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1
Controllable charge transfer via DNA molecules
Published 2015“…Although the comprehensive fundamental description of charge transfer along DNA is still missing, the process can be categorized into oxidative holes and reductive electrons transfer/transport. …”
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Thesis-Doctor of Philosophy -
2
Electrochemical DNA biosensor based on nanoporous alumina membrane
Published 2014“…In recent years, due to the high sensitivity and sequence specificity, as well as rapid detection, the electrochemical DNA biosensors are promising for genetic screening and detection of deoxyribonucleic acid. …”
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Thesis -
3
Characterization of ubiquitin-activated DNA-protein crosslink repair in vitro
Published 2024“…DPCs repair is critical for maintaining genome stability, however, the knowledge of the DPC repair pathways is still limited. SPRTN, a DNA-dependent metalloprotease, has been identified as the major protease in repairing DPCs. …”
Thesis -
4
Multifunctional systems in synthetic biology: Single-stranded DNA signals controls precise gene activation
Published 2025“…Selective gene activation was achieved by using different promoters or by using inhibitors to remove undesired signals by the DNA strand displacement reaction. Moreover, DNA signals were divided in half to construct complex logic gates (AND-OR-AND-OR-AND gates) that controlled gene activation. …”
Thesis -
5
Mapping the structural and dynamical features of multiple p53 DNA binding domains : insights into loop 1 intrinsic dynamics
Published 2014“…The transcription factor p53 regulates cellular integrity in response to stress. p53 is mutated in more than half of cancerous cells, with a majority of the mutations localized to the DNA binding domain (DBD). …”
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Journal Article -
6
Enhancing early warning: A DNA biosensor with polyaniline/graphene nanocomposite for label-free voltammetric detection of saxitoxin-producing harmful algae
Published 2024“…Yearly reports of detrimental effects resulting from harmful algal blooms (HAB) are still received in Malaysia and other countries, particularly concerning fish mortality and seafood contamination, both of which bear consequences for the fisheries industry. …”
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Article -
7
Multidose transient transfection of human embryonic kidney 293 cells modulates recombinant adeno‐associated virus2/5 Rep protein expression and influences the enrichment fraction o...
Published 2024“…We report that the availability of preformed empty capsids and viral DNA copies per cell are not limiting to the capsid-filling reaction. …”
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Article -
8
iN6-methylat (5-step) : identifying DNA N⁶-methyladenine sites in rice genome using continuous bag of nucleobases via Chou's 5-step rule
Published 2021“…DNA N⁶-methyladenine is a non-canonical DNA modification that occurs in different eukaryotes at low levels and it has been identified as an extremely important function of life. …”
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Journal Article -
9
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10
Leveraging imperfect restoration for data availability attack
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Conference Paper -
11
Studies of the Fanconi anemia pathway
Published 2016“…Upon the appearance of ICLs, the FANCD2/FANCI complex is monoubiquitinated, and localised to the sites of DNA lesion. While the molecular mechanism of how the FA pathway operates is emerging, there are still questions remaining, such as if there is a sensor for ICLs being able to activate the FA pathway, or the timing of the recruitment of the FANCD2/FANCI heterodimer to damaged chromatin. …”
Thesis -
12
An experimental design of a robotic delivery company
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Final Year Project (FYP) -
13
Structural features that affect β2 integrin expression and regulation of adhesion
Published 2013“…To establish the correlation between LAD-1 genotype and phenotype, as well as better understand integrin function and structure, 19 LAD-1 missense mutants that recently identified were introduced into the pcDNA3 plasmid containing the ITGB2 cDNA. These plasmids were transfected into HEK293T cells together with that of either the αL, αM, αX subunits. …”
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Thesis -
14
Clonal phylogenies inferred from bulk, single cell, and spatial transcriptomic analysis of epithelial cancers
Published 2025“…While these inferred SNV and CNV states can be used to resolve clonal phylogenies, however, it is still unknown how faithfully transcript-based tumour phylogenies reconstruct ground truth DNA-based tumour phylogenies. …”
Journal article -
15
Complex Queries in a Shared Multi User Relational Cloud Database
Published 2017“…While DaaS is becoming more and more popular enterprises start considering it as an option to reduce IT maintenance costs. …”
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Conference Paper -
16
A synthetic biology platform for malaria parasites based on orthogonal transcriptional control
Published 2024“…Malaria is responsible for half a million deaths each year in some of the poorest communities around the world. …”
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Thesis -
17
Unravelling 2-oxoglutarate turnover and substrate oxidation dynamics in 5-methylcytosine-oxidising TET enzymes
Published 2024“…Here, we profile 5-methylcytosine (5mC)-oxidising Ten-Eleven Translocation (TET) enzymes using MS and 1H NMR spectroscopy methods and reveal a high degree of substrate oxidation-independent 2OG turnover under a range of conditions. 2OG decarboxylase activity is substantial (>20% 2OG turned over after 1 h) in the absence of substrate, while, under substrate-saturating conditions, half of total 2OG consumption is uncoupled from substrate oxidation. 2OG kinetics are affected by substrate and non-substrate DNA oligomers, and the sequence-agnostic effects are observed in amoeboflagellate Naegleria gruberi NgTet1 and human TET2. …”
Journal article -
18
Design and simulation of plasmonic metamaterials for sub-wavelength imaging in the visible range
Published 2013“…The resolution of conventional optical lens system is limited by diffraction to about half-wavelength of the incident light. Plasmonic metamaterials, which rely on surface plasmons (SPs) to confine and transmit the electromagnetic (EM) energy, provide a way to circumvent the diffraction-limit. …”
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Thesis -
19
Elucidating the genomic and transcriptomic profiles contributing to the overall survival of acute myeloid leukaemia patients with normal karyotype in Malaysia
Published 2024“…Acute myeloid leukaemia-normal karyotype (AML-NK) comprises almost half of the AML subtypes and exhibits heterogeneity in overall survival (OS). …”
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Monograph -
20
Conception of conjugative cloning vectors.
Published 2012“…Further experimentation is still required to verify the sustainability and success of this triparental system.…”
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Final Year Project (FYP)