapore Standards Council and Enterprise Singapore will not be responsible for identifying all of such legal obligations. Attention is drawn to the possibility that some of the elements of this Singapore Standard may be the subject of patent rights. …”
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Biofunctional electrospun nanofibrous scaffolds in tissue engineering and the potential application of siRNA-delivery for nerve regeneration by Cao, Haoqing

“…PCL electrospun nanofibers with random and aligned fiber orientations yielded significantly thinner fibrous capsules compared to solid surfaces when implanted subcutaneously in rat. Furthermore, cell infiltration and cell-scaffold interaction were observed on the aligned fibrous scaffolds. …”
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Liposomal nanotherapy for treatment of atherosclerosis : passive versus active targeting by Darwitan, Anastasia

“…In active strategy, active ligands were decorated on nanoliposomal surface for enhancement of cell internalization. In this report, it was demonstrated that foam cells expressed high number of targetable cell surface folate receptors. …”
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Luteolin restricts dengue virus replication through inhibition of the proprotein convertase furin by Peng, Minhua, Watanabe, Satoru, Chan, Kitti Wing Ki, He, Qiuyan, Zhao, Ya, Zhang, Zhongde, Lai, Xiaoping, Luo, Dahai, Vasudevan, Subhash G., Li, Geng

“…In addition, ADE-mediated dengue virus infection of human cell lines and primary PBMCs was inhibited. In a time-of-drug-addition study, luteolin was found to reduce infectious virus particle formation, but not viral RNA synthesis, in Huh-7 cells. …”
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Hybrid, nanoscale phospholipid/block copolymer vesicles by Lim, Seng Koon, Hoog, Hans-Peter de, Nallani, Madhavan, Bo, Liedberg, Parikh, Atul N.

“…In brief, these hybrids may provide alternative tools for drug delivery purposes and molecular imaging/sensing applications and clearly open up new avenues for further investigation.…”
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Characterization of ubiquitin-activated DNA-protein crosslink repair in vitro by Zhu, X

“…<p><strong><em>Introduction:</em></strong> DNA-Protein Crosslinks (DPCs) are a form of DNA damage caused by covalent attachment between proteins and DNA, which can lead to replication fork stalling, disruption of cell division, and ultimately cell death. DPCs repair is critical for maintaining genome stability, however, the knowledge of the DPC repair pathways is still limited. …”