Preclinical development of antisense conjugates for the treatment of myotonic dystrophy 1 by Stoodley, J

“…It was concluded that this was likely due to the specific chemical properties of the compound rather than inherent limitations of anti-TfR1 antibodies, suggesting that further optimization of the conjugate’s chemical characteristics is necessary to improve therapeutic efficacy. …”

Introduction - Oxford Energy Forum – Issue, 98

“…Structural issues are likely to prevent any reversal of these trends in the years to come, unless radical reforms are enacted, as in the case of Mexico.…”

Dietary pattern trajectories in early childhood and their associations with patterns of maternal feeding practices in a multi-ethnic Asian cohort by Appannah, Geeta, Toh, Jia Ying, Lai, Jun Shi, Yong, Heng Yaw, Shariff, Zalilah Mohd, Tint, Mya Thway, Yuan, Wen Lun, Pang, Wei Wei, Godfrey, Keith M., Tan, Kok Hian, Yap, Fabian, Lee, Yung Seng, Eriksson, Johan G., Chong, Mary F. F.

“…Children whose mothers showed high adherence to the structured with autonomy support feeding practices at age 5 years were significantly more likely to be associated with the higher but decreasing ‘healthy’ DP trajectory group [OR = 3.62 (95% CI: 1.64, 7.99)]. …”
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Effective type label-based synergistic representation learning for biomedical event trigger detection by Hao, Anran, Yuan, Haohan, Hui, Siu Cheung, Su, Jian

“…Most state-of-the-art models rely mainly on external resources such as linguistic tools and knowledge bases to improve system performance. …”
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Using brain structural neuroimaging measures to predict psychosis onset for individuals at clinical high-risk by Zhu, Yinghan, Maikusa, Norihide, Radua, Joaquim, Sämann, Philipp G., Fusar-Poli, Paolo, Agartz, Ingrid, Andreassen, Ole A., Bachman, Peter, Baeza, Inmaculada, Chen, Xiaogang, Choi, Sunah, Corcoran, Cheryl M., Ebdrup, Bjørn H., Fortea, Adriana, Garani, Ranjini Rg, Glenthøj, Birte Yding, Glenthøj, Louise Birkedal, Haas, Shalaila S., Hamilton, Holly K., Hayes, Rebecca A., He, Ying, Heekeren, Karsten, Kasai, Kiyoto, Katagiri, Naoyuki, Kim, Minah, Kristensen, Tina D., Kwon, Jun Soo, Lawrie, Stephen M., Lebedeva, Irina, Lee, Jimmy, Loewy, Rachel L., Mathalon, Daniel H., McGuire, Philip, Mizrahi, Romina, Mizuno, Masafumi, Møller, Paul, Nemoto, Takahiro, Nordholm, Dorte, Omelchenko, Maria A., Raghava, Jayachandra M., Røssberg, Jan I., Rössler, Wulf, Salisbury, Dean F., Sasabayashi, Daiki, Smigielski, Lukasz, Sugranyes, Gisela, Takahashi, Tsutomu, Tamnes, Christian K., Tang, Jinsong, Theodoridou, Anastasia, Tomyshev, Alexander S., Uhlhaas, Peter J., Værnes, Tor G., van Amelsvoort, Therese A. M. J., Waltz, James A., Westlye, Lars T., Zhou, Juan H., Thompson, Paul M., Hernaus, Dennis, Jalbrzikowski, Maria, Koike, Shinsuke

“…CHR-PS- and CHR-UNK individuals were more likely to be classified as HC compared to CHR-PS+ (classification rate to HC: CHR-PS+, 30%; CHR-PS-, 73%; CHR-UNK, 80%). …”
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Community noise measure via crowd sourcing by Lim, Yun Jie

“…The study shows that the noise on campus is mainly due to human and mechanical noise. By mashing the noise data with Wi-Fi log data, the results show a good positive correlation between noise level and human density in an area. …”
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Reliability analysis and data driven modelling of railway component failure by Wang, Jinlong

“…The novelty of this research mainly including: designing customized raw data processing, developing robust modelling framework, and providing implementable knowledge feedback for maintenance application. …”
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Water treatment using one-dimensional manganese oxide based materials by Zhang, Tong

“…To overcome the engineering issue, various separation techniques such as free settling, centrifugation, magnetic separation and membrane filtration, have been proposed over the years. This research topic mainly focused on the synthesis and environmental application of 1D nanostructured manganese oxide based materials in the easily separable forms including MnO2 nanowires, magnetic manganese oxide nanocomposites, micro-/nano-structured MnO2 spheres, and manganese oxide nanofibrous membrane. …”
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Development of (TAML) iron complexes for photocatalytic, oxidative water treatment by Lim, Jia Hui

“…The current energy demand is met mainly by the combustion fossil fuels. This unsustainable energy source brings about negative environmental effects. …”
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Early adulthood BMI and cardiovascular disease: a prospective cohort study from the China Kadoorie Biobank by Chen, Y, Yu, W, Lv, J, Sun, D, Pei, P, Du, H, Yang, L, Chen, Y, Zhang, H, Chen, J, Chen, Z, Li, L, Yu, C

“…The primary outcome was the incidence of cardiovascular diseases as a group, ischaemic heart disease, haemorrhagic stroke, and ischaemic stroke, which were obtained mainly through linkage to disease registries and the national database for health insurance claims. …”

Targeting TFEB and TFE3 in iPSC-derived dopaminergic neurons to correct autophagic/lysosomal deficits in Parkinson's disease by McGuinness, W

“…</p> <p>Surprisingly, TFEB overexpression mainly upregulated genes associated with mitochondrial function and bioenergetics in iPSC-DaNs, demonstrating a novel, DaN- specific therapeutic function for TFEB activation in PD.…”

Antimicrobial susceptibility and molecular profiles of acinetobacter baumannii in Makkah hospitals, and the potential use of bacteriophage as a treatment option by Raees, Fahad

“…The aminoglycosides resistance was encoded mainly by aminoglycoside phosphor-transferase gene, aph(3′′)-Ib at 83.8% and aminoglycoside O-phosphotransferase aph(6)-Id at 70.3%. …”
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3D bioprinting of high cell concentrations & cell spheroids to achieve physiologically relevant cell environments by Chua, Cliff Dun An

“…Results proved that the spheroids showed signs of growth and that the spheroids seemed to grow a liking to the alginate hydrogel be it the various concentrations of crosslinkers. …”
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Effective and efficient topic mining and exploration from geo-textual data by Zhao, Kaiqi

“…Worse still, the existing methods are frequency-based (the more a topic is mentioned, the more likely a user prefers the topic), while ignoring the user’s sentiment. …”
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Use of Mid Upper-Arm Circumference (MUAC) as screening tool in an urban township in the Eastern Cape: rationale for testing changed cut-off values to identify malnutrition by McLaren, Shawn, Steenkamp, Liana, Venter, Danie

“…The least squares regression formula (Y = 15.409 + 0.803x (males); Y = 15.13 + 0.83x (females)) was then used to predict where WHZ = -2 is most likely to correspond with a MUAC value in cm. The new predicted MUAC values of 13.8 cm (males) and 13.5 cm (females) were subsequently tested for sensitivity and specificity. …”
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Development and validation of questionnaire on knowledge, attitudes, practices and perceived barriers related to nutrition care process among clinical dietitians in Malaysia by Bahari, Zaini

“…It was appeared that the practice of the NCP was likely to be influenced by the individual dietetics professionals and their administrators. …”
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不一样的移民社会 ：黄乃裳组织福州人迁移诗巫的历史个案研究 = A different immigrant society : a study on Wong Nai Siong planned migration of Foochownese to Sibu... by 陈雯 Chen, Wen

“…The history of Chinese immigrants and immigration has been studied by many, and the impression for this history is mainly deemed in a negative light. It is generally believed that the Chinese immigrants will have to been through a bumpy journey while immigrating, and will have to face a lot of hardships, struggling to survive in Nanyang. …”
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Selective laser melting of ceramic particles strengthened stainless steel by Zhai, Wengang

“…The strength enhancement is mainly achieved through grain refinement and Orowan strengthening. …”
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Perovskite superstructures and heterostructures for enhanced optical performance by Chan, Wen Kiat

“…Studies involving perovskite SSs mainly focus on all-inorganic CsPbBr3 synthesized using either the hot injection or ultrasonication methods. …”
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The combined role of MRI prostate and prostate health index in improving detection of significant prostate cancer in a screening population of Chinese men by Chiu, Peter K. F., Lam, Thomas Y. T., Ng, Chi-Fai, Teoh, Jeremy Y. C., Cho, Carmen C. M., Hung, Hiu-Yee, Hong, Cindy, Roobol, Monique J., Chu, Winnie C. W., Wong, Samuel Y. S., Sung, Joseph Jao Yiu

“…The benefit of MRI prostate was mainly observed in PSA 4.0-9.9 ng ml -1 and PHI ≥35 group. …”
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