Numerical simulation of titanium fibre metallic laminates under various impact loading by Selvadurai Shanmugasundram

“…This thesis is linked to the research project carried out for the development of multi-functionally hierarchical Fiber-Metal Laminates (FMLs) for impact protection. …”
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Detection of low frequency artemisinin resistance mutations, C469Y, P553L and A675V, and fixed antifolate resistance mutations in asymptomatic primary school children in Kenya by Osoti, V, Wamae, K, Ndwiga, L, Gichuki, PM, Okoyo, C, Kepha, S, Keitany, K, Kandie, R, Aricha, S, Kiplagat, R, Mwandawiro, C, Bejon, P, Snow, RW, Ochola-Oyier, LI

“…The Pfdhfr 51I and 108 N pyrimethamine-resistance mutations were at fixation (100% frequency), and the Pfmdr1 Y184F mutation, which is linked to reduced susceptibility to several antimalarial drugs, especially those used in combination therapies for malaria treatment, was detected in 97.5% of the samples as mixed-genotype infections. …”

The sustainable use of species-rich grasslands for forage and biogas production by French, K

“…Finally, by combining palaeoecological and modern vegetation data I demonstrate that grassland biodiversity was temporally and spatially linked to long-term human management and would revert to oscillating between open grassland and woodland if this management ceases. …”

Survey of healthcare-associated sink infrastructure, and sink trap antibiotic residues and biochemistry, in 29 UK hospitals by Rodger, G, Chau, K, Aranega Bou, P, Moore, G, Roohi, A, The SinkBug Consortium, Walker, AS, Stoesser, N

“…<p><strong>Background</strong></p> Hospital sinks are linked to healthcare-associated infections. Antibiotics and chemicals in sink traps can select for pathogens and antimicrobial resistance (AMR). …”

Most of the world's largest flowers (genus Rafflesia) are now on the brink of extinction by Malabrigo Jr, P, Tobias, AB, Witono, J, Mursidawati, S, Susatya, A, Siti-Munirah, MY, Wicaksono, A, Raihandhany, R, Edwards, S, Thorogood, CJ

“…We suggest action devolved to local communities and awareness campaigns linked to social media networks will be crucial outside of protected jurisdictions. …”

Barriers and opportunities for WHO ‘best buys’ non-communicable disease policy adoption and implementation from a political economy perspective: a complexity systematic review by Loffreda, G, Arakelyan, S, Bou-Orm, I, Holmer, H, Allen, LN, Witter, S, Ager, A, Diaconu, K

“…</p> <p><strong>Results:</strong> Our CLD highlights a central feedback loop encompassing three vital variables: (1) the ability to define, (re)shape, and pass appropriate policy into law; (2) the ability to implement the policy (linked to the enforceability of the policy and to addressing NCD local burden); and (3) ability to monitor progress, evaluate and correct the course. …”

Characterising the functional role of GATA1short isoform in normal and malignant haematopoiesis by Cruz Hernandez, D

“…Both TAM and ML-DS are driven by mutations in the gene encoding the X-linked erythroid-megakaryocyte transcription factor GATA1 that result in truncation of 83 N-terminal amino acids to produce GATA1short (GATA1s). …”

External validation of the QCovid risk prediction algorithm for risk of COVID-19 hospitalisation and mortality in adults: national validation cohort study in Scotland by Simpson, CR, Robertson, C, Kerr, S, Shi, T, Vasileiou, E, Moore, E, McCowan, C, Agrawal, U, Docherty, A, Mulholland, R, Murray, J, Ritchie, LD, McMenamin, J, Hippisley-Cox, J, Sheikh, A

“…Primary care data were linked to reverse-transcription PCR (RT-PCR) virology testing, hospitalisation and mortality data. …”

Fracture prediction in rheumatoid arthritis: validation of FRAX with bone mineral density for incident major osteoporotic fractures by Richards, C, Stevens, R, Lix, LM, McCloskey, EV, Johansson, H, Harvey, NC, Kanis, JA, Leslie, WD

“…</p> <p><strong>Methods:</strong> Administrative data from patients receiving BMD testing were linked to the Manitoba Population Health Research Data Repository. …”

Participation and cooperation in global climate governance by Rowan, SS

“…First, state participation in climate institutions is linked to their dissatisfaction. Second, patterns of participation are associated with the ambition of countries’ greenhouse gas mitigation targets in the Paris Agreement. …”

Spontaneous ventricular tachyarrhythmias in β2-adrenoceptor transgenic mice in relation to cardiac interstitial fibrosis by Nguyen, M-N, Kiriazis, H, Ruggiero, D, Gao, X-M, Su, Y, Jian, A, Han, L-P, McMullen, JR, Du, X-J

“…The number of VEBs or VT episodes correlated with age (r = 0.83 and r = 0.73) and the content of total or cross-linked collagen (r = 0.62∼0.66, all P &lt;0.01). While having no effect in younger β2-TG mice, β2-AR blockade reduced the frequency of VTA in old β2-TG mice with more severe fibrosis. …”

Global marine flyways identified for long-distance migrating seabirds from tracking data by Davies, T, Guilford, T

“…Generally, the flyways were used bidirectionally, and individuals either followed sections of a flyway, a complete flyway, or their movements linked two or more flyways. Transhemispheric figure-of-eight routes in the Atlantic and Pacific oceans, and a circumnavigation flyway in the Southern Ocean correspond with major wind-driven ocean currents.…”

Contribution of rare chromosome 22q11.2 copy number variants to non-syndromic bicuspid aortic valve by DiGregorio, H, Mansoorshahi, S, Carlisle, SG, Tovar Pensa, C, Watts, A, McNeely, C, Sabate-Rotes, A, Yetman, A, Michelena, HI, De Backer, JFA, Mosquera, LM, Bissell, MM, Andreassi, MG, Foffa, I, Hui, DS, Caffarelli, A, Kim, YY, Citro, R, De Marco, M, Tretter, JT, McBride, KL, Body, SC, Milewicz, DM, Prakash, SK

“…This study is aimed to assess the role of rare 22q11.2 CNVs in patients with early-onset BAV (EBAV) and to determine whether these variants are linked to an increased risk of complications. Methods: Whole genome microarray genotyping was conducted on 272 patients with BAV with early onset valve or aortic disease (EBAV) and 272 biological relatives. …”

Elucidating the mechanism of mRNA transport using novel imaging technologies by Stoychev, D

“…I apply this assay to investigate a specific mRNA, <em>shot</em>, previously identified as encoding important protein regulators of synaptic development and linked to neurodevelopmental disorders.…”

Antiquity as authority: Jesus and the patriarchs in the Gospel of John by Van Dyk, SL

“…In each instance, the challenge directed to Jesus is contextually linked with his authority to offer eternal life (John 4:10, 13-14; 8:51-52). …”

Understanding health system responsiveness to public feedback at the sub-national level: Insights from Kilifi County, Kenya by Kagwanja, N, Gilson, L, Tsofa, B, Olivier, J, Leli, H, Molyneux, S

“…HFCs are formal structures with community representation linked to a health facility to support community participation in service provision and health outcomes. …”

Factors associated with workplace deviant behavior in a public organization in Malaysia and moderating role of religiosity by Radzali, Farah Mardiana

“…Workplace deviant behavior is a multidimensional issue which is linked to wide variety of factors. However, there are limited studies that focus on the predictors of workplace deviant behavior and factors that can reduce workplace deviant behavior. …”
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Addressing Unmet Clinical Needs with UV Bioadhesives by O’Rorke, Richard D., Pokholenko, Oleksandr, Gao, Feng, Cheng, Ting, Shah, Ankur, Mogal, Vishal, Steele, Terry W. J.

“…Activated bioadhesives, on the other hand, allow control of when and where a bioadhesive cross-links and, in some cases, the extent of cross-linking. …”
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Mitigating marine megafauna captures in fisheries by Arlidge, W

“…In this thesis, I explore mitigating impacts from fisheries on marine megafauna, linking system-wide approaches with individual-level incentives in a unified framework. …”

NAD depletion mediates cytotoxicity in human neurons with autophagy deficiency

“…Our findings elucidate a mechanistic link between autophagy deficiency and neuronal cell death that can be targeted for therapeutic interventions in neurodegenerative and lysosomal storage diseases associated with autophagic defect.…”
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