The LBP gene and its association with resistance to Aeromonas hydrophila in Tilapia by Xia, Jun Hong, Fu, Gui Hong, Liu, Feng, Yue, Gen Hua

“…In immune-related genes, the lipopolysaccharide-binding protein (LBP) gene is an important mediator of the inflammatory reaction. …”
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Digital keywords for China: perceptions and portrayals in English-language novels by Matthews, Graham, Cheung, Cally Hiu Tung

“…To date, we have collected 12,186 passages that include the words china or chinese with full metadata (author, title, country of origin, year of publication) for the years 1900–2017. …”
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Structural and biochemical mechanisms of NLRP1 inhibition by DPP9 by Huang, Menghang, Zhang, Xiaoxiao, Toh, Gee Ann, Gong, Qin, Wang, Jia, Han, Zhifu, Wu, Bin, Zhong, Franklin, Chai, Jijie

“…Nucleotide-binding domain, leucine-rich repeat receptors (NLRs) mediate innate immunity by forming inflammasomes. …”
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Structural studies of PfEMP1 bound to human cluster of differentiation 36 and of an unusual human antibody by Hsieh, F

“…<p>In <em>Plasmodium falciparum</em>-infected humans, parasites escape from splenic clearance and cause severe or chronic symptoms partly through the action of the variable surface antigens expressed on the surfaces of infected erythrocytes, called <em>P. falciparum</em> erythrocyte membrane protein 1 (<em>Pf</em>EMP1). …”

Narrowing the gap between machine learning scoring functions and free energy perturbation using augmented data by Valsson, Í, Warren, MT, Deane, CM, Magarkar, A, Morris, GM, Biggin, PC

“…Machine learning offers great promise for fast and accurate binding affinity predictions. However, current models lack robust evaluation and fail on tasks encountered in (hit-to-) lead optimisation, such as ranking the binding affinity of a congeneric series of ligands, thereby limiting their application in drug discovery. …”

Investigation of Synthetic Proteins Produced via Automated Fast-Flow Peptide Synthesis by Cowfer, Amanda Elizabeth

“…I will discuss the iterative steps my team took to vary both chemical and mechanical and control variables to improve per-coupling yield enough to enable access to full-length single-domain proteins. On this journey, we utilized test peptides to validate synthesis quality and later synthesized a suite of full-length single-domain biologically active proteins. …”
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Hodge theory and its applications to molecular data analysis by Koh, Ronald Joon Wei

“…Nevertheless, there are currently many methods to call TADs, all of which are not based on a rigorous topological mathematical model. …”
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High-resolution HDX-MS reveals distinct mechanisms of RNA recognition and activation by RIG-I and MDA5 by Liu, Chuan-Fa, Zheng, Jie, Yong, Hui Yee, Panutdaporn, Nantika, Tang, Kai, Luo, Dahai

“…RIG-I and MDA5 are the major intracellular immune receptors that recognize viral RNA species and undergo a series of conformational transitions leading to the activation of the interferon-mediated antiviral response. However, to date, full-length RLRs have resisted crystallographic efforts and a molecular description of their activation pathways remains hypothetical. …”
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Conformational landscape of the epidermal growth factor receptor kinase reveals a mutant specific allosteric pocket by Kannan, Srinivasaraghavan, Venkatachalam, Gireedhar, Lim, Hong Hwa, Surana, Uttam, Verma, Chandra

“…[Nature, 2016, 534, 129–132] reported a small molecule inhibitor (called EAI045) that binds at an allosteric pocket, does not compete with ATP and displays high potency and selectivity towards certain activating mutants (L858R, T790M, L858R/T790M) of EGFR, with IC50 values ranging from 3 nM to 49 nM. …”
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Amplifying signals in the tumor microenvironment for drug development and diagnostics by Martin Alonso, Maria Carmen

“…At the same time, improving the sensitivity of ctDNA-based tests, that remains limited by the scarcity of ctDNA in blood, holds the key to unlock the full potential of liquid biopsy across many important clinical applications. …”
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Structural and mechanistic insights into the Rel protein of Mycobacterium tuberculosis by Singal, Bharti

“…The NMR spectroscopy titration experiments with branched chain amino acids revealed the specific binding of valine to the MtRel ACT and showed structural rearrangement upon valine binding. …”
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Targeting NAPE-PLD: assessing its potential in the fight against malaria by Goh, Xiu Ling

“…Malaria remains a major global challenge with increasing artemisinin-resistant Plasmodium falciparum. This calls for an increased need for discovering novel ring-stage drug targets. …”
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Synthesis of Au@Pd core/shell nanomaterials for high-performance ethanol oxidation reactions by Xu, Weichang

“…During CV scans, the onset potential and peak current density of backward peak reveals the binding affinity of –OH group and the catalytic activity, respectively. …”
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PESI: paratope-epitope set interaction for SARS-CoV-2 neutralization prediction by Wan, Zhang, Lin, Zhuoyi, Rashid, Shamima, Ng, Shaun Yue Hao, Yin, Rui, Senthilnath, J., Kwoh, Chee Keong

“…Traditional methods rely on features based on first principles derived from the binding interface. However, they are burdened by arduous data preprocessing from a limited quantity of protein structures. …”
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Targeted hematopoietic stem cell depletion through SCF-blockade by Chan, Yan Y., Ho, Pui Y., Dib, Carla, Swartzrock, Leah, Rayburn, Maire, Willner, Hana, Ko, Ethan, Ho, Katie, Down, Julian D., Wilkinson, Adam C., Nakauchi, Hiro, Denis, Morgane, Cool, Taylor, Czechowicz, Agnieszka

“…Results We confirm that only ACK2 inhibits SCF binding fully and prevents HSC proliferation in vitro. …”
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Purification of miraculin from miracle fruit [Synsepalum dulcifium (Schumach. & Thonn.) Daniell] by He, Zuxing

“…The effect of optimizing crude extract was more important than optimizing the binding buffer. In elution stage, the effect of imidazole was more important than acetic acid. …”
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High-density lipoprotein function is modulated by the SARS-CoV-2 spike protein in a lipid-type dependent manner by Correa, Yubexi, Del Giudice, Rita, Waldie, Sarah, Thépaut, Michel, Micciula, Samantha, Gerelli, Yuri, Moulin, Martine, Delaunay, Clara, Fieschi, Franck, Pichler, Harald, Haertlein, Michael, Forsyth, V. Trevor, Le Brun, Anton, Moir, Michael, Russell, Robert A., Darwish, Tamim, Brinck, Jonas, Wodaje, Tigist, Jansen, Martin, Martín, César, Roosen-Runge, Felix, Cárdenas, Marité

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Structure and protein recognition of G-quadruplexes by Ngo, Khac Huy

“…G-rich oligonucleotides can adopt non-canonical secondary structures called G-quadruplexes (G4s) which are biologically relevant and found in applications and nanotechnology. …”
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The Mark of Cain: The crime of terrorism in times of armed conflict as interpreted by the Court of Appeal of England and Wales in R v. Mohammed Gul by Coco, A

“…On 22 February 2012, the Court of Appeal of England and Wales was called on to interpret the definition of the crime of terrorism as contained in relevant United Kingdom (UK) legislation. …”

Investigating viral glycosylation pathways for drug and vaccine development by Brun, J

“…Compounds of a global anti-COVID-19 effort called the “Moonshot project” targeting the main protease of SARS-CoV-2 were also screened and promising compounds were progressed further to produce a specific direct-acting SARS-CoV-2 antiviral compound. …”