Functional characterisation of multiple sclerosis-­associated single nucleotide polymorphisms in the Eomesodermin region by Leach, O

“…Despite observing significant differences in expression between genotype groups in a pilot study, findings in a larger cohort did not reach the threshold for significance. …”

Industrial policy refraction: how corporate strategy shapes development outcomes in Brazil by Zylberberg, E

“…Refraction is not categorical, but a matter of degree. My findings are brought to bear on three traditionally disparate bodies of research –industrial policy, corporate strategy and institutional theory – extending each and also bringing them into fruitful communion with one another.…”

Pathway and network analysis of more than 2500 whole cancer genomes by Reyna, MA, Haan, D, Paczkowska, M, Verbeke, LPC, Vazquez, M, Kahraman, A, Pulido-Tamayo, S, Barenboim, J, Wadi, L, Dhingra, P, Shrestha, R, Getz, G, Lawrence, MS, Pedersen, JS, Rubin, MA, Wheeler, DA, Brunak, S, Izarzugaza, JMG, Khurana, E, Marchal, K, von Mering, C, Sahinalp, SC, Valencia, A, PCAWG Drivers and Functional Interpretation Working Group, Reimand, J, Stuart, JM, Raphael, BJ, PCAWG Consortium

“…Among these are promoter mutations associated with reduced mRNA expression in TP53, TLE4, and TCF4. We find that biological processes had variable proportions of coding and non-coding mutations, with chromatin remodeling and proliferation pathways altered primarily by coding mutations, while developmental pathways, including Wnt and Notch, altered by both coding and non-coding mutations. …”

The effects of angiotensin-receptor blockade on mood and vigilance behaviour in a gamified foraging task by Morse, L

“…Additionally, we replicated the finding that task environment impacts mood ratings and suggest this task may therefore be useful for investigating mood in future studies.…”

The anatomy of Westlothiana lizziae and a novel phylogenetic analysis of early amniotes by Igielman, B

“…Mine is the first analysis to include substantial, and near equal, representation of taxa typically considered both stem and crown amniotes. I find <em>Westlothiana</em> as the earliest diverging member of a monophyletic Lepospondyli, therefore occupying an important position at the divergence of amniotes and their closest relatives (diadectomorphs, captorhinids, protorothyrids) from other groups. …”

International healthcare workers’ experiences and perceptions of the 2022 multi-country mpox outbreak by Apea, V, Titanji, BK, Dakin, FH, Hayes, R, Smuk, M, Kawu, H, Waters, L, Levy, I, Kuritzkes, DR, Gandhi, M, Rockstroh, J, Schechter, M, Holt, M, Palich, R, Cortes, CP, Nozza, S, Mussini, C, Calmy, A, Crabtree-Ramirez, BE, Blanco, JL, Bhagani, S, Dewsnap, C, Orkin, C, On Behalf of the Mpox SHARE-NET Writing Group

“…Where offered, there were high levels of uptake across all regions. The findings highlight a critical need for addressing the profound gaps in HCW knowledge about re-emerging diseases with pandemic potential. …”

Participation and cooperation in global climate governance by Rowan, SS

“…Second, patterns of participation are associated with the ambition of countries’ greenhouse gas mitigation targets in the Paris Agreement. These findings help illuminate debates about how states use dense institutional environments, why states join institutions, and the depth of cooperation.…”

Quantitative optical probing of plasma accelerators by Kasim, MF

“…It is demonstrated that by running it and letting it learn laser-driven plasma wakefield parameters for a number of days, the software can find optimal parameters in a laser-plasma system without explicitly being taught.…”

Molecular and physiological consequences of prematurity and blood pressure elevation on the young adult left ventricular stress response by Huckstep, O

“…Collectively, these findings suggest preterm-born young adults have reduced myocardial functional reserve which likely contributes to risk of future disease including heart failure. …”

Quantum computing and quantum neural networks: their foundation, optimisation, and application by Pointing, J

“…We provide a mapping for this problem onto a quantum circuit and run simulator and hardware experiments to find solutions to small-scale instances of the problem, which is the first attempt to apply such quantum algorithms to this mining problem. …”

Techniques for analysis and integration of histology data and agent-based modelling of T cell-tumour interactions by Stephens, R

“…In the final part of the thesis we develop a new on-lattice ABM which builds on the findings of our first model, and use it to identify conditions under which spatial statistics enable us to make earlier and more accurate predictions of tumour responses to immunotherapy.…”

Oikeion, Agathon, and Archaia Phusis in Plato’s Symposium by Crüwell, HS

“…Rather, he unwittingly communicates central ethical and psychological ideas which we find developed in key passages of Plato’s dialogues. …”

A Dirichlet-multinomial mixed model for determining differential abundance of mutational signatures by Morrill Gavarró, L, Couturier, D, Markowetz, F

“…We apply our approach to characterise differences of mutational processes between clonal and subclonal mutations across 23 cancer types of the PCAWG cohort. We find ubiquitous differential abundance of clonal and subclonal signatures across cancer types, and higher dispersion of signatures in the subclonal group, indicating higher variability between patients at subclonal level, possibly due to the presence of different clones with distinct active mutational processes. …”

Accessibility, inclusivity, and implementation of COVID-19 clinical management guidelines early in the pandemic: a global survey by Pilbeam, C, Malden, D, Newell, K, Dagens, A, Kennon, K, Michelen, M, Gobat, N, Sigfrid, L

“…<br><strong> Conclusion: </strong>Our findings highlight important gaps in COVID-19 CMG development and implementation challenges during a pandemic, particularly affecting at-risk populations and lower resourced settings. …”

Performance and validation of a digital memory test across the Alzheimer’s disease continuum by Toniolo, S, Attaallah, B, Maio, MR, Tabi, YA, Slavkova, E, Klar, VS, Saleh, Y, Idris, MI, Turner, V, Preul, C, Srowig, A, Butler, C, Thompson, S, Manohar, SG, Finke, K, Husain, M

“…Memory imprecision was able to predict cognitive decline on standard cognitive tests over one year. Overall, these findings show how it might be possible to use a digital memory test in clinics and clinical trial contexts to stratify and track performance across the Alzheimer’s disease continuum.…”

Foreign language learning in the age of the internet: A comparison of informal acquirers and traditional classroom learners in central Brazil by Cole, J

“…The evidence suggests this type of motivation, significantly more associated with FASILs than CTLs, led users to engage deeply with the linguistic details of informal sources.</p> <p>The findings challenge dominant paradigms in several fields of SLA which prioritize expert regulation over independent discovery and controlled, collaborative environments over real-world contexts of use entered into for personal reasons.…”

Characterization of ubiquitin-activated DNA-protein crosslink repair in vitro by Zhu, X

“…</p> <p><strong><em>Conclusion:</em></strong> Our study has demonstrated that ubiquitination of the DPC substrates is a key pathway in regulating SPRTN activity. These findings will not only contribute to the understanding of the mechanisms by which SPRTN proteolysis in DPCs repair, but also provide a powerful <em>in vitro</em> approach for drug screening to develop new cancer treatment strategies.…”

Frailty, multimorbidity and polypharmacy: exploratory analyses of the effects of empagliflozin from the EMPA-KIDNEY trial by Mayne, KM, Sardell, R, Staplin, N, Judge, P, Zhu, D, Sammons, E, Wanner, C, Emberson, J, Preiss, D, Landray, M, Baigent, C, Haynes, R, Herrington, W

“…</p> <br> <p><strong>Conclusions:</strong> These findings support the use of SGLT2 inhibitors in CKD, irrespective of frailty, multimorbidity or polypharmacy.…”

Enhancing trauma triage in low-resource settings using machine learning: a performance comparison with the Kampala Trauma Score by Nsubuga, M, Kintu, TM, Please, H, Stewart, K, Navarro, SM

“…Conclusion: ML models demonstrated superior predictive capabilities over the KTS in predicting triage decisions, even when utilising a limited set of injury information about the patients. These findings suggest a promising opportunity to advance trauma care in LMICs by integrating ML into triage decision-making. …”

Structure of a fully assembled γδ T-cell antigen receptor by Gully, BS, Ferreira Fernandes, J, Gunasinghe, SD, Vuong, MT, Lui, Y, Rice, MT, Rashleigh, L, Lay, C-S, Littler, DR, Sharma, S, Santos, AM, Venugopal, H, Rossjohn, J, Davis, SJ

“…Reducing this conformational heterogeneity by transferring the V&delta;3V&gamma;8 TCR variable domains to an &alpha;&beta; TCR enhanced receptor signaling, suggesting that &gamma;&delta; TCR organization reflects a compromise between efficient signaling and the ability to engage structurally-diverse ligands. Our findings reveal the remarkable structural plasticity of the TCR on evolutionary timescales, and recast it as a highly versatile receptor capable of initiating signaling as either a rigid or flexible structure.…”