Associations of treatment with hypnotics with suicide and attempted suicide: A nationwide cohort study by Høier, NK, Madsen, T, Spira, AP, Hawton, K, Jennum, P, Nordentoft, M, Erlangsen, A

“…<p><strong>Background:</strong> Hypnotics have been linked to suicidal behaviors. While existing evidence has established findings of associations, more knowledge is needed regarding benzodiazepine (BZD) and non-benzodiazepine (n-BZD) hypnotics.…”

Molecular determinants of chromatin accessibility at CpG islands in mouse embryonic stem cells by King, H

“…To examine potential mechanisms by which hypomethylated DNA could serve to promote chromatin accessibility, I profiled chromatin accessibility in mouse ESCs lacking various chromatin-modifying proteins which are normally enriched at CGIs, with the histone demethylases KDM2A/B linked to maintaining open chromatin at CGIs. As an alternative approach to understanding the causes of chromatin accessibility in mouse ESCs, I examined the mechanism by which the pioneer transcription factor OCT4 is able to access previously inaccessible chromatin, and reveal that it requires the chromatin remodeller BRG1 to remodel chromatin and facilitate transcription factor binding at distal regulatory elements. …”

Brain change trajectories in healthy adults correlate with Alzheimer's related genetic variation and memory decline across life by Roe, J, Vidal Pineiro, D, Sørensen, Ø, Grydeland, H, Leonardsen, E, Iakunchykova, O, Pan, M, Mowinckel, A, Strømstad, M, Nawijn, L, Milaneschi, Y, Andersson, M, Pudas, S, Bråthen, AC, Kransberg, J, Falch, E, Øverbye, K, Kievit, R, Ebmeier, KP, Lindenberger, U, Ghisletta, P, Demnitz, N, Boraxbekk, C-J, Drevon, C, Penninx, B, Bertram, L, Nyberg, L, Walhovd, K, Fjell, A, Wang, Y

“…We first show genetic risk links with more brain loss than expected for age in early Braak regions, and find this extends beyond APOE genotype. …”

A critical analysis of current debates in natural law: a theo-cultural engagement with John Finnis, Jean Porter, & John Milbank by Morgan, G

“…The contribution of this thesis is borne out of a two-fold realisation: (1) that despite renewed levels of inter-disciplinary interest within the academy, the discourse has become increasingly fragmented and will continue to fragment in the absence of a critical analysis of the deeper theo-cultural assumptions and aporias that animate current debates in natural law; (2) that by illuminating and attending to the theological and methodological “unsaid(s)” that have, heretofore, been seldom acknowledged, one can begin to appreciate how the fragmentation of the discourse is inexorably linked to the fragmentation of the secular mythos. …”

Transcriptional brain networks and their key regulators across the human lifespan by Wehrspaun, CC

“…In the second project, I demonstrated that gene clusters linked to neurogenesis during fetal life show moderate to strong preservation in the human adult brain. …”

The amygdala and the pursuit of future rewards by Johnson, ST, Grabenhorst, F

“…Success and failure in these processes have been linked to differential life outcomes and psychiatric conditions. …”

Identifying the sources of intestinal colonization with extended-spectrum β-lactamase-producing Escherichia coli in healthy infants in the community by Amin, MB, Hoque, KI, Roy, S, Saha, SR, Islam, MR, Julian, TR, Islam, MA

“…Overall, this study provides empirical evidence that ESBL-Ec colonization in children is linked to the colonization status of mothers and exposure to the household environments contaminated with ESBL-Ec. …”

Neural processing in the primary auditory cortex following cholinergic lesions of the basal forebrain in ferrets by Nodal, FR, Leach, ND, Keating, P, Dahmen, JC, Zhao, D, King, AJ, Bajo, VM

“…<p>Cortical acetylcholine (ACh) release has been linked to various cognitive functions, including perceptual learning. …”

External validation of the QCovid 2 and 3 risk prediction algorithms for risk of COVID-19 hospitalisation and mortality in adults: a national cohort study in Scotland by Kerr, S, Millington, T, Rudan, I, McCowan, C, Tibble, H, Jeffrey, K, Fagbamigbe, AF, Simpson, CR, Robertson, C, Hippisley-Cox, J, Sheikh, A

“…Primary care data were linked to reverse-transcription PCR virology testing, hospitalisation and mortality data. …”

Unlocking the gates: pedestrian route choice in transforming metro station paid areas into mobile public spaces by Chan, HY, Tse, W-Y, Chen, A

“…Using three pairs of interconnected metro stations in Hong Kong&mdash;two linked by private paid walkways (stated preference) and one by public unpaid walkways (revealed preference)&mdash;a questionnaire survey (<em>N</em>=419) and discrete choice modeling were conducted. …”

Oxazolidinone antibiotics impair ex vivo megakaryocyte differentiation from hematopoietic progenitor cells and their maturation into platelets by Milosevic, TV, Vertenoeil, G, Vainchenker, W, Tulkens, PM, Constantinescu, SN, Van Bambeke, F

“…Pharmacological interventions to prevent this toxicity might therefore be difficult as mitochondrial toxicity is most probably inherently linked to their antibacterial activity.…”

Elevated reactive oxygen species can drive the alternative lengthening of telomeres pathway in ATRX-null cancers by Goncalves, T, Cunniffe, S, Ma, T, Mattis, N, Rose, A, Kent, T, Mole, D, Geiller, HB, van Bijsterveldt, L, Humphrey, T, Hammond, E, Gibbons, R, Clynes, D, Rose, A

“…Further, we found a possible causal link between the formation of R-loops and the accumulation of DPCs, in particular, formation of TOP1 complexes covalently linked to DNA (Top1cc). …”

Spatial distribution characteristics of leisure urban spaces and the correlation with population activity intensity: a case study of Nanjing, China by Li, Xinyang, Kozlowski, Marek, Ismail, Sumarni, Salih, Sarah Abdulkareem

“…The spatial distribution of Leisure Urban Spaces (LUSs) is closely linked to urban sustainability and residents’ quality of life. …”
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Development of a Highly Specific RecombinantToxocara canis Second-Stage Larva Excretory-Secretory Antigen for Immunodiagnosis of Human Toxocariasis by Yamasaki, Hiroshi, Araki, Kunioki, Lim, Patricia Kim Chooi, Zasmy, Ngah

“…The specificity of the recombinant Toxocara canis antigen developed for the immunodiagnosis of human toxocariasis was compared with that of the excretory-secretory antigen from T. canis second-stage larvae (TES) by enzyme-linked immunosorbent assay. A total of 153 human serum samples from patients infected with 20 different helminths, including 11 cases of toxocariasis, were examined. …”
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The association of physical activity against depression among Universiti Putra Malaysia undergraduate medical students-a cross sectional study by Lynncilla, Shakira, Koh, Eugene, Chong, Seng Choi

“…Rela- tionships were noted between depression and physical activity, particularly in transport-related activities, walking and total physical activity-higher activity linked to lower depression. However, no significant correlation was found for moderate or vigorous physical activity levels. …”
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A multi-targeted approach of garcinol for obesity intervention: Mechanistic insights and possible clinical applications by Abu Bakar, Mohd Fadzelly

“…While hydroxycitric acid (HCA) has been linked to the anti-obesity effects of certain Garcinia fruits, recent research emphasizes the role of garcinol, either alone or in combination, in mediating these effects. …”
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The Role of Emerging Technologies of Students' Academic Achievement at Politeknik Seberang Perai (PSP) by Omar, Nurul Ihsaniah, Ibrahim, Mohammad Noor

“…Factors like insufficient information, slow progress, and inadequate time management are linked to these failure rates. The study investigates the influence of new technologies on academic achievement at PSP using an ex post facto research strategy and quantitative methods to collect data from 200 respondents across various departments. …”
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Public opinion trend analysis on nuclear energy via aspect-based sentiment analysis methods by Huang, Fan

“…In general, we built a system based on the ABSA Deep Learning model to make fine-grained and topic-specific sentiment analyses on public opinion trends. …”
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Low power DFT filter bank based two-stage spectrum sensing by Nair, Prashob R., Smitha, Kavallur Gopi, Vinod, Achutavarrier Prasad

“…The paper presents a low power discrete Fourier transform (DFT) filter bank based two-stage spectrum sensing with energy detector (ED) for the first stage coarse sensing, complemented by a cyclostationary feature detector (CFD) for fine spectrum sensing. The dynamic power of the sensing operation depends on the sampling rate at which computations are performed. …”
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Without passage by Chee, En Cui

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