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1
Controllable charge transfer via DNA molecules
Published 2015“…Although the comprehensive fundamental description of charge transfer along DNA is still missing, the process can be categorized into oxidative holes and reductive electrons transfer/transport. …”
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Thesis-Doctor of Philosophy -
2
Electrochemical DNA biosensor based on nanoporous alumina membrane
Published 2014“…In recent years, due to the high sensitivity and sequence specificity, as well as rapid detection, the electrochemical DNA biosensors are promising for genetic screening and detection of deoxyribonucleic acid. …”
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Thesis -
3
Characterization of ubiquitin-activated DNA-protein crosslink repair in vitro
Published 2024“…DPCs repair is critical for maintaining genome stability, however, the knowledge of the DPC repair pathways is still limited. SPRTN, a DNA-dependent metalloprotease, has been identified as the major protease in repairing DPCs. …”
Thesis -
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Optimized code design for constrained DNA data storage with asymmetric errors
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Journal Article -
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Alternative splicing in the DBD linker region of p63 modulates binding to DNA and iASPP in vitro
Published 2025“…Moreover, the concomitant loss of the charged amino acids in the alternatively spliced version decreases the affinity of p63 to its cognate DNA element two- to threefold. mRNAs encoding full-length p63, as well as its alternatively spliced version, are present in all tissues that we investigated, albeit in differing ratios. …”
Journal article -
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Enhancing early warning: A DNA biosensor with polyaniline/graphene nanocomposite for label-free voltammetric detection of saxitoxin-producing harmful algae
Published 2024“…Yearly reports of detrimental effects resulting from harmful algal blooms (HAB) are still received in Malaysia and other countries, particularly concerning fish mortality and seafood contamination, both of which bear consequences for the fisheries industry. …”
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Article -
8
iN6-methylat (5-step) : identifying DNA N⁶-methyladenine sites in rice genome using continuous bag of nucleobases via Chou's 5-step rule
Published 2021“…DNA N⁶-methyladenine is a non-canonical DNA modification that occurs in different eukaryotes at low levels and it has been identified as an extremely important function of life. …”
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Journal Article -
9
Molecular and biochemical characterisation of human casein kinase I alpha splice variants
Published 2009“…To date, only a human CKIas cDNA has been published (Tapia et al., 1994; Fish et al., 1995). …”
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Thesis -
10
Whole genome sequencing of hepatitis B virus using tiled amplicon (HEPTILE) and probe based enrichment on Illumina and Nanopore platforms
Published 2025“…Hepatitis B virus (HBV) whole genome sequencing (WGS) is currently limited as the DNA viral loads (VL) of many clinical samples are below the threshold required to generate full genomes using current sequencing methods. …”
Journal article -
11
Studies of the Fanconi anemia pathway
Published 2016“…Upon the appearance of ICLs, the FANCD2/FANCI complex is monoubiquitinated, and localised to the sites of DNA lesion. While the molecular mechanism of how the FA pathway operates is emerging, there are still questions remaining, such as if there is a sensor for ICLs being able to activate the FA pathway, or the timing of the recruitment of the FANCD2/FANCI heterodimer to damaged chromatin. …”
Thesis -
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Amplifying signals in the tumor microenvironment for drug development and diagnostics
Published 2024“…At the same time, improving the sensitivity of ctDNA-based tests, that remains limited by the scarcity of ctDNA in blood, holds the key to unlock the full potential of liquid biopsy across many important clinical applications. …”
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Thesis -
13
Clonal phylogenies inferred from bulk, single cell, and spatial transcriptomic analysis of epithelial cancers
Published 2025“…While these inferred SNV and CNV states can be used to resolve clonal phylogenies, however, it is still unknown how faithfully transcript-based tumour phylogenies reconstruct ground truth DNA-based tumour phylogenies. …”
Journal article -
14
Effectiveness of decellularisation & extraction of surfactant in porcine oesophagus
Published 2019“…Results: Decellularisation with 0.25% SDS at 0.15ml/min flow rate resulted in high percentage of cells and DNA content removal. Histology and microscopy revealed a smooth and denuded surface with papillary structures. …”
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Final Year Project (FYP) -
15
The LBP gene and its association with resistance to Aeromonas hydrophila in Tilapia
Published 2014“…The full-length cDNA (1901 bp) of the gene contained a 1416 bp open reading frame, encoding 471 amino acid residues. …”
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Journal Article -
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HSV-1 amplicon system for human artificial chromosome formation in human ES/iPS cells and pluripotency induction
Published 2012“…<p>Development of safe and efficient approaches for gene delivery in human embryonic stem cells (hESc) and particularly in human induced pluripotent stem (hiPS) cells, which can be derived in a person-specific manner, is considered to be imperative for harnessing their full potential in both the basic and applied research. …”
Thesis -
19
Part I Targeting RNA duplexes with modified triplex-forming oligonucleotides Part II Allostery within a Watson-Crick RNA duplex and its application in studying RNA recognition by R...
Published 2014“…Here, we incorporated Locked Nucleic Acid (LNA), 2-thio U, and 2′-O methyl modified residues in a series of all pyrimidine RNA TFOs, and studied the binding to two RNA hairpin structures. 12-Base-triple major-groove pyrimidine•purine-pyrimidine triplex structures form between the RNA/DNA hairpins and the complementary RNA TFOs. UV-absorbance-detected thermal melting studies reveal that the LNA and 2-thio U modifications in TFOs strongly enhance triplex formation with both parental RNA and DNA duplex regions. …”
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Thesis -
20
Optimising expression and purification of Dengue soluble E protein
Published 2023“…It offers insights into viral-host immune interactions. The full-length E protein is essential for vaccine design. …”
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Final Year Project (FYP)