Controlled-release nanoencapsulating microcapsules to combat inflammatory diseases by Baek, Jong-Suep, Yeo, Eng Wan, Lee, Yin Hao, Tan, Nguan Soon, Loo, Say Chye Joachim

“…The World Health Organization (WHO) has reported that globally 235 million people suffer from chronic and other inflammatory diseases. The short half-lives of nonsteroidal anti-inflammatory drugs (NSAIDs) and their notoriety in causing gastrointestinal discomforts, warrants these drugs to be released in a controlled and sustained manner. …”
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Boronic acid and nitrofuranyl derivatives as potential therapeutics by Dey, AL

“…Whereas in the recent past drug development has often focussed on molecular structures with limited pharmacokinetic parameters e.g. …”

Genomic profiling of mycobacterium tuberculosis strains, Myanmar by Aung, Htin Lin, Nyunt, Wint Wint, Fong, Yang, Biggs, Patrick J., Winkworth, Richard C., Lockhart, Peter J., Yeo, Tsin Wen, Hill, Philip C., Cook, Gregory M., Aung, Si Thu

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Use of peptide asparginyl ligases (PALs) in generating alternative non-Ig protein-drug conjugates for cancer therapy by See, Julia Jing Yi

“…Past research on antibody–drug conjugates (ADCs) focused on protein site-specific modification as chemical conjugation lacks site-selectivity. …”
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AI is a viable alternative to high throughput screening: a 318-target study by Wallach, Izhar, Bernard, Denzil, Nguyen, Kong, Ho, Gregory, Morrison, Adrian, Stecula, Adrian, Rosnik, Andreana, O’Sullivan, Ann Marie, Davtyan, Aram, Samudio, Ben, Thomas, Bill, Worley, Brad, Butler, Brittany, Laggner, Christian, Thayer, Desiree, Moharreri, Ehsan, Friedland, Greg, Truong, Ha, van den Bedem, Henry, Ng, Ho Leung, Stafford, Kate, Sarangapani, Krishna, Giesler, Kyle, Ngo, Lien, Mysinger, Michael, Ahmed, Mostafa, Anthis, Nicholas J., Henriksen, Niel, Gniewek, Pawel, Eckert, Sam, de Oliveira, Saulo, Suterwala, Shabbir, PrasadPrasad, Srimukh Veccham Krishna, Shek, Stefani, Contreras, Stephanie, Hare, Stephanie, Palazzo, Teresa, O’Brien, Terrence E., Van Grack, Tessa, Williams, Tiffany, Chern, Ting-Rong, Kenyon, Victor, Lee, Andreia H., Cann, Andrew B., Bergman, Bastiaan, Anderson, Brandon M., Cox, Bryan D., Warrington, Jeffrey M., Sorenson, Jon M., Goldenberg, Joshua M., Young, Matthew A., DeHaan, Nicholas, Pemberton, Ryan P., Schroedl, Stefan, Abramyan, Tigran M., Gupta, Tushita, Mysore, Venkatesh, Presser, Adam G., Ferrando, Adolfo A., Andricopulo, Adriano D., Ghosh, Agnidipta, Ayachi, Aicha Gharbi, Mushtaq, Aisha, Shaqra, Ala M., Toh, Alan Kie Leong, Smrcka, Alan V., Ciccia, Alberto, de Oliveira, Aldo Sena, Sverzhinsky, Aleksandr, de Sousa, Alessandra Mara, Agoulnik, Alexander I., Kushnir, Alexander, Freiberg, Alexander N., Statsyuk, Alexander V., Gingras, Alexandre R., Degterev, Alexei, Tomilov, Alexey, Vrielink, Alice, Garaeva, Alisa A., Bryant-Friedrich, Amanda, Caflisch, Amedeo, Patel, Amit K., Rangarajan, Amith Vikram, Matheeussen, An, Battistoni, Andrea, Caporali, Andrea, Chini, Andrea, Ilari, Andrea, Mattevi, Andrea, Foote, Andrea Talbot, Trabocchi, Andrea, Stahl, Andreas, Herr, Andrew B., Berti, Andrew, Freywald, Andrew, Reidenbach, Andrew G., Lam, Andrew, Cuddihy, Andrew R., White, Andrew, Taglialatela, Angelo

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Modular Titratable Polypills for Personalized Medicine and Simplification of Complex Medication Regimens by Karavasili, Christina, Babaee, Sahab, Kutty, Shruti, Chu, Jacqueline N., Min, Seokkee, Fitzgerald, Nina, Morimoto, Joshua, Inverardi, Nicoletta, Traverso, Giovanni

“…To fill the existing gap in drug dose personalization and simplification of complex medication regimens commonly encountered in the treatment of cardiovascular disease, tuberculosis, and tapering of corticosteroid therapy, a modular titratable polypill approach that simultaneously addresses both aspects is proposed. …”
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Design of Cleavable Monomers and Cross-Linkers for the Synthesis of Degradable Polymer Architectures by Cardoso da Costa, Leticia

“…The difference in backbone degradation rates, imparted by the silyl ether substituents, leads to different drug release profiles and therapeutic efficacy in vitro (Chapter 3). …”
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A synthetic biology platform for malaria parasites based on orthogonal transcriptional control by Cárdenas Ramírez, Pablo

“…Malaria is responsible for half a million deaths each year in some of the poorest communities around the world. …”
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Disposition kinetics of tylosin administered intravenously and intramuscularly in Desert Sheep and Nubian Goats by Taha, A.A., Elsheikh, H.A., Khalafalla, A.E., Osman, I. A. M., Abdullah, A. Salam

“…The bioavailability (f) of the drug in goats (0.84 ± 0.11) was not significantly higher than that in sheep (0.73 ± 0.08). …”
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Interfacial phenomena and biological recognition of mammalian cells on biomimetic materials by Chan, Vincent.

“…We intend to fill this gap by interrogating the biophysical events involved in membrane-polymer interaction, biological adhesion, tissue engineering and cellular fluid mechanics. …”
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Synergistic effect of 5-fluorouracil and the small molecule Wnt/β-catenin inhibitor iCRT3 on Caco-2 colorectal cancer cells in vitro by Smarslik, Maren, Inal, Jameel

“…Subsequently, the drugs were combined in different ways, and drug combination index (DCI) calculations were performed to evaluate their interaction. iCRT3 was found to be 2.45-fold more potent than 5-FU (p = 0.1982). …”
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Design and Synthesis of Stimuli-Responsive Polymers with Programmable Cleavability by Zafar, Hadiqa

“…The third chapter investigates a synergistic approach to treating pancreatic ductal adenocarcinoma (PDAC) with drug-loaded BBPs by leveraging multiple facets of structural modularity, including linker and drug identities and concentration ratios. …”
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Studies towards the synthesis of bioactive natural products and development of new synthetic methods by Khanizeman, Rabi’ah Nisha

“…It has been estimated that more than half of all approved drugs, from the period 1981 to 2014, are either natural products or their derivatives. …”
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Pathogen diversity and antimicrobial resistance transmission of Salmonella enterica serovars Typhi and Paratyphi A in Bangladesh, Nepal, and Malawi: a genomic epidemiological study... by Dyson, ZA, Ashton, PM, Khanam, F, Chunga Chirambo, A, Shakya, M, Meiring, JE, Tonks, S, Karkey, A, Msefula, C, Clemens, JD, Dunstan, SJ, Baker, S, Dougan, G, Pitzer, VE, Basnyat, B, Qadri, F, Heyderman, RS, Gordon, MA, Holt, KE, Pollard, AJ, STRATAA Study Group

“…</p> <br> <p><strong>Funding:</strong> Wellcome Trust, Bill &amp; Melinda Gates Foundation, EU Horizon 2020, and UK National Institute for Health and Care Research.…”

Tumor-targeted nano-assemblies for energy-blocking cocktail therapy in cancer by Chen, Manling, Liu, Yidu, Li, Yang, Liu, Xue

“…To minimize the dosage of both drugs, we have developed a drug delivery strategy that prepared metformin as a nanoderivative, denoted as MA-dots. …”
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Computational analysis for infectious diseases surveillance and host-pathogen interactions (in the context of Influenza A viruses) by Beyene, Biruhalem Taye

“…While there are few clinically approved anti-IAV drugs for therapeutic and prophylactic use, these drugs have also been challenged by the emergence of drug resistance, toxicity, adverse effects and low efficacy. …”
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Development of image-based method for the quantitative assessment of cartilage damage from CT as a biomarker in osteoarthritis by Zheng, J-Q

“…<p>Preclinical studies, like those for drug development, require quantitative methods to assess osteoarthritis (OA). …”

The influence of additives on the delivery of paclitaxel from bioresorbable PLGA films by Huang, Charlotte Liwen.

“…The study of the influences of additives on the drug delivery characteristics from PLGA thin films as a coating on angioplasty balloons was reported in this thesis. …”
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Synthesis and characterization of silver nanoprism-based nanostructures by Mohammad Mehdi Shahjamali

“…Noble metal nanostructures, ranging from a few atom clusters to micrometer-long nanocrystal, have attracted tremendous attention for more than half a century. They have shown the unique physical and chemical properties, which make them promising candidates in a wide range of applications, such as catalysis, electronics, optics, sensing, bioimaging and gene regulation. …”
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An analysis of heavy silicone oil treatment for inferior proliferative vitreoretinopathy by Hammer, M, Ie, A, Eibenberger, K, Auffarth, GU, Xue, K

“…The number of glaucoma drugs were increased in 45% of patients during Densiron tamponade. …”