Expediting treatments in the 21st century: orphan drugs and accelerated approvals by Domike, Reuben, Raju, G. K., Sullivan, Jamie, Kennedy, Annie

“…In 1983, the United States Congress passed the Orphan Drug Act to provide financial incentives for development of drugs for rare diseases. …”
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Novel drug-eluting stent to reduce fibrosis-induced ureteral stricture by Fong, Timothy Ren Zhong

“…A solution of poly(L-lactide-co-caprolactone) and MMC was spray coated on 2cm long polyurethane stents, with varied drug loading (2.5wt%, 5wt%, 7.5wt%). The stents were then immersed in four different Phosphate Buffer Saline mediums (pH 6, 7, 7.4, 8.5) for drug release over 28 days. …”
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Temporal pressure enhanced topical drug delivery through micropore formation by Lio, Daniel Chin Shiuan, Chia, Ruining, Kwek, Milton Sheng Yi, Wiraja, Christian, Madden, Leigh Edward, Chang, Hao, S. Mohideen Abdul Khadir, Wang, Xiaomeng, Becker, David Lawrence, Xu, Chenjie

“…However, existing platforms require high doses of chemical enhancers or sophisticated equipment, use fragile biomolecules, or are limited to a certain type of drug. Here, we report an innovative methodology based on temporal pressure to enhance the penetration of all kinds of drugs, from small molecules to proteins and nanoparticles (up to 500 nm). …”
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Pathways to prison: economic, personal and relational motivations for drug offending in Indonesia by Hoyle, C, Jabbar, P

Recent advances in the development of liquid crystalline nanoparticles as drug delivery systems by Leu, Jassica S. L., Teoh, Jasy J. X., Ling, Angel L. Q., Chong, Joey, Loo, Yan Shan, Mat Azmi, Intan Diana, Zahid, Noor Idayu, Bose, Rajendran J. C., Madheswaran, Thiagarajan

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Green amorphous nanoplex as a new supersaturating drug delivery system by Cheow, Wean Sin, Hadinoto, Kunn

“…The solubility of curcumin as the least-soluble drug is magnified 9-fold upon its transformation to the nanoplex, and the supersaturated condition is maintained for 5 h.…”
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Ultrasound‐Responsive Aqueous Two‐Phase Microcapsules for On‐Demand Drug Release by Field, Rachel D, Jakus, Margaret A, Chen, Xiaoyu, Human, Kelia, Zhao, Xuanhe, Chitnis, Parag V, Sia, Samuel K

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Layer-by-layer assembled micro and nano carriers for drug delivery applications by Mutukumaraswamy Shaillender

“…In nano- or microparticulate drug delivery, both control of the drug release and interaction of the particles with the cellular environment are critical attributes. …”
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Controlled-release nanoencapsulating microcapsules to combat inflammatory diseases by Baek, Jong-Suep, Yeo, Eng Wan, Lee, Yin Hao, Tan, Nguan Soon, Loo, Say Chye Joachim

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Antibacterial effect of ethanolic Gnetum gnemon L. leaf extract on food-borne pathogens and its application as a natural preservative on raw quail eggs by Trisha, Mansura Rahman, Deavyndra Gunawan, Vyenna, Wong, Jun Xian, Pak Dek, Mohd Sabri, Rukayadi, Yaya

“…Total plate count (TPC) was conducted to measure microbial populations and evaluate the efficacy of EGLE as a natural preservative in raw quail eggs. 100 g of dried and powdered sample yielded an average of 11.58 ± 0.38 % post-extraction. …”
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Near-infrared light for phototherapy : photothermal induced drug release and tumor ablation by Li, Menghuan

“…Since the introduction of nanotechnology into cancer treatment, numerous therapeutic nanoagents have been developed for the detection, imaging and therapy of various types of cancers. Amongst all these efforts, near-infrared-light-involved anticancer therapy has drawn increasing attention in recent years, due to the minimal invasiveness and high tissue penetration of near-infrared light (NIR). …”
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From the body to the brain: Studying drug delivery and physiological interactions using MRI by Dawson, Miranda

“…In all, this work serves as a demonstration of the power of quantitative neuroimaging methods for multifaceted investigation of brain and body relationships.…”
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Hollow microcapsules as periocular drug depot for sustained release of anti-VEGF protein by Radhakrishnan, Krishna, Vincent, Anita, Joseph, Rini Rachel, Moreno, Miguel, Dickescheid, Andreas, Agrawal, Rupesh, Venkatraman, Subbu S.

“…Diseases affecting the posterior segment of the eye such as age-related macular degeneration and diabetic retinopathy are leading causes of blindness all over the world. The current treatment regimen for such diseases involves repeated intravitreal injections of anti- Vascular Endothelial Growth Factor (VEGF) proteins. …”
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Exploring drug consumption rooms as ‘inclusion health interventions’: policy implications for Europe by Scher, BD, Chrisinger, BW, Humphreys, DK, Shorter, GW

Development of oil-based gels as versatile drug delivery systems for pediatric applications by Kirtane, Ameya R., Karavasili, Christina, Wahane, Aniket, Freitas, Dylan, Booz, Katelyn, Le, Dao Thi Hong, Hua, Tiffany, Scala, Stephen, Lopes, Aaron, Hess, Kaitlyn, Collins, Joy, Tamang, Siddartha, Ishida, Keiko, Kuosmanen, Johannes L. P., Rajesh, Netra Unni, Phan, Nhi V., Li, Junwei, Krogmann, Annlyse, Lennerz, Jochen K., Hayward, Alison, Langer, Robert, Traverso, Giovanni

“…In swine, oleogels could deliver four drugs ranging three orders of magnitude in their water solubilities and two orders of magnitude in their partition coefficients. …”
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Electrochemically driven optical and SERS immunosensor for the detection of a therapeutic cardiac drug by Chaudhry, Madeeha, Lim, Dong-Kwon, Kang, Jeon Woong, Yaqoob, Zahid, So, Peter, Bhopal, Muhammad Fahad, Wang, Minqiang, Qamar, Raheel, Bhatti, Arshad Saleem

“…The effectiveness of the drug critically depends on its presence in the therapeutic range (0.8–2.0 ng mL−1) in the patient's serum. …”
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Deep learning methods for genome-based prediction of drug resistance in Mycobacterium tuberculosis by Wang, C

“…<p>Tuberculosis is a highly lethal infectious disease, causing approximately 1.5 million deaths annually. Recent years have seen a concerning rise in drug-resistant tuberculosis cases, calling for the development of new approaches for drug susceptibility testing. …”

Flame-made calcium phosphate nanoparticles with high drug loading for delivery of biologics by Tsikourkitoudi, Vasiliki, Karlsson, Jens, Merkl, Padryk, Loh, Edmund, Henriques-Normark, Birgitta, Sotiriou, Georgios A.

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Structural basis of ligand recognition in 5-HT3 receptors by Thompson, Andrew J., Villalgordo, Jose M., Lummis, Sarah C. R., Smit, August B., Kesters, Divya, Elk, René van, Brams, Marijke, Spurny, Radovan, Geitmann, Matthis, Guskov, Albert, Danielson, U. Helena, Ulens, Chris

“…The 5-HT3 receptor is a pentameric serotonin-gated ion channel, which mediates rapid excitatory neurotransmission and is the target of a therapeutically important class of anti-emetic drugs, such as granisetron. …”
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Immunoprofiling of drug-resistant epilepsy with a focus on glutamic acid decarboxylase 65 antibodies by McGinty, R

“…<p>The urgent need to improve therapies for people with drug-resistant epilepsy (DRE) requires improved understanding of the aetiopathophysiology of epilepsy and the mechanisms responsible for pharmacoresistance. …”