Time-dependent metabolomics uncover dynamic metabolic adaptions in MCF-7 cells exposed to bisphenol A by Zhao, Haoduo., Liu, Min, Yang, Junjie, Chen, Yuyang, Fang, Mingliang

“…This study aims to explore the time-resolved metabolite dysregulation manner and dynamically perturbed biological functions in MCF-7 cells exposed to bisphenol A (BPA), a well-known endocrine-disrupting chemical. …”
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Extensive promoter-centered chromatin interactions provide a topological basis for transcription regulation by Li, Guoliang, Ruan, Xiaoan, Auerbach, Raymond K., Sandhu, Kuljeet Singh, Zheng, Meizhen, Wang, Ping, Poh, Huay Mei, Goh, Yufen, Lim, Joanne, Zhang, Jingyao, Sim, Hui Shan, Peh, Su Qin, Mulawadi, Fabianus Hendriyan, Ong, Chin Thing, Orlov, Yuriy L., Hong, Shuzhen, Zhang, Zhizhuo, Landt, Steve, Raha, Debasish, Euskirchen, Ghia, Wei, Chia-Lin, Ge, Weihong, Wang, Huaien, Davis, Carrie, Fisher-Aylor, Katherine I., Mortazavi, Ali, Gerstein, Mark, Gingeras, Thomas, Wold, Barbara, Sun, Yi, Cheung, Edwin, Liu, Edison, Sung, Wing-Kin, Snyder, Michael, Ruan, Yijun, Fullwood, Melissa Jane

“…Using genome-wide Chromatin Interaction Analysis with Paired-End-Tag sequencing (ChIA-PET), we mapped long-range chromatin interactions associated with RNA polymerase II in human cells and uncovered widespread promoter-centered intragenic, extragenic, and intergenic interactions. …”
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A tight polyethersulfone ultrafiltration membrane fabricated via polyion complex assisted phase inversion for dye desalination by Zhao, Yali, Liao, Yuan, Lai, Gwo Sung, Yin, Yurong, Wang, Rong

“…Morphology, chemical composition, surface charges and pore size analysis characterized via SEM, FTIR, XPS, Zeta potential and Dextran filtration experiment, respectively, testified that a nonporous skin layer comprising of polyion complex and enriched SPSF was successfully constructed on the top of the PES matrix with an effective pore radius of 1.44 nm, which is smaller than that of the reference membrane prepared without using polyion complex assisted phase inversion (2.74 nm). …”
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Spontaneous growth and phase transformation of highly conductive nickel germanide nanowires by Higgins, Jeremy M., Faber, Matthew S., Yan, Chaoyi, Lee, Pooi See, Jin, Song

“…Electrical studies reveal that NiGe NWs are highly conductive, with an average resistivity of 35 ± 15 μΩ·cm, while the resistivity of ε-Ni5Ge3 NWs is more than 4 times that of the NiGe phase. …”
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Polymers at Nanoscale / by He, Jie, editor 655466, Wang, Xin, editor 655467, World Scientific (Online service) 655444

“…It encompasses the various preparation methods of polymer nanoparticles, broadly ranged from single chain collapse to polymerization methods and solution self-assembly. …”
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Representation learning in the artificial and biological neural networks underlying sensorimotor integration by Suhaimi, Ahmad, Lim, Amos W. H., Chia, Xin Wei, Li, Chunyue, Makino, Hiroshi

“…Here, we trained deep RL agents and mice in the same sensorimotor task with high-dimensional state and action space and studied representation learning in their respective neural networks. …”
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Intraperitoneal injection of the Porphyromonas gingivalis outer membrane vesicle (OMV) stimulated expressions of neuroinflammatory markers and histopathological changes in the brai... by Adewoyin, Malik, Hamarsha, Ahmed, Akinsola, Rasaq, Teoh, Seong Lin, Azmai, Mohammad Noor Amal, Abu Bakar, Noraini, Nasruddin, Nurrul Shaqinah

“…This study discovered that nitric oxide and PGE2 were significantly increased at 45 min, while IL-1β and IL-6 were expressed at subsequent 12 h and 24 h time points, respectively. …”
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Thermal self‐protection of zinc‐ion batteries enabled by smart hygroscopic hydrogel electrolytes by Yang, Peihua, Feng, Chunzao, Liu, Yipu, Cheng, Ting, Yang, Xuelong, Liu, Huidong, Liu, Kang, Fan, Hong Jin

“…Here, a self‐adaptive strategy is demonstrated to circumvent the thermal runaway of aqueous zinc‐ion batteries, by using a zinc chloride‐enriched hygroscopic hydrogel electrolyte. …”
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A review of extraction methods for the analysis of pharmaceuticals in environmental waters by Daniels, Kevin D., Park, Minkyu, Huang, Zhenzhen, Jia, Ai, Flores, Guillermo S., Lee, Hian Kee, Snyder, Shane Allen

“…The aim of this review is to provide an overview of extraction methods for environmental water samples containing trace levels of pharmaceuticals and how current applications will mold how they are analyzed in the future.…”
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Epithelial-mesenchymal transition of cancer cells using bioengineered hybrid scaffold composed of hydrogel/3D-fibrous framework by Pal, Mintu, Chen, Huizhi, Lee, Bae Hoon, Lee, Justin Yin Hao, Yip, Yun Sheng, Tan, Nguan Soon, Tan, Lay Poh

“…In this study, we focused on two major points (i) designing and fabrication of 3D hybrid scaffolds comprising electrospun fibers with cancer cells embedded within hydrogels, and (ii) determining the potential roles of 3D hybrid scaffolds associated with EMT in cancer progression and metastasis. …”
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50 Years of quantum chromodynamics by Gross, Franz, Klempt, Eberhard, Brodsky, Stanley J., Buras, Andrzej J., Burkert, Volker D., Heinrich, Gudrun, Jakobs, Karl, Meyer, Curtis A., Orginos, Kostas, Strickland, Michael, Stachel, Johanna, Zanderighi, Giulia, Brambilla, Nora, Braun-Munzinger, Peter, Britzger, Daniel, Capstick, Simon, Cohen, Tom, Crede, Volker, Constantinou, Martha, Davies, Christine, Del Debbio, Luigi, Denig, Achim, DeTar, Carleton, Deur, Alexandre, Dokshitzer, Yuri, Dosch, Hans Günter, Dudek, Jozef, Dunford, Monica, Epelbaum, Evgeny, Escobedo, Miguel A., Fritzsch, Harald, Fukushima, Kenji, Gambino, Paolo, Gillberg, Dag, Gottlieb, Steven, Grafstrom, Per, Grazzini, Massimiliano, Grube, Boris, Guskov, Alexey, Iijima, Toru, Ji, Xiangdong, Karsch, Frithjof, Kluth, Stefan, Kogut, John B., Krauss, Frank, Kumano, Shunzo, Leinweber, Derek, Leutwyler, Heinrich, Li, Hai-Bo, Li, Yang, Malaescu, Bogdan, Mariotti, Chiara, Maris, Pieter, Marzani, Simone, Melnitchouk, Wally, Messchendorp, Johan, Meyer, Harvey, Mitchell, Ryan Edward, Mondal, Chandan, Nerling, Frank, Neubert, Sebastian, Pappagallo, Marco, Pastore, Saori, Peláez, José R., Puckett, Andrew, Qiu, Jianwei, Rabbertz, Klaus, Ramos, Alberto, Rossi, Patrizia, Rustamov, Anar, Schäfer, Andreas, Scherer, Stefan, Schindler, Matthias, Schramm, Steven, Shifman, Mikhail, Shuryak, Edward, Sjöstrand, Torbjörn, Sterman, George, Stewart, Iain W., Stroth, Joachim, Swanson, Eric, de Téramond, Guy F., Thoma, Ulrike, Vairo, Antonio, van Dyk, Danny, Vary, James, Virto, Javier, Vos, Marcel, Weiss, Christian, Wobisch, Markus, Wu, Sau Lan, Young, Christopher, Yuan, Feng, Zhao, Xingbo, Zhou, Xiaorong

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Harnessing Tullock contests and signaling games: a novel weight assignment strategy for Ethereum 2.0 by Doe, Daniel Mawunyo, Li, Jing, Niyato, Dusit, Hu, Yuqing, Li, Jun, Gao, Zhen, Zhang, Xiao-Ping, Han, Zhu

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Evaluation of urban public transport sustainability in China based on the Driving Force-Pressure-State-Impact-Response (DPSIR) framework——a case study of 36 major cities by Hou, Xiaoran, Lv, Tao, Xu, Jie, Deng, Xu, Liu, Feng, Lam, Jasmine Siu Lee, Zhang, Zhenzhen, Han, Xuesen

“…With urbanization and motorization, the sustainable development of urban transport has drawn extensive attention worldwide. As one of the key components of the transport system, urban public transport is the breakthrough. …”
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Towards an optimal and unbiased approach for tumor cell isolation by Sajay, Bhuvanendran Nair Gourikutty, Chang, Chia-Pin, Ahmad, Hamizah, Chung, Wong Chee, Puiu, Poenar Daniel, Rahman, Abdur Rub Abdur

“…This approach achieves an average of >90 % recovery of spiked tumor cells and >99 % total WBC depletion in whole blood across multiple cell lines, in a simple and easy-to-use assay. The results presented herein and ongoing improvements aim to fulfill the need for a highly reliable, unbiased, standardized, and optimized CTC isolation platform, using component technologies that are validated for cell isolation.…”
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Urban vulnerability assessment of sea level rise in Singapore through the World Avatar by Phua, Shin Zert, Lee, Kok Foong, Tsai, Yi-Kai, Ganguly, Srishti, Yan, Jingya, Mosbach, Sebastian, Ng, Trina, Moise, Aurel, Horton, Benjamin Peter, Kraft, Markus

“…We introduce OntoSeaLevel, an ontology to describe sea level rise scenarios, and its impact on broader elements defined in other ontologies such as buildings (OntoBuiltEnv ontology), road networks (OpenStreetMap ontology), and land plots (Ontoplot and Ontozoning ontology). …”
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Nanopore sequencing analysis of integron gene cassettes in sewages and soils by An, Xin-Li, Abass, Olusegun K., Zhao, Cai-Xia, Xu, Mei-Rong, Pan, Ting, Pu, Qiang, Liao, Hu, Li, Hu, Zhu, Yong-Guan, Su, Jian-Qiang

“…Integrons are genetic elements that can facilitate rapid spread of antibiotic resistance by insertion and removal of genes. …”
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Identification of genetic effects underlying type 2 diabetes in South Asian and European populations by Loh, Marie, Zhang, Weihua, Ng, Hong Kiat, Schmid, Katharina, Lamri, Amel, Tong, Lin, Meraj Ahmad, Lee, Jung-Jin, Ng, Maggie C. Y., Petty, Lauren E., Spracklen, Cassandra N., Takeuchi, Fumihiko, Md. Tariqul Islam, Jasmine, Farzana, Kasturiratne, Anuradhani, Muhammad Kibriya, Mohlke, Karen L., Paré, Guillaume, Prasad, Gauri, Mohammad Shahriar, Chee, Miao Ling, de Silva, H. Janaka, Engert, James C., Gerstein, Hertzel C., Mani, K. Radha, Sabanayagam, Charumathi, Vujkovic, Marijana, Wickremasinghe, Ananda R., Wong, Tien Yin, Yajnik, Chittaranjan S., Salim Yusuf, Habibul Ahsan, Bharadwaj, Dwaipayan, Anand, Sonia S., Below, Jennifer E., Boehnke, Michael, Bowden, Donald W., Chandak, Giriraj R., Cheng, Ching-Yu, Kato, Norihiro, Mahajan, Anubha, Sim, Xueling, McCarthy, Mark I., Morris, Andrew P., Kooner, Jaspal S., Saleheen, Danish, Chambers, John C.

“…South Asians are at high risk of developing type 2 diabetes (T2D). We carried out a genome-wide association meta-analysis with South Asian T2D cases (n = 16,677) and controls (n = 33,856), followed by combined analyses with Europeans (neff = 231,420). …”
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Cellular thermal shift assay for the identification of drug-target interactions in the Plasmodium falciparum proteome by Dziekan, Jerzy Michal, Wirjanata, Grennady, Dai, Lingyun, Go, Ka Diam, Yu, Han, Lim, Yan Ting, Chen, Liyan, Wang, Loo Chien, Puspita, Brenda, Prabhu, Nayana, Sobota, Radoslaw M., Nordlund, Pär, Bozdech, Zbynek

“…Methodological optimizations necessary for the analysis of this intracellular parasite are discussed, including enrichment of parasitized cells and hemoglobin depletion strategies to overcome high hemoglobin abundance in the host red blood cells. …”
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Spatial proteomics of immune microenvironment in nonalcoholic steatohepatitis-associated hepatocellular carcinoma by Li, Meiyi, Wang, Lina, Cong, Liang, Wong, Chi Chun, Zhang, Xiang, Chen, Huarong, Zeng, Tao, Li, Bin, Jia, Xian, Huo, Jihui, Huang, Yuhua, Ren, Xiaoxue, Peng, Sui, Fu, Guo, Xu, Lixia, Sung, Joseph Jao Yiu, Kuang, Ming, Li, Xiaoxing, Yu, Jun

“…Approach and Results: We applied the imaging mass cytometry to construct a spatially resolved single-cell atlas from the formalin-fixed and paraffin-embedded tissue sections from patients with NASH-HCC, virus-HCC (HBV-HCC and HCV-HCC), and healthy donors. …”
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Contribution of rare chromosome 22q11.2 copy number variants to non-syndromic bicuspid aortic valve by DiGregorio, H, Mansoorshahi, S, Carlisle, SG, Tovar Pensa, C, Watts, A, McNeely, C, Sabate-Rotes, A, Yetman, A, Michelena, HI, De Backer, JFA, Mosquera, LM, Bissell, MM, Andreassi, MG, Foffa, I, Hui, DS, Caffarelli, A, Kim, YY, Citro, R, De Marco, M, Tretter, JT, McBride, KL, Body, SC, Milewicz, DM, Prakash, SK

“…While BAV is frequently associated with 22q11.2 deletion syndrome (22q11.2DS), the contribution of rare copy number variants (CNVs) in this region to non-syndromic BAV is less clear. This study is aimed to assess the role of rare 22q11.2 CNVs in patients with early-onset BAV (EBAV) and to determine whether these variants are linked to an increased risk of complications. …”