Development of immune-modulatory RNAS to regulate RIG-I-like receptors mediated antiviral immune response for therapy and vaccination by Yong, Hui Yee

“…Next, the encapsulation of ImmRNAs into virus-like particles (VLP) was carried out. The coat protein for two different RNA bacteriophage, MS2 and Q beta were cloned and recombinantly expressed in E.coli. …”
Get full text
Get full text

Template-free formation of uniform urchin-like α-FeOOH hollow spheres with superior capability for water treatment by Wang, Bao, Wu, Hao Bin, Yu, Le, Xu, Rong, Lim, Teik-Thye, Lou, David Xiong Wen

“…Uniform urchin-like α-FeOOH hollow spheres assembled from nanoneedles have been synthesized via a facile and green one-pot method. …”
Get full text
Get full text

CuOx nanotubes via an unusual complexation induced block copolymer-like self-assembly of poly(acrylic acid) by Liang, Yen Nan, Hu, Jinhua, Tam, Michael Kam Chiu, Hu, Xiao

“…Such a unique copolymer-like self-assembly behaviour of the PAA–Cu2+ complex manifests within a specific window of [Cu2+] : [COOH]0 ratio around the binding limit. …”
Get full text
Get full text

Binding of TCR multimers and a TCR-like antibody with distinct fine-specificities is dependent on the surface density of HLA complexes by Low, Jianrong L., Gehring, Adam J., Kranz, David M., Grotenbreg, Gijsbert M., Yau, Yin Hoe, Shochat, Susana Geifman, Bertoletti, Antonio, Naidoo, Anneta, Yeo, Gladys, Ho, Zi Zong

“…In line with this, we report the construction of a soluble tetrameric form of an αβ T cell receptor (TCR) specific for the HBV epitope Env183–191 restricted by HLA-A*02:01, and compare its avidity and fine-specificity with a TCR-like monoclonal antibody generated against the same HLA target. …”
Get full text
Get full text

Like the sea: living communityship as a form of participatory leadership within the creativity for learning in HE (#creativeHE) community by Nerantzi, Chrissi, Gillaspy, Emma, Sinfield, Sandra, Karatsiori, Marianthi, Burns, Tom, Hunter, Anna, Seat, Hannah, Tasler, Nathalie

Get full text

Immunotherapy-resistant neuropathic pain and fatigue predict quality-of-life in contactin-associated protein-like 2 antibody disease by Ceronie, B, Strippel, C, Uy, C, Paneva, S, Makuch, M, Soleimani, B, Turaga, S, Binks, S, Ramanathan, S, Michael, S, Varley, J, Easton, A, Themistocleous, A, John Dawes, Bennett, DL, Irani, A, Handel, AE, Irani, SR

“…The long-term clinical outcomes and associated prognostic factors in contactin-associated protein-like 2 (CASPR2)-antibody diseases are unknown. A total of 75 participants with CASPR2 antibodies were longitudinally assessed for disability, quality-of-life, and chronic pain. …”

Nationwide spatial epidemiological dataset of over 100,000 influenza-like illness notifications in Iran by county (2015–2019) by Sedghian, A, MohammadEbrahimi, S, Sartorius, B, Kiani, B

“…Objectives: This data note documents influenza-like illness (ILI) notifications in Iran by county from 2015 to 2019 as a pre-COVID-19 dataset, providing individual and spatial data for further comprehensive spatiotemporal analysis. …”

Development of superhydrophobic ceramic membrane decorated with flake-like structure by two-step synthesis for seawater desalination by membrane distillation by Omar, Najib Meftah Almukhtar, Othman, Mohd. Hafiz Dzarfan, Tai, Zhong Sheng, Puteh, Mohd. Hafiz, Wong, Keng Yinn, Tan, Huiyi, Tonni Agustiono Kurniawan, Tonni Agustiono Kurniawan, Ooi, Boon Seng, Nomura, Mikihiro, Iwamoto, Yuji

“…Significant findings: The results revealed that the MK-SS/4 h HFM, characterized by its flake-like structure, exhibited optimal superhydrophobic behavior. …”

晚明男色小说中的性别书写和意义 ：《宜春香质〉为例 = Gender writings and significance in late ming male erotic novels : a case study on Yi Chun Xiang Zhi by 王昀诗 Ong, Cheryl Yun Shi

“…The works of Zui Xi Hu Xin Yue Zhu Ren (醉西湖心月主人), namely Yi Chun Xiang Zhi, from the late-Ming era is one of the most significant illustrations of China’s male erotic novels. …”
Get full text

Deactivation of the parvalbumin-positive interneurons in the hippocampus after fear-like behaviour following electrical stimulation of the dorsolateral periaqueductal gray of rats by Temel, Yasin., Blokland, Arjan., Lim, Lee Wei.

“…In conclusion, our findings indicate that the inhibition of this subpopulation of hippocampal parvalbumin-positive interneurons induced a long lasting anxiety- or fear-like behaviour.…”
Get full text
Get full text

The political economy of oil and economic diversification: a neglected research field Robert Mabro would certainly like us to revive by Aissaoui, A

Modern Game Testing : Learn how to test games like a pro, optimize testing effort, and skyrocket your QA career / by Finska, Nikolina, author 656259

“…What you will learn Conduct compliance, regression, and localization tests, among others Build and optimize test sets for testing mobile games Find out how to set up an efficient bug flow Write optimal bug reports that differentiate between priority and severity Pick the optimal testing approach for each phase of game development Discover how to use equivalence partitioning, boundary analysis, and decision tables Master live ops QA and handle live bugs Who this book is for This book is for game testers, game producers, game developers, testing managers, and other QA professionals who want to learn more about modern approaches to QA and utilizing them to build more efficient and cost-effective QA teams and products. …”
Get full text
Get full text

Zeolitic imidazolate frameworks activate endosomal Toll-like receptors and potentiate immunogenicity of SARS-CoV-2 spike protein trimer by Alsaiari, Shahad K., Nadeef, Seba, Daristotle, John L., Rothwell, William, Du, Bujie, Garcia, Johnny, Zhang, Linzixuan, Sarmadi, Morteza, Forster, Timothy A., Menon, Nandita, Lin, Stacey Qiaohui, Tostanoski, Lisa H., Hachmann, Nicole, Wang, Erika Yan, Ventura, John D., Barouch, Dan H., Langer, Robert, Jaklenec, Ana

“…In this work, we report the Toll-like receptor agonist activity of a nanoscale adjuvant zeolitic imidazolate framework–8 (ZIF-8). …”
Get full text

Testosterone, sex hormone-binding globulin, insulin-like growth factor-1 and endometrial cancer risk: observational and Mendelian randomization analyses by Mullee, A, Dimou, N, Allen, N, O'Mara, T, Gunter, MJ, Murphy, N

“…<p><strong>Background</strong></p> Dysregulation of endocrine pathways related to steroid and growth hormones may modify endometrial cancer risk; however, prospective data on testosterone, sex hormone-binding globulin (SHBG) and insulin-like growth factor (IGF)−1 are limited. To elucidate the role of these hormones in endometrial cancer risk we conducted complementary observational and Mendelian randomization (MR) analyses. …”

Nanofiltration-like forward osmosis membranes with graphene oxide modified polymer-blended subtrate for aerobically-treated palm oil mill effluent treatment / by Wan Nur Ain Shuhada Abdullah, 1994-, author 655804, Lau, Woei Jye, 1983-, supervisor 483710, Farhana Aziz, supervisor 638316, Fakulti Kejuruteraan Kimia Dan Kejuruteraan Tenaga 599090

Nanofiltration-like forward osmosis membranes with graphene oxide modified polymer-blended subtrate for aerobically-treated palm oil mill effluent treatment / by Wan Nur Ain Shuhada Abdullah, 1994-, author 655804

Rapid and Scalable Production of Functional SARS-CoV-2 Virus-like Particles (VLPs) by a Stable HEK293 Cell Pool by Puarattana-aroonkorn, Sitthiphol, Tharakaraman, Kannan, Suriyawipada, Disapan, Ruchirawat, Mathuros, Fuangthong, Mayuree, Sasisekharan, Ram, Artpradit, Charlermchai

“…We employed the membrane, envelope, and highly immunogenic spike proteins of SARS-CoV-2 to produce virus-like particles (VLPs) using the HEK293-F cell line as a host system with an economical transfection reagent. …”
Get full text

Antigen presentation dynamics shape the antibody response to variants like SARS-CoV-2 Omicron after multiple vaccinations with the original strain by Yang, Leerang, Van Beek, Matthew, Wang, Zijun, Muecksch, Frauke, Canis, Marie, Hatziioannou, Theodora, Bieniasz, Paul D, Nussenzweig, Michel C, Chakraborty, Arup K

“…After the first dose, limited antigen availability in germinal centers (GCs) results in a response dominated by B cells that target immunodominant epitopes that are mutated in an Omicron-like variant. After the second dose, these memory cells expand and differentiate into plasma cells that secrete antibodies that are thus ineffective for such variants. …”
Get full text

One Plus One is More than Two: A Practical Combination of Power and Fault Analysis Attacks on PRESENT and PRESENT-Like Block Ciphers by Patranabis, Sikhar, Mukhopadhyay, Debdeep, Breier, Jakub, Bhasin, Shivam

“…Our attack sheds light on a hitherto unexplored vulnerability of PRESENT and PRESENT-like block ciphers that use bit-permutations instead of maximum distance separable (MDS) layers for diffusion.…”
Get full text
Get full text

Experimental medicine study with stabilised native-like HIV-1 Env immunogens drives long-term antibody responses, but lacks neutralising breadth by Pollock, K, Cheeseman, H, McFarlane, L, Day, S, Tolazzi, M, Turner, H, Joypooranachandran, J, Shramko, K, Dispinseri, S, Mundsperger, P, Bontjer, I, Lemm, N-M, Coelho, S, Tanaka, M, Cole, T, Korber, B, Katinger, D, Ward, A, Scarlatti, G, Sanders, R, Sattentau, Q, Shattock, R

“…<p><strong>Background:</strong> We report findings from an experimental medicine study of rationally designed prefusion stabilised native-like HIV envelope glycoprotein (Env) immunogens, representative of global circulating strains, delivered by sequential intramuscular injection.…”