The combined activation of KCa3.1 and inhibition of Kv11.1/hERG1 currents contribute to overcome Cisplatin resistance in colorectal cancer cells by Pillozzi, Serena, D'Amico, Massimo, Bartoli, Gianluca, Gasparoli, Luca, Petroni, Giulia, Crociani, Olivia, Marzo, Tiziano, Guerriero, Angela, Messori, Luigi, Severi, Mirko, Udisti, Roberto, Wulff, Heike, Chandy, Kanianthara George, Becchetti, Andrea, Arcangeli, Annarosa

“…Methods: The functional expression of Ca2+-activated (KCa3.1, also known as KCNN4) and voltage-dependent (Kv11.1, also known as KCNH2 or hERG1) K+ channels was determined in two CRC cell lines (HCT-116 and HCT-8) by molecular and electrophysiological techniques. …”
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Towards depth-resolved multi-cubic-centimeter field of view endoscopic camera for intraoperative nerve identification. by Yoon, Yong-Chul

“…In the second component of this thesis, we provide extensive theoretical and experimental studies on how optical amplifiers can be used in OCT to address sensitivity challenges of high-speed surgical OCT platforms like CL-OCT. Together, these lines of research define a new approach to meeting the need for OCT-based solutions for intraoperative nerve identification. …”
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P2P energy trading among isolated microgrids in the remote area by Huang, Rui

“…As for the power supply in remote areas, the traditional transmission method by using the central grid has the drawbacks of large transmission loss and long transmission lines, which are easy to be broken. At the same time, there are areas where electricity is not available because of costly transmission losses, for the transmission networks are not yet widespread. …”
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Induction of apoptosis and the signalling pathways involved by dillenia suffruticosa dichloromethane root extract in mcf-7 and mda-mb-231 breast cancer cells by Foo, Jhi Biau

“…DCMDS induced apoptosis and oxidative stress in these two cell lines. Treatment with α- tocopherol reduced the cytotoxicity of DCM-DS at 50 µg/mL in the cells, suggesting that DCM-DS induced lipid peroxidation to destroy the cancer cells. …”
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Detection and characterisation of a sixth Candida auris clade in Singapore: a genomic and phenotypic study by Suphavilai, Chayaporn, Ko, Karrie Kwan Ki, Lim, Kar Mun, Tan, Mei Gie, Boonsimma, Patipan, Chu, Joash Jun Keat, Goh, Sui Sin, Rajandran, Prevena, Lee, Lai Chee, Tan, Kwee Yuen, Bushra Binte Shaik Ismail, Aung, May Kyawt, Yang, Yong, Sim, Jean Xiang Ying, Venkatachalam, Indumathi, Cherng, Benjamin Pei Zhi, Spruijtenburg, Bram, Chan, Kian Sing, Oon, Lynette Lin Ean, Tan, Ai Ling, Tan, Yen Ee, Wijaya, Limin, Tan, Ban Hock, Ling, Moi Lin, Koh, Tse Hsien, Meis, Jacques F., Tsui, Clement Kin Ming, Nagarajan, Niranjan

“…We further implemented Bayesian logistic regression models to classify isolates into known clades and simulate the automatic detection of isolates belonging to novel clades as their WGS data became available. Findings: The three investigated isolates were separated by at least 37 000 SNPs (range 37 000–236 900) from all existing C auris clades. …”
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The prospective associations of 24-hour movement behaviors and domain-specific activities with executive function and academic achievement among school-aged children in Singapore by Padmapriya, Natarajan, Bernard, Jonathan Y., Tan, Sarah Yi Xuan, Chu, Anne H. Y., Goh, Claire Marie Jie Lin, Tan, Shuen Lin, Shek, Lynette P., Chong, Yap Seng, Tan, Kok Hian, Chan, Shiao-Yng, Yap, Fabian, Godfrey, Keith M., Lee, Yung Seng, Meaney, Michael J., Eriksson, Johan G., Tan, Chuen Seng, Law, Evelyn C., Müller-Riemenschneider, Falk

“…This study underscores the importance of participation in organized PA/sports, outdoor active play, and reading books, while ensuring adequate sleep and limiting screen viewing, to enhance cognitive outcomes. These findings underscore the need for further research into time-use trade-offs. …”
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Advanced attack and defense techniques in machine learning systems by Zhao, Mengchen

“…For multiple-credential scenarios, we formulate it as a bilevel optimization problem for finding the optimal defense strategy and then reduce it to a single level optimization problem called PEMS using complementary slackness conditions. …”
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Effectiveness of digital education on communication skills among medical students : systematic review and meta-analysis by the digital health education collaboration by Kyaw, Bhone Myint, Posadzki, Pawel, Paddock, Sophie, Car, Josip, Campbell, James, Car, Lorainne Tudor

“…For knowledge outcome, two studies comparing the effectiveness of blended online digital education and traditional learning reported no difference in postintervention knowledge scores between the groups (SMD=0.18; 95% CI: –0.2 to 0.55; I2=61%; N=2 studies [292 students]; small effect size; low-quality evidence). The findings on attitudes, satisfaction, and patient-related outcomes were limited or mixed. …”
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Brain computer interface for post-stroke motor rehabilitation by Mane, Ravikiran Tanaji

“…Future research can use the findings presented in this thesis to design robust and more accurate BCI systems for highly personalized and holistic post-stroke rehabilitation.…”
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Compositionally graded alloys fabricated using the laser powder bed fusion technique by Wei, Siyuan

“…On the basis of the findings, it is believed that such method can contribute greatly to the alloy designing and further development of AM.…”
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Scaling up parametric human recovery by Cai, Zhongang

“…This dataset is notable for its diversity in subjects, actions, and scenarios (which HuMMan lacks), obtained through gameplay with automatically annotated 3D ground truths. Our findings reveal that: 1) game-playing data is remarkably effective, 2) synthetic data provides essential supplements to real data, 3) the scale of the dataset is crucial, 4) strong supervision labels are key, and 5) synthetic data enhances the performance of larger models. …”
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Colloidal quantum dot light-emitting diode architectures for high performance by Leck, Kheng Swee

“…QD-LEDs have made great progress in terms of device performance over the years and there is room for further improvement. With all these findings and demonstrations in this thesis, we conclude that QD-LEDs hold great promise for potential applications in lighting and displays…”
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“British English is much more prestigious, everybody knows that!”: reproducing and resisting hegemonic language ideologies in Chilean English teacher education by Pérez Andrade, Gonzalo

“…Using Irvine and Gal’s (2009) framework of linguistic differentiation – iconisation, fractal recursivity and erasure – as an interpretive tool in the analysis of the interview data, I investigated the extent to which and how language ideologies regarding English operate in a group of Chilean ELT programmes. Findings from this study revealed the existence and promotion of opposing language ideologies that coexist within and across the teacher education programmes under scrutiny. …”
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Two-dimensional metal-organic frameworks for gas sensing by Lister, AM

“…This method successfully generates uniform distributions of the desired MOFs in situ on glass, gold, paper and cotton substrates, and is therefore anticipated to be a significant finding in the fields of wearable electronics, chemiresistive sensors and capacitor devices.…”

The limits of liberalization: WTO entry and Chinese state-owned firms by Tan, Y, Davis, CL

“…However, where strategic goods targeted by industrial policy hold a large share of bilateral trade, lowering tariffs has no impact on SOE trade. These findings highlight the tensions between state-led economic models and global trade law premised upon market principles.…”

Effects of nnav1.5 expression modulation on mhc I antigen processing machinery and invasion potential of breast cancer cells by Din, Ahmad Hafiz Murtadha Noor

“…Overall, the study’s current findings support the influence of nNav1.5 on the expression regulation of immune component molecules in breast cancer.…”
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Development of an application to improve mental health (A) by Khor, Chin Yi

“…As the mental health concern grew, most countries developed new mental health information and phone support lines, offering tips to the public on coping measures. …”
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Grid optimization and demand side mangement for electric vehicles penetration in remote area by Zhang, Yixiao, Ng, Eddie Yin Kwee, Li, Ning

“…Power grid model simulation: use government data to predict that Trincomalee's electricity demand will increase from the current 40MW to 640MW in five years and build a grid simulation model for Sri Lanka's national high-voltage transmission lines. Optimization will target transmission cables that provide higher voltage loads while considering cable properties includes resistance and reactance for optimal power loss and voltage drop respectively, thermal capacity, and power quality. …”
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杜牧“‘秋’意象诗”研究 = Research on Du Mu’s autumn imagery poems by 林宛仪 Lim, Wan Yi

“…Close reading will be used to uncover the emotions between the lines in Du Mu’s poems that may contain feelings other than grief. …”
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Climate change: crop performance and potential by Ramlan, Mohd Fauzi

“…In addition, a biological control using other species of bamboo to reduce the domination of buluh semantan under high voltage transmission lines is also included. In the studies regarding growth of forest species meant for domestication purposes, the suitability of Syzygium campanulatum and Hopea odorata for beautification and landscaping plants has shown some potential. …”
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