Depletion of lamins B1 and B2 promotes chromatin mobility and induces differential gene expression by a mesoscale-motion-dependent mechanism by Pujadas Liwag, Emily M., Wei, Xiaolong, Acosta, Nicolas, Carter, Lucas M., Yang, Jiekun, Almassalha, Luay M., Jain, Surbhi, Daneshkhah, Ali, Rao, Suhas S. P., Seker-Polat, Fidan, MacQuarrie, Kyle L., Ibarra, Joe, Agrawal, Vasundhara, Aiden, Erez Lieberman, Kanemaki, Masato T., Backman, Vadim, Adli, Mazhar

“…Conclusions Our findings suggest that, while B-type lamin degradation does not significantly change genome topology, it has major implications for three-dimensional chromatin conformation at the single-cell level both at the lamina-associated periphery and the non-LAD-associated nuclear interior with concomitant genome-wide transcriptional changes. …”
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p27 is regulated independently of Skp2 in the absence of Cdk2 by Kaldis, Philipp, Kotoshiba, Shuhei, Gopinathan, Lakshmi, Pfeiffenberger, Elisabeth, Rahim, Anisa, Vardy, Leah Karen Anne, Nakayama, Keiko, Nakayama, Keiichi I.

“…Cyclin-dependent kinase 2 (Cdk2) is dispensable for mitotic cell cycle progression and Cdk2 knockout mice are viable due to the compensatory functions of other Cdks. …”
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Engineered terahertz emission from spintronic heterostructures: amplitude, phase and chirality by Agarwal, Piyush

“…This thesis aims to identify and answer a few of them by unveiling efficient spin manipulation methods. The main findings of the thesis are divided into two parts. …”
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Green logistics practices in Malaysian food-based manufacturing industry by Hussin, Hilda

“…From the analysis, it was found that majority of the Malaysian food-based manufacturers green logistics practices fall into light green colour band for each one of three logistics activities. …”
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In-vitro validation of potential modulators of non-alcoholic fatty liver disease (NAFLD) by Tang, Daryl Woon Tat

“…On the other hand, the downregulation of Target01 had no significant effect on cell proliferation and migration. These findings suggest that Target02 may offer a therapeutic pathway to improve liver regeneration in NAFLD, though further assays are necessary to confirm its potential.…”
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Functional roles of transforming growth factor activated Kinase-1 (TAK1) in skin wound healing by Tan, Siew Hwey

“…This TAK1 regulation of the dual PDGF/HGF paracrine signaling system can regulate keratinocyte cell proliferation and is required for proper wound healing. …”
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Cooperative spectrum sensing in a medium-traffic primary network using double-threshold scheme over imperfect reporting channels by Rabiee, Ramtin, Li, Kwok Hung

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An empirical bioethical examination of Norwegian and British doctors' views of responsibility and (de)prioritization in healthcare by Everett, JAC, Maslen, H, Nussberger, A-M, Bringedal, B, Wilkinson, D, Savulescu, J

“…A large proportion of doctors in both countries supported including responsibility for illness in prioritization decisions. This finding was more prominent in zero-sum scenarios where allocation to one patient means that another patient is denied treatment. …”

Minimum number of inertial measurement units needed to identify signiicant variations in walk patterns of overweight individuals walking on irregular surfaces by Sikandar, Tasriva, Rabbi, Mohammad Fazle, Kamarul Hawari, Ghazali, Altwijri, Omar, Almijalli, Mohammed, Ahamed, Nizam Uddin

“…Our results revealed two combinations of body locations, including the thigh and shank (i.e., the left and right shank, and the right thigh and right shank), from which IMU data should be collected to accurately classify walking patterns over real-world irregular surfaces (with classification accuracies of 97.24 and 95.87%, respectively). Our findings suggest that the identified numbers and locations of IMUs could potentially reduce the amount of data recorded and processed to develop a fall prevention system for overweight individuals.…”
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Postural stability in cyclists by Preece, Mia, Grainger, Karl, Starrs, Paul

“…Conclusion: MTB balance was worse than RC balance, but both cycling groups were found to have better balance scores than the control. These findings have implications for public health, as cycling, an inexpensive and accessible activity already known to offer substantial health benefits, could additionally help maintain postural stability and potentially reduce risk of falls in later life.…”
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Quality space computations for consciousness by Fleming, SM, Shea, N

Chromatin laser imaging reveals abnormal nuclear changes for early cancer detection by Chen, Yu-Cheng, Chen, Qiushu, Tan, Xiaotain, Chen, Grace, Bergin, Ingrid, Muhammad Nadeem Aslam, Fan, Xudong

“…We developed and applied rapid scanning laser-emission microscopy (LEM) to detect abnormal changes in cell nuclei for early diagnosis of cancer and cancer precursors. …”
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Role of angiopoietin-like 4 in tumor growth. by Zhu, Pengcheng.

“…Cancer is a leading cause of death worldwide. Tumor cells exploit various signaling molecules to promote their growth and metastasis. …”
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Bacterial Biofilm Control by Perturbation of Bacterial Signaling Processes by Jakobsen, Tim Holm, Tolker-Nielsen, Tim, Givskov, Michael

“…In particular, bacterial cell to cell signaling called “Quorum Sensing” together with intracellular signaling by bis-(3′-5′)-cyclic-dimeric guanosine monophosphate (cyclic-di-GMP) have gained a lot of attention over the last two decades. …”
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SARS-CoV-2 human challenge reveals biomarkers that discriminate early and late phases of respiratory viral infections by Rosenheim, J, Gupta, RK, Thakker, C, Mann, T, Bell, LCK, Broderick, CM, Madon, K, Papargyris, L, Dayananda, P, Kwok, AJ, Greenan-Barrett, J, Wagstaffe, HR, Conibear, E, Fenn, J, Hakki, S, Lindeboom, RGH, Dratva, LM, Lemetais, B, Weight, CM, Venturini, C, Kaforou, M, Levin, M, Kalinova, M, Mann, AJ, Knight, JC

“…Another ISG, IFI27, shows a delayed but sustained response restricted to myeloid cells, attributable to gene and cell-specific epigenetic regulation. …”

Security enhancements to prevent DNS cache poisoning attacks by Chong, Soon Seng

“…One of it is DNS Cache Poisoning where attackers forcefully gain access to the names server and change the cache record, diverting users to malicious websites meant to steal confidential information for financial gain or ill-intent. DNSSEC has been introduced as a solution to DNS Cache Poisoning but has not been very popular with the internet community. …”
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READY PLAYER ONE / by Cline, Ernest, author 655943

“…And then Wade stumbles onto the key to the first puzzle. Suddenly, he finds himself pitted against thousands of competitors in a desperate race to claim the ultimate prize, a chase that soon takes on terrifying real-world dimensions - and that will leave both Wade and his world profoundly changed.…”

Design of a 100W PV based power supply for lead acid battery charging with MPPT circuit by Erping

“…Modelling of each component namely the Photovoltaic cell, DC-DC Converter, MPPT Circuit and Battery Charging circuit are being done all through the PSIM software and are simulated to provide the results of the findings given the variables involved. …”
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Differential growth and shape formation in plant organs by Huang, Changjin, Wang, Zilu, Quinn, David, Suresh, Subra, Hsia, K. Jimmy

“…Much effort has been devoted to identifying the role of genetic and biomolecular pathways in regulating cell division and cell expansion and in influencing shape formation in plant organs. …”
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PRMT5 controls the innate immune response by Zhang, C

“…Although additional experiments are required to precisely identify the dsRNA-producing intronic regions, our results support the role of the PRMT5-E2F1 axis in modulating immune responses through the regulation of RNA splicing. The findings suggest that inhibiting PRMT5 may enhance the IFN response in cancer cells, potentially improving the efficacy of existing immunotherapies.…”