Electrochemically driven optical and SERS immunosensor for the detection of a therapeutic cardiac drug by Chaudhry, Madeeha, Lim, Dong-Kwon, Kang, Jeon Woong, Yaqoob, Zahid, So, Peter, Bhopal, Muhammad Fahad, Wang, Minqiang, Qamar, Raheel, Bhatti, Arshad Saleem

“…The effectiveness of the drug critically depends on its presence in the therapeutic range (0.8–2.0 ng mL−1) in the patient's serum. …”
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Flame-made calcium phosphate nanoparticles with high drug loading for delivery of biologics by Tsikourkitoudi, Vasiliki, Karlsson, Jens, Merkl, Padryk, Loh, Edmund, Henriques-Normark, Birgitta, Sotiriou, Georgios A.

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Structural basis of ligand recognition in 5-HT3 receptors by Thompson, Andrew J., Villalgordo, Jose M., Lummis, Sarah C. R., Smit, August B., Kesters, Divya, Elk, René van, Brams, Marijke, Spurny, Radovan, Geitmann, Matthis, Guskov, Albert, Danielson, U. Helena, Ulens, Chris

“…The 5-HT3 receptor is a pentameric serotonin-gated ion channel, which mediates rapid excitatory neurotransmission and is the target of a therapeutically important class of anti-emetic drugs, such as granisetron. …”
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Functional genomics reveals an off-target dependency of drug synergy in gastric cancer therapy by Leylek, Ozen, Honeywell, Megan E., Lee, Michael J., Hemann, Michael T., Ozcan, Gulnihal

“…However, realizing the full potential of this approach requires a clear comprehension of the genetic dependencies underlying drug synergy. …”
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Immunoprofiling of drug-resistant epilepsy with a focus on glutamic acid decarboxylase 65 antibodies by McGinty, R

“…<p>The urgent need to improve therapies for people with drug-resistant epilepsy (DRE) requires improved understanding of the aetiopathophysiology of epilepsy and the mechanisms responsible for pharmacoresistance. …”

A hydrophilic polyimidazolium antibiotic targeting the membranes of Gram-negative bacteria by Chen, Yahua, Yong, Melvin, Li, Ming, Si, Zhangyong, Koh, Chong Hui, Lau, Pearlyn, Chang, Yi Wei, Teo, Jeanette, Chan-Park, Mary B., Gan, Yunn-Hwen

“…The rise of MDR Gram-negative bacteria (GNB), especially those resistant to last-resort drugs such as carbapenems and colistin, is a global health risk and calls for increased efforts to discover new antimicrobial compounds. …”
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Development and in vitro bioevaluation of cockle shell-calcium carbonate (Aragonite) nanoparticles for intracellular drug delivery by Isa, Tijani

“…The mean diameter of inhibition zone was 18.6 ± 0.5 mm, which was better than ciprofloxacin alone (11.7 ± 0.9 mm), while the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) of the formulation were lower than those of free drugs. …”
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Antibiotic resistance profile, potential drivers and genotype of Escherichia coli, Salmonella sp. and Vibrio sp. isolated from hybrid red tilapia and Asian seabass in the West Coas... by Dewi, Rita Rosmala

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RoboCap: Robotic mucus-clearing capsule for enhanced drug delivery in the gastrointestinal tract by Srinivasan, Shriya S., Alshareef, Amro, Hwang, Alexandria V., Kang, Ziliang, Kuosmanen, Johannes, Ishida, Keiko, Jenkins, Joshua, Liu, Sabrina, Madani, Wiam Abdalla Mohammed, Lennerz, Jochen, Hayward, Alison, Morimoto, Josh, Fitzgerald, Nina, Langer, Robert, Traverso, Giovanni

“…Oral drug delivery of proteins is limited by the degradative environment of the gastrointestinal tract and poor absorption, requiring parenteral administration of these drugs. …”
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Dynamic actuation enhances transport and extends therapeutic lifespan in an implantable drug delivery platform by Whyte, William, Goswami, Debkalpa, Wang, Sophie X., Fan, Yiling, Ward, Niamh A., Levey, Ruth E., Beatty, Rachel, Robinson, Scott T., Sheppard, Declan, O’Connor, Raymond, Monahan, David S., Trask, Lesley, Mendez, Keegan L., Varela, Claudia E., Horvath, Markus A., Wylie, Robert, O’Dwyer, Joanne, Domingo-Lopez, Daniel A., Rothman, Arielle S., Duffy, Garry P., Dolan, Eimear B., Roche, Ellen T.

“…Firstly, daily intermittent actuation (cycling at 1 Hz for 5 minutes every 12 hours) preserves long-term, rapid delivery of a model drug (insulin) over 8 weeks of implantation, by mediating local immunomodulation of the cellular FBR and inducing multiphasic temporal FC changes. …”
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Defining proteoform-specific interactions for drug targeting in a native cell signalling environment by Lutomski, CA, Bennett, JL, El-Baba, TJ, Wu, D, Hinkle, JD, Burnap, SA, Liko, I, Mullen, C, Syka, JEP, Struwe, WB, Robinson, CV

“…Given reports of undesirable side-effects involving vision, we characterized the off-target drug binding of two phosphodiesterase 5 inhibitors, vardenafil and sildenafil, to the retina rod phosphodiesterase 6 (PDE6). …”

Application of variational graph encoders as an effective generalist algorithm in computer-aided drug design by Lam, Hilbert Yuen In, Pincket, Robbe, Han, Hao, Ong, Xing Er, Wang, Zechen, Hinks, Jamie, Wei, Yanjie, Li, Weifeng, Zheng, Liangzhen, Mu, Yuguang

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Investigating novel drug delivery systems to enhance tissue regeneration in the central nervous system by Lin, Vincent Po Hen

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Development of high-affinity peptide-drug conjugates for investigating the TRIM24 PHD and bromodomain by Platt, MA

“…Furthermore, by BROMO<em>scan</em> the PDCs demonstrated 13-fold selectivity for TRIM24 (PHD-BRD) over BRPF1 (BRD). PDC5 demonstrated some cell permeability, despite its peptidomimetic structure, and so was evaluated in proliferation assays. …”

Boronic acid and nitrofuranyl derivatives as potential therapeutics by Dey, AL

“…‘Rule of 5’, there has been extensive research on lead-like compounds other than those in the realm of small molecule drug-likeness. …”

Combined drug delivery and treatment monitoring using a single high frequency ultrasound system by Yildiz, YO, Ruan, J-R, Gray, MD, Bau, L, Mannaris, C, Kiltie, AE, Vojnovic, B, Stride, E, Browning, RJ

“…This study investigates the feasibility of using a single commercial ultrasound imaging transducer operating at 5 MHz for both drug delivery and real-time imaging. …”

Pyrimidino piperazinyl acetamides : innovative class of hybrid acetamide drugs as potent antimicrobial and antimycobacterial agents by Kanagarajan, V., Gopalakrishnan, M.

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Extensively drug-resistant Klebsiella pneumoniae associated with complicated urinary tract infection in Northern India by Kaza, P, Xavier, BB, Mahindroo, J, Singh, N, Baker, S, Nguyen, TNT, Mavuduru, RS, Mohan, B, Taneja, N

“…Klebsiella pneumoniae (Kp), which is associated with hospital-acquired infections, is extensively drug-resistant (XDR), making treatment difficult. …”

A bilayer swellable drug-eluting stent for the treatment of fibrosis-induced ureteral stricture recurrence by Lim, Wei Shan

“…It is hypothesized that a bilayer swellable drug-eluting stent (BSDES) that can co-apt with the urothelium for the localized and sustained delivery of drugs into the diseased section can reduce or eliminate stricture recurrence. …”
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Synergistic antibacterial effect of Persicaria odorata synthesised silver nanoparticles with antibiotics on drug-resistant bacteria. by Abdul Hadi, Atieya, Nik Malek, Nik Ahmad Nizam, Matmin, Juan, Asraf, Muhammad Hariz, Susanto, Hendra, Mohammad Din, Shahrulnizahana, Shamsuddin, Mustaffa