Autoimmune encephalitis by Irani, SR

“…In turn, these clinical features in combination with serologic findings and selective paraclinical testing, direct the rationale for the administration of immunotherapies. …”

Justice for strangers: culture and communication in the Singapore war crimes trials 1946-1948 by Ling, CW

“…<p>This study is organised around three questions: (a) How did the cultural difference between trial participants give rise to problems of language, participation, and argumentation; (b) How did judges respond to these problems and why did they choose to do so in particular ways; (c) What could have been done better in the Singapore Trials and what lessons do these trials hold for present-day war crimes trials. Among others, my findings confirm that participants need to share a certain amount of shared cultural knowledge for effective communication at trial. …”

The association between the proportion of Brexiters and COVID-19 death rates in England by Phalippou, L, Wu, B

“…Scientific prowess – such as finding effective vaccines – may not be sufficient to solve crises.…”

Cortical neurophysiology of ALS by Proudfoot, M

“…</p> <p>In conclusion, the results demonstrated considerable support for proposed excitotoxic disease mechanisms and were in alignment with reported findings in other neurodegenerative diseases. Finally, a pilot study by which the neural mechanisms for cognitive impairment in ALS are explored via antisaccade performance is described. …”

Energy waste: the challenge of decarbonising office buildings by Suliman, A, Wheeler, S, Topouzi, M, Lizana, J

“…These gaps are divided into three interventional areas: occupancy, thermal comfort, and building characteristics. The findings also demonstrate the opportunity to mitigate energy waste by integrating a better understanding of the occupancy patterns in spaces (1), real-time thermal comfort satisfaction of occupants (2), and the combination of lower centralised thermal requirements with individual environmental control systems (3). …”

Conservation planning in Europe: ecological, financial, and political challenges by Hannemann, H

“…</p> <p>Overall these findings significantly improve the understanding of conservation and resource management in Europe and fill a number of important knowledge gaps. …”

Diagnostic accuracy of point-of-care lung ultrasound for community-acquired pneumonia in children in ambulatory settings: a systematic review and meta-analysis by Hughes-Davies, H, Ukwatte, U, Roberts, N, Turner, PJ, Hayward, GN, Fanshawe, TR, Bird, C

“…</p> <p><strong>Results:&nbsp;</strong>The six studies included in this systematic review described point-of-care lung ultrasound performed primarily by paediatric emergency medicine clinicians on a total of 1099 paediatric patients, with a reference standard of chest radiography or chest radiography with clinical findings. The majority of included studies lacked clarity on training for the index test with potential bias around flow and timing of testing. …”

PRMT5 controls the innate immune response by Zhang, C

“…Although additional experiments are required to precisely identify the dsRNA-producing intronic regions, our results support the role of the PRMT5-E2F1 axis in modulating immune responses through the regulation of RNA splicing. The findings suggest that inhibiting PRMT5 may enhance the IFN response in cancer cells, potentially improving the efficacy of existing immunotherapies.…”

A realist evaluation to explain and understand the role of paramedics in primary care by Eaton, G, Wong, G, Tierney, S, Williams, V, Mahtani, KR

“…Results: The culmination of findings from each phase led to the development of a final programme theory, comprising of 50 context-mechanism-outcome configurations (CMOCs) encompassing three conceptual categories: Expectations associated with paramedics in primary care, the transition of paramedics into primary care roles, and the roles and responsibilities of paramedics in primary care. …”

DNA-damage orchestrates self-renewal and differentiation via reciprocal p53 family and Hippo/Wnt/TGF-β pathway activation in embryonic stem cells by Ye, Y, Xie, W, Wang, X, Tan, S, Yang, L, Ma, Z, Zhu, Z, Chen, X, Liu, X, O’Neill, E, Chang, L, Zhang, W

“…Here we show the impact of ionizing irradiation on the maintenance and early differentiation of mouse embryonic stem cells (ESCs). Our findings demonstrate that irradiation induces the upregulation of the p53 family genes, including p53, p63, and p73, resulting in elevated expression of the E3 ubiquitin ligases Itch and Trim32. …”

Numerical investigations of detonation reinitiation and failure modes from Mach reflection by Zhang, S, Lai, S, Tang, S, Yang, L, Qi, F, Fang, X

“…From different geometric parameters of the obstacle, we observe different detonation propagation modes after Mach reflection: detonation reinitiation characterized by the transverse detonation waves, decaying shock decoupled with flame, and inert shock with no ignition corresponding well to the experimental findings. Relying on the high resolution of the numerical simulations, we are able to obtain critical information about the detonation wave formation processes, and the corresponding detailed mechanisms are analyzed for various modes. …”

Resolution of proteotoxic stress in the endoplasmic reticulum by ubiquitin ligase complexes by Lari, F

“…To understand the contribution of ER E3s to cellular and organelle homeostasis, this study used mass spectrometry of purified E3 complexes to identify cofactors and build interaction networks of ER-resident E3s. These findings will form the foundation for investigating the biological roles of these ubiquitin ligases. …”

Iranian and Saudi mutual (mis)representations: a study of the relationship between discourses of othering, political confrontation and sectarian strife by Mohammad, T

“…Finally, by investigating three main Iranian and Saudi spheres/discourses, namely the political (speeches of the elite), religious (Friday prayer sermons) and media (newspaper editorials) discourses, this study will try to explain how <em>Othering</em> is understood and functions in the Iranian-Saudi discourse, its relationship to political rivalry and religious conflict and how they are understood as cases of political propaganda or religious polemics.</p> <p>The study findings identify a paradigm shift in analysis of the Saudi-Iranian relationship, moving away from conventional geopolitical and sectarian paradigms, which have been dominant. …”

Experience and perceptions of mental ill-health in people with epilepsy in rural Ethiopia: A qualitative study by Tsigebrhan, R, Newton, CR, Selamu, M, Hanlon, C

“…Participants sought to mitigate these interconnected psychosocial impacts through finding spiritual meaning in, or acceptance of, their experiences, drawing on family care and, for some, emotional support from health professionals. …”

A comparison of lesion mapping analyses based on CT versus MR imaging in stroke by Moore, MJ, Jenkinson, M, Griffanti, L, Huygelier, H, Gillebert, CR, Demeyere, N

“…<br> Overall, these results suggest that CT and MR-derived lesion-symptom mapping results do not reliably differ in accuracy. This finding is critically important as it suggests that future studies can employ CT-derived lesion masks if these scans are available within the appropriate time-window.…”

Characterisation of the genomes of brain metastases by Ulahannan, D

“…Although my sample size was modest the brain metastases had an increased number of copy number alterations in comparison to primary tumours. Furthermore, my findings suggest that chromothripsis may occur more frequently in brain metastases. …”

Community responses to a novel house design: A qualitative study of “Star Homes” in Mtwara, southeastern Tanzania by Mshamu, S, Meta, J, Adhikari, B, Halifa, S, Mmbando, A, Wood, HS, Wood, OS, Bøjstrup, TC, Day, NPJ, Lindsay, SW, Knudsen, J, Deen, J, Seidlein, LV, Pell, C

“…Star Homes residents described how the structures triggered praise but also envy from other community members. Conclusions: The findings highlight the need for close attention to the use of novel design houses and careful sensitization around the potential benefits of dwellings to ensure that the intended health impacts of interventions are achieved.…”

Mendelian Randomization analysis of the causal effect of cigarette smoking on hospital costs by Dixon, P, Sallis, H, Munafo, M, Davey Smith, G, Howe, L

“…</p> <br> <p><strong>CONCLUSIONS:</strong> Our findings have implications for the potential cost-effectiveness of smoking interventions.…”

Of blood and belonging: the practice of antiretroviral treatment among HIV-positive youth in South Africa's Eastern Cape by Vale, B

“…Data for this study was gathered through eight months of multi-method ethnographic fieldwork with 23 HIV-positive youth, their families, and local health workers.</p> <p>The findings elucidate adolescent ART as a complex (and often volatile) form of social incorporation, through which young people negotiate survival, care and moral connection in contemporary South Africa. …”

Risk factors for PTSD symptoms following PICU admission for childhood septic shock by Corbet Burcher, GJ, O’Dea, LA, Cooper, MK, Lancaster, R, McCutcheon, RA, Garralda, ME, Nadel, S

“…PTS symptoms in children who have survived septic shock are prevalent. These findings support a possible contribution of acute inflammatory changes, cumulative traumatic exposure, and female gender in post-PICU PTSD development.…”