G4-PROTAC: targeted degradation of a G-quadruplex binding protein by Patil, Kiran M., Chin, Danielle, Seah, Hui Ling, Shi, Qi, Lim, Kah Wai, Phan, Anh Tuân

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A comprehensive review of the utilization of alternative binding properties in the construction of asphalt pavements by Ferdaus, R., Khairil Azman, Masri, Hasan, Kamrul, Putra Jaya, Ramadhansyah

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Ultra-fast all-optical switching based on nanoantenna coupled to monolayer TMDs by Song, Qige

“…In the dissertation, a spatial all-optical switch based on dimer and monolayer TMDs is designed. …”
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Validating the ratio of insulin like growth factor binding protein 4 to sex hormone binding globulin as a prognostic predictor of preterm birth in Viet Nam: a case-cohort study by Hirst, JE, Boniface, JJ, Le, DP, Polpitiya, AD, Fox, AC, Vu, TTK, Dang, TT, Fleischer, TC, Bui, NTH, Hickok, DE, Kearney, PE, Thwaites, G, Kennedy, SH, Kestelyn, E, Le, TQ

“…Relative insulin-like growth factor binding protein 4 (IGFBP4) and sex hormone binding globulin (SHBG) abundances were measured by mass spectrometry and their ratio compared between PTB cases and term controls. …”

YY1 binding is a gene-intrinsic barrier to Xist-mediated gene silencing by Bowness, JS, Almeida, M, Nesterova, T, Brockdorff, N

Investigation on chemical protease, nuclease and catecholase activity of two copper complexes with flexidentate Schiff base ligands by Das, Mriganka, Kundu, Bidyut Kumar, Tiwari, Ritudhwaj, Mandal, Poulami, Nayak, Debasis, Ganguly, Rakesh, Mukhopadhyay, Suman

“…Screening tests were conducted to quantify the binding ability of complexes (1 and 2) towards BSA and DNA as well as the protease and nuclease activity of these complexes using gel electrophoresis technique. …”
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Impact of pyridyl moieties on the inhibitory properties of prominent acyclic metal chelators against metallo-β-lactamase-producing Enterobacteriaceae : investigating the molecular... by Sosibo, Sphelele C., Somboro, Anou M., Amoako, Daniel G., Osei Sekyere, John, Bester, Linda A., Ngila, Jane C., Sun, Darren Delai, Kumalo, Hezekiel M.

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Identification and application of self-binding zipper-like sequences in SARS-CoV spike protein by Zhang, Si Min, Liao, Ying, Neo, Tuan Ling, Lu, Yanning, Liu, Ding Xiang, Vahlne, Anders, Tam, James Pingkwan

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Use of ladle furnace slag containing heavy metals as a binding material in civil engineering by Xu, Bo, Yi, Yaolin

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Alternative splicing in the DBD linker region of p63 modulates binding to DNA and iASPP in vitro by Lotz, R, Osterburg, C, Chaikuad, A, Weber, S, Akutsu, M, Machel, AC, Beyer, U, Gebel, J, Löhr, F, Knapp, S, Dobbelstein, M, Lu, X, Dötsch, V

“…This stretch contains a degenerate class II SH3 domain binding motif that is responsible for interaction with iASPP, as well as two positively charged amino acids. …”

Structural analysis of protein tyrosine phosphatase 1B reveals potentially druggable allosteric binding sites by Kumar, Ammu Prasanna, Nguyen, Minh Nhan, Verma, Chandra, Lukman, Suryani

“…Catalytic proteins such as human protein tyrosine phosphatase 1B (PTP1B), with conserved and highly polar active sites, warrant the discovery of druggable nonactive sites, such as allosteric sites, and potentially, therapeutic small molecules that can bind to these sites. Catalyzing the dephosphorylation of numerous substrates, PTP1B is physiologically important in intracellular signal transduction pathways in diverse cell types and tissues. …”
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Functional characterization of plasmodium falciparum reticulocyte binding like protein homologue 1 (PfRH1) by Yap, Sally Shu Lin

“…One of the protein families involved in invasion, reticulocyte binding like protein homologues (PfRHs) has been suggested to be involved in host cell selection. …”
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Persistent spectral hypergraph based machine learning (PSH-ML) for protein-ligand binding affinity prediction by Liu, Xiang, Feng, Huitao, Wu, Jie, Xia, Kelin

“…We test our PSH-GBT model on three most commonly used datasets, including PDBbind-2007, PDBbind-2013 and PDBbind-2016. Our results, for all these databases, are better than all existing machine learning models with traditional molecular descriptors, as far as we know.…”
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Finding transcription factor binding motifs for coregulated genes by combining sequence overrepresentation with cross-species conservation by Jia, Hui., Li, Jinming.

“…We applied the method to 35 S. cerevisiae transcriptional factors with known DNA binding motifs (with the support of orthologous sequences from genomes of S. mikatae, S. bayanus, and S. paradoxus), and the proposed method outperformed the single-genome-based motif finding methods MEME and AlignACE as well as the multiple-genome-based methods PHYME and Footprinter for the majority of these transcriptional factors. …”
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Analysis of the role played by ligand-induced folding of the cocaine-binding aptamer in the photochrome aptamer switch assay by Shoara, Aron A., Churcher, Zachary R., Steele, Terry W. J., Johnson, Philip E.

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Characterizing the conformational landscape of MDM2-binding p53 peptides using molecular dynamics simulations by Yadahalli, Shilpa, Li, Jianguo, Lane, David P., Gosavi, Shachi, Verma, Chandra Shekhar

“…The conformational landscapes of p53 peptide variants and phage derived peptide (12/1) variants, all known to bind to MDM2, are studied using hamiltonian replica exchange molecular dynamics simulations. …”
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Multiscale topological indices for the quantitative prediction of SARS CoV-2 binding affinity change upon mutations by Bi, Jialin, Wee, JunJie, Liu, Xiang, Qu, Cunquan, Wang, Guanghui, Xia, Kelin

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Regulation of mRNA abundance by polypyrimidine tract-binding protein-controlled alternate 5′ splice site choice by Hamid, Fursham M., Makeyev, Eugene V.

“…Here we report that polypyrimidine tract-binding protein 1 (Ptbp1/PTB/hnRNP-I) controls alternate 5′ and 3′ splice site (5′ss and 3′ss) usage in a large set of mammalian transcripts. …”
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The novel quinoline derivative SKA-346 as a KCa3.1 channel selective activator by Wong, Brandon Han Siang, Shim, Heesung, Goay, Stephanie Shee Min, Ong, Seow Theng, Nur Ayuni Binte Muhammad Taib, Chai, Kelila Xin Ye, Lim, Kerry, Huang, Dachuan, Ong, Choon Kiat, Vaiyapuri, Thamil Selvan, Cheah, Yeong Cheng, Wang, Yulan, Wulff, Heike, Webster, Richard David, Shelat, Vishalkumar G., Verma, Navin Kumar

“…In silico analysis using RosettaLigand and GLIDE demonstrated a well-converged pose of SKA-346 in a binding pocket at the interface between the calmodulin N-lobe and the S45A helix in the S4-S5 linker of the KCa3.1 channel. …”
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Binding of TCR multimers and a TCR-like antibody with distinct fine-specificities is dependent on the surface density of HLA complexes by Low, Jianrong L., Gehring, Adam J., Kranz, David M., Grotenbreg, Gijsbert M., Yau, Yin Hoe, Shochat, Susana Geifman, Bertoletti, Antonio, Naidoo, Anneta, Yeo, Gladys, Ho, Zi Zong

“…Collectively, the results highlight the promiscuity of our soluble TCR, which could be an advantageous feature when targeting cells infected with a mutation-prone virus, but that binding of the soluble oligomeric TCR relies considerably on the surface density of the presented antigen.…”
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