Development of ISB 1442, a CD38 and CD47 bispecific biparatopic antibody innate cell modulator for the treatment of multiple myeloma by Grandclément, C, Estoppey, C, Dheilly, E, Panagopoulou, M, Monney, T, Dreyfus, C, Loyau, J, Labanca, V, Drake, A, De Angelis, S, Rubod, A, Frei, J, Caro, LN, Blein, S, Martini, E, Chimen, M, Matthes, T, Kaya, Z, Edwards, CM, Edwards, JR, Menoret, E, Kervoelen, C, Pellat-Deceunynck, C, Moreau, P, Mbow, ML, Srivastava, A, Dyson, MR, Zhukovsky, EA, Perro, M, Sammicheli, S

“…ISB 1442 consists of two anti-CD38 arms targeting two distinct epitopes that preferentially drive binding to tumor cells and enable avidity-induced blocking of proximal CD47 receptors on the same cell while preventing on-target off-tumor binding on healthy cells. …”

Improved reverse bias stability in p–i–n perovskite solar cells with optimized hole transport materials and less reactive electrodes by Jiang, F, Shi, Y, Rana, TR, Morales, D, Gould, IE, McCarthy, DP, Smith, JA, Christoforo, MG, Yaman, MY, Mandani, F, Terlier, T, Contreras, H, Barlow, S, Mohite, AD, Snaith, HJ, Marder, SR, MacKenzie, JD, McGehee, MD, Ginger, DS

“…As perovskite photovoltaics stride towards commercialization, reverse bias degradation in shaded cells that must current match illuminated cells is a serious challenge. …”

Unraveling microglial spatial organization in the developing human brain with DeepCellMap, a deep learning approach coupled with spatial statistics by Perochon, T, Krsnik, Z, Massimo, M, Ruchiy, Y, Romero, AL, Mohammadi, E, Li, X, Long, KR, Parkkinen, L, Blomgren, K, Lagache, T, Menassa, DA, Holcman, D

“…This pipeline is designed to map microglial organization during normal and pathological brain development and has the potential to be adapted to any cell type. Using DeepCellMap, we capture the morphological diversity of microglia, identify strong coupling between proliferative and phagocytic phenotypes, and show that distinct spatial clusters rarely overlap as human brain development progresses. …”

Assessing the kinetics of oxygen-unloading from red cells using FlowScore, a flow-cytometric proxy of the functional quality of blood by Rabcuka, J, Smethurst, P, Dammert, K, Saker, J, Aran, G, Walsh, G, Tan, J, Codinach, M, McTaggart, K, Marks, D, Bakker, S, McMahon, A, Di Angelantonio, E, Roberts, D, Blonski, S, Korczyk, P, Shirakami, A, Cardigan, R, Swietach, P

“…<p><strong>Background: </p></strong>Metrics evaluating the functional quality of red blood cells (RBCs) must consider their role in oxygen delivery. …”

Studies on the antioxidant mechanisms of betacyanins from improved fermented red dragon fruit (Hylocereus polyrhizus) drink in HepG2 cells by Lim, Teck Wei, Lim, Renee Lay Hong, Pui, Liew Phing, Tan, Chin Ping, Ho, Chun Wai

“…Red dragon fruit (RDF, Hylocereus polyrhizus) is high in betacyanins content but is understudied for its antioxidant mechanisms in liver cells. The present study aimed to investigate the antioxidant mechanisms of the stabilised betacyanins in a novel RDF functional drink, Improved-FRDFD-dH2O (produced from mild, sustainable approaches) using HepG2 cell line. …”
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Apoptotic-related signalling pathways in mcf-7 cells treated with ethyl acetate extract of dillenia suffruticosa, and isolation of its major compounds by Yin, Sim Tor

“…MTT assay was used to determine the cytotoxicity of EADs, which was demonstrated to be dose- and time-dependent, with IC50 of 39 ± 3.6 µg/mL at 72 hours. Flow cytometry cell cycle analysis displayed that EADs induced non-phase specific cell cycle arrest. …”
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In vitro anti-proliferative mechanism of combination therapy with tannic acid and cisplatin against human osteosarcoma cell line U2OS by Kasiram, Mohamad Zahid Mohd

“…Hence, this study aimed to investigate the effect of TA treatment combined with cisplatin on human osteosarcoma cell line (U2OS). The half-maximal inhibitory concentration (IC50) values of TA and its combination with cisplatin against U2OS cells were determined using MTT assay. …”
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Influence Of Different Ratios Of Gdc-Sdc On Ssc/Gdc–Sdc Dual Composite Cathode For Intermediate-Temperature Solid Oxide Fuel Cells by Roslan, Mohammad Fikrey, Abd Rahman, Hamimah, Azmi, Mohd Azham, MohdTukimon, Mohd Faizal, Jaidi, Zolhafizi, Abdul Ghani, Muhammad Zul Idzham

“…Solid oxide fuel cells (SOFCs) have emerged as highly promising contenders in the field of energy conversion, offering enhanced efficiency and environmental sustainability. …”
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Reduced mRNA and protein expression levels of Tet Methylcytosine Dioxygenase 3 in endothelial progenitor cells of patients of type 2 diabetes with peripheral artery disease by Zhao, Shi, Jia, Ting, Tang, Yang, Zhang, Xiaotong, Mao, Hong, Tian, Xiaojia, Li, Rui, Ma, Lu, Chen, Guoxun

Subjects: “…Endothelial Progenitor Cells…”
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Novel plasma-assisted low-temperature-processed SnO2 thin films for efficient flexible perovskite photovoltaics by Subbiah, Anand S., Mathews, Nripan, Mhaisalkar, Subodh, Sarkar, Shaibal K.

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Targeting TFEB and TFE3 in iPSC-derived dopaminergic neurons to correct autophagic/lysosomal deficits in Parkinson's disease by McGuinness, W

Subjects: “…Induced pluripotent stem cells…”

The impact of a brief online mindfulness intervention to support erectile dysfunction in African Caribbean men: a Pilot waitlist controlled randomised controlled trial and content analysis = El impacto de una breve intervención de atención plena en línea para apoyar la disfunción eréctil en hombres afrocaribeños: un ensayo piloto controlado, aleatorio, controlado en lista de espera y análisis de contenido by Banbury, Samantha, Jean-Marie, Dellian, Lusher, Joanne, Chandler, Chris, Turner, John

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Hydrothermal Synthesis, Structure Investigation, and Oxide Ion Conductivity of Mixed Si/Ge-Based Apatite-Type Phases by Li, Henan, Baikie, Tom, Pramana, Stevin S., Shin, J. Felix, Keenan, Philip J., Slater, Peter R., Brink, Frank, Hester, James, An, Tao, White, Timothy John

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A novel human stem cell platform for probing adrenoceptor signaling in iPSC derived cardiomyocytes including those with an adult atrial phenotype by Ahmad, F

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Divergent acute versus prolonged pharmacological GLP-1R responses in adult β cell-specific β-arrestin 2 knockout mice by Bitsi, Stavroula, El Eid, Liliane, Manchanda, Yusman, Oqua, Affiong I., Mohamed, Nimco, Hansen, Ben, Suba, Kinga, Rutter, Guy A., Salem, Victoria, Jones, Ben, Tomas, Alejandra

“…Here, we have assessed in vivo glycemic responses to the pharmacological GLP-1R agonist exendin-4 in adult β cell-specific β-arrestin 2 knockout (KO) mice. KOs displayed a sex-dimorphic phenotype consisting of weaker acute responses that improved 6 hours after agonist injection. …”
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Rapid and Scalable Production of Functional SARS-CoV-2 Virus-like Particles (VLPs) by a Stable HEK293 Cell Pool by Puarattana-aroonkorn, Sitthiphol, Tharakaraman, Kannan, Suriyawipada, Disapan, Ruchirawat, Mathuros, Fuangthong, Mayuree, Sasisekharan, Ram, Artpradit, Charlermchai

“…Typical biologics production relies on using the lengthy and arduous approach of stable single-cell clones. Here, we used an alternative approach, a stable cell pool that takes only weeks to generate compared to a stable single-cell clone that needs several months to complete. …”
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A maskless synthesis of TiO2-nanofiber-based hierarchical structures for solid-state dye-sensitized solar cells with improved performance by Pramana, Stevin S., Sabba, Dharani, Agarwala, Shweta, Mhaisalkar, Subodh

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PPARβ/δ prevents endoplasmic reticulum stress-associated inflammation and insulin resistance in skeletal muscle cells through an AMPK-dependent mechanism by Salvadó, Laia, Barroso, Emma, Gómez-Foix, Anna Maria, Palomer, Xavier, Michalik, Liliane, Wahli, Walter, Vázquez-Carrera, Manuel

“…In this study, we assessed whether peroxisome proliferator-activated receptor (PPAR)β/δ prevented ER stress-associated inflammation and insulin resistance in skeletal muscle cells. Methods Studies were conducted in mouse C2C12 myotubes, in the human myogenic cell line LHCN-M2 and in skeletal muscle from wild-type and PPARβ/δ-deficient mice and mice exposed to a high-fat diet. …”
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Whole-cell phenotypic screening of Medicines for Malaria Venture Pathogen Box identifies specific inhibitors of Plasmodium falciparum late-stage development and egress by Patra, Alok Tanala, Hingamire, Tejashri, Belekar, Meenakshi A., Xiong, Aoli, Subramanian, Gowtham, Bozdech, Zbynek, Preiser, Peter, Shanmugam, Dhanasekaran, Chandramohanadas, Rajesh

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Leucine-rich α-2-glycoprotein 1 suppresses endothelial cell activation through ADAM10-mediated shedding of TNF-α receptor by Pang, Kuin Tian, Ghim, Mean, Liu, Chenghao, Tay, Hui Min, Fhu, Chee Wai, Chia, Rui Ning, Qiu, Beiying, Sarathchandra, Padmini, Chester, Adrian H., Yacoub, Magdi H., Wilkinson, Fiona L., Weston, Ria, Warboys, Christina M., Hou, Han Wei, Weinberg, Peter D., Wang, Xiaomeng

“…This study aims to investigate the role of LRG1 in endothelial activation. LRG1 in endothelial cells (ECs) of arteries and serum of patients with critical limb ischemia (CLI) was assessed by immunohistochemistry and ELISA, respectively. …”
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