Centrioles generate two scaffolds with distinct biophysical properties to build mitotic centrosomes by Wong, S-S, Monteiro, JM, Chang, C-C, Peng, M, Mohamad, N, Steinacker, TL, Xiao, B, Saurya, S, Wainman, A, Raff, JW

“…Here, we show that Drosophila Spd-2 (human CEP192) fluxes out from centrioles, recruiting Polo and Aurora A kinases to catalyze the assembly of two distinct mitotic-PCM scaffolds: a Polo-dependent Cnn scaffold, and an Aurora A–dependent TACC scaffold, which exhibit solid- and liquid-like behaviors, respectively. Both scaffolds can independently recruit PCM proteins, but both are required for proper centrosome assembly, with the Cnn scaffold providing mechanical strength, and the TACC scaffold concentrating centriole and centrosome proteins. …”

Universal in-context approximation by prompting fully recurrent models by Petrov, A, Lamb, TA, Paren, A, Torr, PHS, Bibi, A

“…Hence, these findings do not apply to fully recurrent architectures like RNNs, LSTMs, and the increasingly popular SSMs. …”

A regulatory SNP causes a human genetic disease by creating a new transcriptional promoter by De Gobbi, M, Viprakasit, V, Hughes, JR, Fisher, C, Buckle, V, Ayyub, H, Gibbons, RJ, Vernimmen, D, Yoshinaga, Y, de Jong, P, Cheng, J-F, Rubin, EM, Wood, Wg, Bowden, D, Higgs, DR

“…The rSNP creates a new promoterlike element that interferes with normal activation of all downstream α-like globin genes. Thus, our work illustrates a strategy for distinguishing between neutral and functionally important rSNPs, and it also identifies a pathogenetic mechanism that could potentially underlie other genetic diseases.…”

Specialized replication mechanisms maintain genome stability at human centromeres by Scelfo, A, Angrisani, A, Grillo, M, Barnes, BM, Muyas, F, Sauer, CM, Leung, CWB, Dumont, M, Grison, M, Mazaud, D, Garnier, M, Guintini, L, Nelson, L, Esashi, F, Cortés-Ciriano, I, Taylor, SS, Déjardin, J, Wilhelm, T, Fachinetti, D

“…Prolonged stress causes centromeric alterations like ruptures and translocations, as observed in ovarian cancer models experiencing replication stress. …”

A survey of few-shot learning for biomedical time series by Li, C, Denison, T, Zhu, T

“…An emerging approach to overcome the scarcity of labeled data is to augment AI methods with human-like capabilities to leverage past experiences to learn new tasks with limited examples, called few-shot learning. …”

Strike a pose: tracking people by finding stylized poses by Ramanan, D, Forsyth, DA, Zisserman, A

“…Our basic assumption is that people tend to take on certain canonical poses, even when performing unusual activities like throwing a baseball or figure skating. We build a person detector that quite accurately detects and localizes limbs of people in lateral walking poses. …”

Lost in quantization: improving particular object retrieval in large scale image databases by Philbin, J, Chum, O, Isard, M, Sivic, J, Zisserman, A

“…Our results exceed the current state of the art retrieval performance on these datasets, particularly on queries with poor initial recall where techniques like query expansion suffer. Overall we show that soft-assignment is always beneficial for retrieval with large vocabularies, at a cost of increased storage requirements for the index.…”

Ant, spider and DNA: letting mindless generative mechanisms speak by Bråten, E

“…ANT and SPIDER share a blindness with respect to invisible beings like itself, DNA argues. Their privileging of spatiotemporal immediacy entails a one-dimensional (flat) ontology that tends to push mindless generative mechanisms out of view. …”

Baturaja inscription: a threats to Miańga by Andhifani, Wahyu Rizky, Tedjowasono, Ninny Susanti

“…This inscription, if seen from its paleographic form, most likely originates from around the VII century, like the early inscriptions of the Sriwijaya Kingdom, namely: the Kedukan Bukit inscription, the Talang Tuwo inscription, the Telaga Batu inscription, the Kota Kapur inscription, the Karang Brahi inscription, the Palas Pasemah inscription, and some the short Siddhayatra inscription. …”
Get full text

Thismia perlisensis (Thismiaceae), a new red-annulus Thismia species from Peninsular Malaysia by Besi, Edward Entalai, Mad Jabar, Qistina Anis, Abd Rahman, Syamil, Saad, Mohd Zulkifly, Ag Ahmadni, Ag Shaffie, Go, Rusea

“…The new species is easily distinguished from the similar species, T. arachnites, T. javanica, T. tentaculata, and T. kenyirensis by the prominent reddish dome-shaped annulus instead of ring-like with rim, deeply trilobed stigma with bifid and subulate lobes, and claviform apices of the inner tepals.…”
Get full text

The Role of Institutional Trust and Political Accountability in Pakistan: An Empirical Study by Sadiq, Saiqa, Mohd. Zain, Zawiyah, Ajis, Mohd Na'eim

“…However, data is thematically analyzed, that is expedient technique for multiethnic country like Pakistan. Therefore, it is find out that weak political accountability and lower government performance have robust trust eroding effects in Pakistan.Thus the overall results are categorical about people lacking trust over political accountability institutions…”
Get full text

The Role of Social Media Towards Political Accountability in Pakistan: A Literature Review by Sadiq, Saiqa, Mohd. Zain, Zawiyah, Ajis, Mohd Na'eim

“…However, an emerging democracy like Pakistan, where social media trend is up surging and accountability condition is destitute. …”
Get full text

Developing Animation Projects that Foster Student's Creativity: An Application of Design Thinking Process (S/O 14722) by Mohd Suki, Norbayah, Mohd Suki, Norazah, Ahmad, Rosliza

“…Minimal research has been investigated on nurturing students' behavioural intention and actual usage of creative animation using design thinking as the digital social innovation agent to foster creativity at tertiary level within Malaysia context, particularly from the aspects like performance expectancy, effort expectancy, social influence, and facilitating conditions. …”
Get full text

Development of differential optical absorption spectroscopy (DOAS) system for hazardous methane gas detection in the near infrared region by Khandaker, Sayma, Hasan, Md Mahmudul, Nurulain Nadhirah, Shaipizaman, Mohd Amir Shahlan, Mohd Aspar, Hadi, Manap

“…An in-depth examination of the absorption lines was conducted to determine the optimal wavelength for measurement. …”
Get full text

Quality of life and healthcare service utilization among methadone maintenance patients in a mountainous area of Northern Vietnam by Nguyen, Long Hoang, Nguyen, Lan Huong Thi, Boggiano, Victoria L., Hoang, Canh Dinh, Van Nguyen, Hung, Le, Huong Thi, Le, Hai Quan, Tran, Tho Dinh, Tran, Bach Xuan, Latkin, Carl A., Zary, Nabil, Vu, Minh Thuc Thi

“…Individuals who were multiple substance abusers and those who recently had inpatient care were more likely to have a lower VAS. Older respondents, those taking their medications at the more impoverished clinic, substance abusers, and individuals who were struggling with anxiety/depression or their usual daily activities were more likely to use both inpatient and outpatient care.Conclusions: In summary, we observed good HRQOL, but high prevalence of anxiety/depression and low rates of service utilization among MMT patients in Tuyen Quang province. …”
Get full text
Get full text

G-VOILA: Gaze-Facilitated Information Querying in Daily Scenarios by Wang, Zeyu, Shi, Yuanchun, Wang, Yuntao, Yao, Yuchen, Yan, Kun, Wang, Yuhan, Ji, Lei, Xu, Xuhai, Yu, Chun

“…Modern information querying systems are progressively incorporating multimodal inputs like vision and audio. However, the integration of gaze --- a modality deeply linked to user intent and increasingly accessible via gaze-tracking wearables --- remains underexplored. …”
Get full text

Elucidation of thermally induced internal porosity in zinc oxide nanorods by Handoko, Albertus D., Liew, Laura-Lynn, Lin, Ming, Sankar, Gopinathan, Du, Yonghua, Su, Haibin, Dong, Zhili, Goh, Gregory Kia Liang

“…Mechanistic studies using X-ray absorption spectroscopy indicated that the pore formation is linked to the significant reduction of the number of zinc vacancies after heat treatment. …”
Get full text

Curvature sensing amphipathic helix in the C-terminus of RTNLB13 is conserved in all endoplasmic reticulum shaping reticulons in Arabidopsis thaliana by Brooks, Rhiannon L., Mistry, Chandni S., Dixon, Ann M.

“…This may facilitate functional flexibility as previous studies have linked these isoforms not only to ER remodeling but other cellular activities.…”
Get full text

Detection of road markings for advanced driver assistance by Suchitra Sathyanarayana

“…Evaluation of the AHPD on the 101 CMU object database confirms that it can successfully detect the major line features of interest, including lines of close proximity and lines of varying lengths amidst noise. …”
Get full text

Data-driven approach to spatiotemporal dynamic risk assessment of urban flooding based on shared socio-economic pathways by Wang, Mo, Chen, Furong, Zhang, Dongqing, Chen, Zijing, Su, Jin, Zhou, Shiqi, Li, Jianjun, Chen, Jintang, Li, Jiaying, Tan, Soon Keat

“…Under SSP126 scenario, nearly no change was predicted in the area with high flooding risk, with only increase of 1%, future urbanization hotspots associated with serious flooding risks will likely to be found on the fringe of the GBA's construction areas, in line with the extent of construction land expansion. …”
Get full text