Exploring the therapeutic potential of 5-fluorouracil-loaded calcium carbonate nanoparticles combined with natural compound thymoquinone for colon cancer treatment by Deng, Xi, Yang, Zhongming, Chan, Kim Wei, Abu Bakar, Md Zuki

“…The combination of 5FU-CaCO3np (1.875 μM) and TQ (30 μM) showed significantly superior anti-colon cancer effects to 5FU-CaCO3np alone in terms of cell proliferation and migration inhibition, cell apoptosis induction, and spheroid growth suppression in CT26 cells (p < 0.05), with strong interactions between the drugs and targets (E-cadherin, Bcl-2, PCNA, and MMP-2). …”
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Mortality rates among patients successfully treated for hepatitis C in the era of interferon-free antivirals: population based cohort study by Hamill, V, Wong, S, Benselin, J, Krajden, M, Hayes, PC, Mutimer, D, Yu, A, Dillon, JF, Gelson, W, Velásquez García, HA, Yeung, A, Johnson, P, Barclay, ST, Alvarez, M, Toyoda, H, Agarwal, K, Fraser, A, Bartlett, S, Aldersley, M, Bathgate, A, Binka, M, Richardson, P, Morling, JR, Ryder, SD, Barnes, E

“…The leading causes of death were drug related mortality (n=383, 24%), liver failure (n=286, 18%), and liver cancer (n=250, 16%). …”

Chitosan nanofibrous scaffold with graded and controlled release of ciprofloxacin and BMP-2 nanoparticles for the conception of bone regeneration by Zhang, Sihan, Zhao, Guanglei, Mahotra, Manish, Ma, Shiyuan, Li, Wenrui, Lee, Hiang Wee, Yu, Hong, Sampathkumar, Kaarunya, Xie, Denghui, Guo, Jinshan, Loo, Joachim Say Chye

“…The microscopic nanofiber structure of the scaffold with 27.28 m2/g specific surface area promotes cell adhesion, high porosity provides space for cell growth, and facilitates drug loading and release. …”
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Shedding Light on Chemoresistance: The Perspective of Photodynamic Therapy in Cancer Management by Viana Cabral, Fernanda, Quilez Alburquerque, Jose, Roberts, Harrison James, Hasan, Tayyaba

“…Photodynamic therapy (PDT) has emerged as a promising photochemistry-based approach to address chemoresistance in cancer regimens. PDT not only induces cell death but also primes surviving cells, enhancing their susceptibility to subsequent therapies. …”
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Peripheral Nervous System Modulation with Wireless Cellular Sized Freestanding Injectable Devices by Patel, Preet

“…One of the foundations of neural interface and bioelectronic medicine is the electrical stimulation of excitable cells, to interface the body with electronics and treat a variety of diseases. …”
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Optimising expression and purification of Dengue soluble E protein by Poh, Nina Yong Xin

“…The E protein is crucial for viral fusion and host cell entry. The soluble E (sE) protein, obtained by truncation of Transmembrane Domain (TMD), serves as an antigen for serological assays, aiding diagnosis and seroprevalence assessment. …”
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The study of radiotherapy resistance of hypoxic tumour for improving survival of cancer patient. by Goh, Yeek Teck.

“…These proteins are likely to promote cell survival pathways such as DNA repairs in hypoxic cells upon radiation exposure. …”
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Transport and inhibition of the sphingosine-1-phosphate exporter SPNS2 by Li, HZ, Pike, ACW, Chang, Y, Prakaash, D, Gelova, Z, Stanka, J, Moreau, C, Scott, HC, Wunder, F, Wolf, G, Scacioc, A, McKinley, G, Batoulis, H, Mukhopadhyay, S, Garofoli, A, Pinto-Fernández, A, Kessler, BM, Burgess-Brown, NA, Štefanić, S, Wiedmer, T, Dürr, KL, Puetter, V, Ehrmann, A, Khalid, S, Sauer, DB

“…Accordingly, mutations in the S1P transporter SPNS2 are associated with reduced white cell count and hearing defects. SPNS2 also exports the S1P-mimicking FTY720-P (Fingolimod) and thereby is central to the pharmacokinetics of this drug when treating multiple sclerosis. …”

Thermal-disrupting interface mitigates intercellular cohesion loss for accurate topical antibacterial therapy by Hu, Benhui, Berkey, Christopher, Feliciano, Timothy, Chen, Xiaohong, Li, Zhuyun, Chen, Chao, Amini, Shahrouz, Nai, Mui Hoon, Lei, Qun-Li, Ni, Ran, Wang, Juan, Leow, Wan Ru, Pan, Shaowu, Li, Yong-Qiang, Cai, Pingqiang, Miserez, Ali, Li, Shuzhou, Lim, Chwee Teck, Wu, Yun-Long, Odom, Teri W., Dauskardt, Reinhold H., Chen, Xiaodong

“…Bacterial infections remain a leading threat to global health because of the misuse of antibiotics and the rise in drug-resistant pathogens. Although several strategies such as photothermal therapy and magneto-thermal therapy can suppress bacterial infections, excessive heat often damages host cells and lengthens the healing time. …”
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Non-traditional security issues : securitisation of transnational crime in Asia by Laki, James

“…Transnational crime involving all forms of domestic crime that tranverse the international boundary with another one or more states have become a concern amongst all peoples of the Asia Pacific region. …”
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Piezoelectric fibers for flexible and wearable electronics by Qian, Shengtai, Wang, Xingbei, Yan, Wei

“…As a new emerging flexible and wearable technology, fiber-shaped piezoelectric devices offer unique advantages over conventional thin-film counterparts. In this review, we survey the recent scientific and technological breakthroughs in thermally drawn piezoelectric fibers and fiber-enabled intelligent fabrics. …”
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Implementation of AFS approach for web data analysis by Liu, Yuyang.

“…In this report, the proposed design and implementation of the AFS in Java is given. The class diagram is drawn using UML. All the 25 MatLab AFS codes are documented using flowchart, and 9 out of them have been implemented using Java codes. …”
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Evaluation of the music collection at the National Institute of Education Library by Yu, Bee Lian.

“…However, the Library fared relatively better, with 71.5% holdings, when a list of "Recommended Readings/References" drawn up by the Institute's academic staff was list-checked.…”
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Neuroblastoma and its targets therapies: a medicinal chemistry review by Gerges, Amgad, Canning, Una

“…It concludes by proposing that future medicinal chemistry research into NB should consider other possible target therapies and adopt a multi‐target drug approach rather than a one‐drug‐one‐target approach for improved efficacy and less drug‐drug interaction for the treatment of NB Stage 4 (NBS4) patients.…”
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Structural and molecular characterization of ligands activating the orphan nuclear receptor Nurr1 (NR4A2) by Ng, Xin Yi

“…Moreover, L1 was also identified to increase the expression levels of dopamine-related genes in a LRRK2 G2019S cell-based model. This establishes the potential of L1 as a Nurr1-activating drug and lays the foundation for future development of disease-modifying drugs for PD to prevent or slow down its progression.…”
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Magnetic Droplet Merging by Hybrid Magnetic Fields by Ray, Ayan, Varma, Vijaykumar B., Wang, Zhaomeng, Wang, Zhiping, Jayaneel, P.J., Sudharsan, Natteri M., Ramanujan, Raju V.

“…The present work can be used for magnetically controlled, remote, wireless and programmable droplet actuation and merging relevant to biomedical assay, cell manipulation, tissue culture, drug efficacy and synthesis of magnet-polymer composite particles.…”
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Isolation and characterization of extracellular vesicles and future directions in diagnosis and therapy by De Sousa, Karina P., Rossi, Izadora, Abdullahi, Mahamed, Ramirez, Marcel I., Stratton, Dan, Inal, Jameel

“…With interest in therapeutic applications of EVs growing, we address fundamental points of EV-related cell biology, such as cellular uptake mechanisms and their biodistribution in tissues as well as challenges to their application as drug carriers or biomarkers for less invasive diagnosis or as immunogens.…”
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Outer-membrane permeabilization, LPS transport inhibition: activity, interactions, and structures of thanatin derived antimicrobial peptides by Swaleeha Jaan Abdullah, Yan, Bernice Tan Siu, Palanivelu, Nithya, Dhanabal, Vidhya Bharathi, Bifani, Juan Pablo, Bhattacharjya, Surajit

“…Currently, viable antibiotics available to mitigate infections caused by drug-resistant Gram-negative bacteria are highly limited. …”
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Design and development of energy saver electrical plug by Lee, Hong Eng

“…Recent years, climate change and decrement in natural resources become common concerns for all around the world. Efforts are putting on research of possibility of new resources replacement and ways to save energy. …”
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Investigation of phenylpropanoid sucrose esters as antidiabetic compounds by Wong, Kathy Pooi Wen

“…Further exposure of MTT cells to hybrid 77 (at a higher concentration) for 48 hours, resulted in a cytotoxicity of 11%. …”
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