Mortality risks in different subtypes of masked hypertension in the Spanish ambulatory blood pressure monitoring registry by de la Sierra, A, Ruilope, LM, Staplin, N, Stergiou, GS, Williams, B

“…All-cause and cardiovascular death (median follow-up 9.7 years) were assessed in each of these subtypes in comparison to 10 006 patients with normal both office and 24-h BP. …”

The development of CT urography for investigating haematuria by Cowan, N

“…</p> <p>Patients with haematuria are classified as low risk or high risk for UTUC and BCa, by a risk score, determined by the presence / absence of risk factors: age &gt; 50 years, visible or nonvisible haematuria, history of smoking and occupational exposure.…”

Relapse after cessation of weekly tocilizumab for giant cell arteritis: a multicentre service evaluation in England by Quick, V, Abusalameh, M, Ahmed, S, Alkoky, H, Bukhari, M, Carter, S, Coath, FL, Davidson, B, Doddamani, P, Dubey, S, Ducker, G, Griffiths, B, Gullick, N, Heaney, J, Holloway, A, Htut, EEP, Hughes, M, Irvine, H, Kinder, A, Kurshid, A, Lim, J, Ludwig, DR, Malik, M, Mercer, L, Mulhearn, B, Nair, JR, Patel, R, Robson, J, Saha, P, Tansley, S, TOC STOP 2022 Investigators, Mackie, SL

“…Time to relapse was shorter in those that had previously also relapsed during qwTCZ treatment (P = 0.0017), in those not in remission at qwTCZ cessation (P = 0.0036) and in those with large vessel involvement on imaging (P = 0.0296). Age ≥65 years, gender, GCA-related sight loss, qwTCZ treatment duration, TCZ taper, prednisolone dosing and conventional synthetic DMARD use were not associated with time to relapse.…”

Uptake and safety of Sotrovimab for prevention of severe COVID-19 in a cohort and self-controlled case series study by Patone, M, Snelling, AJ, Tibble, H, Coupland, C, Sheikh, A, Hippisley-Cox, J

“…Results: Here we show that among treated and untreated eligible individuals, the mean ages (54.6 years, SD: 16.1 vs 54.1, SD: 18.3) and sex distribution (women: 60.9% vs 58.1%; men: 38.9% vs 41.1%) are similar. …”

Predictive factors for the diagnosis of coeliac disease in children and young people in primary care: A systematic review and meta-analysis by Farrier, CE, Wanat, M, Harnden, A, Paterson, A, Roberts, N, Saatci, D, Hirst, J

“…Included studies were observational or randomized trials reporting the risk of CD when exposed to predictive factor(s) in people ≤25 years of age. Genetic factors were excluded. Risk of Bias was assessed using the Newcastle-Ottawa Scale. …”

Understanding the consequences of education inequality on cardiovascular disease: mendelian randomisation study by Carter, AR, Gill, D, Davies, NM, Taylor, AE, Tillmann, T, Vaucher, J, Wootton, RE, Munafò, MR, Hemani, G, Malik, R, Seshadri, S, Woo, D, Burgess, S, Davey Smith, G, Holmes, MV, Tzoulaki, I, Howe, LD, Dehghan, A

“…Results: Each additional standard deviation of education (3.6 years) was associated with a 13% lower risk of coronary heart disease (odds ratio 0.86, 95% confidence interval 0.84 to 0.89) in observational analysis and a 37% lower risk (0.63, 0.60 to 0.67) in mendelian randomisation analysis. …”

The prognostic impact of minimally invasive esophagectomy on survival after esophagectomy following a delayed interval after chemoradiotherapy; a secondary analysis of the DICE stu... by Markar, SR, Sgromo, B, Evans, R, Griffiths, EA, Alfieri, R, Castoro, C, Gronnier, C, Gutschow, CA, Piessen, G, Capovilla, G, Grimminger, PP, Low, DE, Gossage, J, Gisbertz, SS, Ruurda, J, van Hillegersberg, R, D'journo, XB, Phillips, AW, Rosati, R, Hanna, GB, Maynard, N, Hofstetter, W, Ferri, L, Berge Henegouwen, MI, Owen, R

“…<p><strong> Results: </strong></p> 428 patients (145 MIE and 283 OE) had surgery between 12 weeks and two years after CRT. Significant differences were observed in ASA grade, radiation dose, clinical T stage, and histological subtype. …”

Effectiveness and safety of COVID-19 vaccination in people with blood cancer by Copland, E, Hirst, J, Mi, E, Patone, M, Chen, D, Coupland, C, Hippisley-Cox, J

“…</p> <br> <p><strong>Methods:</strong> Individuals aged ≥12 years as of 1st December 2020 in the QResearch primary care database were included. …”

Determining targets for antiretroviral drug concentrations: a causal framework illustrated with pediatric efavirenz data from the CHAPAS-3 trial by Schomaker, M, Denti, P, Bienczak, A, Burger, D, Díaz, I, Gibb, DM, Walker, AS, McIlleron, H

“…</p> <p><strong>Methods:&nbsp;</strong>The proposed framework is applied in an analysis including longitudinal observational data from 125 HIV-positive children treated with efavirenz-based regimens within the CHAPAS-3 trial, which enrolled children &lt;&thinsp;13&thinsp;years in Zambia/Uganda. A directed acyclic graph was developed to visualize the mechanisms affecting antiretroviral concentrations. …”

A 24-month National Cohort Study examining long-term effects of COVID-19 in children and young people by Stephenson, T, Pinto Pereira, SM, Nugawela, MD, Dalrymple, E, Harnden, A, Whittaker, E, Heyman, I, Ford, T, Segal, T, Chalder, T, Ladhani, SN, McOwat, K, Simmons, R, Xu, L, Fox-Smith, L, Shafran, R

“…Methods: CloCk is a cohort of CYP in England aged 11-to-17-years when they had a SARS-CoV-2 PCR-test (between September 2020 and March 2021). …”

Accessibility, inclusivity, and implementation of COVID-19 clinical management guidelines early in the pandemic: a global survey by Pilbeam, C, Malden, D, Newell, K, Dagens, A, Kennon, K, Michelen, M, Gobat, N, Sigfrid, L

“…Only 20% of respondents reported having access to CMGs covering care for children, 25% for pregnant women, and 50% for older adults (>65 years). Identified themes were for CMGs to include recommendations for at-risk populations and settings, include supportive care guidance, and be updated as evidence emerges, and for clinicians to have training and access to recommended treatments to support implementation. …”

Response of appetite and potential appetite regulators following intake of high energy nutritional supplements by Fatima, S, Gerasimidis, K, Wright, C, Tsiountsioura, M, Arvanitidou, E-I, Malkova, D

“…</p> <p><strong>Design</strong> Twenty three females of 24.4 ± 2.8 years with BMI of 18.2 ± 0.8 kg/m2 consumed HENSD (2.5 MJ) or PLACEBO (0.4 MJ) in fasted state in a single blind randomized cross-over study. …”

Non-stationary modeling of seasonal precipitation series in Turkey: estimating the plausible range of seasonal extremes by Tosunoglu, F, Slater, LJ, Kowal, KM, Gu, X, Yin, J

“…Using the non-stationary models, we then computed seasonal precipitation estimates for different return periods (i.e., 20, 50, and 100 years) and considered the minimum and maximum possible extreme precipitation scenarios at each site. …”

Knowledge, attitude and practice on cardiopulmonary resuscitation (cpr) among critical care nurses in Hospital Universiti Sains Malaysia by Mughni, Muhamad Hafizuddin

“…The chi-square test result (χ² = 22.609, p < 0.001) suggests a significant association between the years of working experience in critical care and the level of knowledge.…”
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Supporting activex-based client for large-scale collaborative virtual environment by Wu, Liang.

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#Hooked? Extending the social cognitive model in examining the antecedents of problematic social network sites use among Singaporean adolescents and adults by Lee, Edmund Wei Jian

“…Cases of social network sites (SNSs) users potentially developing problematic SNSs use have revived scholarly interest in addictive media research in the last few years. As a nascent research area, there is a need for clear communication-centric theoretical paradigms and rigorous methods in guiding empirical inquiry in problematic SNSs use. …”
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Integrating quantitative and qualitative methodologies to build a national R&amp;D plan using data envelopment analysis based on R&amp;D stakeholders’ perspectives by Park, Wan, Kim, Sang-Gook

“…The yearly increase in government R&amp;D investment and top-down national R&amp;D investment allocation requires a more quantitative decision-making system that maximizes R&amp;D performance and efficient budget allocation. …”
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Expanding the CRISPR Toolbox for Engineering Lycopene Biosynthesis in Corynebacterium glutamicum by Zhan, Zhimin, Chen, Xiong, Ye, Zhifang, Zhao, Ming, Li, Cheng, Gao, Shipeng, Sinskey, Anthony J., Yao, Lan, Dai, Jun, Jiang, Yiming, Zheng, Xueyun

“…The microbial production of lycopene has received increasing concern in recent years. Corynebacterium glutamicum (C. glutamicum) is considered to be a safe and beneficial industrial production platform, naturally endowed with the ability to produce lycopene. …”
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Compact Capabilities: Developing and Evaluating a Field-Portable Neutron Resonance Capture Analysis System by Rahon, Jill M.

“…Technological advances in the thorium fuel cycle and other advanced reactor concepts suggest their possible commercialization for nuclear power use in the next ten years. Although the thorium cycle shares many aspects with the uranium and plutonium fuel cycles, it introduces the requirement for the nondestructive assay of multiple isotopes (²³8U, ²³²Th, ²³³U, ²³⁵U, or ²³⁹Pu) in varied concentrations and chemical or physical forms. …”
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Tectonics of the semi-permanent: Reassembling fit-out architecture by Schnitzler, Jenna

“…The uneven wearing that Bolton wrote about in 1911, appears again in the iconic shearing layers diagram from Frank Duffy and Stewart Brand, who make a very similar economic argument, demonstrating that the economically fast-wearing interior layer accumulates the most investment over time, rebuilt on a cycle of every 5-10 years. We are facing a turning point in building; as of 2020, over 35% of total construction activity is renovation work, and we are making increasingly rapid changes to building function. …”
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