Distinctive antibody responses to Mycobacterium tuberculosis in pulmonary and brain infection by Spatola, M, Nziza, N, Irvine, EB, Cizmeci, D, Jung, W, Van, LH, Nhat, LTH, Ha, VTN, Phu, NH, Nghia, HDT, Thwaites, GE, Lauffenburger, DA, Fortune, S, Thuong, NTT, Alter, G

“…<br> In individuals with TBM, we identified CSF-specific antibody profiles that marked a unique and compartmentalized humoral response against <i>M. tuberculosis</i>, characterized by an enrichment of <i>M. tuberculosis</i>-specific antibodies able to robustly activate complement and drive phagocytosis by monocytes and neutrophils, all of which were associated with milder TBM severity at presentation. …”

Large-scale profiling of antibody reactivity to glycolipids in patients with Guillain-Barré syndrome by Thomma, RCM, Halstead, SK, de Koning, LC, Fehmi, J, Rinaldi, S, IGOS consortium

“…Antibody specificities and reactivity patterns were analysed in relation to clinical features.<br> Of all patients, 1309 (92.6%) were positive for at least one anti-glycolipid (complex) antibody. …”

Overexpression of 4EBP1, p70S6K, Akt1 or Akt2 differentially promotes Coxsackievirus B3-induced apoptosis in HeLa cells by Xing, X., Huang, L., Li, X., Li, Z., Zhou, W., Tian, L., Chen, J., Chen, C., Ma, Xing, Yang, Z.

“…To further illustrate it, Homo sapiens eIF4E-binding protein 1 (4EBP1), p70S6 kinase (p70S6K), Akt1 and Akt2 were transfected to HeLa cells, respectively. …”
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Changes in gene expression in human skeletal stem cells transduced with constitutively active Gsα correlates with hallmark histopathological changes seen in fibrous dysplastic bone... by Raimondo, Domenico, Remoli, Cristina, Astrologo, Letizia, Burla, Romina, La Torre, Mattia, Vernì, Fiammetta, Tagliafico, Enrico, Corsi, Alessandro, Del Giudice, Simona, Persichetti, Agnese, Giannicola, Giuseppe, Robey, Pamela G., Riminucci, Mara, Saggio, Isabella

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Unveiling the chirality of the quantum anomalous Hall effect by Chen, Hongyu, Jin, Yuanjun, Mohammad Yahyavi, Belopolski, Ilya, Shao, Sen, Hou, Tao, Wang, Naizhou, Hsu, Chia-Hsiu, Zhao, Yilin, Yang, Bo, Ma, Qiong, Yin, Jia-Xin, Xu, Su-Yang, Gao, Weibo, Chang, Guoqing

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PESI: paratope-epitope set interaction for SARS-CoV-2 neutralization prediction by Wan, Zhang, Lin, Zhuoyi, Rashid, Shamima, Ng, Shaun Yue Hao, Yin, Rui, Senthilnath, J., Kwoh, Chee Keong

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Negative auto-regulation of myostatin expression is mediated by SMAD3 and microRNA-27 by Ge, XiaoJia, McFarlane, Craig, Vajjala, Anuradha, Arigela, Harikumar, Lokireddy, Sudarsanareddy, Bonala, Sabeera, Manickam, Ravikumar, Kambadur, Ravi, Sharma, Mridula

“…Consistent with this, miR-27a over expression resulted in reduced Mstn expression, skeletal muscle hypertrophy and an increase in the number of activated satellite cells, all features consistent with impaired Mstn function. …”
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Identification of RNA-Tis11b complexes in activated B cells. by Tang, Ngang Heok.

“…A type of RBPs, called 12-O-tetradecanoylphorbol-13-acetate (TPA) inducible sequence (TIS11) family members (Tis11, Tis11b and Tis11d), can bind to AU-rich elements (AREs) in 3’-untranslated region (3’ UTR) of mRNAs. …”
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Investigating viral glycosylation pathways for drug and vaccine development by Brun, J

“…Compounds of a global anti-COVID-19 effort called the “Moonshot project” targeting the main protease of SARS-CoV-2 were also screened and promising compounds were progressed further to produce a specific direct-acting SARS-CoV-2 antiviral compound. …”

Targeted hematopoietic stem cell depletion through SCF-blockade by Chan, Yan Y., Ho, Pui Y., Dib, Carla, Swartzrock, Leah, Rayburn, Maire, Willner, Hana, Ko, Ethan, Ho, Katie, Down, Julian D., Wilkinson, Adam C., Nakauchi, Hiro, Denis, Morgane, Cool, Taylor, Czechowicz, Agnieszka

“…Results We confirm that only ACK2 inhibits SCF binding fully and prevents HSC proliferation in vitro. …”
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YAP-DKK1 axis restricts regeneration to the isthmus of the human gastric glands by Zagami, C

“…</p> <p>The human stomach is organised into epithelial invaginations called gastric glands. While tissue damage can trigger regeneration at the gland base, in healthy conditions, stem cell activity is restricted to an anatomical niche called the isthmus. …”

Synthesis, biological evaluation, and stability studies of raloxifene mono- and bis-sulfamates as dual-targeting agents by Zaraei, S-O, Dohle, W, Anbar, HS, El-Gamal, R, Leblond, B, Foster, PA, Al-Tel, TH, Potter, BVL, El-Gamal, MI

“…All three possible sulfamate derivatives of the selective estrogen receptor modulator Raloxifene (bis-sulfamate 7 and two mono-sulfamates 8–9) were synthesized and evaluated as inhibitors of the clinical drug target steroid sulfatase (STS), both in cell-free and in cell-based assays, and also as estrogen receptor (ER) modulators. …”

Investigating cofactor transfer for a B₁₂-dependent enzyme by Duong, Alexander T.

“…MCM relies on two other proteins, a G-protein metallochaperone called methylmalonic aciduria type A protein (MMAA) and a protein called adenosyltransferase (ATR), to load and off-load cofactor. …”
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Exciton Dynamics and Anisotropy in 2D Metal Organochalcogenolate Semiconductors by Lee, Woo Seok

“…Third, we study alloying between AgEPh. we demonstrate that AgSePh and AgTePh form homogeneous alloys with tunable excitonic properties across all compositions, whereas AgSPh and AgSePh/AgTePh exhibit a miscibility gap. …”
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Kinetic modelling of 70S ribosome and F1-ATPase by Le, Quang Luan

“…It is the state just after ATP binding and before ADP release.…”
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Using machine learning to discover candidate localised transcripts from microscopy and genome-wide bioinformatics data by Kiourlappou, M

“…I then create a conglomerate of heterogeneous datasets, all related to mRNA localisation. I then transform the datasets into inter- operable and compatible, gene-centric datasets ready to be used by machine-learning algorithms.…”

Co-translational integration of the light harvesting complex II and its associated pigments into polymeric membranes by Zapf, Thomas

“…Fluorescence measurements of purified proteopolymersomes indicate successful binding of pigments to the proteins within this new environment. …”
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Part I : Peptide functionalized materials for gram-negative bacteria targeted PDT and LPS sensing. Part II : Small peptide and membrane lipid based self-assembled nanostructures fo... by Liu, Fang

“…Generally, Gram-negative bacterial pathogens have additional outer membranes mainly composed of highly conserved and unique lipopolysaccharide (LPS) molecules, which serve as permeability barriers to prevent the cell bodies from toxic antimicrobial molecules1-2 including many photosensitizers, which have been successfully used in photoinactivation of Gram-positive strains.3-4 Furthermore, LPS, a potent inducer to human innate immune systems, hence called endotoxin, is now primarily responsible for sepsis associated with the infections of Gram-negative pethogens.5-6 Therefore, the most promising strategy is use of LPS neutralizing peptide as the binding ligand to deliver antibacterial agents meanwhile minimize the side effects.7 The first objective of the research in part I is the design and synthesis of photosensitizer-peptide conjugates for multivalent targeted cellular imaging and photodynamic inactivation (PDI) against Gram-negative bacterial strains. …”
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Clinical course, immunogenicity, and efficacy of BNT162b2 mRNA vaccination against SARS-CoV-2 infection in liver transplant recipients by Tan, Eunice X., Lim, Wen Hui, Thong, Elizabeth, Chavatte, Jean-Marc, Zhang, Jinyan, Lim, Jonathan, Jin, Jocelyn Y., Lim, Daniel R. X., Kang, Jaclyn Y. T., Tang, Ansel Shao Pin, Chan, Kai En, Tan, Caitlyn, Tan, Shi Ni, Nah, Benjamin, Huang, Daniel Q., Wang, Lin-Fa, Tambyah, Paul A., Somani, Jyoti, Young, Barnaby Edward, Muthiah, Mark D.

“…We studied the factors associated with decreased antibody response to SARS-CoV-2 vaccination and risk factors for subsequent breakthrough infections in liver transplant (LT) patients undergoing coronavirus disease 2019 vaccination with at least 2 doses of messenger RNA vaccine from April 28, 2021, to April 28, 2022. Methods. All LT recipients received at least 2 doses of the BNT162b2 (Pfizer BioNTech) vaccine 21 d apart. …”
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Employment of a high throughput functional assay to define the critical factors that influence vaccine induced cross-variant neutralizing antibodies for SARS-CoV-2 by Gu, Yue, Shunmuganathan, Bhuvaneshwari, Qian, Xinlei, Gupta, Rashi, Tan, Rebecca S. W., Kozma, Mary, Purushotorman, Kiren, Murali, Tanusya M., Tan, Nikki Y. J., Preiser, Peter Rainer, Lescar, Julien, Nasir, Haziq, Somani, Jyoti, Tambyah, Paul A., Smith, Kenneth G. C., Renia, Laurent, Ng, Lisa F. P., Lye, David C., Young, Barnaby E., MacAry, Paul A.

“…We also present an accurate quantitation of serological responses for SARS-CoV-2 that exploits a unique set of in-house, recombinant human monoclonal antibodies targeting the viral Spike and nucleocapsid proteins and demonstrate a reduction in neutralizing antibody titres across all groups 6 months post-vaccination. We also observe a marked reduction in the serological binding activity and neutralizing responses targeting recently newly emerged Omicron variants including XBB 1.5 and highlight a significant increase in cross-protective neutralizing antibody responses following a third dose (boost) of vaccine. …”
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