Molecular features underlying neurodegeneration identified through in vitro modeling of genetically diverse parkinson’s disease patients by Lin, Lin, Göke, Jonathan, Cukuroglu, Engin, Dranias, Mark R., VanDongen, Antonius M.J., Stanton, Lawrence W.

“…Notably, PD neurons show that elevated RBFOX1, a gene previously linked to neurodevelopmental diseases, underlies a pattern of alternative RNA-processing associated with PD-specific phenotypes.…”
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Ex vivo analysis of the association of GFP-expressing L. aethiopica and L. mexicana with human peripheral blood-derived (PBD) leukocytes over 24 hours by Ranatunga, Medhavi, Deacon, Andrew, Harbige, Laurence S., Dyer, Paul, Boateng, Joshua, Getti, Giulia

“…In mice models, the disease development or resolution is linked to T cell responses involving inflammatory cytokines and the activation of macrophages with the M1/M2 phenotype. …”
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Curvature sensing amphipathic helix in the C-terminus of RTNLB13 is conserved in all endoplasmic reticulum shaping reticulons in Arabidopsis thaliana by Brooks, Rhiannon L., Mistry, Chandni S., Dixon, Ann M.

“…This may facilitate functional flexibility as previous studies have linked these isoforms not only to ER remodeling but other cellular activities.…”
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Detection of single-nucleotide polymorphisms in Plasmodium falciparum by PCR primer extension and lateral flow immunoassay by Moers, APHA, Hallett, R, Burrow, R, Schallig, HDFH, Sutherland, CJ, van Amerongen, A

“…The resistance of Plasmodium falciparum to some antimalarial drugs is linked to single-nucleotide polymorphisms (SNPs). …”

Wages, family background, on-campus performance and gender: an investigation of Chinese graduates’ first job salaries by Liu, S

“…It investigates whether and how university graduates’ family background, on-campus performance (OCP) and gender are linked with their first job salaries. The thesis distinguishes three dimensions of graduates’ family background: Hukou status, parental CCP membership and income. …”

Strategic and operational issues in sustaining community-based dementia support groups: the Get Real with Meeting Centres realist evaluation part 2 by Morton, T, Evans, SB, Swift, R, Bray, J, Frost, F, Russell, C, Brooker, D, Wong, G, Hullah, N

“…This is the second of two linked articles outlining learning from this realist evaluation of Meeting Centres (MCs) for people with dementia and carers, which focusses on findings regarding their operational and strategic running.…”

In situ nanoscopy of single-grain nanomorphology and ultrafast carrier dynamics in metal halide perovskites by Zizlsperger, M, Nerreter, S, Yuan, Q, Lohmann, KB, Sandner, F, Schiegl, F, Meineke, C, Gerasimenko, YA, Herz, LM, Siday, T, Huber, MA, Johnston, MB, Huber, R

“…The record-breaking efficiencies of metal halide perovskite solar cells have been linked to effective charge-carrier diffusion, yet the exact nature of charge-carrier out-of-plane transport remains notoriously difficult to explain. …”

The big five personality traits and eating habits among female students at Zayed University by AlBlooshi, S, AlSabbah, K, Thani, S, Hijazi, R, Al Dhaheri, AS, Zeb, F, Cheikh Ismail, L

“…The study found that certain personality traits, particularly neuroticism and agreeableness, were linked to dietary habits. Specifically, personality traits were associated with emotional eating (p < 0.003), but not with cognitive restraint (p = 0.25) or disinhibition (p = 0.308). …”

Associations of treatment with hypnotics with suicide and attempted suicide: A nationwide cohort study by Høier, NK, Madsen, T, Spira, AP, Hawton, K, Jennum, P, Nordentoft, M, Erlangsen, A

“…<p><strong>Background:</strong> Hypnotics have been linked to suicidal behaviors. While existing evidence has established findings of associations, more knowledge is needed regarding benzodiazepine (BZD) and non-benzodiazepine (n-BZD) hypnotics.…”

Molecular determinants of chromatin accessibility at CpG islands in mouse embryonic stem cells by King, H

“…To examine potential mechanisms by which hypomethylated DNA could serve to promote chromatin accessibility, I profiled chromatin accessibility in mouse ESCs lacking various chromatin-modifying proteins which are normally enriched at CGIs, with the histone demethylases KDM2A/B linked to maintaining open chromatin at CGIs. As an alternative approach to understanding the causes of chromatin accessibility in mouse ESCs, I examined the mechanism by which the pioneer transcription factor OCT4 is able to access previously inaccessible chromatin, and reveal that it requires the chromatin remodeller BRG1 to remodel chromatin and facilitate transcription factor binding at distal regulatory elements. …”

Brain change trajectories in healthy adults correlate with Alzheimer's related genetic variation and memory decline across life by Roe, J, Vidal Pineiro, D, Sørensen, Ø, Grydeland, H, Leonardsen, E, Iakunchykova, O, Pan, M, Mowinckel, A, Strømstad, M, Nawijn, L, Milaneschi, Y, Andersson, M, Pudas, S, Bråthen, AC, Kransberg, J, Falch, E, Øverbye, K, Kievit, R, Ebmeier, KP, Lindenberger, U, Ghisletta, P, Demnitz, N, Boraxbekk, C-J, Drevon, C, Penninx, B, Bertram, L, Nyberg, L, Walhovd, K, Fjell, A, Wang, Y

“…We first show genetic risk links with more brain loss than expected for age in early Braak regions, and find this extends beyond APOE genotype. …”

A critical analysis of current debates in natural law: a theo-cultural engagement with John Finnis, Jean Porter, & John Milbank by Morgan, G

“…The contribution of this thesis is borne out of a two-fold realisation: (1) that despite renewed levels of inter-disciplinary interest within the academy, the discourse has become increasingly fragmented and will continue to fragment in the absence of a critical analysis of the deeper theo-cultural assumptions and aporias that animate current debates in natural law; (2) that by illuminating and attending to the theological and methodological “unsaid(s)” that have, heretofore, been seldom acknowledged, one can begin to appreciate how the fragmentation of the discourse is inexorably linked to the fragmentation of the secular mythos. …”

Transcriptional brain networks and their key regulators across the human lifespan by Wehrspaun, CC

“…In the second project, I demonstrated that gene clusters linked to neurogenesis during fetal life show moderate to strong preservation in the human adult brain. …”

The amygdala and the pursuit of future rewards by Johnson, ST, Grabenhorst, F

“…Success and failure in these processes have been linked to differential life outcomes and psychiatric conditions. …”

Identifying the sources of intestinal colonization with extended-spectrum β-lactamase-producing Escherichia coli in healthy infants in the community by Amin, MB, Hoque, KI, Roy, S, Saha, SR, Islam, MR, Julian, TR, Islam, MA

“…Overall, this study provides empirical evidence that ESBL-Ec colonization in children is linked to the colonization status of mothers and exposure to the household environments contaminated with ESBL-Ec. …”

Neural processing in the primary auditory cortex following cholinergic lesions of the basal forebrain in ferrets by Nodal, FR, Leach, ND, Keating, P, Dahmen, JC, Zhao, D, King, AJ, Bajo, VM

“…<p>Cortical acetylcholine (ACh) release has been linked to various cognitive functions, including perceptual learning. …”

External validation of the QCovid 2 and 3 risk prediction algorithms for risk of COVID-19 hospitalisation and mortality in adults: a national cohort study in Scotland by Kerr, S, Millington, T, Rudan, I, McCowan, C, Tibble, H, Jeffrey, K, Fagbamigbe, AF, Simpson, CR, Robertson, C, Hippisley-Cox, J, Sheikh, A

“…Primary care data were linked to reverse-transcription PCR virology testing, hospitalisation and mortality data. …”

Unlocking the gates: pedestrian route choice in transforming metro station paid areas into mobile public spaces by Chan, HY, Tse, W-Y, Chen, A

“…Using three pairs of interconnected metro stations in Hong Kong&mdash;two linked by private paid walkways (stated preference) and one by public unpaid walkways (revealed preference)&mdash;a questionnaire survey (<em>N</em>=419) and discrete choice modeling were conducted. …”

Oxazolidinone antibiotics impair ex vivo megakaryocyte differentiation from hematopoietic progenitor cells and their maturation into platelets by Milosevic, TV, Vertenoeil, G, Vainchenker, W, Tulkens, PM, Constantinescu, SN, Van Bambeke, F

“…Pharmacological interventions to prevent this toxicity might therefore be difficult as mitochondrial toxicity is most probably inherently linked to their antibacterial activity.…”

Elevated reactive oxygen species can drive the alternative lengthening of telomeres pathway in ATRX-null cancers by Goncalves, T, Cunniffe, S, Ma, T, Mattis, N, Rose, A, Kent, T, Mole, D, Geiller, HB, van Bijsterveldt, L, Humphrey, T, Hammond, E, Gibbons, R, Clynes, D, Rose, A

“…Further, we found a possible causal link between the formation of R-loops and the accumulation of DPCs, in particular, formation of TOP1 complexes covalently linked to DNA (Top1cc). …”