Alternative splicing in the DBD linker region of p63 modulates binding to DNA and iASPP in vitro by Lotz, R, Osterburg, C, Chaikuad, A, Weber, S, Akutsu, M, Machel, AC, Beyer, U, Gebel, J, Löhr, F, Knapp, S, Dobbelstein, M, Lu, X, Dötsch, V

“…Here we characterize the interaction of iASPP with p63 and show that it binds to the linker region between the DNA binding domain and the oligomerization domain. …”

Characterizing the conformational landscape of MDM2-binding p53 peptides using molecular dynamics simulations by Yadahalli, Shilpa, Li, Jianguo, Lane, David P., Gosavi, Shachi, Verma, Chandra Shekhar

“…The conformational landscapes of p53 peptide variants and phage derived peptide (12/1) variants, all known to bind to MDM2, are studied using hamiltonian replica exchange molecular dynamics simulations. …”
Get full text
Get full text

Multiscale topological indices for the quantitative prediction of SARS CoV-2 binding affinity change upon mutations by Bi, Jialin, Wee, JunJie, Liu, Xiang, Qu, Cunquan, Wang, Guanghui, Xia, Kelin

Get full text

Regulation of mRNA abundance by polypyrimidine tract-binding protein-controlled alternate 5′ splice site choice by Hamid, Fursham M., Makeyev, Eugene V.

“…Here we report that polypyrimidine tract-binding protein 1 (Ptbp1/PTB/hnRNP-I) controls alternate 5′ and 3′ splice site (5′ss and 3′ss) usage in a large set of mammalian transcripts. …”
Get full text
Get full text

Impact of molecular linker size on physicochemical properties of assembled gold nanoparticle mono-/multi-layers and their applicability for functional binding of biomolecules by Krikstolaityte, Vida, Hamit-Eminovski, Jildiz, Abariute, Laura, Niaura, Gediminas, Meskys, Rolandas, Arnebrant, Thomas, Lisak, Grzegorz, Ruzgas, Tautgirdas

Get full text

Linking dual mode of action of host defense antimicrobial peptide thanatin: structures, lipopolysaccharide and LptAm binding of designed analogs by Sinha, Sheetal, Dhanabal, Vidhya Bharathi, Sperandeo, Paola, Polissi, Alessandra, Bhattacharjya, Surajit

Get full text

Curvature sensing amphipathic helix in the C-terminus of RTNLB13 is conserved in all endoplasmic reticulum shaping reticulons in Arabidopsis thaliana by Brooks, Rhiannon L., Mistry, Chandni S., Dixon, Ann M.

“…The reticulon family of integral membrane proteins are conserved across all eukaryotes and typically localize to the endoplasmic reticulum (ER), where they are involved in generating highly-curved tubules. …”
Get full text

A conserved arginine in NS5 binds genomic 3' stem-loop RNA for primer-independent initiation of flavivirus RNA replication by Wang, Sai, Chan, Kitti Wing Ki, Tan, Min Jie Alvin, Flory, Charlotte, Luo, Dahai, Lescar, Julian, Forwood, Jade K., Vasudevan, Subhash G.

“…We show that DENV2 NS5 arginine 888, located within the carboxy-terminal 18 residues, is completely conserved in all flaviviruses and interacts specifically with the top-loop of 3'SL in the 3'UTR which contains the pentanucleotide 5'-CACAG-3' previously shown to be critical for flavivirus RNA replication. …”
Get full text

The binding interface of kindlin-2 and ILK involves Asp344/Asp352/Thr356 in kindlin-2 and Arg243/Arg334 in ILK by Tan, Hui-Foon, Guan, Si-Yu, Chng, Choon-Peng, Ong, Li-Teng, Tan, Suet-Mien, Law, Alex Sai Kit

Get full text
Get full text

Sequence- and structure-specific probing of RNAs by short nucleobase-modified dsRNA-binding PNAs incorporating a fluorescent light-up uracil analog by Krishna, Manchugondanahalli Shivakumar, Toh, Desiree-Faye Kaixin, Meng, Zhenyu, Ong, Alan Ann Lerk, Wang, Zhenzhang, Lu, Yunpeng, Xia, Kelin, Prabakaran, Mookkan, Chen, Gang

Get full text

Bond order resolved 3d 5/2 and valence band chemical shifts of Ag surfaces and nanoclusters by Sun, Changqing, Qin, Wei, Wang, Yan, Huang, Yongli, Zhou, Zhaofeng, Yang, Chao

“…Incorporating the tight-binding theory and the bond order–length–strength (BOLS) correlation into the X-ray photoelectron spectra of Ag(111) and (100) surfaces and the Auger electron spectra of Ag nanoparticles deposited on Al2O3 and CeO2 substrates has led to quantitative information of the 3d5/2 and the valence binding energies of an isolated Ag atom and their shifts upon bulk, defect, surface, and nanocrystal formation. …”
Get full text
Get full text

Membrane reconstitution of monoamine oxidase enzymes on supported lipid bilayers by Wang, Liulin, Kabir H. Biswas, Yoon, Bo Kyeong, Kawakami, Lisa M., Park, Soohyun, Groves, Jay T., Li, Lin, Huang, Wei, Cho, Nam-Joon

Get full text

Unconventional split aptamers cleaved at functionally essential sites preserve biorecognition capability by Wang, Ruoyu, Zhang, Qiansen, Zhang, Yi, Shi, Hanchang, Nguyen, Kim Truc, Zhou, Xiaohong

“…An allosteric binding mechanism of BPSPAs, in which a new binding pocket is formed upon the target binding, is revealed by all-atom microsecond-scale molecular dynamics simulations. …”
Get full text

Part I Targeting RNA duplexes with modified triplex-forming oligonucleotides Part II Allostery within a Watson-Crick RNA duplex and its application in studying RNA recognition by R... by Zhou, Yuan

“…Here, we incorporated Locked Nucleic Acid (LNA), 2-thio U, and 2′-O methyl modified residues in a series of all pyrimidine RNA TFOs, and studied the binding to two RNA hairpin structures. 12-Base-triple major-groove pyrimidine•purine-pyrimidine triplex structures form between the RNA/DNA hairpins and the complementary RNA TFOs. …”
Get full text

Membrane cholesterol modulates oligomeric status and peptide-membrane interaction of severe acute respiratory syndrome coronavirus fusion peptide by Meher, Geetanjali, Bhattacharjya, Surajit, Chakraborty, Hirak

Get full text

CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil by Almqvist, Helena, Axelsson, Hanna, Jafari, Rozbeh, Dan, Chen, Mateus, André, Haraldsson, Martin, Larsson, Andreas, Molina, Daniel Martinez, Artursson, Per, Lundbäck, Thomas, Nordlund, Pär

“…Assessment of compound binding to native target proteins in live cells is therefore highly desirable in all stages of drug discovery. …”
Get full text
Get full text

Resonance modes of tall plasmonic nanostructures and their applications for biosensing by Soehartono, Alana M., Tobing, Landobasa Y. M., Mueller, Aaron D., Yong, Ken-Tye, Zhang, Dao Hua

Get full text

Macrobrachium rosenbergii De Man nodavirus recombinant capsid protein production and its interactions with RNA by Goh, Zee Hong

“…Studies on the other members of the Nodaviridae family revealed that the RNA binding site is important for virus assembly and removal of this region inhibits the virus maturation. …”
Get full text

Synthesis and application of peptidoglycan oligomers as metabolic labeling agents for bacteria by He, Jingxi

“…Using super-resolution STED confocal microscopy, PGO-rhodamine were found to be localized into the cell walls of all bacterial strains tested. Furthermore, the PGO-rhodamine was not taken up or incorporated into mammalian cells at all, thus confirming that PGOs can be a powerful tool for pan-bacteria-specific labeling and imaging. …”
Get full text

In silico screening of sugar alcohol compounds to inhibit viral matrix protein VP40 of Ebola virus by Nagarajan, Nagasundaram, Yapp, Edward Kien Yee, Le, Nguyen Quoc Khanh, Yeh, Hui-Yuan

Get full text