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141
Employment of a high throughput functional assay to define the critical factors that influence vaccine induced cross-variant neutralizing antibodies for SARS-CoV-2
Published 2024“…We also present an accurate quantitation of serological responses for SARS-CoV-2 that exploits a unique set of in-house, recombinant human monoclonal antibodies targeting the viral Spike and nucleocapsid proteins and demonstrate a reduction in neutralizing antibody titres across all groups 6 months post-vaccination. We also observe a marked reduction in the serological binding activity and neutralizing responses targeting recently newly emerged Omicron variants including XBB 1.5 and highlight a significant increase in cross-protective neutralizing antibody responses following a third dose (boost) of vaccine. …”
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Journal Article -
142
Hippocampal neurons code individual episodic memories in humans
Published 2023“…In particular, it is debated whether each hippocampal neuron represents an invariant element within an episode or whether single neurons bind together all the elements of a discrete episodic memory. …”
Journal article -
143
Characterisation of Topoisomerase 1-cleavage complex repair
Published 2024“…In human cancer cells, proteomics, sequencing, biochemistry techniques, and live imaging all demonstrate TOP1cc lysosomal uptake after induction of replication stress. …”
Thesis -
144
Trichostrongylus colubriformis extract upregulates TNF-α receptor expression and enhances TNF-α sensitivity of L929 cells
Published 2000“…Within 1 h of exposure, T. colubriformis factors bind L929 cells in a stable fashion, yet it takes up to 24 h for the cells to become sensitised to TNF-α. …”
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145
The dual GGDEF/EAL domain enzyme PA0285 is a Pseudomonas species housekeeping phosphodiesterase regulating early attachment and biofilm architecture
Published 2024“…It was reported that deletion of the EAL/GGDEF dual enzyme PA0285, one of five c-di-GMP-related enzymes conserved across all Pseudomonas species, impacts biofilms. PA0285 is anchored in the membrane and carries two PAS domains. …”
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Journal Article -
146
Structure and interaction of telomeric and telomerase RNA G-quadruplexes.
Published 2013“…G-rich oligonucleotides are able to form four-stranded nucleic acid structures called G-quadruplexes in cationic solution. These structures are composed of multiple tetrad planes, in which each tetrad plane consists of four guanines that are Hoogsteen base-paired to one another. …”
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Thesis -
147
Defect chemistry in 2D atomic layers for energy photocatalysis
Published 2023Get full text
Journal Article -
148
The structure of hadrons and other potential phases of QCD
Published 2024“…Quantum chromodynamics (QCD) is a mathematical theory describing subatomic particles called quarks and gluons, and the strong force that binds them together into protons and neutrons. …”
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Thesis