Collective synthesis of 4-Hydroxy-2-pyridone alkaloids and their antiproliferation activities by Ding, Feiqing, Leow, Min Li, Ma, Jimei, William, Ronny, Liao, Hongze, Liu, Xue-Wei

“…Hence, this approach could potentially contribute to the synthesis of bioactive small-molecule libraries as well as drug discovery.…”
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Viral content: a theory of vaccine hesitancy based on information encountering in the greater Manila area, Philippines by Sacramento, Simon Philip R., Sipin, Ian Dominic P.

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Transcriptional profiling and network-based gene annotations of human malaria parasite plasmodium falciparum by Hu, Guang An

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Discovery of stabilized functional mutants of human aquaporin 1 by Soh, Miao Yi

“…Aquaporins (AQPs) are essential water channel proteins found in the cell membranes of all forms of life. In this project, a random mutagenesis library for human aquaporin 1 (hAQP1) is generated and screened for functional mutants. …”
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Studies towards the synthesis of bioactive natural products and development of new synthetic methods by Khanizeman, Rabi’ah Nisha

“…It has been estimated that more than half of all approved drugs, from the period 1981 to 2014, are either natural products or their derivatives. …”
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The political economy of oil and economic diversification: a neglected research field Robert Mabro would certainly like us to revive by Aissaoui, A

“…The less obvious reason is that multiple country case studies can help reflect the diversity of contexts and conditions and draw on distinct sources of evidence to discern national idiosyncrasies.…”

Mitigating marine megafauna captures in fisheries by Arlidge, W

“…</p> <p>Throughout the fishery case study, I draw on established decision-making processes to better understand the conservation issue at hand and to develop an understanding of what is necessary to empirically calculate net outcomes in data-poor fishing systems using the proposed framework. …”

Compressible hollow microlasers in organoids for high-throughput and real-time mechanical screening by Fang, Guocheng, Ho, Beatrice Xuan, Xu, Hongmei, Gong, Chaoyang, Qiao, Zhen, Liao, Yikai, Zhu, Song, Lu, Hongxu, Nie, Ningyuan, Zhou, Tian, Kim, Munho, Huang, Changjin, Soh, Boon Seng, Chen, Yu-Cheng

“…Here, we introduce biocompatible and compressible hollow microlasers that realize all-optical assessment of cellular stress within organoids. …”
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Childhood bullying and mental health: understanding risk, resilience, and the role of anti-bullying interventions by Guzman Holst, C

“…The best approaches to study causal effects are natural experiments, longitudinal data, and randomised controlled trials of interventions. This thesis combines all these approaches to examine the relationship between bullying and mental health across different contexts.…”

Self-propelled autonomous Mg/Pt janus micromotor interaction with human cells by Kong, Lei, Chia, Hui Ling, Guan, Jianguo, Pumera, Martin, Nur Farhanah Rosli

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Dearomatization of (hetero)arenes through photodriven interplay between polysulfide anions and formate by Tan, Eugene Yew Kun, Mat Lani, Amirah S, Sow, Wayne, Liu, Yuliang, Li, Haoyu, Chiba, Shunsuke

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Integrate Traditional Chinese Medicine (TCM) into cognitive behavioural therapy to treat postpartum depression in Chinese culture contexts. by Han, Shuyu.

“…As in Chinese cultures, it is believed that any kind of drug has certain degree of side effects. In the end, all different kinds of factors have lead to the fact that most women suffering from postpartum disorders or depression left unwell treated. …”
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Predicting rifampicin resistance in M. tuberculosis using machine learning informed by protein structural and chemical features by Lynch, C, Adlard, D, Fowler, P

“…We have trained a learning models with the aim of complementing genetics-based drug susceptibility testing.</p> <br> <p><strong>Methods:</strong> We built a Test+Train dataset comprising 219 susceptible mutations. …”

Sharing is caring? International Society for Pharmacoepidemiology review and recommendations for sharing programming code by Tazare, J, Wang, SV, Gini, R, Prieto Alhambra, D, Arlett, P, Morales Leaver, DR, Morton, C, Logie, J, Popovic, J, Donegan, K, Schneeweiss, S, Douglas, I, Schultze, A

“…<p><strong> Methods: </p></strong>We conducted a literature review identifying all studies published in Pharmacoepidemiology and Drug Safety (PDS) between 2017 and 2022. …”

Tumor-targeted nano-assemblies for energy-blocking cocktail therapy in cancer by Chen, Manling, Liu, Yidu, Li, Yang, Liu, Xue

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Revealing the biotoxicity of phosphorene oxide nanosheets based on the villin headpiece by Zhang, Wei, Gou, Yuanyuan, Cheng, Li, Dong, Kaiwei, Sheng, Yijie, Ye, Chao, Yang, Xianqing, Mu, Yuguang

“…Phosphorene, a novel member of the two-dimensional nanomaterial family, has demonstrated great potential in biomedical applications, such as photothermal therapy, drug delivery and antibacterial. However, phosphorene is unstable and easily oxidized in an aerobic environment. …”
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The Relationship between Linguistic Representations in Biological and Artificial Neural Networks by Kauf, Carina

“…This thesis work makes progress on all three questions by combining evidence from neuroimaging, behavioral research, and computational modeling. …”
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Engineering pressure retarded osmosis membrane bioreactor (PRO-MBR) for simultaneous water and energy recovery from municipal wastewater by Liu, Shuyue, Song, Weilong, Meng, Manli, Xie, Ming, She, Qianhong, Zhao, Pin, Wang, Xinhua

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Data-Driven Classification of Pharmaceutical and Biotechnology Companies by Xu, Angelina

“…We use fundamental financial data, 10-K filings, and company drug development data to develop this new classification scheme. …”
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Structure and function of the smoothened extracellular domain in vertebrate hedgehog signaling by Rohatgi, Rajat, Nachtergaele, Sigrid, Whalen, Daniel M, Mydock, Laurel K, Zhao, Zhonghua, Malinauskas, Tomas, Krishnan, Kathiresan, Covey, Douglas F, Siebold, Christian, Ingham, Philip William

“…Indeed, targeting of the Smo CRD by oxysterol-inspired small molecules can block signaling by all known classes of Hh activators and by clinically relevant Smo mutants.…”
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