Immune Checkpoint Blockade sensitivity and Progression-Free Survival associates with baseline CD8+ T cell clone size and cytotoxicity by Watson, R, Tong, O, Taylor, C, Kumar Sharma, P, Verge De Los Aires, A, Mahe, E, Ruffieux, H, Nassiri, I, Middleton, M, Fairfax, B

“…This data forms the key input files for the analysis of single cell data as outlined in the publication titled: Immune Checkpoint Blockade sensitivity and Progression-Free Survival associates with baseline CD8+ T cell clone size and cytotoxicity. …”

DOK3 promotes atopic dermatitis by enabling the phosphatase PP4C to inhibit the T cell signaling mediator CARD11 by Loh Jia Tong, Teo, Joey Kay Hui, Kannan, Srinivasaraghavan, Verma, Chandra Shekhar, Andiappan, Anand Kumar, Lim, Hong-Hwa, Lam, Kong-Peng

“…A subset of hypomorphic CARD11 variants found in patients with atopic dermatitis bound more strongly than wild-type CARD11 to DOK3. Our findings suggest that the strength of the interaction of DOK3 with CARD11 may predispose individuals to developing atopic dermatitis.…”
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Nontoxic, biodegradable hyperbranched poly(β-amino ester)s for efficient siRNA delivery and gene silencing by Ooi, Ying Jie, Huang, Chongquan, Lau, Kieran, Chew, Sing Yian, Park, Jong Gu, Chan-Park, Mary B.

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Cytomegalovirus infection is associated with an increase in aortic stiffness in older men which may be mediated in part by CD4 memory T-cells by Kirkham, Frances, Pera, Alejandra, Simanek, Amanda M., Bano, Aalia, Morrow, George, Reus, Bernhard, Caserta, Stefano, Smith, Helen Elizabeth, Davies, Kevin A., Rajkumar, Chakravarthi, Kern, Florian

“…Human Cytomegalovirus (CMV) infection is associated with atherosclerosis, higher cardiovascular disease (CVD) risk, and an increase in memory T-cells (Tmem). T-cells have also been implicated in CVD, independently of CMV infection. …”
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Relative deficiency in interferon-γ-secreting CD4+ T cells is strongly associated with poorer COVID-19 vaccination responses in older adults by Ho, Vanda W. T., Boon, Low Heng, Cui, Jianzhou, Juequn, Zhou, Shunmuganathan, Bhuvaneshwari, Gupta, Rashi, Tan, Nikki Y. J., Qian, Xinlei, Purushotorman, Kiren, Fong, Siew-Wai, Renia, Laurent, Ng, Lisa F. P., Angeli, Veronique, Chen, Jinmiao, Kennedy, Brian K., Ong, Catherine W. M., Macary, Paul A.

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Insights on the characteristics and therapeutic potential of mesenchymal stem cell-derived exosomes for mitigation of Alzheimer’s disease’s pathogenicity: a systematic review by Mohammed Yousuf Abdi, Sarah, Mustaffa Al-Bakri, Siti Sarah, Nordin, Norshariza

“…Delivery of exosomal micro-RNAs was also found to reduce neuroinflammation. Findings from this review provided convincing systematic evidence highlighting the therapeutic properties of MSC-derived exosomes as a prospective source for cell-free (acellular) therapy in treating AD.…”

The rickettsial effector Sca4 has a conserved interaction with host clathrin and a tick cell specific role in infection by Vondrak, Cassandra Joan

“…Intracellular bacterial pathogens secrete effectors to manipulate the host cell environment, create a hospitable niche, and promote infection. …”
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Effects of nnav1.5 expression modulation on mhc I antigen processing machinery and invasion potential of breast cancer cells by Din, Ahmad Hafiz Murtadha Noor

“…TSA showed increased spheroid invasion, but nNav1.5-plasmid pre-transfected cells formed spheroids with lower relative perimeter diameter. …”
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Roseburia intestinalis generated butyrate boosts anti-PD-1 efficacy in colorectal cancer by activating cytotoxic CD8⁺ T cells by Kang, Xing, Liu, Changan, Ding, Yanqiang, Ni, Yunbi, Ji, Fenfen, Lau, Harry Cheuk Hay, Jiang, Lanping, Sung, Joseph Jao Yiu, Wong, Sunny Hei, Yu, Jun

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Dual role of Cu-chalcogenide as hole-transporting layer and interface passivator for p–i–n architecture perovskite solar cell by Sadhu, Anupam, Rai, Monika, Salim, Teddy, Jin, Xin, Tan, Joel Ming Rui, Leow, Shin Woei, Ahmed, Mahmoud Gamal, Magdassi, Shlomo, Mhaisalkar, Subodh Gautam, Wong, Lydia Helena

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Elucidating the non-apoptotic role of the caspases in the Drosophila intestinal system by Arthurton, L

“…<p>The deregulation of caspase activity and stem cell properties are often correlated with the appearance and propagation of cancer, including colorectal cancer. …”

Assessing the kinetics of oxygen-unloading from red cells using FlowScore, a flow-cytometric proxy of the functional quality of blood by Rabcuka, J, Smethurst, P, Dammert, K, Saker, J, Aran, G, Walsh, G, Tan, J, Codinach, M, McTaggart, K, Marks, D, Bakker, S, McMahon, A, Di Angelantonio, E, Roberts, D, Blonski, S, Korczyk, P, Shirakami, A, Cardigan, R, Swietach, P

“…<p><strong>Background: </p></strong>Metrics evaluating the functional quality of red blood cells (RBCs) must consider their role in oxygen delivery. …”

Identification of mechanism of cancer-cell-specific reactivation of hTERT offers therapeutic opportunities for blocking telomerase specifically in human colorectal cancer by Akıncılar, Semih Can, Chua, Joelle Yi Heng, Ng, Qin Feng, Chan, Claire Hian Tzer, Eslami-S, Zahra, Chen, Kaijing, Low, Joo-Leng, Arumugam, Surendar, Aswad, Luay, Chua, Clarinda, Tan, Iain Beehuat, DasGupta, Ramanuj, Fullwood, Melissa Jane, Tergaonkar, Vinay

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In situ growth of [hk1]-oriented Sb2S3 for solution-processed planar heterojunction solar cell with 6.4% efficiency by Jin, Xin, Fang, Yanan, Salim, Teddy, Feng, Minjun, Hadke, Shreyash, Leow, Shin Woei, Sum, Tze Chien, Wong, Lydia Helena

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Unraveling microglial spatial organization in the developing human brain with DeepCellMap, a deep learning approach coupled with spatial statistics by Perochon, T, Krsnik, Z, Massimo, M, Ruchiy, Y, Romero, AL, Mohammadi, E, Li, X, Long, KR, Parkkinen, L, Blomgren, K, Lagache, T, Menassa, DA, Holcman, D

“…This pipeline is designed to map microglial organization during normal and pathological brain development and has the potential to be adapted to any cell type. Using DeepCellMap, we capture the morphological diversity of microglia, identify strong coupling between proliferative and phagocytic phenotypes, and show that distinct spatial clusters rarely overlap as human brain development progresses. …”

Studies on the antioxidant mechanisms of betacyanins from improved fermented red dragon fruit (Hylocereus polyrhizus) drink in HepG2 cells by Lim, Teck Wei, Lim, Renee Lay Hong, Pui, Liew Phing, Tan, Chin Ping, Ho, Chun Wai

“…Red dragon fruit (RDF, Hylocereus polyrhizus) is high in betacyanins content but is understudied for its antioxidant mechanisms in liver cells. The present study aimed to investigate the antioxidant mechanisms of the stabilised betacyanins in a novel RDF functional drink, Improved-FRDFD-dH2O (produced from mild, sustainable approaches) using HepG2 cell line. …”
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The hollow fiber bioreactor as a stroma-supported, serum-free ex vivo expansion platform for human umbilical cord blood cells by Xue, Cao, Kwek, Kenneth Y. C., Chan, Jerry Kok Yen, Chen, Qingfeng, Lim, Mayasari

“…These findings demonstrate the feasibility of utilizing the HFBR for creating a complex cell matrix architecture, which may provide good in vitro mimicry of the bone marrow, supporting large-scale expansion of HSCs.…”
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Influence Of Different Ratios Of Gdc-Sdc On Ssc/Gdc–Sdc Dual Composite Cathode For Intermediate-Temperature Solid Oxide Fuel Cells by Roslan, Mohammad Fikrey, Abd Rahman, Hamimah, Azmi, Mohd Azham, MohdTukimon, Mohd Faizal, Jaidi, Zolhafizi, Abdul Ghani, Muhammad Zul Idzham

“…Solid oxide fuel cells (SOFCs) have emerged as highly promising contenders in the field of energy conversion, offering enhanced efficiency and environmental sustainability. …”
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In vitro anti-proliferative mechanism of combination therapy with tannic acid and cisplatin against human osteosarcoma cell line U2OS by Kasiram, Mohamad Zahid Mohd

“…Hence, this study aimed to investigate the effect of TA treatment combined with cisplatin on human osteosarcoma cell line (U2OS). The half-maximal inhibitory concentration (IC50) values of TA and its combination with cisplatin against U2OS cells were determined using MTT assay. …”
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PPARβ/δ prevents endoplasmic reticulum stress-associated inflammation and insulin resistance in skeletal muscle cells through an AMPK-dependent mechanism by Salvadó, Laia, Barroso, Emma, Gómez-Foix, Anna Maria, Palomer, Xavier, Michalik, Liliane, Wahli, Walter, Vázquez-Carrera, Manuel

“…In this study, we assessed whether peroxisome proliferator-activated receptor (PPAR)β/δ prevented ER stress-associated inflammation and insulin resistance in skeletal muscle cells. Methods Studies were conducted in mouse C2C12 myotubes, in the human myogenic cell line LHCN-M2 and in skeletal muscle from wild-type and PPARβ/δ-deficient mice and mice exposed to a high-fat diet. …”
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