The role of CD1a in dengue infection by Yang, J

“…To investigate the effect of dengue infection on the function of CD1a-reactive T cells, polyclonal blood T cells from patients and controls, and CD1a-autoreactive T cells clone/lines were utilised. The production of IFN-γ and GM-CSF by CD1a-autoreactive T cells was reduced when co-cultured with dengue-infected presenting cells. …”

Development of coherent detector technologies for sub-millimetre wave astronomy observations by Tan, B-K

“…</p> <p>Using the current 16-pixel 350 GHz SIS receiver, HARP-B, we have observed the ¹²CO J=3→2 emission lines from two nearby galaxies. An important result we found is that the ¹²CO J=3→2 correlates strongly with the 8 μm Polycyclic Aromatic Hydrocarbon emission.…”

Structure and inhibition of novel cyclin-dependent kinases by Dixon-Clarke, S

“…Preliminary trials using these relatively non-selective compounds to inhibit CDK16 in melanoma and medulloblastoma cancer cell lines revealed rebastinib as the more efficacious drug causing loss of cell proliferation in the 1-2 micromolar range. …”

Dwelling encounters: migration, diversity and ambivalence in an Istanbul neighborhood by Biehl, K

“…In this dissertation I apply a novel theoretical approach drawing on the concept of dwelling for understanding how residents of Kumkapı relate to their environment and make sense of it. I propose three lines of argument that unfold sequentially through the organizing structure of the thesis. …”

Nanoparticles enhanced laser-induced breakdown spectroscopy for characterisation and discrimination of gemstones by Al-Juboori, Haider, Haider, Zhaib, Hang, Wei, Roslan, Sufi

“…Results have shown a significant enhancement in spectral features, i.e., the emergence of several new spectral lines of major gemstone elements in the UV-Vis regions of the NELIBS spectra, while the CLIBS spectra were devoid of any meaningful spectral information. …”
Get full text

Current evidence and future direction on evaluating the anticancer effects of curcumin, gingerols, and shogaols in cervical cancer: a systematic review by Rahim, Unwaniah Abdull, Mustapa, Marami, Mohamed Shakrin, Nik Noorul Shakira, Nurdin, Armania, Mohamad Taridi, Nursiati, Mohd Yusof, Yasmin Anum, Mad Nordin, Mariam Firdhaus, Che Roos, Nur Aishah

“…Only studies investigating the effects of curcumin, gingerol, shogaol, and/ or their combination in human cervical cancer cell lines and/or rodent animal models implanted with cervical cancer xenografts were included. …”
Get full text

Synthetic, spectroscopic, biological and X-ray crystallographic structural studies on a novel pyridine-nitrogen-bridged dimeric nickel(II) complex of a pentadentate N3S2 ligand by Akbar Ali, Mohammad, Mirza, Aminul Huq, Butcher, Ray J., Tarafder, M.T.H.

“…The anticancer properties of these compounds were also evaluated against Human T-lymphoblastic leukaemia cell lines. The Schiff base exhibits marked cytotoxicity against these cells, but its nickel(II) complex is inactive.…”
Get full text

The identification of significant features towards travel mode choice and its prediction via optimised random forest classifier : An evaluation for active commuting behavior by Nur Fahriza, Mohd Ali, Ahmad Farhan, Mohd Sadullah, P.P. Abdul Majeed, Anwar, Mohd Azraai, Mohd Razman, Musa, Rabiu Muazu

“…Conclusions: The study has illustrated the efficacy of the optimised RF in predicting travel mode choice as well as identified the significant factors for the selection. The findings of the present study provide significant insight for policymakers to improve the performance of the public transportation system so that the users will benefit in terms of health and well-being from active commuting.…”
Get full text
Get full text

Increased consumption of unsaturated fatty acids improves body composition in a hypercholesterolemic Chinese population by Haldar, Sumanto, Ponnalagu, Shalini, Osman, Farhana, Tay, Shia Lyn, Wong, Long Hui, Jiang, Yuan Rong, Leow, Melvin Khee-Shing, Henry, Christiani Jeyakumar

“…Long-term studies are needed to confirm findings. This study had been registered on clinicaltrials.gov (Identifier No.: NCT03964857, https://www.clinicaltrials.gov/ct2/show/NCT03964857).…”
Get full text

Patient and Health Care Worker Perceptions of Communication and Ability to Identify Emotion When Wearing Standard and Transparent Masks by Chu, Jacqueline N., Collins, Joy E., Chen, Tina T., Chai, Peter R., Dadabhoy, Farah, Byrne, James D., Wentworth, Adam, DeAndrea-Lazarus, Ian A., Moreland, Christopher J., Wilson, Jaime A. B., Booth, Alicia, Ghenand, Omkar, Hur, Chin, Traverso, Giovanni

“…CONCLUSIONS AND RELEVANCE: The findings of this study suggest that transparent masks could help improve communication during the COVID-19 pandemic, particularly for individuals who are deaf and hard of hearing.…”
Get full text

Targeted hematopoietic stem cell depletion through SCF-blockade by Chan, Yan Y., Ho, Pui Y., Dib, Carla, Swartzrock, Leah, Rayburn, Maire, Willner, Hana, Ko, Ethan, Ho, Katie, Down, Julian D., Wilkinson, Adam C., Nakauchi, Hiro, Denis, Morgane, Cool, Taylor, Czechowicz, Agnieszka

“…This combination was the only non-genotoxic conditioning approach that enabled robust donor engraftment post HSCT in WT mice. Conclusion These findings shed new insights into the mechanism of αCD117 mAb-mediated HSC depletion. …”
Get full text

Exploring and Exploiting Ribonuclease 1: from Protein Biochemistry to Protein Engineering by Wralstad, Evans Christian

“…Sulfur–arene interactions appear to tune the reactivity of methionine residues in a manner consistent with rates of oxidation. These findings highlight an underappreciated role for methionine—to protect catalytic histidine residues—and indicate a means by which ptRNases remain functional in oxidatively challenging physiological environments. …”
Get full text
Get full text

Boon or bane? : The role of filial piety, relationship quality, caregiver gender on work-family interface among working caregivers of the elderly by Leong, Anthony Xueheng

“…This is the first study to examine the relationship between the multi-dimensional filial piety and the work-family interface among working caregivers of the elderly, with considerations of relationship quality and gender. Findings point to potential directions for future research and offer suggestions on how to aid working caregivers to optimize interactions between work and family domains. …”
Get full text

Metal-organic architectures driven by a multifunctional 6-aminouracil spacer : structures, noncovalent interactions, and conductivity by Purkayastha, Atanu, Dhar, Sourab, Mondal, Suvra Prakash, Franconetti, Antonio, Frontera, Antonio, Ganguly, Rakesh, Kirillov, Alexander M., Misra, Tarun Kumar

“…The computational study for molecular electrostatic potential (MEP) surface energies revealed an important finding, namely a decrease of the π-acidity of the uracil ring upon coordination and a consequent increase of the π-basicity of the phenyl-sulfonate ring, resulting in effective anti-parallel π–π stacking interactions in 1 and 2. …”
Get full text

Preliminary environmental risk consideration for small UAV ground risk mapping by Chung, Han Jie, Mohd Hasrizam Che Man, Sivakumar, Anush Kumar, Low, Kin Huat

“…The regions with high rainfall, increased bird population per site and strong signal interference can be extracted.These high-risk locations can be expected to be more hazardous for sUAVs to fly in. Findings for environmental risk-tiering and risk-mapping are preliminary and based on the available environmental data as identified in this study. …”
Get full text

Lactate cross-feeding between Bifidobacterium species and Megasphaera indica contributes to butyrate formation in the human colonic environment by Zhao, Sainan, Lau, Raymond, Zhong, Yang, Chen, Ming-Hsu

“…We concluded that lactate generated by Bifidobacterium through catabolizing xylose fueled the growth of M. indica and triggered the synthesis of butyrate. Our findings demonstrated a novel cross-feeding mechanism to generate butyrate in the human colon. …”
Get full text

Growth and physical properties of organic semiconducting single crystals by Tan, Ke Jie

“…Therefore, experimental studies aids in finding parameters responsible for the physical properties of materials. …”
Get full text

New multi-target based therapeutics against an opportunistic superbug by Premkumar, Jayaraman.

“…Additionally, expansion of the phytochemical-antibiotic interaction profiles were also carried out with various classes of antibiotics and phytochemicals to understand the interaction patterns by establishing a novel interaction network that provides a baseline to identify the mechanism of action of the phytochemicals and molecular mechanism of synergy. The above findings have potential implications in delaying the development of resistance as the antibacterial effect is achieved with lower concentrations of both drugs (antibiotics and phytochemicals). …”
Get full text

Improved life cycle assessment for desalination : handling the choices and uncertainties by Zhou, Jin

“…The system boundary and characterization approach was selected based on our previous findings. This work provided the environment profile of Singapore’s desalinations with improved reliability. …”
Get full text

Occurrence, human exposure and dynamics of phthalates in ACMV indoor environments : method development and field studies by Chen, Ailu

“…The increases are because of either resuspension of phthalates bound to settled dust or partitioning of gas-phase phthalates to the airborne particles. The findings also demonstrate that the gas fractions of the low-volatile phthalates decrease when the airborne particle concentrations increase.…”
Get full text