Foot care behaviours and associated factors among patients with type 2 diabetes: a cross-sectional study by Ang, Chin-Siang, Goh, Kelley Fann Ing, Lodh, Nandika, Qin, Vicky Mengqi, Liew, Huiling, Sidhu, Harvinder Raj Singh, Ng, Jun Jie, Subramaniam, Tavintharan, Tan, Elaine, Koh, Gerald Choon Huat, Best, James, Wong, Julian, Car, Josip, Ho, Andy Hau Yan, Venkataraman, Kavita

“…Additionally, more FC knowledge increased the likelihood by 20% (OR=1.21; 95% CI=1.10–1.33), and higher diabetes-related stress increased it by 1.03 times (OR=1.03; 95% CI=1.02–1.05). Conclusions: Our findings underscore the interplay of various factors influencing FC behaviours among individuals with diabetes and call for targeted interventions and tailored strategies to improve FC practices in this vulnerable population.…”
Get full text

Chronic oxidative stress promotes GADD34-mediated phosphorylation of the TAR DNA-binding protein TDP-43, a modification linked to neurodegeneration by Goh, Catherine Wenhui, Lee, Irene Chengjie, Sundaram, Jeyapriya Rajameenakshi, George, Simi Elizabeth, Yusoff, Permeen, Brush, Matthew Hayden, Sze, Newman Siu Kwan, Shenolikar, Shirish

“…Concomitant with TDP-43 aggregation and proteolysis after prolonged arsenite exposure, GADD34-bound CK1ϵ catalyzed TDP-43 phosphorylations at serines 409/410, which were diminished or absent in GADD34−/− cells. Our findings highlight that the phosphatase regulator, GADD34, also functions as a kinase scaffold in response to chronic oxidative stress and recruits CK1ϵ and oxidized TDP-43 to facilitate its phosphorylation, as seen in TDP-43 proteinopathies.…”
Get full text
Get full text

Augmented Object Intelligence with XR-Objects by Dogan, Mustafa Doga, Gonzalez, Eric, Ahuja, Karan, Du, Ruofei, Cola?o, Andrea, Lee, Johnny, Gonzalez-Franco, Mar, Kim, David

Get full text

Site-specific chemical and topological modifications to augment mRNA therapeutic potential by Aditham, Abhishek J.

“…We show that mocRNAs are subject to slower deadenylation and enhance therapeutic protein expression in cell lines and primary cell cultures. We expanded on this technology by creating mRNAs with chemically branched poly(A) tails, or multitail mRNAs, which increase the density of modifications at the 3’ end of mocRNA and further stabilize mRNA against deadenylation. …”
Get full text

Rhetorical contestation and the mediterranean migration crisis, 2013-2018 by He, Wendy Qingli

“…In addition, I argue that the securitization of the migration crisis is perpetuated by the EU and Italy’s use of complicity to construct a political narrative that blurs the lines of responsibility and culpability. By ascribing complicity to others using highly politicized rhetoric, the EU and Italy complicate the narrative of the migration crisis, making it more challenging to attribute responsibility to any one party. …”
Get full text

Engineering a surface to enhance endothelial cell adhesion towards creating a 'roll-up' blood vessel prosthesis by Chua, Hui Yee.

“…The optimized gelatin “ink” allowed extended viability for the entrapped HUVECs and the drawn scaffold lines to retain their integrity whilst in growth media. …”
Get full text

Impact of BREXIT on key stakeholders of the maritime industry in UK by Ching, Claudia Loke Wei

“…By and large, UK will generally experience detrimental effects in the near future, but the long term effects of BREXIT still awaits to be seen as UK seeks to establish new trade relations and construct necessary infrastructure in supporting the UK economy post-BREXIT. UK shipping lines and port operators are therefore recommended to look to alternative sources of labour to replace the productivity gap of the EU nationals in the worst case scenario of a hard BREXIT should restrictions in the free movement of labour occur after BREXIT. …”
Get full text

In vitro and in silico investigation of TRPC3 mechanism and dynamics by Collingridge, J

“…This work provides computational evidence for the ability of TRPC3 to form a widely conserved, mechanistically important π-helix structural component in the pore-lining S6 helix. This has not previously been reported for TRPC3, and simulations presented here suggest a role for the π-helix in promoting a transition towards an open state of the channel. …”

Psoriatic Arthritis Priority Setting Partnership: patient and clinician informed considerations for future UK health service delivery by James, L, Hailey, L, Bundy, C, Burstow, H, Chandler, D, Cowper, R, Helliwell, P, Joannes, L, Kelly, A, Kennedy, B, Kinsella, S, McAteer, H, Mukherjee, S, Packham, J, Wise, E, Young, H, Dures, E, Coates, LC

“…Further analysis within the rheumatology service theme revealed additional sub-themes that emphasised integrating multidisciplinary services, improving access to advice lines and ensuring fair access to treatments.</p> <br> <p><strong>Conclusion:</strong> The five key themes provide valuable insights into the important areas of interest within health service delivery in the UK. …”

Nebular dominated galaxies: insights into the stellar initial mass function at high redshift by Cameron, AJ, Katz, H, Witten, C, Saxena, A, Laporte, N, Bunker, A

“…In contrast, modelling the spectrum as primarily nebular provides a good fit to both the continuum and emission lines, motivating scenarios in which (a) we are observing only nebular emission or (b) the ionizing source is powering extreme nebular emission that outshines the stellar emission. …”

Investigating the contribution of the unfolded protein response to prostate cancer bone metastasis by Kaya, Z

“…Using paired androgen refractory cancer of the prostate (ARCaP) cell lines ARCaPE and ARCaPM which differ in their epithelial (E) and mesenchymal (M) characteristics, I found that components of IRE1 and ATF6 ER stress pathways are higher in ARCaPE cells than in ARCaPM and decreased upon osteogenic differentiation of ARCaPM cells. …”

Engineering control of rhizobacteria for plant growth promotion by Green, PWL

“…The rhizopine system was used to demonstrate tight transcriptional control of the NifA master transcriptional regulator of <em>nif</em> genes for nitrogen fixation <em>in vitro</em>, thereby developing a rhizopine responsive diazotrophic strain which can be assayed for plant growth promotion on rhizopine producing barley lines. To test the feasibility of controlled synthetic symbiosis in a nodule environment, rhizopine control of nitrogen fixation was assayed in the model symbiotic rhizobium <em>S. meliloti</em>. …”

Elevated reactive oxygen species can drive the alternative lengthening of telomeres pathway in ATRX-null cancers by Goncalves, T, Cunniffe, S, Ma, T, Mattis, N, Rose, A, Kent, T, Mole, D, Geiller, HB, van Bijsterveldt, L, Humphrey, T, Hammond, E, Gibbons, R, Clynes, D, Rose, A

“…We also demonstrate that elevation of ROS can trigger over-activity of the ALT pathway in osteosarcoma and glioma cell lines, resulting in excessive DNA damage and cell death. …”

Physical properties of keropok (fried crisps) in relation to the amylopectin content of the starch flours by Mohamed, Suhaila, Abdullah, Norakiah, Muthu, Mangayar Karasi

“…Linear expansion, oil absorption and elasticity were positively correlated to the total amylopectin content in the whole flour (r2 = 0.99, 0.97 and 0.97 respectively). The best fitted lines for prediction of linear expansion, oil absorption and elasticity of the fried crisps were 21y ≦ 0.35x ‐ 162, y=0.15x‐ 74 and y=0.0008x‐0.41 respectively, where x is the amylopectin content of the whole flour. …”

Potential biological control agents of Geosmithia morbida restrict fungal pathogen growth via mycoparasitism and antibiosis by Onufrak, Aaron J., Gazis, Romina, Gwinn, Kimberly, Klingeman, William, Khodaei, Sima, Perez Oñate, Luis I., Finnell, Autumn, Givens, Spencer, Chen, Cristine, Holdridge, David R., Hadziabdic, Denita

“…Additionally, one metabolite-producing Trichoderma isolate, TN4-47, completely inhibited the growth of all three G. morbida isolates across all tested metabolite concentrations and had comparatively greater tolerance to juglone compared to other Trichoderma isolates. Future lines of research should focus on characterizing the active antagonistic compound present in the metabolite filtrates, determine the mode of action of the active component(s), and elucidate how abiotic and biotic factors may influence the growth, persistence, and antagonistic activity of candidate biological control agents in planta.…”
Get full text

HiTrip: Historical trajectory interpolation for trawlers via deep learning on multi-source data by Zhao, Zhongning, Chen, Jiaxuan, Shi, Yuqi, Hong, Feng, Jiang, Guiyuan, Huang, Haiguang, Zhao, Jinhua

“…One inherent challenge for precise interpolation is the stark contrast between trawler movement patterns during steaming, characterized by straight lines, and fishing, which often involves consecutive turns. …”
Get full text

Rectified and Salt Concentration Dependent Wetting of Hydrophobic Nanopores by Polster, Jake W, Aydin, Fikret, de Souza, J Pedro, Bazant, Martin Z, Pham, Tuan Anh, Siwy, Zuzanna S

“…Nanopores lined with hydrophobic groups function as switches for water and all dissolved species, such that transport is allowed only when applying a sufficiently high transmembrane pressure difference or voltage. …”
Get full text

The capabilities of Multiclass Support Vector Machine (MSVM) training algorithms in grading agarwood essential oil by Anis Hazirah ‘Izzati H., Al-Hadi, Siti Mariatul Hazwa, Mohd Huzir, Nurlaila, Ismail, Zakiah, Mohd Yusoff, Saiful Nizam, Tajuddin, Mohd Nasir, Taib

“…The agarwood essential was graded into five grades (low, medium low, upper low, medium high, and high) and six grades (low, medium low, upper low, medium high, high, and upper high). The findings of this paper show the confusion matrix for five grades and six grades have no mismatch between actual and predicted data. …”
Get full text
Get full text

Experimental and Computational Advancements in Peptidomimetic Ligand Discovery by Lee, Michael Alan

“…At the same time, discovery tools for finding peptides that modify PPIs have evolved, including advances in affinity selection techniques and combinatorial chemistry. …”
Get full text
Get full text

Revealing Structural and Spin-state Dependent Reactivity of Single Atom Catalysts (SACs) with Systematically Improvable Computational Tools by Jia, Haojun (贾皓钧)

“…The ML models demonstrate superior accuracy in predicting reaction energetics compared to traditional scaling relationships. The findings validate codoping as a powerful strategy for tuning the properties of SACs to achieve enhanced ORR performance. …”
Get full text
Get full text