Non-normal distribution of residual flexural strengths of steel fiber reinforced concretes and its impacts on design and conformity assessment by He, Shan, Yang, En-Hua

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Digital health eco-systems: an epochal review of practice-oriented research by Stephanie, Lena, Sharma, Ravi S.

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Load tests and moments evaluation of aircraft pylon using refurbished test assembly by Subas Chandrabose Satheesh Kumar

“…Other inferences and deductions drawn from this study are deliberated. Apart from that, two different approaches for reducing the probable error are also attempted.…”
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Tumor-targeted nano-assemblies for energy-blocking cocktail therapy in cancer by Chen, Manling, Liu, Yidu, Li, Yang, Liu, Xue

“…This study proposes a tumor energy cocktail therapy that combines metformin, an oxidative phosphorylation inhibitor, with 2-deoxy-d-glucose (2-DG), a glycolysis inhibitor, to target tumor cells. To minimize the dosage of both drugs, we have developed a drug delivery strategy that prepared metformin as a nanoderivative, denoted as MA-dots. …”
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Translation termination mechanism studied by solution state NMR by Li, Yan

“…In eukaryotes, class-I release factor (eRF1) directly recognizes all three stop-codons in the A site on the small ribosomal subunit and stimulates peptide release. …”
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European biologic training course for type 2 inflammation by EUFOREA in 2024: key facts and lessons learned by Conti, DM, Backer, V, Fokkens, W, Gevaert, P, Peters, A, Scadding, GK, Pavord, I, Lau, S, Wechsler, M, Bertels, X, Liva, G, Doulaptsi, M, Prokopakis, E, Hellings, PW

“…EUFOREA is an international non-for-profit organization forming an alliance of all stakeholders dedicated to reducing the prevalence and burden of chronic respiratory diseases through the implementation of optimal patient care via educational, research, and advocacy activities. …”

The relationship between leisure time physical activity patterns, Alzheimer’s disease markers and cognition by James, S, Sudre, CH, Barnes, J, Cash, DM, Chiou, Y, Coath, W, Keshavan, A, Lu, K, Malone, I, Murray-Smith, H, Nicholas, JM, Orini, M, Parker, T, Almeida-Meza, P, Fox, NC, Richards, M, Schott, JM

“…There was little evidence that leisure time physical activity had direct effects on other brain health measures (all P > 0.05). However, leisure time physical activity patterns modified and attenuated the association between poorer cognitive functioning at age 70 and a range of Alzheimer’s disease-related neurodegenerative markers (Aβ status; hippocampal and whole-brain volume; cortical thickness in Alzheimer’s disease regions) (all P < 0.05). …”

21W.775 Writing about Nature and Environmental Issues, Spring 2006 by Lioi, Anthony

“…Students will keep a web log as a journal. Writings are drawn from the tradition of nature writing and from contemporary forms of the environmentalist essay. …”
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Synthesis of densely functionalized pyrroles from unprotected carbohydrates by Xia, Mengxin

“…The activity of pyrrole-based drugs is tuned with the type of substituents on the pyrrole core and on the substitution pattern on the core pyrrole ring. …”
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Polymers at Nanoscale / by He, Jie, editor 655466, Wang, Xin, editor 655467, World Scientific (Online service) 655444

“…It showcases a wide range of advanced applications of polymer nanoparticles in several fields that include pharmaceutics (drug and nucleotide delivery), biomedicals (bioimaging, diagnosis, and therapeutics), energy (batteries and solar cells) and environmental (catalysis and water purification). …”
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Financial forecasting using meta-cognitive fuzzy neural networks by Singh Akhand Pratap

“…Some potential ways to address the above issues could be usage of synthetic data through time-series models to train the model till the test date; usage of manual inferences drawn from the indicators to make judgements about the present day; usage of multiple machine learning models and combining the results from all; usage of dynamic feature selection mechanism to make improvements to the prediction; and usage of dynamic thresholds that are dependent on the market conditions. …”
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Viral content: a theory of vaccine hesitancy based on information encountering in the greater Manila area, Philippines by Sacramento, Simon Philip R., Sipin, Ian Dominic P.

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Transcriptional profiling and network-based gene annotations of human malaria parasite plasmodium falciparum by Hu, Guang An

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Studies towards the synthesis of bioactive natural products and development of new synthetic methods by Khanizeman, Rabi’ah Nisha

“…It has been estimated that more than half of all approved drugs, from the period 1981 to 2014, are either natural products or their derivatives. …”
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Migration of magnetic microparticles through a liquid–liquid interface under an external magnetic field by Mondal, S, Abbasi, N, Tsai, SSH, Griffiths, IM

“…Liquid–liquid interfaces play a pivotal role in various microfluidic processes involving microparticles, including coating, dissolution, controlled release of polyelectrolytes or drugs, and self-assembly processes. In all of these cases, non-invasive techniques to manipulate the microparticle transport are essential. …”

Interaction-mediating sequences within class I viral fusion glycoproteins : their roles in viral infection and in applications by Zhang, Simin

“…Class I viral fusion glycoproteins facilitate fusion of the viral envelope with cell membranes and entry of the virus into the cell, through extensive short sequence-specific interactions. …”
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In vivo bone marrow microenvironment siRNA delivery using lipid–polymer nanoparticles for multiple myeloma therapy by Guimarães, Pedro PG, Figueroa-Espada, Christian G, Riley, Rachel S, Gong, Ningqiang, Xue, Lulu, Sewastianik, Tomasz, Dennis, Peter S, Loebel, Claudia, Chung, Amanda, Shepherd, Sarah J, Haley, Rebecca M, Hamilton, Alex G, El-Mayta, Rakan, Wang, Karin, Langer, Robert, Anderson, Daniel G, Carrasco, Ruben D, Mitchell, Michael J

“…We demonstrate that our strategy inhibits CyPA in BMECs, preventing MM cell extravasation in vitro. Finally, we show that siRNA-based silencing of CyPA in a murine xenograft model of MM, either alone or in combination with the Food and Drug Administration (FDA)-approved MM therapeutic bortezomib, reduces tumor burden and extends survival. …”
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Oncofetal HMGA2 attenuates genotoxic damage induced by topoisomerase II target compounds through the regulation of local DNA topology by Ahmed, Syed Moiz, Dröge, Peter

“…Rapidly dividing cells maintain chromatin supercoiling homeostasis via two specialized classes of enzymes, DNA topoisomerase type 1 and 2 (TOP1/2).Several important anticancer drugs perturb this homeostasis by targetingTOP1/2, thereby generating genotoxic DNA damage. …”
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The role of fibroblasts in cancer progression, therapy resistance and field cancerization by Chan, Jeremy Soon Kiat

“…The overexpression or knockdown of specific nuclear receptors in CAFs resulted in the attenuation of one or more aggressive phenotypes in tumor epithelial cells, namely, proliferation, invasiveness, drug resistance, energy metabolism and oxidative stress. …”
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Practitioner, patient and public views on the acceptability of mobile stroke units in England and Wales: A mixed methods study by Moseley, L, McMeekin, P, Price, C, Shaw, L, Laws, A, Allen, M, Ford, GA, James, M, McCarthy, S, McClelland, G, Park, LJ, Pearn, K, Phillips, D, White, P, Wilson, D, Scott, J

“…Results: The study results, drawn from 25 respondents to the survey and 21 participants in qualitative workshops, found that almost all participants had positive affective attitudes to the concept of MSUs. …”