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An NKX2-1GFP and TP63tdTomato dual fluorescent reporter for the investigation of human lung basal cell biology
Published 2021Get full text
Journal Article -
263
tobac v1.5: introducing fast 3D tracking, splits and mergers, and other enhancements for identifying and analysing meteorological phenomena
Published 2024“…A number of scientific improvements (three spatial dimensions, splits and mergers of features, an internal spectral filtering tool) and procedural enhancements (increased computational efficiency, internal regridding of data, and treatments for periodic boundary conditions) have been included in tobac as a part of the tobac v1.5 update. These improvements have made tobac one of the most robust, powerful, and flexible identification and tracking tools in our field to date and expand its potential use in other fields. …”
Journal article -
264
Ultrafast time-resolved fluorescence study on formation and excitation dynamics of human telomeric and homo-oligomeric i-motifs at neutral pH
Published 2020“…Asides from the common double stranded structure, nucleic acids depending on the base content and environmental condition may take many non-canonical secondary structures, including the fourstranded intercalated i-motif structure formed from cytosine-rich sequences that are abundant throughout the human genome.[1,2] The structures of i-motifs are known to be stable at slightly acidic condition, whether they can also be formed at the physiologically relevant neutral pH condition remains elusive and currently one of the frontier issues in the study of non-canonical nucleic acid structures.[3,4] Herein we present a comparative steady-state and ultrafast time-resolved fluorescence investigation of a homo-oligomeric and human telomeric cytosine-rich sequence at both the acidic and neutral pH.…”
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Conference Paper -
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High p16 expression and heterozygous RB1 loss are biomarkers for CDK4/6 inhibitor resistance in ER+ breast cancer
Published 2023Get full text
Journal Article -
268
The role of dendritic cells in determining the breadth and epitope specificity of the initial CD8+ T cell response during acute HIV-1 infection
Published 2016“…<p>During acute HIV-1 infection (AHI), CD8<sup>+</sup> T cell responses are initially induced to only 1-3 viral epitopes in many patients, and Nef-derived epitopes are very commonly targeted. …”
Thesis -
269
Antimicrobial susceptibility and molecular profiles of acinetobacter baumannii in Makkah hospitals, and the potential use of bacteriophage as a treatment option
Published 2022“…Besides, these MDR isolates were also acquired of sulphonamide resistant genes of sul1 (32.4%) and sul2 (18.9%). Part of the core of this project was to find the potential bacteriophage that has capability to infect and lyse A. baumannii cells. …”
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Thesis -
270
Human-Computer Interaction : Interaction Techniques and Novel Applications : Thematic Area, HCI 2021, Held as Part of the 23rd HCI International Conference, HCII 2021, Virtual Even...
Published [202“…The 139 papers included in this HCI 2021 proceedings were organized in topical sections as follows: Part I, Theory, Methods and Tools: HCI theory, education and practice; UX evaluation methods, techniques and tools; emotional and persuasive design; and emotions and cognition in HCI Part II, Interaction Techniques and Novel Applications: Novel interaction techniques; human-robot interaction; digital wellbeing; and HCI in surgery Part III, Design and User Experience Case Studies: Design case studies; user experience and technology acceptance studies; and HCI, social distancing, information, communication and work.…”
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271
Near-IR and mid-IR (1.55 μm – 2 μm) silicon photonics devices on silicon-on-insulator (SOI) platform
Published 2018“…In the last several decades, there has been considerable research interest in silicon photonics based on silicon-on-insulator (SOI) platform. Many useful applications have been developed in the near-infrared (NIR) data- and tele- communication band (1.3-1.6 µm), such as sensors, switches, modulators, and various passive devices. …”
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Thesis -
272
Commercialization strategy for FormaCyte therapeutics: Type 1 diabetes patient insights and regulatory pathway analysis on US FDA's impact on other jurisdictions
Published 2024“…This report aims to strengthen the commercialization strategy of FormaCyte, an innovative treatment for Type 1 Diabetes (T1D), by obtaining firsthand patient insights to bolster a patient-centered development and investigating the US’s regulatory impact for cell therapy on other jurisdictions to support regulatory development efforts. …”
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Final Year Project (FYP) -
273
Optimization, encapsulation and characterization of bromelain-generated angiotensin I-converting enzyme (Ace) - inhibitory hydrolysates from stone fish (Actinopyga lecanora Jaeger)
Published 2018“…The hydrolysates were further profiled in which five novel ACE-inhibitory peptides including ALGPQFY, KVPPKA, LAPPTM, EVLIQ and EHPVL were identified with their respective IC50 values of 0.012 mM, 0.980 mM, 1.31 mM, 1.44 mM and 1.68 mM. The ACE-inhibitory hydrolysates were then nanoencapsulated in chitosan nanoparticles and optimized based on 3-factor 3-level Box–Behnken experimental design. …”
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Thesis -
274
Dysregulation of the Pdx1/Ovol2/Zeb2 axis in dedifferentiated β-cells triggers the induction of genes associated with epithelial-mesenchymal transition in diabetes
Published 2022“…We found that the mesenchymal reprogramming ofb-cells isexplained in part by the downregulation ofPdx1and its inability to regulate a myriad of epithelial-specific genes expressed inb-cells. …”
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Journal Article -
275
Structural study of ribosome : 1) structural basis of EF-G in translocation. 2) molecular mechanism of ribosome-dependent toxin YoeB in mRNA cleavage
Published 2015“…During bacterial protein synthesis, elongation factor G (EF-G) facilitates the forward movement of the tRNA–mRNA by one codon, which is coupled to the ratchet-like movement of the ribosome and triggered by EF-G–mediated GTP hydrolysis. …”
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Thesis -
276
The iHealth-T2D study, prevention of type 2 diabetes amongst South Asians with central obesity and prediabetes: study protocol for a randomised controlled trial
Published 2022“…Endpoints: The primary endpoint is new-onset T2D at 3 years, defined as (i) HbA1c ≥ 6.5% or (ii) physician diagnosis and on treatment for T2D. …”
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Journal Article -
277
试论宇文所安《剑桥中国文学史》的理念与呈现 = Principle and presentation on the Cambridge history of Chinese literature (Volume I)
Published 2016“…Based on analyzing the Cambridge History of Chinese Literature (Volume I) edited by Prof. Stephen Owen, combined with his previous researches and compared with the History of Chinese Literature edited by Prof. …”
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Asymmetric synthesis of N-benzyl-5-methylhydroxy-piperidone and modular synthesis of C1-substituent tetrahydroisoquinolines (THIQ) and C2-symmetric bisisoquinolines (C2-BIQ) and th...
Published 2015“…Two main approaches were investigated: (1) chiral auxiliary, and (2) asymmetric catalysis. …”
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Thesis