Electrophysiological approaches to informing therapeutic interventions with deep brain stimulation by Asadi, A, Wiesman, AI, Wiest, C, Baillet, S, Tan, H, Muthuraman, M

“…Here, we discuss how electrophysiological brain recording and imaging at multiple scales, from cells to large-scale brain networks, contribute to defining the target location and stimulation parameters of neuromodulation, with an emphasis on deep brain stimulation (DBS).…”

An Epitaxial Ferroelectric Tunnel Junction on Silicon by Li, Zhipeng, Guo, Xiao, Lu, Hui-Bin, Zhang, Zaoli, Song, Dongsheng, Cheng, Shaobo, Bosman, Michel, Zhu, Jing, Dong, Zhili, Zhu, Weiguang

“…The obtained results suggest the possibility of integrating ferroelectric tunnel junctions as binary data storage media in non-volatile memory cells on a silicon platform.…”
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Biological evaluation of folic acid functionalized nano‐zeolitic imidazolate framework‐8 for cancer therapy by Lai, Xie Yong, Muhamad Ibrahim, Abdul Malek, Azren Aida, Asmawi, Rosniza, Razali, Afiq, Azil, Nur Aininie, Yusoh, Nurul Akmarina, Mohd Abdul Kamal

“…Conventional chemotherapy often results in toxicity to normal cells and hampers cancer treatment efficacy. Cancer targeting via surface-functionalized nanocarrier offers an excellent opportunity for tackling this unwanted issue. …”
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Membrane vesicles of clostridioides difficile and other clostridial species by Goh, Shan, Inal, Jameel

“…Membrane vesicles are secreted by growing bacterial cells and are important components of the bacterial secretome, with a role in delivering effector molecules that ultimately enable bacterial survival. …”
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Development of ratiometric fluorescent pH nanoprobe to study endocytic uptake pathways of antisense oligonucleotides by Liew, Donn Hou Feng

“…We observe a greater distinction between pH profiles of endosomal population for U2OS cells incubated with a higher concentration of ASO. …”
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Opto-mechatronics instrumentation of a specialty optical fiber based optogenetic probe by Gokulnath, Rajendran

“…The discovery of light-gated proteins that can be expressed with neuronal cells for targeted stimulation made optogenetics a powerful tool. …”
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Hodge theory and its applications to molecular data analysis by Koh, Ronald Joon Wei

“…One of the types of materials that are used to make these solar cells are hybrid organic-inorganic perovskites (HOIPs). …”
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Biological characterization of RNA polymerase proteins from human 2009 pandemic H1N1 and low pathogenic avian H5N2 and H9N2 influenza viruses by Myaing, Myint Zu

“…Interestingly, two mAbs-PA(9F5 and 2E2) against pH1N1/471 strain recognized PA protein in virus-infected cells with different staining patterns, which may be explained by their different epitope recognition. …”
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Variational Multiscale Models for Charge Transport by Wei, Guo-Wei, Zheng, Qiong, Chen, Zhan, Xia, Kelin

“…This work presents a few variational multiscale models for charge transport in complex physical, chemical, and biological systems and engineering devices, such as fuel cells, solar cells, battery cells, nanofluidics, transistors, and ion channels. …”
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Design of a 54x54-bit multiplier using radix-16 redundant binary booth encoding by Soh, Sing Yu.

“…These RB partial products were added in the RB adder (RBA) array block. Some of the RBA cells in the RBA circuit were optimised for the multiplier in this project.…”
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A new therapeutic avenue for bronchiectasis : dry powder inhaler of ciprofloxacin nanoplex exhibits superior ex vivo mucus permeability and antibacterial efficacy to its native cip... by Tran, The-Thien, Vidaillac, Celine, Yu, Hong, Yong, Valerie Fei Lee, Roizman, Dan, Chandrasekaran, Ravishankar, Lim, Albert Yick Hou, Low, Teck Boon, Tan, Gan Liang, Abisheganaden, John A., Koh, Mariko Siyue, Teo, Jeanette, Chotirmall, Sanjay Haresh, Hadinoto, Kunn

“…The DPI of CIP nanoplex exhibited similar cytotoxicity towards the lung epithelial cells as the native CIP indicating its low risk of toxicity. …”
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Discovery of a new predominant cytosine DNA modification that is linked to gene expression in malaria parasites by Hammam, Elie, Ananda, Guruprasad, Sinha, Ameya, Scheidig-Benatar, Christine, Bohec, Mylene, Preiser, Peter Rainer, Dedon, Peter C., Scherf, Artur, Vembar, Shruthi S.

“…DNA cytosine modifications are key epigenetic regulators of cellular processes in mammalian cells, with their misregulation leading to varied disease states. …”
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The impact of protozoan predation on the pathogenicity of Vibrio cholerae by Espinoza-Vergara, Gustavo, Hoque, M. Mozammel, McDougald, Diane, Noorian, Parisa

“…Protozoa engulf bacteria and package them into phagosomes where the cells are exposed to low pH, antimicrobial peptides, reactive oxygen/nitrogen species, proteolytic enzymes, and low concentrations of essential metal ions such as iron. …”
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Metformin alters human host responses to Mycobacterium tuberculosis in healthy subjects by Lachmandas, Ekta, Eckold, Clare, Böhme, Julia, Koeken, Valerie A. C. M., Mardiana Marzuki, Blok, Bastiaan, Arts, Rob J. W., Chen, Jinmiao, Teng, Karen W. W., Ratter, Jacqueline, Smolders, Elise J., Van den Heuvel, Corina, Stienstra, Rinke, Dockrell, Hazel M., Newell, Evan, Netea, Mihai G., Singhal, Amit, Cliff, Jacqueline M., Van Crevel, Reinout

“…These in vivo effects were accompanied by a metformin-induced shift in myeloid cells from classical to nonclassical monocytes. …”
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Structural and biochemical mechanisms of NLRP1 inhibition by DPP9 by Huang, Menghang, Zhang, Xiaoxiao, Toh, Gee Ann, Gong, Qin, Wang, Jia, Han, Zhifu, Wu, Bin, Zhong, Franklin, Chai, Jijie

“…Activation of the NLR protein NLRP1 requires autocleavage within its function-to-find domain (FIIND)1-7. In resting cells, the dipeptidyl peptidases DPP8 and DPP9 interact with the FIIND of NLRP1 and suppress spontaneous NLRP1 activation8,9; however, the mechanisms through which this occurs remain unknown. …”
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Electrochemical microfluidic multiplexed bioanalysis by a highly active bottlebrush-like nanocarbon microelectrode by Xu, Yun, Huang, Wei, Zhang, Yan, Duan, Hongwei, Xiao, Fei

“…The structural characteristics, high catalytic activities, and favorable biocompatibility of the bottlebrush nanocarbon electrodes provide opportunities for multichannel, microfluidic detection of redox-active biomolecules, including hydrogen sulfide (H2S), dopamine (DA), uric acid (UA), and ascorbic acid (AA), and have been applied to on-chip monitoring of H2S and DA released from live cancer cells or neuroblastoma cells and DA, UA, and AA in trace amounts of body fluids such as sweat, finger blood, tears, saliva, and urine, which is of great significance for clinical diagnosis and prognosis in point-of-care testing.…”
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Tunable anti-ambipolar vertical bilayer organic electrochemical transistor enable neuromorphic retinal pathway by Laswick, Zachary, Wu, Xihu, Surendran, Abhijith, Zhou, Zhongliang, Ji, Xudong, Matrone, Giovanni Maria, Leong, Wei Lin, Rivnay, Jonathan

“…Combining these components, a mimic of the retinal pathway reproducing the wavelength and light intensity encoding of horizontal cells to spiking retinal ganglion cells is demonstrated. …”
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The evolution of complexity in self-maintaining cellular information processing networks by Decraene, James, McMullin, Barry

“…We examine the role of self-maintenance (collective autocatalysis) in the evolution of computational biochemical networks. In primitive proto-cells (lacking separate genetic machinery) self-maintenance is a necessary condition for the direct reproduction and inheritance of what we here term Cellular Information Processing Networks (CIPNs). …”
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SRAM-based NATURE: A dynamically reconfigurable FPGA based on 10T low-power SRAMs by Jha, Niraj K., Lin, Ting-Jung, Zhang, Wei

“…We use fast and low-power SRAM blocks that are based on 10T SRAM cells. We have also laid out the various FPGA components in a 65-nm technology to evaluate the FPGA performance. …”
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Coordination chemistry and biological activity of bidentate and quadridentate nitrogen–sulfur donor ligands and their complexes by H. Tarafder, M. Tofazzal, Ali, A. Manaf, Elias, M. Suhaimi, Crouse, Karen A., Silong, Sidik

“…The SnII complex and the SNNS free Schiff base were very effective against Melanoma (skin cancer cells). The SBDTC and its SnII complex were also very effective against Renal carcinoma (kidney cancer cells). …”