Biointerface design for vertical nanoprobes by Elnathan, Roey, Barbato, Maria Grazia, Guo, Xiangfu, Mariano, Anna, Wang, Zixun, Santoro, Francesca, Shi, Peng, Voelcker, Nicolas H., Xie, Xi, Young, Jennifer L., Zhao, Yunlong, Zhao, Wenting, Chiappini, Ciro

“…Vertical nanoprobes have substantially improved our ability to control and characterize the intracellular environment, guide biophysical stimuli with nanoscale precision to defined cell compartments, stimulate and record the electrical activity of cells, and transport hard-to-deliver drugs. These capabilities are enabling substantial advances in bioelectronics, spatiotemporally resolved molecular diagnostics, and cell and gene therapy — all underpinned by the design versatility of the nanoprobe biointerface. …”
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Duration of carbapenemase-producing enterobacteriaceae carriage in hospital patients by Mo, Yin, Hernandez-Koutoucheva, Anastasia, Musicha, Patrick, Bertrand, Denis, Lye, David C., Ng, Oon Tek, Fenlon, Shannon N., Chen, Swaine L., Ling, Moi Lin, Tang, Wen Ying, Barkham, Timothy, Nagarajan, Niranjan, Cooper, Ben S., Marimuthu, Kalisvar

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Prediction of pyrazinamide resistance in Mycobacterium tuberculosis using structure-based machine learning approaches by Carter, J, Walker, T, Walker, A, Whitfield, M, Morlock, G, Lynch, C, Adlard, D, Peto, T, Posey, J, Crook, D, Fowler, P

“…<p><strong>Methods</p></strong> We curated a dataset of 664 non-redundant, missense amino acid mutations in PncA with associated high-confidence phenotypes from published studies and then trained three different machine-learning models to predict pyrazinamide resistance. All models had access to a range of protein structural-, chemical- and sequence-based features. …”

The role of SPRTN protease in colorectal cancer chemotherapy by Peron, C

“…<p>Colorectal cancer (CRC) currently represents one of the most commonly diagnosed tumors, accounting for 10% of all cancer diagnoses and cancer-related deaths. …”

Cheaper Than A Funeral: Considering Ibogaine’s Psychedelic Journey and Therapeutic Potential by Daly, Noah

“…It is also considered the most extreme of the psychedelic drugs currently known to researchers. For the past fifty years, it’s been used to treat severe substance use disorders, particularly with highly addictive opioids and stimulants. …”
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Nickel-catalyzed enantioselective reductive arylation and heteroarylation of aldimines via an elementary 1,4-addition by Zhang, Luoqiang, Wang, Xiuhua, Pu, Maoping, Chen, Caiyou, Yang, Peng, Wu, Yun-Dong, Chi, Robin Yonggui, Zhou, Steve Jianrong

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Mechanism of damnacanthal induced apoptosis in CEM-SS cell line by Gopalsamy, Banulata, Saiful Yazan, Latifah, Abdul Hamid, Hisyam

“…Due to the harsh effects of currently used cancer drugs, damnacanthal, an anthraquinone obtained from the roots of Morinda elliptica is tested as a potential anticancer agent. …”
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Pharmacological PPARβ/δ activation upregulates VLDLR in hepatocytes by Zarei, Mohammad, Barroso, Emma, Palomer, Xavier, Escolà-Gil, Joan Carles, Cedó, Lidia, Wahli, Walter, Vázquez-Carrera, Manuel

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Examining patient choice and provider competition under the National Health Insurance Fund outpatient cover in Kenya: does it enhance access and quality of care? by Kazungu, J, Barasa, E, Quaife, M, Nonvignon, J

“…Most providers ensured the availability of drugs, provided a wider range of services and leveraged on marketing to attract and retain NHIF members. …”

Phaleria macrocarpa fruit protein aqueous extract affects viral entry, virucidal activity, and progeny release by Ismaeel, Mahmud Yusef Yusef, Chee, Wai Yip, Norefrina Shafinaz Md Nor, Nazlina Ibrahim

“…PMFPAE mode of action is hence different from ACV and worthy for the development of future antiviral drugs.…”
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Synthesis, Characterisation Of Stilbene–Arylcinnamide Hybrids And Cytotoxic Studies Against Lung Cancer Cell A549 by Mohd Zaki, Nurain Syazwani

“…Numerous anticancer drugs have been designed from natural products. Several compounds derived from nature such as alkaloid, flavonoid, cinnamic acid and stilbene, were reported to possess various biological properties primarily as an anticancer agent. …”
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An analysis of heavy silicone oil treatment for inferior proliferative vitreoretinopathy by Hammer, M, Ie, A, Eibenberger, K, Auffarth, GU, Xue, K

“…The number of glaucoma drugs were increased in 45% of patients during Densiron tamponade. …”

The potential of fluocinolone acetonide to mitigate inflammation and lipid accumulation in 2D and 3D foam cell cultures by Nguyen, Luong T. H., Muktabar, Aristo, Tang, Jinkai, Wong, Yee Shan, Thaxton, Colby S., Venkatraman, Subbu Subramanian, Ng, Kee Woei

“…Inflammation plays an important role in all stages of atherosclerosis development. Therefore, the use of anti-inflammatory drugs could reduce the risk of major adverse cardiovascular events due to atherosclerosis. …”
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Protein Folding, Host Cell Proteostasis, and Viral Evolution by Yoon, Jimin

“…Interestingly, virtually all RNA viruses rely on their host’s proteostasis network components for viral protein folding. …”
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Evaluation of Enterococcus hirae isolated from vegetable wastes as probiotic and improvement of immune response in African catfish (Clarias spp.) by Hamid, Nur Hidayahanum

“…Tanks setup were arranged as a completely randomized design (CDR) with three replicates. All experimental fish were fed to satiation twice daily (09:00 hr and 15:00 hr) for 50 days. …”
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Inorganic nanoparticles–driven self–assembly of natural small molecules in water for constructing multifunctional nanocapsules against plant diseases by Liu, Li-Wei, Ding, Zheng-Hao, Ren, Gang-Gang, Wang, Guang-Di, Pan, Xin, Wei, Guo-Hai, Zhou, Xiang, Wu, Zhi-Bing, Jin, Zhi-Chao, Chi, Robin Yonggui, Yang, Song

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Maximizing dissimilarity in resting state detects heterogeneous subtypes in healthy population associated with high substance use and problems in antisocial personality by Kashyap, Rajan, Bhattacharjee, Sagarika, Yeo, Thomas B. T., Chen, Annabel Shen-Hsing

“…Here, we use an alternative way to extract the rs-fMRI features that are common across all the scans by applying common-and-orthogonal-basis-extraction (COBE) technique. …”
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The combined activation of KCa3.1 and inhibition of Kv11.1/hERG1 currents contribute to overcome Cisplatin resistance in colorectal cancer cells by Pillozzi, Serena, D'Amico, Massimo, Bartoli, Gianluca, Gasparoli, Luca, Petroni, Giulia, Crociani, Olivia, Marzo, Tiziano, Guerriero, Angela, Messori, Luigi, Severi, Mirko, Udisti, Roberto, Wulff, Heike, Chandy, Kanianthara George, Becchetti, Andrea, Arcangeli, Annarosa

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Development of axially chiral urazole scaffolds for antiplant virus applications against potato virus Y by Jin, Jiamiao, Mou, Chengli, Zou, Juan, Xie, Xin, Wang, Chen, Shen, Tingwei, Deng, Youlin, Li, Benpeng, Jin, Zhichao, Li, Xiangyang, Chi, Robin Yonggui

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Advancements in Management Science: Applications to Online Retail, Healthcare, and Non-Profit Fundraising by Zhai, Chen Wen (Sabrina)

“…Previous work on this topic have adopted a classical online learning setup, where the retailer begins the selling horizon with no information about the problem and gains all knowledge about the demand function from the online selling phase. …”
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