Regulation of the hif-1-dependent hypoxic stress response by C. elegans by Diehl, Calista Sorine

“…Secondly, we found that loss of the neprilysin metallopeptidase, nep-2, suppressed the egl-9 Egl phenotype through the degradation of multiple neuropeptides including the known NEP-2 target SNET-1. Our findings reveal two different pathways that function downstream of egl-9 to regulate aspects of the hypoxic stress response, both providing a new pathway with which to study the neuromuscular control of egg laying using NEP-2, and critically showing the integration of the evolutionarily conserved hypoxic-stress response and nonsense-mediated decay pathways.…”
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Mesoscale Brain Mapping: Bridging Scales and Modalities in Neuroimaging – A Symposium Review by Marchant, Joshua K., Ferris, Natalie G., Grass, Diana, Allen, Magdelena S., Gopalakrishnan, Vivek, Olchanyi, Mark, Sehgal, Devang, Sheft, Maxina, Strom, Amelia, Bilgic, Berkin, Edlow, Brian, Hillman, Elizabeth M. C., Juttukonda, Meher R., Lewis, Laura

“…Many CMM faculty presented or participated in a panel discussion, thus contributing to the dissemination of both the technologies they have developed under the auspices of the CMM and the findings they have obtained using those technologies. …”
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Visual Acuity Outcomes and Influencing Factors in a Cohort of UK Real-World Diabetic Macular Oedema Patients During the First Two Years of Anti-VEGF Treatment by Wen, Qing, Karcher, Helene, Wright, David M., Sinha, Samriddhi Buxy, Chakravarthy, Usha, Santos, Catarina, Igwe, Franklin, Salongcay, Recivall, Curran, Katie, Peto, Tunde

“…An elder age, a better baseline VA, low annual injection numbers (<5), and less frequent injection intervals (≥12 weeks) were negatively associated with ISVA success in the first two years. These findings have implications for managing patient expectations, allocating resources, and understanding DMO clinical management.…”
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Application of in vitro erythropoiesis from bone marrow derived progenitors to detect and study genotoxicity by Shuga, Joseph F. (Joseph Francis)

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Molecular insights into evolution, mutations and receptor-binding specificity of influenza A and B viruses from outpatients and hospitalized patients in Singapore by Ivan, Fransiskus Xaverius, Zhou, Xinrui, Lau, Suk Hiang, Rashid, Shamima, Teo, Jasmine S. M., Lee, Hong Kai, Koay, Evelyn S., Chan, Kwai Peng, Leo, Yee Sin, Chen, Mark I. Cheng, Kwoh, Chee Keong, Chow, Vincent T.

“…Conclusions: Overall, our findings extend our understanding of the molecular and structural evolution of influenza virus strains in Singapore within the global context of these dynamic viruses.…”
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Creative AI : a data-driven design approach for creative online ad optimisation using artificial intelligence and big data by Phay, Han

“…Performance data for the ads are presented, as well as a discussion on the implications of the findings, specifically on the positive potentials of data-driven design and the importance of ad agencies becoming like tech companies. …”
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Investigating the role of self-sacrificing prosociality in intragroup and intergroup contexts by Katna, Dashalini P.

“…Studies 4 to 6 integrated the findings into a serial mediational pathway from identity fusion to outgroup aggression, through self-sacrificial readiness and anticipations of outgroup hostility. …”
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Impact of hypertension on retinal capillary microvasculature using optical coherence tomographic angiography by Chua, Jacqueline, Chin, Calvin Woon Loong, Hong, Jimmy, Chee, Miao Li, Le, Thu-Thao, Ting, Daniel Shu Wei, Wong, Tien Yin, Schmetterer, Leopold

“…Conclusion: In adults with treated systemic hypertension, retinal capillary density reduced with higher BP and poorer eGFR. These findings highlight the potential role of OCT-A to study early microvascular changes because of systemic hypertension.…”
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Optical study of excitonic complexes in transition metal dichalcogenides monolayers by Bao, Di

“…By examining the valley Zeeman splitting of different excitonic features of the hBN-encapsulated WS2 and MoS2 monolayers, information regarding the band configuration and valley magnetic moment of the electrons and holes that form the excitonic states is revealed. Our findings presented in this thesis gain critical insights into the excitonic structures and many-body physics, leading towards a complete understanding of optical and electronic properties of TMDs monolayers.…”
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Genomic insights into Vibrio cholerae O1 responsible for cholera epidemics in Tanzania between 1993 and 2017 by Hounmanou, Yaovi Mahuton Gildas, Leekitcharoenphon, Pimlapas, Kudirkiene, Egle, Mdegela, Robinson H., Hendriksen, Rene S., Olsen, John Elmerdahl, Dalsgaard, Anders

“…Methodology / Principal findings: Genome-wide analysis was performed to characterize V. cholerae O1 responsible for the Tanzanian 2015-2017 outbreak along with strains causing outbreaks in the country for the past three decades. …”
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Research into the impacts of electronic road pricing and in-vehicle unit on commercial drivers' perception and behaviour by Ang, Shang Le

“…With the survey results and feedback from drivers, the report is able to give recommendations on how to improve the OBU design and enhance its user experience. Based on the findings of the study, commercial drivers are negative when it comes to Road Pricing Scheme (RPS) in Singapore. …”
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Structure-aware generation network for recipe generation from images by Wang, Hao, Lin, Guosheng, Hoi, Steven C. H., Miao, Chunyan

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Constructing 3D self-supporting surfaces with isotropic stress using 4D minimal hypersurfaces of revolution by Ma, Long, He, Ying, Sun, Qian, Zhou, Yuanfeng, Zhang, Caiming, Wang, Wenping

“…Armed with our theoretical findings, we develop an iterative algorithm to construct 3D self-supporting surfaces from triangle meshes. …”
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A hybrid bandit framework for diversified recommendation by Ding, Qinxu, Liu, Yong, Miao, Chunyan, Cheng, Fei, Tang, Haihong

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Speeding up deep neural network training with decoupled and analytic learning by Zhuang, Huiping

“…The first challenge lies in the difficulty of finding analytical solutions for multilayer networks. …”
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Strong edge stress in molecularly thin organic-inorganic hybrid ruddlesden-popper perovskites and modulations of their edge electronic properties by Kripalani, Devesh Raju, Cai, Yongqing, Lou, Jun, Zhou, Kun

“…Moreover, the desorption energy of the organic molecule can also be much lower at the free edges, making it easier for functionalization and/or substitution events to take place. The findings reported in this work elucidate the underlying mechanisms responsible for edge states in HRPPs and will be important in guiding the rational design and development of high-performance layer-edge devices. …”
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Noise matters in image restoration: from synthetic degradation to real-world challenges by Guo, Lanqing

“…Image restoration (IR) plays a crucial role in recovering high-quality image content from degraded observations, finding applications in surveillance, computational photography, and medical imaging. …”
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A generalised study of 3D confined jet at a wall by Lim, Raine Jia Ying

“…Additionally, the wall reflected water back onto the sediment bed, intensifying scour in this confined environment. The findings revealed an interesting observation regarding the influence of these two parameters: lateral distance of the jet exhibited minimal impact on the scour hole size. …”
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Air-cooled slag derived from municipal solid waste (MSW) and sewage sludge as coarse aggregate for sustainable construction by Tan, Jun Ying

“…In conclusion, this study advocates for the viability of sewage sludge slag as a substitute for gravel in coarse aggregate applications and MSW slag as a feasible alternative to sand for fine aggregate applications. These findings present a compelling case for a more environmentally sustainable approach to concrete production.…”
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The opioid receptor influences circadian rhythms in human keratinocytes through the β-arrestin pathway by Bigliardi, Paul, Junnarkar, Seetanshu, Markale, Chinmay, Lo, Sydney, Bigliardi, Elena, Kalyuzhny, Alex, Ong, Sheena, Dunn, Ray, Wahli, Walter, Bigliardi-Qi, Mei

“…Through the ChIP assay, we determined that Met-Enkephalin enhances β-arrestin-1 binding to acetylated H4 in the PER2 promoter. In summary, our findings suggest that DOPr activation leads to a phase shift in PER2 expression via β-arrestin-1-facilitated chromatin remodeling. …”
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