Development of CRISPR gene therapy for retinal degenerations by Fry, LE

“…Gene-supplementation therapies using adeno-associated viral (AAV) vectors have been developed, however, they are limited to the treatment of recessive IRDs and genes with small coding sequences. …”

The influence of polarisation on the behaviour of anions within ion channels and nanopores by Phan, LX

“…Whilst cation channels have been studied in great depth, general mechanisms underlying anion selectivity and permeation within such pores remain unclear. …”

Fabrication and characterization of Si doped ZnO and Cu2P2O7 thin films by Wang, J

“…However, the two issues of ITO are the high cost of indium as well as its incomplete coverage of blockage in the NIR range, especially in the 790–1100 nm range that contains nearly 60% of the NIR solar irradiance. For decades, ZnO has been considered as a potentially low-cost replacement for ITO. …”

Deep brain stimulation of the hypothalamic region: a systematic review by Mofatteh, M, Mohamed, A, Mashayekhi, MS, Skandalakis, GP, Neudorfer, C, Arfaie, S, MohanaSundaram, A, Sabahi, M, Anand, A, Aboulhosn, R, Liao, X, Horn, A, Ashkan, K

“…Background: Deep brain stimulation (DBS) has been successfully used for the treatment of circuitopathies including movement, anxiety, and behavioral disorders. …”

Preterm birth and cardiometabolic health trajectories from birth to adulthood: the Avon Longitudinal Study of Parents and Children by Clayton, GL, Howe, LD, O’Keeffe, LM, Lewandowski, A, Lawlor, DA, Fraser, A

“…Our aim was to compare trajectories of multiple cardiometabolic risk factors from childhood to early adulthood between those who had and had not been born preterm.</p> <br> <p><strong>Methods and Results:</strong> Multilevel models were used to compare trajectories from early childhood (&lt;9 years) to age 25 of BMI, fat and lean mass, systolic and diastolic blood pressure (BP), lipids, glucose and insulin, between individuals born preterm (N=311-676, range 25-36 gestation) and term (N=4973-10534) in a UK birth cohort study. …”

Serological cross-reactivity between Crimean-Congo haemorrhagic fever virus and Nairobi sheep disease virus glycoprotein C by Maze, EA, Booth, G, Limon, G, Belij-Rammerstorfer, S, Tchakarova, SR, Alexandrov, T, Browning, C, Wilsden, G, Ludi, AB, Charleston, B, Lambe, T

“…Crucially, only one seropositive sample to NSDV Gc-specific out of a set of 224 (0.4%) showed a neutralizing capacity at the lowest serum dilution (1:8), suggesting these field sera have not been exposed to NSDV. Based on an analysis of known epitopes in NP targeted by antibodies in sheep serum, we propose that NP is less cross-reactive because dominant epitopes are highly dissimilar between CCHFV and NSDV. …”

Methane precipitation in ice giant atmospheres by Toledo, D, Rannou, P, Irwin, PG, de Batz de Trenquelléon, B, Roman, M, Apestigue, V, Arruego, I, Yela, M

“…However, no clear spectral signatures of such a cloud have been detected thus far in the spectra acquired from both planets.…”

The fragmented COVID-19 therapeutics research landscape: a living systematic review of clinical trial registrations evaluating priority pharmacological interventions by McLean, ARD, Rashan, S, Tran, L, Arena, L, Lawal, A, Maguire, BJ, Adele, S, Antonio, ES, Brack, M, Caldwell, F, Carrara, VI, Charles, R, Citarella, BW, Epie, TB, Feteh, VF, Kennon, K, Makuka, GJ, Ngu, R, Nwosu, A-P, Obiesie, S, Ogbonnaa-Njoku, C, Paul, P, Richmond, C, Singh-Phulgenda, S, Strudwick, S, Tyrrell, CSB, Stepniewska, K, Strub-Wourgaft, N, White, NJ, Guérin, PJ

“…<p><strong>Background:</strong> Many available medicines have been evaluated as potential repurposed treatments for coronavirus disease 2019 (COVID-19). …”

Characterising the metabolic functionality of the preterm neonatal gut microbiome prior to the onset of necrotising enterocolitis: a pilot study by Chapman, JA, Wroot, E, Brown, T, Beck, LC, Embleton, ND, Berrington, JE, Stewart, CJ

“…While gut microbiome compositions associated with NEC have been well studied, there is a lack of experimental work investigating microbiota functions and their associations with disease onset. …”

Identifying falsified COVID-19 vaccines by analysing vaccine vial label and excipient profiles using MALDI-ToF mass spectrometry by Arman, BY, Clarke, R, Bharucha, T, Gomez Fernandez, L, Walsby-Tickle, J, Deats, M, Mosca, S, Lin, Q, Banerjee, S, Chunekar, S, Patil, K, Gairola, S, Dunachie, S, Merchant, H, Stokes, R, Kuwana, R, Maes, A, Charrier, J-P, Probert, F, Caillet, C, Matousek, P, McCullagh, J, Newton, P, Zitzmann, N, Gangadharan, B

“…However, these developments are associated with the risk of a surge of substandard and falsified (SF) vaccines, as illustrated by the 184 incidents with SF and diverted COVID-19 vaccines which have been reported during the pandemic in 48 countries, with a paucity of methods for their detection in supply chains. …”

Mobile health (mHealth) interventions for health promotion during the perinatal period in India: a scoping review by Small, Z, Thompson, SE, Sharma, A, Majumdar, S, Thout, SR, Praveen, D, Hirst, JE

“…Many mobile health (mHealth) interventions have been developed to improve maternal and infant health outcomes in India, however it is unclear how mHealth can best support women in this culturally and resource diverse setting. …”

An aerodynamic investigation of a high-pressure turbine using rotor casing static pressure measurements at engine representative conditions with different tip designs, tip gaps and... by Singh, D, Beard, PF, Cardwell, D, Staelens, V, Bahulekar, P, Stokes, M, Bather, S, Chana, KS

“…Since the 1970s, extensive research has been undertaken to understand the over-tip leakage flow, and develop mitigation strategies such as novel tip designs, to minimize the losses and heat load. …”

Combined electron imaging and diffraction methods for understanding disordered rocksalt cathodes by Hedley, E

“…The nature of short range order (SRO) has been identified as a determining factor in the lithium migration properties, yet very few in-depth studies exist in the literature. …”

Malaria as a cause of morbidity and mortality in children with homozygous sickle cell disease on the coast of Kenya by Komba, A, Makani, J, Sadarangani, M, Ajala-Agbo, T, Berkley, J, Newton, CRJC, Marsh, K, Williams, T

“…<p><strong>Background</p></strong>To date, it has been widely assumed that malaria is a common cause of morbidity and mortality in children with sickle cell disease (SCD) in malaria-endemic countries, and as a result, malarial prophylaxis is commonly recommended. …”

The development of electrochemical sensors based on the use of different forms of carbon materials by Chaisiwamongkhol, K

“…</p> <p>In this thesis, carbon based materials such as pyrolytic graphite; carbon nanotubes and carbon fibre have been used for a number of analytical and fundamental investigations. …”

Self-harm-related mental imagery: a content analysis study of imagery reported by young people referred to mental health services by Susi, K, Stewart, A, Knowles Bevis, R, Hawton, K

“…<p><strong>Background: </p></strong>Growing evidence suggests that self-harm-related mental imagery is involved in the transition from self-harm ideation to enactment. However, there has been little research on this important phenomenon in adolescent populations. …”

Mitigating marine megafauna captures in fisheries by Arlidge, W

“…Yet to date, the exploration of the biodiversity mitigation process to the primary resource sectors has not been widely investigated as a subject of study in conservation. …”

Citizenship and the politics of poverty definition during the segregation, apartheid and democratic eras in South Africa: 1910-2010 by Magasela, W

“…</p> <p>In the post-apartheid era with a Constitution that enshrines a Bill of Rights with explicit and specific social and economic rights, and human dignity, social justice and the commitment to improve the quality of life of all citizens as foundational values aimed at addressing extensive multi-dimensional poverty, apartheid era concepts and definitions of poverty (mainly the HSL and MLL) continue. This has been reinforced by the analyses of poverty undertaken by the World Bank in the post-apartheid era. …”

Clouds and hazes in Saturn's troposphere and stratosphere by Merlet, CTC

“…At such pressure levels, thermochemical models predict the formation of condensed clouds made of ammonia and ammonium hydrosulphide ices, although none of these species has been spectrally detected so far. In addition, phosphine and ammonia are responsible for most of the gaseous absorption at these wavelengths. …”

Respiratory quality indices for automated monitoring of respiration from sensor data by Birrenkott, D

“…This is primarily because of the lack of a non-invasive, robust, automated method for estimating RR. It has previously been shown that the amplitude modulation (AM), frequency modulation (FM), and baseline wander (BW) of both the electrocardiogram (ECG) and photoplethysmogram (PPG) contain respiratory waveform information. …”