Synthesis and development of novel small molecule inhibitors of nucleophilic hydrolases by Gayatri

“…The work focused on the synthesis and structure activity relationship (SAR) exploration of two small molecule templates, i.e. …”

TPepRet: a deep learning model for characterizing T-cell receptors–antigen binding patterns by Wang, M, Fan, W, Wu, T, Li, M

“…While several computational tools have been developed, they neglect the directional semantics inherent in sequence data, which are essential for accurately characterizing TCR-peptide interactions. …”

Optimising the surveillance and control of communicable diseases: the effects of population heterogeneity on early outbreak transmission dynamics by Lovell-Read, F

“…Then, we extend our model to account for age-dependent factors that affect SARS-CoV-2 transmission, including patterns of social contacts, variation in susceptibility to infection, and the likelihood of developing clinical symptoms. …”

Biovalorisation of food waste in Singapore : synergistic effect of a mixed culture in solid-state fermentation by Ong, Adwin Reng Jun

“…Okara and brewer’s spent grain (BSG) are manufacturing side streams produced in massive amounts from the soy and beer industries, respectively, and contributes significantly to food waste. …”
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Practical and analytical considerations when performing interim analyses in diagnostic test accuracy studies by Fleming, S, Mwandigha, L, Fanshawe, T

“…The method is illustrated using two simulated data sets and data from a published diagnostic accuracy study for point-of-care testing for SARS-CoV-2. The considerations described in this paper can be used to guide decisions as to when an interim analysis in a diagnostic accuracy study is suitable and highlight areas for further methodological development.…”

Cost-utility analysis of molnupiravir plus usual care versus usual care alone as early treatment for community-based adults with COVID-19 and increased risk of adverse outcomes in... by Png, ME, Harris, V, Grabey, J, Hart, ND, Jani, BD, Butler, D, Carson-Stevens, A, Coates, M, Cureton, L, Dobson, M, Dorward, J, Evans, P, Francis, N, Gbinigie, OA, Hayward, G, Holmes, J, Hood, K, Khoo, S, Ahmed, H, Lown, M, McKenna, M, Mort, S, Nguyen-Van-Tam, J, Rahman, N, Richards, DB, Thomas, N, van Hecke, O, Hobbs, FR, Little, P, Yu, L-M, Butler, CC, Petrou, S

“…<p><strong>Background </p></strong>The cost-effectiveness of molnupiravir, an oral antiviral for early treatment of SARS-CoV-2, has not been established in vaccinated populations. …”

The neurological consequences of contracting COVID-19 by Aknin, LB, De Neve, JE, Dunn, EW, Fancourt, DE, Goldberg, E, Helliwell, JF, Jones, SP, Karam, E, Layard, R, Lyubomirsky, S, Rzepa, A, Saxena, S, Thornton, EM, VanderWeele, TJ, Whillans, AV, Zaki, J, Caman, O, Amor, YB

“…Since the first confirmed case in Wuhan, China on December 31, 2019, the novel coronavirus (SARS-CoV-2) has spread quickly, infecting 165 million people as of May 2021. …”

Rapid electrochemical detection of COVID-19 genomic sequence with dual-function graphene nanocolloids based biosensor by Ang, Wei Li, Lim, Rachel Rui Xia, Ambrosi, Adriano, Bonanni, Alessandra

“…Over 329 million people have been infected till date and over 5.5 million people could not survive the respiratory illness known as COVID-19 syndrome. …”
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Generation of self-replicating airway organoids from the cave nectar bat Eonycteris spelaea as a model system for studying host-pathogen interactions in the bat airway epithelium by Chan, Louisa L. Y., Gamage, Akshamal M., Tan, Chee Wah, Tan, Kai Sen, Liu, Jing, Tay, Douglas Jie Wen, Foo, Randy Jee Hiang, Rénia, Laurent, Wang, De Yun, Wang, Lin-Fa

“…However, these ALI-AECs did not support SARS-CoV-2 infection, despite E. spelaea ACE2 receptor being capable of mediating SARS-CoV-2 spike pseudovirus entry. …”
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Topic extraction and sentiment analysis of a subreddit (r/coronavirus) by Chong, You Min

“…The coronavirus (COVID-19) pandemic has spread its roots globally since the first outbreak in early 2020, and the first global crisis since SARS in 2002. COVID-19 has negatively impacted the world in more ways than one and has completely changed the way lives are being led. …”
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Unraveling microglial spatial organization in the developing human brain with DeepCellMap, a deep learning approach coupled with spatial statistics by Perochon, T, Krsnik, Z, Massimo, M, Ruchiy, Y, Romero, AL, Mohammadi, E, Li, X, Long, KR, Parkkinen, L, Blomgren, K, Lagache, T, Menassa, DA, Holcman, D

“…Additionally, we uncover an association between microglia and blood vessels in fetal brains exposed to maternal SARS-CoV-2. These findings offer insights into whether various microglial phenotypes form networks in the developing brain to occupy space, and in conditions involving haemorrhages, whether microglia respond to, or influence changes in blood vessel integrity. …”

Safety outcomes following COVID-19 vaccination and infection in 5.1 million children in England by Copland, E, Patone, M, Saatci, D, Handunnetthi, L, Hirst, J, Hunt, DPJ, Mills, NL, Moss, P, Sheikh, A, Coupland, CAC, Harnden, A, Robertson, C, Hippisley-Cox, J

“…An additional 12 (95%CI 0–23) hospitalisations with epilepsy and 4 (95%CI 0–6) with demyelinating disease (in females only, mainly optic neuritis) were estimated per million following a second dose with BNT162b2. SARS-CoV-2 infection was associated with increased risks of hospitalisation from seven outcomes including multisystem inflammatory syndrome and myocarditis, but these risks were largely absent in those vaccinated prior to infection. …”

Fast and accurate variant identification tool for sequencing-based studies by Gaston, Jeffry M., Alm, Eric J., Zhang, An-Ni

“…This accuracy extends to variant identification in virus samples, including SARS-CoV-2, particularly with significantly fewer false negative indels than bcftools. …”
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Site-specific chemical and topological modifications to augment mRNA therapeutic potential by Aditham, Abhishek J.

“…Despite clinical demonstrations of mRNA for SARS-CoV-2 vaccines, mRNAs remain limited in application by their susceptibility to nucleases and overall short expression lifetime in vivo. …”
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The Pandemic EVIDENCE Collaboration Pillar 1: diagnostics and transmission by Conly, J, Plüddemann, A, Jefferson, T, Rosca, C, Heneghan, C

“…The evidence produced to support the optimal deployment of NPIs to reduce transmission of SARS-CoV-2 was often of poor quality, and decisions were made without considering the wealth of previous research on respiratory virus transmission from human challenge studies. …”

The Pandemic EVIDENCE Collaboration Pillar 2: interventions and evidence by Fretheim, A, Onakpoya, I, Bartoszko, J, Jones, M, Gandini, S

“…The use of non-pharmacological interventions (NPIs) on a global scale to reduce the transmission of SARS-CoV-2 was unprecedented. However, there was a lack of high-quality evidence to fully understand the benefits and harms of these interventions. …”

The IDentif.AI-x pandemic readiness platform: rapid prioritization of optimized COVID-19 combination therapy regimens by Blasiak, Agata, Truong, Anh T. L., Remus, Alexandria, Hooi, Lissa, Seah, Shirley Gek Kheng, Wang, Peter, Chye, De Hoe, Lim, Angeline Pei Chiew, Ng, Kim Tien, Teo, Swee Teng, Tan, Yee-Joo, Allen, David Michael, Chai, Louis Yi Ann, Chng, Wee Joo, Lin, Raymond T. P., Lye, David C., Wong, John Eu-Li, Tan, Gladys Gek-Yen, Chan, Conrad En Zuo, Chow, Edward Kai-Hua, Ho, Dean

“…IDentif.AI-x, a clinically actionable artificial intelligence platform, was used to rapidly pinpoint and prioritize optimal combination therapies against COVID-19 by pairing a prospective, experimental validation of multi-drug efficacy on a SARS-CoV-2 live virus and Vero E6 assay with a quadratic optimization workflow. …”
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The relationship between viral clearance rates and disease progression in early symptomatic COVID-19: a systematic review and meta-regression analysis by Singh, S, Boyd, S, Schilling, WHK, Watson, JA, Mukaka, M, White, NJ

“…Treatment benefit was defined clinically as the relative risk of hospitalization/death during follow-up (&ge;14 days), and virologically as the SARS-CoV-2 viral clearance rate ratio (VCRR). The VCRR is the ratio of viral clearance rates between the intervention and control arms. …”

Multicenter diagnostic evaluation of onsite COVID-19 Rapid Test (CTK Biotech) among symptomatic individuals in Brazil and the United Kingdom by Thompson, CR, Torres, PM, Kontogianni, K, Byrne, RL, LSTM Diagnostic group, Noguera, SV, Luna-Muschi, A, Marchi, AP, Andrade, PS, Dos Santos Barboza, A, Nishikawara, M, CONDOR steering group, Body, R, de Vos, M, Escadafal, C, Adams, E, Figueiredo Costa, S, Cubas-Atienzar, AI

“…Concurrently, analytical evaluation of the Ag-RDT was assessed using direct culture supernatant of SARS-CoV-2 strains from wild-type (WT), Alpha, Delta, Gamma, and Omicron lineages. …”

Brewers’ spent grains as potential novel functional food ingredients for food security by Tan, Yong Xing

“…BSG are residues generated as side streams from beer production. Currently, BSG are used as animal feed or disposed in landfills and these massive amount of BSG generated annually are causing significant environmental, economic, and climatic issues. …”
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