Synthesis, biological evaluation, and stability studies of raloxifene mono- and bis-sulfamates as dual-targeting agents by Zaraei, S-O, Dohle, W, Anbar, HS, El-Gamal, R, Leblond, B, Foster, PA, Al-Tel, TH, Potter, BVL, El-Gamal, MI

“…All three possible sulfamate derivatives of the selective estrogen receptor modulator Raloxifene (bis-sulfamate 7 and two mono-sulfamates 8–9) were synthesized and evaluated as inhibitors of the clinical drug target steroid sulfatase (STS), both in cell-free and in cell-based assays, and also as estrogen receptor (ER) modulators. …”

Optical properties of semi-conductive MXene Sc2COx, CsPbBr3 nanoplatelets and quantum dots by Chen, Qiran

“…For any given NPL with a certain thickness, there is a slight blue shift in the peak position of optical gain as the carrier density increases because of band filling effect. The maximum optical gain of thinner NPLs needs higher carrier density to reach saturation. …”
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Investigating cofactor transfer for a B₁₂-dependent enzyme by Duong, Alexander T.

“…MCM relies on two other proteins, a G-protein metallochaperone called methylmalonic aciduria type A protein (MMAA) and a protein called adenosyltransferase (ATR), to load and off-load cofactor. …”
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Exciton Dynamics and Anisotropy in 2D Metal Organochalcogenolate Semiconductors by Lee, Woo Seok

“…Third, we study alloying between AgEPh. we demonstrate that AgSePh and AgTePh form homogeneous alloys with tunable excitonic properties across all compositions, whereas AgSPh and AgSePh/AgTePh exhibit a miscibility gap. …”
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Kinetic modelling of 70S ribosome and F1-ATPase by Le, Quang Luan

“…It is the state just after ATP binding and before ADP release.…”
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Using machine learning to discover candidate localised transcripts from microscopy and genome-wide bioinformatics data by Kiourlappou, M

“…I then create a conglomerate of heterogeneous datasets, all related to mRNA localisation. I then transform the datasets into inter- operable and compatible, gene-centric datasets ready to be used by machine-learning algorithms.…”

Co-translational integration of the light harvesting complex II and its associated pigments into polymeric membranes by Zapf, Thomas

“…Fluorescence measurements of purified proteopolymersomes indicate successful binding of pigments to the proteins within this new environment. …”
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Part I : Peptide functionalized materials for gram-negative bacteria targeted PDT and LPS sensing. Part II : Small peptide and membrane lipid based self-assembled nanostructures fo... by Liu, Fang

“…Generally, Gram-negative bacterial pathogens have additional outer membranes mainly composed of highly conserved and unique lipopolysaccharide (LPS) molecules, which serve as permeability barriers to prevent the cell bodies from toxic antimicrobial molecules1-2 including many photosensitizers, which have been successfully used in photoinactivation of Gram-positive strains.3-4 Furthermore, LPS, a potent inducer to human innate immune systems, hence called endotoxin, is now primarily responsible for sepsis associated with the infections of Gram-negative pethogens.5-6 Therefore, the most promising strategy is use of LPS neutralizing peptide as the binding ligand to deliver antibacterial agents meanwhile minimize the side effects.7 The first objective of the research in part I is the design and synthesis of photosensitizer-peptide conjugates for multivalent targeted cellular imaging and photodynamic inactivation (PDI) against Gram-negative bacterial strains. …”
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Clinical course, immunogenicity, and efficacy of BNT162b2 mRNA vaccination against SARS-CoV-2 infection in liver transplant recipients by Tan, Eunice X., Lim, Wen Hui, Thong, Elizabeth, Chavatte, Jean-Marc, Zhang, Jinyan, Lim, Jonathan, Jin, Jocelyn Y., Lim, Daniel R. X., Kang, Jaclyn Y. T., Tang, Ansel Shao Pin, Chan, Kai En, Tan, Caitlyn, Tan, Shi Ni, Nah, Benjamin, Huang, Daniel Q., Wang, Lin-Fa, Tambyah, Paul A., Somani, Jyoti, Young, Barnaby Edward, Muthiah, Mark D.

“…We studied the factors associated with decreased antibody response to SARS-CoV-2 vaccination and risk factors for subsequent breakthrough infections in liver transplant (LT) patients undergoing coronavirus disease 2019 vaccination with at least 2 doses of messenger RNA vaccine from April 28, 2021, to April 28, 2022. Methods. All LT recipients received at least 2 doses of the BNT162b2 (Pfizer BioNTech) vaccine 21 d apart. …”
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Employment of a high throughput functional assay to define the critical factors that influence vaccine induced cross-variant neutralizing antibodies for SARS-CoV-2 by Gu, Yue, Shunmuganathan, Bhuvaneshwari, Qian, Xinlei, Gupta, Rashi, Tan, Rebecca S. W., Kozma, Mary, Purushotorman, Kiren, Murali, Tanusya M., Tan, Nikki Y. J., Preiser, Peter Rainer, Lescar, Julien, Nasir, Haziq, Somani, Jyoti, Tambyah, Paul A., Smith, Kenneth G. C., Renia, Laurent, Ng, Lisa F. P., Lye, David C., Young, Barnaby E., MacAry, Paul A.

“…We also present an accurate quantitation of serological responses for SARS-CoV-2 that exploits a unique set of in-house, recombinant human monoclonal antibodies targeting the viral Spike and nucleocapsid proteins and demonstrate a reduction in neutralizing antibody titres across all groups 6 months post-vaccination. We also observe a marked reduction in the serological binding activity and neutralizing responses targeting recently newly emerged Omicron variants including XBB 1.5 and highlight a significant increase in cross-protective neutralizing antibody responses following a third dose (boost) of vaccine. …”
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Hippocampal neurons code individual episodic memories in humans by Kolibius, LD, Roux, F, Parish, G, Ter Wal, M, Van Der Plas, M, Chelvarajah, R, Sawlani, V, Rollings, DT, Lang, JD, Gollwitzer, S, Walther, K, Hopfengärtner, R, Kreiselmeyer, G, Hamer, H, Staresina, BP, Wimber, M, Bowman, H, Hanslmayr, S

“…In particular, it is debated whether each hippocampal neuron represents an invariant element within an episode or whether single neurons bind together all the elements of a discrete episodic memory. …”

Characterisation of Topoisomerase 1-cleavage complex repair by Lascaux, P

“…In human cancer cells, proteomics, sequencing, biochemistry techniques, and live imaging all demonstrate TOP1cc lysosomal uptake after induction of replication stress. …”

Trichostrongylus colubriformis extract upregulates TNF-α receptor expression and enhances TNF-α sensitivity of L929 cells by Riffkin, M.C., Seow, H.-F., Wood, P.R., Brown, L.E.

“…Within 1 h of exposure, T. colubriformis factors bind L929 cells in a stable fashion, yet it takes up to 24 h for the cells to become sensitised to TNF-α. …”
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The dual GGDEF/EAL domain enzyme PA0285 is a Pseudomonas species housekeeping phosphodiesterase regulating early attachment and biofilm architecture by Eilers, Kira, Yam, Joey Kuok Hoong, Liu, Xianghui, Goh, Yu Fen, To, Ka-Ning, Paracuellos, Patricia, Morton, Richard, Brizuela, Jaime, Yong, Adeline Mei Hui, Givskov, Michael, Freibert, Sven-Andreas, Bange, Gert, Rice, Scott A., Steinchen, Wieland, Filloux, Alain

“…It was reported that deletion of the EAL/GGDEF dual enzyme PA0285, one of five c-di-GMP-related enzymes conserved across all Pseudomonas species, impacts biofilms. PA0285 is anchored in the membrane and carries two PAS domains. …”
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Structure and interaction of telomeric and telomerase RNA G-quadruplexes. by Martadinata, Herry.

“…G-rich oligonucleotides are able to form four-stranded nucleic acid structures called G-quadruplexes in cationic solution. These structures are composed of multiple tetrad planes, in which each tetrad plane consists of four guanines that are Hoogsteen base-paired to one another. …”
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Defect chemistry in 2D atomic layers for energy photocatalysis by Di, Jun, Hao, Gazi, Jiang, Wei, Liu, Zheng

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The structure of hadrons and other potential phases of QCD by Schindler, Stella T.

“…Quantum chromodynamics (QCD) is a mathematical theory describing subatomic particles called quarks and gluons, and the strong force that binds them together into protons and neutrons. …”
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